JP6889433B2 - 薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド - Google Patents
薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド Download PDFInfo
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- JP6889433B2 JP6889433B2 JP2016551716A JP2016551716A JP6889433B2 JP 6889433 B2 JP6889433 B2 JP 6889433B2 JP 2016551716 A JP2016551716 A JP 2016551716A JP 2016551716 A JP2016551716 A JP 2016551716A JP 6889433 B2 JP6889433 B2 JP 6889433B2
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- 0 CNc1ccc(COP(NCC*)(NCC*)=O)cc1 Chemical compound CNc1ccc(COP(NCC*)(NCC*)=O)cc1 0.000 description 5
- DQMMQIVLIFMXCG-UHFFFAOYSA-N CC(c1ccccc1-c1c(-c2ccccc2C)nn[n]1C)OC Chemical compound CC(c1ccccc1-c1c(-c2ccccc2C)nn[n]1C)OC DQMMQIVLIFMXCG-UHFFFAOYSA-N 0.000 description 1
- VIOCGHCTISSYLX-UHFFFAOYSA-N CC1OOC(CCC2)(CC2OC(NCC(C)(C)N)=O)OC(CC2C3)C2C3C1 Chemical compound CC1OOC(CCC2)(CC2OC(NCC(C)(C)N)=O)OC(CC2C3)C2C3C1 VIOCGHCTISSYLX-UHFFFAOYSA-N 0.000 description 1
- KTRKFUNKCZLOGC-UHFFFAOYSA-N CCCCC(C(COc(c(F)c(cc1F)F)c1F)=O)[n]1nnc(C2(CCCCC2)NC(OC2COC3(C4CC(C5)CC3CC5C4)OOCCC2)=O)c1 Chemical compound CCCCC(C(COc(c(F)c(cc1F)F)c1F)=O)[n]1nnc(C2(CCCCC2)NC(OC2COC3(C4CC(C5)CC3CC5C4)OOCCC2)=O)c1 KTRKFUNKCZLOGC-UHFFFAOYSA-N 0.000 description 1
- UQFMGSUPDGCZOZ-FTLITQJKSA-N CCNC(C=CN1[C@@H](C2(F)F)O[C@H](CO)[C@H]2O)=NC1=O Chemical compound CCNC(C=CN1[C@@H](C2(F)F)O[C@H](CO)[C@H]2O)=NC1=O UQFMGSUPDGCZOZ-FTLITQJKSA-N 0.000 description 1
- MQEDCLYHADIJDW-UHFFFAOYSA-N CCSC(CC(N1CC(CC2)CCC2C(NC)=O)=O)C1=O Chemical compound CCSC(CC(N1CC(CC2)CCC2C(NC)=O)=O)C1=O MQEDCLYHADIJDW-UHFFFAOYSA-N 0.000 description 1
- PCBZRNYXXCIELG-DQBHJYGJSA-N CN(C)c1ncnc2c1nc[n]2[C@@H]([C@@H]1O)O[C@H](CO)C1NC([C@H](Cc(cc1)ccc1OC)NC(OC(CCC1)CC11OOC2(C3CC(C4)CC2CC4C3)O1)=O)=O Chemical compound CN(C)c1ncnc2c1nc[n]2[C@@H]([C@@H]1O)O[C@H](CO)C1NC([C@H](Cc(cc1)ccc1OC)NC(OC(CCC1)CC11OOC2(C3CC(C4)CC2CC4C3)O1)=O)=O PCBZRNYXXCIELG-DQBHJYGJSA-N 0.000 description 1
- ACCGQBAYKNFRJX-LPBLVHEISA-N CNC(C=CN1[C@@H](C2(F)F)O[C@H](CO)[C@H]2O)=NC1=O Chemical compound CNC(C=CN1[C@@H](C2(F)F)O[C@H](CO)[C@H]2O)=NC1=O ACCGQBAYKNFRJX-LPBLVHEISA-N 0.000 description 1
- MIVCQQGVEMZWJA-OJRHAOMCSA-N CNC(CCCNC(OCC1[C@H](CC2)[C@@H]1CCc1c2nn[n]1C)=O)=O Chemical compound CNC(CCCNC(OCC1[C@H](CC2)[C@@H]1CCc1c2nn[n]1C)=O)=O MIVCQQGVEMZWJA-OJRHAOMCSA-N 0.000 description 1
- OHURTXYRRGPIIK-UHFFFAOYSA-N C[n]1nnc(-c2c(CC3OC)cccc2)c1-c1c3cccc1 Chemical compound C[n]1nnc(-c2c(CC3OC)cccc2)c1-c1c3cccc1 OHURTXYRRGPIIK-UHFFFAOYSA-N 0.000 description 1
- DOTLCSUQVDYLTO-UHFFFAOYSA-N Cc1ccccc1-c1c(C2C=CC=CC2N(C)C)[n](C)nn1 Chemical compound Cc1ccccc1-c1c(C2C=CC=CC2N(C)C)[n](C)nn1 DOTLCSUQVDYLTO-UHFFFAOYSA-N 0.000 description 1
- DYUPVDDDZKVQLN-UHFFFAOYSA-N O=C(C(C(CC1)CCC11OOC2(C3CC(C4)CC2CC4C3)O1)=C1Cl)c(cccc2)c2C1=O Chemical compound O=C(C(C(CC1)CCC11OOC2(C3CC(C4)CC2CC4C3)O1)=C1Cl)c(cccc2)c2C1=O DYUPVDDDZKVQLN-UHFFFAOYSA-N 0.000 description 1
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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| US6906205B2 (en) * | 2002-06-21 | 2005-06-14 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| JP2005112799A (ja) | 2003-10-08 | 2005-04-28 | Toshiaki Miura | オレイン酸アルキルエステルオゾニド |
| FR2862304A1 (fr) | 2003-11-14 | 2005-05-20 | Centre Nat Rech Scient | Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
| US20050256184A1 (en) | 2004-04-12 | 2005-11-17 | O'neill Paul M | 1,2,4-Trioxanes and 1,2,4-trioxepanes |
| US7776916B2 (en) | 2004-04-28 | 2010-08-17 | The Uab Research Foundation | Nitrated lipids and methods of making and using thereof |
| US8067620B2 (en) | 2005-05-04 | 2011-11-29 | Medicines For Malaria Venture Mmv | Dispiro 1,2,4-trioxolane antimalarials |
| WO2010011684A2 (en) * | 2008-07-21 | 2010-01-28 | The Regents Of The University Of California | Prodrug and fluoregenic compositions and methods for using the same |
| US8305807B2 (en) | 2010-07-09 | 2012-11-06 | Sandisk Technologies Inc. | Detection of broken word-lines in memory arrays |
| WO2012059932A1 (en) | 2010-11-01 | 2012-05-10 | Aurigene Discovery Technologies Limited | 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors |
| US10287312B2 (en) | 2014-02-14 | 2019-05-14 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| JP6675030B1 (ja) * | 2019-06-20 | 2020-04-01 | 株式会社フッコー | 高炉スラグ系塗料 |
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|---|---|
| JP2021080257A (ja) | 2021-05-27 |
| JP2022191236A (ja) | 2022-12-27 |
| US20200317714A1 (en) | 2020-10-08 |
| CA2937752A1 (en) | 2015-08-20 |
| WO2015123595A1 (en) | 2015-08-20 |
| CA2937752C (en) | 2023-02-07 |
| US10287312B2 (en) | 2019-05-14 |
| EP3104857A4 (en) | 2017-10-11 |
| US20160362439A1 (en) | 2016-12-15 |
| US11014955B2 (en) | 2021-05-25 |
| JP2017511795A (ja) | 2017-04-27 |
| US20190284224A1 (en) | 2019-09-19 |
| EP3104857A1 (en) | 2016-12-21 |
| US10662215B2 (en) | 2020-05-26 |
| US20220017559A1 (en) | 2022-01-20 |
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