JP6918827B2 - 新規なｎ−［（ピリジルオキシ）プロパニル］ベンズアミド - Google Patents
新規なｎ−［（ピリジルオキシ）プロパニル］ベンズアミド Download PDFInfo
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- JP6918827B2 JP6918827B2 JP2018554080A JP2018554080A JP6918827B2 JP 6918827 B2 JP6918827 B2 JP 6918827B2 JP 2018554080 A JP2018554080 A JP 2018554080A JP 2018554080 A JP2018554080 A JP 2018554080A JP 6918827 B2 JP6918827 B2 JP 6918827B2
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- WIHTZNYDEPXHMQ-ZETCQYMHSA-N CCN[C@@H](C)COc1ncc(C(F)(F)F)cc1F Chemical compound CCN[C@@H](C)COc1ncc(C(F)(F)F)cc1F WIHTZNYDEPXHMQ-ZETCQYMHSA-N 0.000 description 1
- JRHPOFJADXHYBR-UHFFFAOYSA-N CNC(CCCC1)C1NC Chemical compound CNC(CCCC1)C1NC JRHPOFJADXHYBR-UHFFFAOYSA-N 0.000 description 1
- NORJRQVQTYNLAO-UHFFFAOYSA-N Nc(c(F)cc(F)c1)c1C(O)=O Chemical compound Nc(c(F)cc(F)c1)c1C(O)=O NORJRQVQTYNLAO-UHFFFAOYSA-N 0.000 description 1
- VSQRNJJXFKBXGV-UHFFFAOYSA-N OC(c(ccc(F)c1F)c1-[n]1nccn1)=O Chemical compound OC(c(ccc(F)c1F)c1-[n]1nccn1)=O VSQRNJJXFKBXGV-UHFFFAOYSA-N 0.000 description 1
- SPVFFPDJYPMULI-UHFFFAOYSA-N OC(c(ccc(F)c1F)c1Br)=O Chemical compound OC(c(ccc(F)c1F)c1Br)=O SPVFFPDJYPMULI-UHFFFAOYSA-N 0.000 description 1
- MQJOFVNKPFELDT-UHFFFAOYSA-N OC(c1cc(F)cc(F)c1-[n]1nccn1)=O Chemical compound OC(c1cc(F)cc(F)c1-[n]1nccn1)=O MQJOFVNKPFELDT-UHFFFAOYSA-N 0.000 description 1
- UWTIWSCJIVFCKE-UHFFFAOYSA-N OC(c1cc(F)cc(F)c1I)=O Chemical compound OC(c1cc(F)cc(F)c1I)=O UWTIWSCJIVFCKE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16165529 | 2016-04-15 | ||
| EP16165529.5 | 2016-04-15 | ||
| PCT/EP2017/058315 WO2017178340A1 (en) | 2016-04-15 | 2017-04-07 | Novel n-[(pyridyloxy)propanyl]benzamides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019511548A JP2019511548A (ja) | 2019-04-25 |
| JP2019511548A5 JP2019511548A5 (enExample) | 2021-05-20 |
| JP6918827B2 true JP6918827B2 (ja) | 2021-08-11 |
Family
ID=55755463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554080A Active JP6918827B2 (ja) | 2016-04-15 | 2017-04-07 | 新規なｎ−［（ピリジルオキシ）プロパニル］ベンズアミド |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10787432B2 (enExample) |
| EP (1) | EP3442958B1 (enExample) |
| JP (1) | JP6918827B2 (enExample) |
| WO (1) | WO2017178340A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6643501B2 (ja) * | 2016-04-15 | 2020-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なｎ−［（ピラジニルオキシ）プロパニル］ベンズアミド |
| WO2017178344A1 (en) | 2016-04-15 | 2017-10-19 | Boehringer Ingelheim International Gmbh | Novel n-[(heteroaryloxy)propanyl]heteroaryl carboxamides |
| US10710984B2 (en) | 2016-04-15 | 2020-07-14 | Boehringer Ingelheim International Gmbh | N-[(Pyrimidinylamino)propanyl]-and N-[(Pyridinylamino)-propanyl]arylcarboxamides |
| JP6591698B2 (ja) * | 2016-04-15 | 2019-10-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なｎ−［（ピリミジニルアミノ）プロパニル］−およびｎ−［（ピラジニルアミノ）プロパニル］アリールカルボキサミド |
| WO2017178340A1 (en) | 2016-04-15 | 2017-10-19 | Boehringer Ingelheim International Gmbh | Novel n-[(pyridyloxy)propanyl]benzamides |
| WO2017178338A1 (en) | 2016-04-15 | 2017-10-19 | Boehringer Ingelheim International Gmbh | Novel n-[(pyrimidinyloxy)propanyl]benzamides |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130341D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| WO2009011775A1 (en) | 2007-07-13 | 2009-01-22 | Merck & Co., Inc. | Amidoethyl alkylamino orexin receptor antagonists |
| KR20150023390A (ko) | 2012-06-15 | 2015-03-05 | 다이쇼 세이야꾸 가부시끼가이샤 | 분지쇄 알킬 헤테로 방향환 유도체 |
| JP2016028017A (ja) | 2012-12-13 | 2016-02-25 | 大正製薬株式会社 | フッ素置換ピペリジン化合物 |
| JP2017100950A (ja) | 2014-04-04 | 2017-06-08 | 大正製薬株式会社 | オキソ複素環誘導体 |
| GB201415569D0 (en) * | 2014-09-03 | 2014-10-15 | C4X Discovery Ltd | Therapeutic Compounds |
| JP6643501B2 (ja) * | 2016-04-15 | 2020-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なｎ−［（ピラジニルオキシ）プロパニル］ベンズアミド |
| WO2017178344A1 (en) | 2016-04-15 | 2017-10-19 | Boehringer Ingelheim International Gmbh | Novel n-[(heteroaryloxy)propanyl]heteroaryl carboxamides |
| US10710984B2 (en) * | 2016-04-15 | 2020-07-14 | Boehringer Ingelheim International Gmbh | N-[(Pyrimidinylamino)propanyl]-and N-[(Pyridinylamino)-propanyl]arylcarboxamides |
| JP6591698B2 (ja) | 2016-04-15 | 2019-10-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なｎ−［（ピリミジニルアミノ）プロパニル］−およびｎ−［（ピラジニルアミノ）プロパニル］アリールカルボキサミド |
| WO2017178340A1 (en) | 2016-04-15 | 2017-10-19 | Boehringer Ingelheim International Gmbh | Novel n-[(pyridyloxy)propanyl]benzamides |
| WO2017178338A1 (en) | 2016-04-15 | 2017-10-19 | Boehringer Ingelheim International Gmbh | Novel n-[(pyrimidinyloxy)propanyl]benzamides |
-
2017
- 2017-04-07 WO PCT/EP2017/058315 patent/WO2017178340A1/en not_active Ceased
- 2017-04-07 JP JP2018554080A patent/JP6918827B2/ja active Active
- 2017-04-07 EP EP17715182.6A patent/EP3442958B1/en active Active
- 2017-04-07 US US16/090,343 patent/US10787432B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017178340A1 (en) | 2017-10-19 |
| EP3442958B1 (en) | 2020-05-06 |
| US20190112291A1 (en) | 2019-04-18 |
| US10787432B2 (en) | 2020-09-29 |
| EP3442958A1 (en) | 2019-02-20 |
| JP2019511548A (ja) | 2019-04-25 |
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