JP6911187B1 - Hair restorer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a hair growth agent having a hair growth effect and having a good usability. SOLUTION: This hair restorer is a hair restorer containing a particulate matter, and the particulate matter is formed on core magnetic fine particles coated with silicon oxide so as to cover the surface of the magnetic fine particles. The active ingredient layer containing the active ingredient of the hair restorer and the water-soluble polymer layer containing the water-soluble polymer formed so as to cover the active ingredient layer are coated, and the water-soluble polymer is 2-. Includes methacryloyloxyethyl phosphorylcholine / stearyl methacrylate copolymer. [Selection diagram] Fig. 4

Description

The present invention relates to a hair restorer, and more particularly to a hair restorer composed of a particulate matter having nano-sized magnetic fine particles as nuclei and the magnetic fine particles coated with an active ingredient.

After the active ingredient contained in a normal hair restorer is applied directly to the scalp, it is difficult to effectively penetrate the inside of the scalp, and it is difficult to exert the effect. Therefore, the development of a hair restorer having high permeability that can penetrate into the scalp is an important issue. Patent Document 1 discloses a hair-growth agent in which the surface of magnetic fine particles is coated with hydrophilic lecithin, and the hair-growth active ingredient and LIPIDURE (registered trademark) -NR are coated in this order.

Japanese Patent No. 5549034

As a result of diligent studies by the present inventor, the particulate matter contained in the hair restorer disclosed in Patent Document 1 has a zeta potential close to zero, so that the particulate matter has a weak repulsive force against each other and aggregates. It turned out to be easy. The agglomerated particulate matter is too large to penetrate into the scalp, and the hair growth effect may not be sufficiently exerted. Further, in the hair restorer disclosed in Patent Document 1, since lecithin has a high viscosity, the hair and scalp may become sticky at the time of use, and the feeling of use may be deteriorated. The technique described in Patent Document 1 still has room for improvement in these respects.

Therefore, an object of the present disclosure is to provide a hair-growth agent having a hair-growth effect and a good usability.

The hair-growth agent according to the present invention is a hair-growth agent containing a particulate matter, and the particulate matter is formed into core magnetite fine particles coated with silicon oxide so as to cover the surface of the magnetic fine particles. In addition, an active ingredient layer containing the active ingredient of the hair restorer and a water-soluble polymer layer containing a water-soluble polymer formed so as to cover the active ingredient layer are coated, and the water-soluble polymer is 2-methacryloyl. It is characterized by containing an oxyethylphosphorylcholine / stearyl methacrylate copolymer.

According to the hair-growth agent according to the present invention, an excellent hair-growth effect can be obtained while obtaining a good feeling of use.

It is a figure which shows the measurement result of the zeta potential of the particulate matter contained in the hair restorer of an Example. It is a figure which shows the measurement result of the zeta potential of the particulate matter contained in the hair restorer of Comparative Example 1. FIG. It is a figure which shows an example of the back photograph of the mouse in the hair-growth agent application of Example, the hair-growth agent application of Comparative Example 1, the hair-growth agent application of Comparative Example 2, and the application of purified water. 28 days after the start of evaluation of the hair growth agent application of Examples, the hair growth agent application of Comparative Example 1, the hair growth agent application of Comparative Example 2, and the application of purified water, the results of observing the vicinity of the hair bulb of the back hair of the mouse with a digital microscope. It is a figure which shows. It is a figure which shows an example of the back photograph of a mouse in the hair-growth agent application of Example, the hair-growth agent application of Comparative Example 3, and the purification water application. It is a figure which shows the result of having observed the vicinity of the hair bulb of the back hair of a mouse with a digital microscope 14 days after the start of evaluation of the hair growth agent application of Example, the hair growth agent application of Comparative Example 3, and the purification water application. It is a figure which shows the state after holding the hair-growth agent of Example, Comparative Example 4, Comparative Example 5, and Comparative Example 6 at room temperature for 5 months.

Hereinafter, the hair restorer according to the present invention will be described in detail. The embodiments described below are merely examples, and the present invention is not limited to these embodiments.

The hair restorer according to the present invention contains a nano-sized particulate matter. Here, the nano-sized particulate matter in the present specification is a particulate matter having a diameter of several nm to several tens of nm. The diameter of the particulate matter can be observed by, for example, a method such as a transmission electron microscope.

As will be described later, the particulate matter is coated with an active ingredient related to hair growth (hereinafter referred to as an active ingredient), and is a main component for exhibiting a hair growth effect. Since the particulate matter is sufficiently small as described above, it can penetrate into the scalp without being hindered by sebum and the like accumulated in the scalp, and the active ingredient can reach the dermal papilla cells.

The particulate substance covers the active ingredient layer containing the active ingredient of the hair restorer, which is formed so as to cover the surface of the magnetic fine particles, which is the core of the magnetic fine particles coated with silicon oxide on the surface, and the active ingredient layer. The water-soluble polymer layer containing the water-soluble polymer formed in is coated, and the water-soluble polymer contains a 2-methacryloyloxyethyl phosphorylcholine / stearyl methacrylate copolymer. According to the hair restorer containing this particulate matter, an excellent hair growth effect can be obtained while obtaining a good feeling of use.

Hereinafter, each component contained in the hair restorer, particularly particulate matter, will be described in detail.

<Particulate matter>
The particulate matter is formed so as to cover the magnetite fine particles whose surface is coated with silicon oxide (hereinafter referred to as SiO _2- coated magnetite fine particles), the active ingredient layer formed so as to cover the surface of the magnetite fine particles, and the active ingredient layer. Includes a water-soluble polymer layer. Hereinafter, the magnetite fine particles, the active ingredient layer, and the water-soluble polymer layer will be described.

[SiO _2- coated magnetite fine particles]
Magnetite fine particles are the core components of particulate matter, and are nano-sized fine particles having a diameter of several nm to several tens of nm. The composition of the magnetite fine particles is Fe ₃ O ₄ , and contains divalent Fe ions and trivalent Fe ions. The magnetite fine particles can be produced, for example, by crushing a magnetite mass produced by the coprecipitation method.

The SiO _2- coated magnetite fine particles are fine particles in which the surface of the magnetite fine particles is coated with _{silicon oxide (SiO 2).} Like the magnetite fine particles, the SiO _2- coated magnetite fine particles are nano-sized fine particles having a diameter of several nm to several tens of nm. The diameters of the magnetite fine particles and the SiO _2- coated magnetite fine particles can be measured by, for example, a dynamic scattering method. The SiO ₂ coating makes the surface of the magnetite fine particles hydrophilic, making it easier to coat the active ingredient layer. In addition, since the viscosity of the hair restorer does not increase, the feeling of use of the hair restorer is improved as compared with the one containing lecithin.

For the SiO ₂ coat, for example, a slurry in which magnesium fine particles are dispersed in ion-exchanged water is prepared, and 50 parts by mass to 500 parts by mass of an aqueous sodium silicate solution is added dropwise to 100 parts by mass of the slurry. Then, it can be produced by adding hydrochloric acid to neutralize the slurry until the pH reaches 7. Here, the concentration of the sodium silicate aqueous solution is, for example, 1% by mass to 50% by mass, preferably 5% by mass to 25% by mass.

[Active ingredient layer]
The active ingredient layer contains the active ingredient for hair growth and covers the surface of the gnetite fine particles. When the hair restorer is used, after the particulate matter permeates the scalp, the active ingredient contained in the active ingredient layer dissolves and reaches the dermal papilla cells to exhibit the hair growth effect. The active ingredient contained in the active ingredient layer is an ingredient effective for hair growth, and is, for example, a component called a blood circulation promoter or a cell activator. Examples of substances capable of promoting blood circulation and activating cells include Tamasaki tsudurafu dialkaloid (Tamasaki tsudurafu dialkaloid contains cepharanthin, isotetlandrin, cycleanin, and velvamin), cepharanthin, and carrot. Extract, dipotassium glycyrrhizinate, glycyrrhizinic acid, hinokithiol, alanitoin, kujin extract, senburi extract, shokyotinki, tocopherol acetate, cherry extract, biwa leaf extract, vitamins and their salts, amino acids and their salts, pantenol derivatives, carpronium chloride, Oryzanol, camphor, tocopherol, linoleic acid ester, nicotinic acid, methyl nicotinate, benzyl nicotinate, butoxyethyl nicotinate, nicotinic acid ester, tocopherol nicotinic acid, tocopherol nicotinic acid ester, inositol hexanicotinic acid ester, tocopherol linoleic acid ester, Vanillyl amide nonanoic acid, tocopherol succinate, sodium dextran sulfate, acetylcholine, togarashi tincture, cantalis tincture, ginger tincture, otane carrot, chixetsu carrot, nicotinic acid, pinacidil, garlic extract, toki extract, gentian extract, garlic extract, citrus extract , Minoxydil, Senkyu, Chixetsu carrot, Ginger, Gio, Aloe, Spironolactone, Hinokiol, Korean carrot, Momohito, Shiroyakuko, Mikami, Bone-relief, Huangya, Red flower, Photosensitizer 101, Photosensitizer 201, Photosensitizer Examples thereof include element 301 and photosensitive element 401.

The active ingredient contained in the active ingredient layer is selected from the group consisting of Tamasaki tsudurafu dialkaloid, cepharanthin, carrot extract, dipotassium glycyrrhizinate, glycyrrhizic acid, hinokitiol, alanintoin, kujin extract, swertia japonica extract, shokyotinki, and tocopherol acetate. It is preferably more than a seed. In addition, the active ingredient is two or more selected from the group consisting of Tamasaki tsudurafu dialkaloid, cepharanthin, carrot extract, dipotassium glycyrrhizinate, glycyrrhizic acid, hinokitiol, alanintoin, kujin extract, Swertia japonica extract, shokyotinki, and tocopherol acetate. Is more preferable. Examples of the raw material containing the carrot extract include HAR carrot extract manufactured by Technoble Co., Ltd. Examples of the raw material containing dipotassium glycyrrhizinate include dipotassium glycyrrhizinate manufactured by Maruzen Pharmaceuticals Co., Ltd. Further, as a raw material containing Tamasaki Tsuzurafu dialkaloid, for example, Biscotin manufactured by Technoble Co., Ltd. can be mentioned.

The active ingredient contained in the active ingredient layer includes various ingredients having hair growth, hair growth, hair growth, and hair thickening effects in addition to the above-mentioned blood circulation promoter and cell activator. For example, the active ingredient contained in the active ingredient layer may include a bactericidal agent, an anti-male hormone agent, a fat secretion inhibitor, an immunosuppressant, an antihistamine, a local stimulant, a keratin softener, an anti-apoptotic agent and the like. In addition, the active ingredient contained in the active ingredient layer may contain an anti-inflammatory agent such as glycyrrhizic acid and its derivative, licorice extract, diphenhydramine hydrochloride, shikon extract, agetsu extract, and hydrocortisone acetate.

The ratio of the active ingredient contained in the active ingredient layer to the total mass of the hair restorer is, for example, 0.01% by mass to 10% by mass, preferably 0.1% by mass to 5% by mass, and 0.2% by mass. % To 1% by mass is more preferable.

[Water-soluble polymer layer]
The water-soluble polymer layer contains a water-soluble polymer containing a 2-methacryloyloxyethyl phosphorylcholine / stearyl methacrylate copolymer and covers the active ingredient layer. The water-soluble polymer layer contributes to the stabilization of the active ingredient layer. The water-soluble polymer layer may contain, for example, a water-soluble polymer containing a phosphorylcholine functional group other than the 2-methacryloyloxyethyl phosphorylcholine / stearyl methacrylate copolymer. Examples of the raw material containing the 2-methacryloyloxyethyl phosphorylcholine / stearyl methacrylate copolymer include LIPIDURE (registered trademark) -NR manufactured by NOF CORPORATION.

<Ingredients other than particulate matter contained in hair restorer>
The hair restorer preferably contains the above-mentioned particulate matter in the range of 0.1% by mass to 10% by mass, more preferably in the range of 0.3% by mass to 5% by mass, and 0.5% by mass. It is particularly preferable to contain it in the range of mass% to 2% by mass.

The hair restorer may contain, for example, water, an active ingredient related to hair growth, a surfactant, an alcohol, a fragrance, an oxidizing agent, a pH adjuster, or the like as components other than the particulate matter. As the water, for example, purified water, ion-exchanged water, distilled water and the like can be used. Examples of the hair-growth component contained in the solution portion of the hair-growth agent include Tamasaki tsudurafu dialkaloid, cepharanthin, carrot extract, dipotassium glycyrrhizinate, glycyrrhizinic acid, hinokithiol, alanintoin, kujin extract, senburi extract, shokyotinki, tocopherol acetate, and cherry tree. Extracts, biwa leaf extracts, vitamins and their salts, amino acids and their salts, pantenol derivatives, carpronium chloride, oryzanol, camphor, tocopherol, linoleic acid ester, nicotinic acid, methyl nicotinate, benzyl nicotinate, butoxyethyl nicotinate , Nicotinic acid ester, Tocopherol nicotinic acid, Tocopherol nicotinic acid ester, Inositol hexanicotinic acid ester, Tocopherol linoleic acid ester, Nonanoic acid vanillylamide, Tocopherol succinate, Sodium dextran sulfate, Acetylcholine, Togarashi tincture, Cantalistinki, Shokyo tincture, Otaneninjin, Chixetsu carrot, Circletin, Nicolanzil, Pinacidil, Garlic extract, Touki extract, Gentiana extract, Iodized garlic extract, Kanzo, Minoxidil, Senkyu, Chixetsu carrot, Ginger, Jio, Aloe, Spironolactone, Hinokiol, Korean carrot, Momohito, Shiroyakuko, Minami, Bone-relief, Huangya, Benihana, Photosensitizer 101, Photosensitizer 201, Photosensitizer 301, Photosensitizer 401, Bactericide, Anti-male hormone agent, Fat secretion inhibitor, Immunosuppressant , Antihistamine, topical stimulant, keratin softener, anti-apoptotic agent, glycyrrhetinic acid and its derivatives, kanzo extract, diphenhydramine hydrochloride, shikon extract, agetsu extract, hydrocortisone acetate and the like. The solution portion of the hair restorer may contain the same hair restorer as the active ingredient layer. In addition, various commercially available raw materials can be used for surfactants, alcohols, fragrances, oxidizing agents, pH adjusters and the like.

The dosage form of the hair restorer is preferably an aerosol agent. In particular, the propellant gas preferably contains at least dimethyl ether (DME) gas. By including DME gas in the injection gas, oxidation of magnetite fine particles can be suppressed. The amount of DME gas contained in the hair restorer is, for example, 10% by volume to 50% by volume with respect to the volume of the liquid of the hair restorer.

Next, a method for producing a hair restorer will be described.

<Preparation of particulate matter>
The above-mentioned SiO _2- coated magnetite fine particles, a hair-growth component, and purified water were mixed at a predetermined ratio, and absolute ethanol was further added and stirred to obtain a mixed solution. As a result, a hair growth component layer can be formed on the surface of the magnetite fine particles.

Next, a water-soluble polymer containing a 2-methacryloyloxyethyl phosphorylcholine / stearyl methacrylate copolymer is added to the above mixed solution, and ultrasonic waves are added to stir. As a result, a particulate matter in which a water-soluble polymer layer is coated on the hair-growth component layer is formed, and a concentrated liquid containing the particulate matter can be prepared.

<Making a hair restorer>
The concentrate, purified water, hair growth components other than the components contained in the hair growth component layer, antioxidants, surfactants, alcohol, fragrances, etc. are mixed and stirred, and the pH is adjusted to 5 ± 0.5 using a pH adjuster. By doing so, a hair restorer can be prepared. Further, by adding a certain amount of gas such as dimethyl ether (DME) to the hair restorer, it can be used as an aerosol agent.

Hereinafter, the present invention will be further described with reference to Examples, but the present invention is not limited to these Examples.

<Example 1>
[Preparation of SiO _2- coated magnetite fine particles]
100 parts by mass of ion-exchanged water and 12 parts by mass of nano-sized magnetite fine particles were mixed to prepare a slurry in which magnetite fine particles were dispersed.

To 100 parts by mass of this slurry, 200 parts by mass of a 10% by mass sodium silicate aqueous solution was added dropwise little by little. Then, 0.1 mol / L hydrochloric acid was added and neutralized until the pH of the slurry became 5, to prepare a reaction slurry.

The reaction slurry was suction filtered through a funnel and then washed with ion-exchanged water until the electrical conductivity of the filtrate became sufficiently small. The washed filtered cake was dried to produce SiO _2- coated magnetite fine particles.

[Preparation of concentrate containing particulate matter]
SiO _2- coated magnetite fine particles, purified water, and hair-growth components (HAR carrot extract manufactured by Technoble Co., Ltd., dipotassium glycyrrhizinate manufactured by Maruzen Pharmaceuticals Co., Ltd., viscotin manufactured by Technoble Co., Ltd.) were added in a mass ratio of 0.5. The mixture was mixed at a ratio of 0.1: 0.002, and anhydrous ethanol was further added and stirred. As a result, a hair-growth component layer was formed on the surface of the magnetite fine particles.

Next, LIPIDURE (registered trademark) -NR manufactured by NOF CORPORATION was added to this mixed solution so as to have a content of 0.8% by mass, and ultrasonic waves were added to stir. As a result, a particulate matter coated with a water-soluble polymer layer containing a 2-methacryloyloxyethyl phosphorylcholine / stearyl methacrylate copolymer is formed on the hair-growth component layer, and a concentrated solution containing the particulate matter is formed. Made.

[Preparation of hair restorer]
Mix and stir the concentrate, purified water, hair growth ingredients other than the ingredients contained in the hair growth ingredient layer, antioxidants, surfactants, alcohol, fragrances, etc., and adjust the pH to 5 using a pH adjuster to make the hair growth agent. Prepared. Further, the hair restorer contained 30% by volume of dimethyl ether (DME) gas with respect to the volume of the liquid of the hair restorer to prepare an aerosol agent. Table 1 shows the composition of the hair restorer of Examples.

<Comparative example 1>
By the method shown in Patent Document 1 (Patent No. 554903), a hydrophilic film made of lecithin and a water-soluble polymer layer made of LIPIDURE (registered trademark) -NR are formed in this order on the surface of the magnetic fine particles. A hair restorer containing a particulate matter was prepared. As with the hair restorer of Example 1, a pH adjuster was used to set the pH to 5.

<Comparative example 2>
In the preparation of the hair restorer, the hair restorer was prepared in the same manner as in Example 1 except that the concentrated solution containing the particulate matter was not mixed.

<Comparative example 3>
In _{the preparation of SiO 2-} coated magnetite fine particles, the same as in Example 1 except that magnesium oxide (MgO) -coated magnesium fine particles were prepared by using a 20% by mass magnesium hydroxide aqueous solution instead of a 10% by mass sodium silicate aqueous solution. A hair restorer was prepared in the same manner.

<Comparative example 4>
In the preparation of the hair restorer, the hair restorer was prepared in the same manner as in Example 1 except that the hair restorer did not contain gas.

<Comparative example 5>
In the preparation of the hair restorer, the hair restorer was prepared in the same manner as in Example 1 except that the hair restorer contained _{carbon dioxide (CO 2) gas instead of DME gas.}

<Comparative Example 6>
In the preparation of the hair restorer, the hair restorer was prepared in the same manner as in Example 1 except that the hair restorer contained _{nitrogen (N 2) gas instead of DME gas.}

[Measurement of zeta potential]
A predetermined amount of particulate matter was taken out from the hair restorer of the example and dispersed in purified water to prepare a dispersion liquid A. Further, similarly to the method for producing the dispersion liquid A, a predetermined amount of particulate matter was taken out from the hair restorer of Comparative Example 1 and dispersed in purified water to prepare the dispersion liquid B. The zeta potential of the particulate matter contained in the dispersions A and B was measured using a zeta potential measuring device of Kyowa Interface Science Co., Ltd.

FIG. 1 shows the measurement results for the dispersion liquid A according to the examples. Further, FIG. 2 shows the measurement results of the dispersion liquid B according to Comparative Example 1. It can be seen that the peak of the dispersion liquid A is shifted toward the larger absolute value of the zeta potential than that of the dispersion liquid B, and the dispersibility is better than that of the dispersion liquid B. Therefore, the particulate matter contained in the hair restorer of Example 1 is less likely to aggregate than the particulate matter contained in the hair restorer of Comparative Example 1, so that the particle size is kept small and penetrates more into the scalp. It is considered easy. Further, the viscosity of the hair restorer of Comparative Example 1 containing lecithin is much higher than that of the hair restorer of Example 1, and it is considered that the viscosity tends to remain on the hair and scalp during use, causing deterioration of usability.

[Evaluation of hair growth effect 1 (comparison of Examples, Comparative Example 1, and Comparative Example 2)]
Using C3H / HeN S1c mice, the hair growth effect of the hair restorer was evaluated by the following procedure. C3H / HeN S1c mice are characterized by the fact that the hair cycle enters the telogen phase when shaving, and hair does not grow for 2 weeks after shaving.
(1) Shave the hair with a hair clipper at the lower part of the back of a C3H / HeN S1c mouse (male, 8 weeks old) acclimatized for 2 weeks, taking care not to damage or irritate the skin, and 1 day later. The skin was shaved with a shaver to expose the skin, and the evaluation was started from this day.
(2) In the sample of the example, 100 μL of the hair restorer of the example was uniformly applied to the shaved part of the mouse once a day with a micropipetman. In the sample of Comparative Example 1, 100 μL of the hair restorer of Comparative Example 1 was uniformly applied to the shaved site of the mouse once a day with a micropipetman. In the sample of Comparative Example 2, 100 μL of the hair restorer of Comparative Example 2 was uniformly applied to the shaved site of the mouse once a day with a micropipetman. In addition, as a comparison target, a sample in which 100 μL of purified water was uniformly applied once a day with a micropipetman was provided.
(3) For each of the application of the hair restorer of Example, the application of the hair restorer of Comparative Example 1, the application of the hair restorer of Comparative Example 2, and the application of purified water, a set of 5 mice was used as a set 14 days after the start of evaluation and 21 days after the start of evaluation. 28 days after the start of the evaluation, the movement of the mouse was stopped and the back of the mouse was photographed.

FIG. 3 shows an example of a back photograph of a mouse 14 days after the start of evaluation, 21 days after the start of evaluation, and 28 days after the start of evaluation for each of Examples, Comparative Example 1, Comparative Example 2, and application of purified water. It can be clearly confirmed that the mouse to which the hair growth agent of Example has been applied has a higher hair growth effect than the mouse to which the hair growth agent of Comparative Example 1 has been applied and the mouse to which the hair growth agent of Comparative Example 2 has been applied.

FIG. 4 shows photographs of Examples, Comparative Example 1, Comparative Example 2, and the vicinity of the hair bulb of the back hair of the mouse taken with a digital microscope 28 days after the start of evaluation of the application of purified water. The mouse to which the hair restorer of Example 1 was applied had a significantly larger hair root volume and the dermal papilla cells developed than the mouse to which the hair restorer of Comparative Example 1 was applied and the mouse to which the hair restorer of Comparative Example 2 was applied. It can be confirmed that there is. Therefore, it can be seen that the hair-growth agent of the example has a better hair-growth effect than the hair-growth agent of Comparative Example 1 which is a conventional example and the hair-growth agent of Comparative Example 2 which does not contain particulate matter.

[Evaluation of hair growth effect 2 (Example, Comparative Example 3)]
Using C3H / HeN S1c mice, the hair growth effect of the hair restorer was evaluated by the following procedure. C3H / HeN S1c mice are characterized by the fact that the hair cycle enters the telogen phase when shaving, and hair does not grow for 2 weeks after shaving.
(1) Shave the hair with a hair clipper at the lower part of the back of a C3H / HeN S1c mouse (male, 8 weeks old) acclimatized for 2 weeks, taking care not to damage or irritate the skin, and 1 day later. The skin was shaved with a shaver to expose the skin, and the evaluation was started from this day.
(2) In the sample of the example, 100 μL of the hair restorer of the example was uniformly applied to the shaved part of the mouse once a day with a micropipetman. In the sample of Comparative Example 3, 100 μL of the hair restorer of Comparative Example 3 was uniformly applied to the shaved site of the mouse once a day with a micropipetman. In addition, as a comparison target, a sample in which 100 μL of purified water was uniformly applied once a day with a micropipetman was provided.
(3) For each of the application of the hair restorer of Example, the application of the hair restorer of Comparative Example 3, and the application of purified water, a set of 5 mice was used as a set, and the mice were set at the start of hair growth evaluation, 9 days after the start of evaluation, and 14 days after the start of evaluation. I stopped moving and took a picture of the back of the mouse.

FIG. 5 shows an example of a photograph of the back of a mouse at the start of hair growth evaluation, 9 days after the start of evaluation, and 14 days after the start of evaluation for each of Examples, Comparative Example 3, and application of purified water. Nine days after the start of the evaluation, the hair-growth effect can be clearly confirmed in the mice to which the hair-growth agent of the example was applied. On the other hand, although the hair-growth effect can be confirmed to some extent in the mouse to which the hair-growth agent of Comparative Example 3 is applied, the concentration of the back hair is lower than that of the mouse to which the hair-growth agent of Example 3 is applied. For the mice coated with purified water, the hair growth state was almost the same as that at the start of the evaluation. A similar tendency can be confirmed 14 days after the start of evaluation.

FIG. 6 shows photographs of the vicinity of the hair bulb of the back hair of the mouse taken with a digital microscope 14 days after the start of evaluation of Examples, Comparative Example 3, and the application of purified water. It was confirmed that the mice to which the hair growth agent of Example was applied had a significantly larger hair root volume and the dermal papilla cells were developed than the mice to which the hair growth agent of Comparative Example 3 was applied and the mice to which purified water was applied. can. Therefore, it can be seen that the hair-growth agent of the example has a better hair-growth effect than the hair-growth agent of Comparative Example 3 in which the coating components of the magnetite fine particles are different.

[Evaluation of discoloration]
A predetermined amount of each of the hair growth agents of Examples, Comparative Example 4, Comparative Example 5, and Comparative Example 6 was put into a glass container and sealed. All containers were kept at room temperature for 5 months and the discoloration of the hair restorer was evaluated.

FIG. 7 is a photograph showing the state of each hair restorer after being kept at room temperature for 5 months. Visually, the hair restorer of the example containing DME gas maintained a colorless and transparent state with almost no change, whereas Comparative Example 4 (without propellant gas) and Comparative Example 5 (CO _2). gas-containing), and Comparative example 6 (N ₂ gas containing) had discolored thin black. This discoloration is considered to be due to the oxidation of magnetite fine particles, which are the nuclei of particulate matter. Therefore, it can be seen that the hair restorer of the example can specifically suppress discoloration.

Claims (4)

A hair restorer containing particulate matter,
The particulate matter is
For core magnetite fine particles coated with silicon oxide on the surface,
An active ingredient layer containing an active ingredient related to hair growth, which is formed so as to cover the surface of the magnetite fine particles,
A water-soluble polymer layer containing a water-soluble polymer, which is formed so as to cover the active ingredient layer, is coated.
The water-soluble polymer, see contains a 2-methacryloyloxyethyl phosphorylcholine-stearyl methacrylate copolymer,
A hair restorer whose dosage form is an aerosol agent and further contains a propellant gas containing at least dimethyl ether (DME) gas. The active ingredient is Stephania cepharantha Hayata alkaloids, cepharanthine, ginseng extract, dipotassium glycyrrhizinate, glycyrrhizinic acid, hinokitiol, click Jin'ekisu, assembly extract, Shokyochinki, and one or more selected from the group consisting of tocopherol acetate, claim 1 The hair restorer described in. The active ingredient is Stephania cepharantha Hayata alkaloids, cepharanthine, ginseng extract, dipotassium glycyrrhizinate, glycyrrhizinic acid, hinokitiol, click Jin'ekisu, assembly extract, Shokyochinki, and 2 or more selected from the group consisting of tocopherol acetate, claim 1 The hair restorer described in. The hair restorer according to any one of claims 1 to 3, which does not contain lecithin.

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