JP6910072B2 - チモシンベータ４およびクエン酸を活性成分として含む角膜損傷予防／治療用組成物 - Google Patents

チモシンベータ４およびクエン酸を活性成分として含む角膜損傷予防／治療用組成物 Download PDF

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JP6910072B2
JP6910072B2 JP2018503784A JP2018503784A JP6910072B2 JP 6910072 B2 JP6910072 B2 JP 6910072B2 JP 2018503784 A JP2018503784 A JP 2018503784A JP 2018503784 A JP2018503784 A JP 2018503784A JP 6910072 B2 JP6910072 B2 JP 6910072B2
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composition
thymosin
citric acid
salt
acid
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Japanese (ja)
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JP2018523648A5 (enExample
JP2018523648A (ja
Inventor
カン・シヌク
キム・ギョンスン
ソン・ジヘ
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HLB Therapeutics Co Ltd
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G TreeBNT Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2292—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2018503784A 2015-08-18 2016-08-12 チモシンベータ４およびクエン酸を活性成分として含む角膜損傷予防／治療用組成物 Active JP6910072B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20150116089 2015-08-18
KR10-2015-0116089 2015-08-18
PCT/KR2016/008924 WO2017030328A1 (ko) 2015-08-18 2016-08-12 티모신 베타4 및 시트르산을 유효성분으로 포함하는 각막 손상 예방 또는 치료용 조성물

Publications (3)

Publication Number Publication Date
JP2018523648A JP2018523648A (ja) 2018-08-23
JP2018523648A5 JP2018523648A5 (enExample) 2019-09-19
JP6910072B2 true JP6910072B2 (ja) 2021-07-28

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ID=58050857

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JP2018503784A Active JP6910072B2 (ja) 2015-08-18 2016-08-12 チモシンベータ４およびクエン酸を活性成分として含む角膜損傷予防／治療用組成物

Country Status (6)

Country Link
US (1) US9867868B2 (enExample)
EP (1) EP3338792B1 (enExample)
JP (1) JP6910072B2 (enExample)
KR (1) KR20170021745A (enExample)
ES (1) ES2895923T3 (enExample)
WO (1) WO2017030328A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102696362B1 (ko) 2017-02-17 2024-08-20 삼성전자주식회사 전자 장치 및 전자 장치의 체성분 측정 방법
KR101910908B1 (ko) * 2017-06-14 2018-10-24 (주)휴온스 Gly-Tβ4 (Gly-티모신β4)을 함유하는 안구건조증 치료용 약학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086449A1 (en) * 2002-04-12 2003-10-23 Yale University ANTI-INFLAMMATORY AND WOUND HEALING EFFECTS OF LYMPHOID THYMOSIN β 4
JP2008543878A (ja) * 2005-06-17 2008-12-04 リジェナークス・バイオファーマスーティカルズ・インコーポレイテッド 凍結乾燥したかまたは凍結乾燥させることができる形態であるｌｋｋｔｅｔおよび／またはｌｋｋｔｎｔペプチド組成物
WO2008108927A2 (en) * 2007-03-06 2008-09-12 Regenerx Biopharmaceuticals, Inc. Methods and compositions for stabilizing polypeptides
CA2691914C (en) * 2007-07-11 2012-06-26 Pfizer Inc. Pharmaceutical compositions and methods of treating dry eye disorders
RU2013117209A (ru) * 2010-11-08 2014-10-27 Хилор Лтд. Буферные глазные композиции и способы их применения
US10406208B2 (en) * 2014-10-22 2019-09-10 G-Treebnt Co., Ltd. Composition containing thymosin beta 4, and pharmaceutical formulation comprising same

Also Published As

Publication number Publication date
WO2017030328A1 (ko) 2017-02-23
EP3338792A1 (en) 2018-06-27
KR20170021745A (ko) 2017-02-28
US20170049857A1 (en) 2017-02-23
EP3338792B1 (en) 2021-09-29
EP3338792A4 (en) 2019-05-15
ES2895923T3 (es) 2022-02-23
JP2018523648A (ja) 2018-08-23
US9867868B2 (en) 2018-01-16

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