JP6908591B2 - Ｉｌ２ｒベータ／共通ガンマ鎖抗体 - Google Patents

Ｉｌ２ｒベータ／共通ガンマ鎖抗体 Download PDF

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JP6908591B2
JP6908591B2 JP2018506135A JP2018506135A JP6908591B2 JP 6908591 B2 JP6908591 B2 JP 6908591B2 JP 2018506135 A JP2018506135 A JP 2018506135A JP 2018506135 A JP2018506135 A JP 2018506135A JP 6908591 B2 JP6908591 B2 JP 6908591B2
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antibody
antigen
cells
binding fragment
seq
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JP2018527912A (ja
JP2018527912A5 (OSRAM
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ワン，チェン−イ
ブラウアー，ピーター
ヨー，ショク・ピン
タン，ウィー・チン
コノリー，ジョン・エドワード
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Agency for Science Technology and Research Singapore
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
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    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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JP2018506135A 2015-08-06 2016-08-05 Ｉｌ２ｒベータ／共通ガンマ鎖抗体 Active JP6908591B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SG10201506227V 2015-08-06
SG10201506227V 2015-08-06
PCT/EP2016/068780 WO2017021540A1 (en) 2015-08-06 2016-08-05 Il2rbeta/common gamma chain antibodies

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JP2018527912A JP2018527912A (ja) 2018-09-27
JP2018527912A5 JP2018527912A5 (OSRAM) 2019-09-19
JP6908591B2 true JP6908591B2 (ja) 2021-07-28

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US (5) US10167338B2 (OSRAM)
EP (2) EP3328894B1 (OSRAM)
JP (1) JP6908591B2 (OSRAM)
KR (1) KR102753399B1 (OSRAM)
CN (2) CN107922496B (OSRAM)
AU (1) AU2016301970A1 (OSRAM)
CA (1) CA2994906A1 (OSRAM)
CY (1) CY1121197T1 (OSRAM)
DK (1) DK3328894T3 (OSRAM)
ES (2) ES2841799T3 (OSRAM)
HU (1) HUE043421T2 (OSRAM)
PL (1) PL3328894T3 (OSRAM)
PT (1) PT3328894T (OSRAM)
TR (1) TR201901445T4 (OSRAM)
TW (1) TW201713699A (OSRAM)
WO (1) WO2017021540A1 (OSRAM)

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EP2712655B1 (en) 2011-04-28 2019-12-18 The Broad Institute, Inc. Inhibitors of histone deacetylase
DK3328894T3 (en) 2015-08-06 2019-02-04 Agency Science Tech & Res IL2RBETA / COMMON GAMMA CHAIN ANTIBODIES
EP4099015A1 (en) 2016-06-10 2022-12-07 Gadeta B.V. Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response
AU2018268087B2 (en) 2017-05-18 2022-03-17 Umc Utrecht Holding B.V. Compositions and methods for cell targeting therapies
EP3707162A1 (en) * 2017-11-10 2020-09-16 Agency for Science, Technology and Research Il2rbeta/common gamma chain antibodies
WO2019178518A1 (en) * 2018-03-16 2019-09-19 The Regents Of The University Of California Cellular signaling domain engineering in chimeric antigen receptor-modified regulatory t cells
AU2019269628A1 (en) * 2018-05-17 2020-12-03 The Board Of Trustees Of The Leland Stanford Junior University Receptor inhibition by phosphatase recruitment
EP4023667A1 (en) * 2018-08-06 2022-07-06 Medikine, Inc. Il-2 receptor binding compounds
SG11202101779RA (en) 2018-08-30 2021-03-30 Hcw Biologics Inc Multi-chain chimeric polypeptides and uses thereof
WO2020047333A1 (en) 2018-08-30 2020-03-05 HCW Biologics, Inc. Single-chain chimeric polypeptides and uses thereof
EP4592314A3 (en) 2018-08-30 2025-11-05 ImmunityBio, Inc. Single-chain and multi-chain chimeric polypeptides and uses thereof
TWI897855B (zh) * 2018-10-26 2025-09-21 美商免疫遺傳股份有限公司 Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途
TW202039557A (zh) 2018-11-09 2020-11-01 新加坡商優其洛伊生物私人有限公司 介白素2受體β(IL2Rβ)/共同γ鏈抗體
WO2020094834A1 (en) 2018-11-09 2020-05-14 Euchloe Bio Pte. Ltd. Il2rbeta/common gamma chain antibodies
EP3917962A1 (en) 2019-02-01 2021-12-08 Regeneron Pharmaceuticals, Inc. Anti-il2 receptor gamma antigen-binding proteins
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