JP6884920B2

JP6884920B2 - 錠剤の保存安定性を向上させる方法

錠剤の保存安定性を向上させる方法 Download PDF

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Publication number: JP6884920B2
Authority: JP; Japan
Prior art keywords: mass; less; cellulose powder; tablet; xylose
Prior art date: 2019-04-02
Legal status : Active

Application number

JP2020507130A

Other languages

English (en)

Japanese (ja)

Other versions

JPWO2020202598A1 (ja

Inventor

忠浩熊谷

楓玉利

裕司林

Current Assignee

Asahi Kasei Corp

Original Assignee

Asahi Kasei Corp

Priority date

2019-04-02

Filing date

2019-09-05

Publication date

2021-06-09

2019-09-05 Application filed by Asahi Kasei Corp filed Critical Asahi Kasei Corp

2021-02-10 Priority to JP2021020166A priority Critical patent/JP2021105172A/ja

2021-04-30 Publication of JPWO2020202598A1 publication Critical patent/JPWO2020202598A1/ja

2021-06-09 Application granted granted Critical

2021-06-09 Publication of JP6884920B2 publication Critical patent/JP6884920B2/ja

Status Active legal-status Critical Current

2039-09-05 Anticipated expiration legal-status Critical

Links

238000003860 storage Methods 0.000 title claims description 32
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 134
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 114
238000000034 method Methods 0.000 claims description 101
239000002245 particle Substances 0.000 claims description 59
239000004480 active ingredient Substances 0.000 claims description 58
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 57
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 57
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 57
-1 rice starch Polymers 0.000 claims description 43
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 36
239000008103 glucose Substances 0.000 claims description 36
229920002472 Starch Polymers 0.000 claims description 19
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 19
238000002156 mixing Methods 0.000 claims description 18
238000007906 compression Methods 0.000 claims description 17
230000006835 compression Effects 0.000 claims description 17
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 16
239000007884 disintegrant Substances 0.000 claims description 15
235000019698 starch Nutrition 0.000 claims description 15
239000008107 starch Substances 0.000 claims description 13
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DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 9
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 8
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 7
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims description 7
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235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 7
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
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238000004128 high performance liquid chromatography Methods 0.000 claims description 4
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125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
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239000003826 tablet Substances 0.000 description 121
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CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
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239000002253 acid Substances 0.000 description 9
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GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 8
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AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 8
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MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 8
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
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