JP6920343B2 - コンパニオンアニマルにおける心臓保護のための栄養組成物 - Google Patents
コンパニオンアニマルにおける心臓保護のための栄養組成物 Download PDFInfo
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- JP6920343B2 JP6920343B2 JP2018554553A JP2018554553A JP6920343B2 JP 6920343 B2 JP6920343 B2 JP 6920343B2 JP 2018554553 A JP2018554553 A JP 2018554553A JP 2018554553 A JP2018554553 A JP 2018554553A JP 6920343 B2 JP6920343 B2 JP 6920343B2
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Description
[0001]本出願は、2016年5月20日に出願された米国仮出願第62/339,436号の優先権を主張するものであり、その開示の全容が参照により本明細書に組み込まれる。
[0029]
[0031]以下、いくつかの定義を示す。しかしながら定義が以下の「実施形態」の項にある場合もあり、上記の見出し「定義」は、「実施形態」の項におけるそのような開示が定義ではないことを意味するものではない。
[0043]本開示の一態様は、変性性僧帽弁疾患(DMVD)のコンパニオンアニマルにおいて、DMVDを治療する方法である。本開示の別の態様は、DMVDの危険性があるコンパニオンアニマルにおいてDMVDを予防する方法である。本開示の更に別の態様は、コンパニオンアニマルにおける心臓の健康を維持又は改善する方法である。
[0061]19匹の健康なイヌ及び21匹の心雑音があるイヌを選び、6ケ月にわたって試験した。認定心臓専門獣医が心エコー検査を用いて全てのイヌを診断し、健康であるか、又は早期段階の変性性僧帽弁疾患(DMVD)であるかのいずれかとして確認した。各群内のイヌを、年齢、性別、品種、体重、及び心雑音の悪性度によって、2つの食餌治療群に無作為に割り付けた。対照食は、Nestle Purina PetCare Company製であり、完全でバランスのとれた栄養を提供し、米国飼料検査官協会(AAFCO)により規定された要件に合致するか、又はそれをしのぐものである。実験食は、対照食における全ての成分を、以下の追加成分と共に含有するものとした。追加成分は、5.000重量%の量の中鎖トリグリセリド(MCT)、0.7489重量%の量のω−3脂肪酸、2.3000重量%の量のリジン、2.1000重量%の量のメチオニン及びシステイン、0.1500重量%の量の硫酸マグネシウム、0.9206IU/gの量のビタミンE、並びに0.2162重量%の量のタウリンとした。DMVD群においては、イヌを、対照食群では10匹、及び実験食群では11匹とした一方、健康な群においては、対照食群では9匹、及び実験食群では10匹とした。
[0066]7匹のビーグル犬及び1匹のミニチュアシュナウザーの全てを、認定心臓専門獣医が変性性僧帽弁疾患(DMVD)について心エコー検査を用いて診断及び分類し、研究のために選別した。イヌを、無作為抽出により2つの食餌治療群に割り付けた。対照食は、Nestle Purina PetCare Company製であり、完全でバランスのとれた栄養を提供し、米国飼料検査官協会(AAFCO)により規定された要件に合致するか、又はそれをしのぐものである。実験食は、7%の中鎖トリグリセリド(MCT)を追加したことを除き対照食と同じ成分を含有するものとした。食餌は、等カロリーかつ等窒素分としている。食餌を表1に示す。
Claims (16)
- 変性性僧帽弁疾患(DMVD)を治療する必要があるコンパニオンアニマルにおいて、前記疾患を治療する方法であって、治療有効量の中鎖トリグリセリドを含む組成物を、前記コンパニオンアニマルに経口摂取させること、を含み、
前記中鎖トリグリセリドが、カプロン酸、カプリル酸、カプリン酸、及びラウリン酸からなる群から選択される中鎖脂肪酸を含む、方法。 - 前記組成物が、ω−3脂肪酸、ビタミンE、マグネシウム、タウリン、リジン、硫黄含有アミノ酸、及びこれらの混合物からなる群から選択される成分を更に含む、請求項1に記載の方法。
- 前記ω−3脂肪酸が、エイコサペンタエン酸(EPA)、ドコサヘキサエン酸(DHA)、及びこれらの混合物からなる群から選択される、請求項2に記載の方法。
- 前記硫黄含有アミノ酸が、メチオニン、システイン、ホモシステイン、タウリン、及びこれらの混合物からなる群から選択される、請求項2に記載の方法。
- 前記中鎖トリグリセリドが、前記組成物の0.5重量%〜60重量%である、請求項1に記載の方法。
- 前記中鎖トリグリセリドが、カプリル酸、カプリン酸、及びこれらの混合物からなる群から選択される中鎖脂肪酸を含む、請求項1に記載の方法。
- 前記組成物が、カルニチン、リジン及びメチオニン、グルタチオン、並びにこれらの混合物からなる群から選択される成分を更に含む、請求項1に記載の方法。
- 前記組成物が、(i)カリウムのナトリウムに対する比が4:1〜1:1、(ii)マグネシウムの量が0.08重量%〜0.25重量%、(iii)タンパク質の量が少なくとも20重量%、及び(iv)これらの組み合わせからなる群から選択される特性を有する、請求項1に記載の方法。
- 前記組成物を、前記コンパニオンアニマルに、少なくとも1週間にわたり毎日摂取させる、請求項1に記載の方法。
- 前記組成物を摂取させるのが、1日あたり、前記コンパニオンアニマルの体重1kgあたり0.001g〜50.0gの前記中鎖トリグリセリドを提供する量である、請求項1に記載の方法。
- 前記コンパニオンアニマルが、イヌ科の動物である、請求項1に記載の方法。
- 変性性僧帽弁疾患(DMVD)の危険性があるコンパニオンアニマルにおいて、前記疾患を予防する方法であって、予防量の中鎖トリグリセリドを含む組成物を、前記コンパニオンアニマルに経口摂取させること、を含み、
前記中鎖トリグリセリドが、カプロン酸、カプリル酸、カプリン酸、及びラウリン酸からなる群から選択される中鎖脂肪酸を含む、方法。 - 前記中鎖トリグリセリドが、前記組成物の0.5重量%〜60重量%である、請求項12に記載の方法。
- 前記組成物が、ω−3脂肪酸、ビタミンE、マグネシウム、タウリン、リジン、硫黄含有アミノ酸、及びこれらの混合物からなる群から選択される成分を更に含む、請求項12に記載の方法。
- 前記組成物を前記コンパニオンアニマルに摂取させる前に、前記コンパニオンアニマルをDMVDの危険性があるものとして特定すること、を含む、請求項12に記載の方法。
- 前記特定することが、(i)前記コンパニオンアニマルにおけるN−末端プロB型ナトリウム利尿ペプチドの濃度を測定するステップ、(ii)前記コンパニオンアニマルにおける心臓肥大を検知するステップ、(iii)前記コンパニオンアニマルにおける心雑音を検知するステップ、(iv)前記コンパニオンアニマルにおける、咳き込み、運動不耐性、食欲減退、呼吸困難、又は血圧低下によって起きた一時的意識喪失のうちの1つ以上の履歴を特定するステップ、(v)前記コンパニオンアニマルを小型種として特定するステップ、(vi)僧帽弁逆流を検知するステップ、(vii)セロトニン、形質転換成長因子β、又は一酸化窒素シグナル伝達経路の変化を測定するステップ、(viii)長鎖脂肪酸のβ酸化の不全、分枝鎖脂肪酸のα酸化の不全、ケトン分解の不全、又はグルコース摂取及び解糖の増大をはじめとするエネルギー代謝の変化を測定するステップ、並びに(ix)これらの組み合わせからなる群から選択されるステップ、を含む、請求項15に記載の方法。
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PCT/IB2017/052981 WO2017199223A1 (en) | 2016-05-20 | 2017-05-19 | Nutritional compositions for cardciac protection in companion animals |
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EP3630088B1 (en) | 2017-05-29 | 2023-07-12 | Société des Produits Nestlé S.A. | Medium chain fatty acids for use in the prevention or treatment of valvular heart disease |
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JP2022524491A (ja) * | 2019-03-22 | 2022-05-06 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 中鎖トリグリセリド(mct)からのケトン産生を増加させるために食前にmctの投与を用いる方法 |
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JP2005047851A (ja) * | 2003-07-29 | 2005-02-24 | Nisshin Pharma Inc | ユビデカレノン含有組成物 |
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US9596870B2 (en) * | 2013-06-28 | 2017-03-21 | Nestec Sa | Compositions and methods for enhancing exercise performance |
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EP3458046B1 (en) | 2021-01-13 |
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PL3458046T3 (pl) | 2021-07-05 |
BR112018072064A2 (pt) | 2019-02-12 |
US20170332686A1 (en) | 2017-11-23 |
CN109069465A (zh) | 2018-12-21 |
CA3021169A1 (en) | 2017-11-23 |
RU2018145067A3 (ja) | 2020-09-11 |
CN109069465B (zh) | 2021-08-17 |
EP3458046A1 (en) | 2019-03-27 |
BR112018072064B8 (pt) | 2022-08-23 |
MX2018014083A (es) | 2019-04-04 |
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