JP6899848B2 - 抗vegfr−2抗体医薬品の治療効果を予測するバイオマーカー、検査方法、及び検査キット - Google Patents

抗vegfr−2抗体医薬品の治療効果を予測するバイオマーカー、検査方法、及び検査キット Download PDF

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JP6899848B2
JP6899848B2 JP2018559559A JP2018559559A JP6899848B2 JP 6899848 B2 JP6899848 B2 JP 6899848B2 JP 2018559559 A JP2018559559 A JP 2018559559A JP 2018559559 A JP2018559559 A JP 2018559559A JP 6899848 B2 JP6899848 B2 JP 6899848B2
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vegf
vegfr
ramucirumab
therapeutic effect
treatment
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JPWO2018124153A1 (ja
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哲夫 馬島
哲夫 馬島
尊 若槻
尊 若槻
啓之 清宮
啓之 清宮
研成 山口
研成 山口
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Japanese Foundation for Cancer Research
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Japanese Foundation for Cancer Research
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475Assays involving growth factors
    • G01N2333/515Angiogenesic factors; Angiogenin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2018559559A 2016-12-28 2017-12-27 抗vegfr−2抗体医薬品の治療効果を予測するバイオマーカー、検査方法、及び検査キット Active JP6899848B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016255887 2016-12-28
JP2016255887 2016-12-28
PCT/JP2017/046831 WO2018124153A1 (fr) 2016-12-28 2017-12-27 Biomarqueur pour la prédiction de l'effet thérapeutique d'un médicament à base d'anticorps anti-vegfr-2, procédé de criblage et kit de criblage

Publications (2)

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JPWO2018124153A1 JPWO2018124153A1 (ja) 2019-11-07
JP6899848B2 true JP6899848B2 (ja) 2021-07-07

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JP2018559559A Active JP6899848B2 (ja) 2016-12-28 2017-12-27 抗vegfr−2抗体医薬品の治療効果を予測するバイオマーカー、検査方法、及び検査キット

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US (1) US11415584B2 (fr)
JP (1) JP6899848B2 (fr)
WO (1) WO2018124153A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7299700B2 (ja) * 2018-12-28 2023-06-28 公益財団法人がん研究会 VEGF-A/VEGFR2経路のdual inhibition療法、及びこれに使用する医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9469876B2 (en) 2010-04-06 2016-10-18 Caris Life Sciences Switzerland Holdings Gmbh Circulating biomarkers for metastatic prostate cancer
KR20140044341A (ko) 2011-06-02 2014-04-14 알막 다이아그노스틱스 리미티드 암에 대한 분자적 진단 검사
KR20150090246A (ko) 2012-12-03 2015-08-05 알막 다이아그노스틱스 리미티드 암을 위한 분자 진단 테스트
GB201409479D0 (en) * 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular diagnostic test for cancer

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Publication number Publication date
US11415584B2 (en) 2022-08-16
JPWO2018124153A1 (ja) 2019-11-07
WO2018124153A1 (fr) 2018-07-05
US20200355699A1 (en) 2020-11-12

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