JP6853819B2 - Ｗｎｔシグナル伝達経路阻害剤およびその治療用途 - Google Patents

Ｗｎｔシグナル伝達経路阻害剤およびその治療用途 Download PDF

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JP6853819B2
JP6853819B2 JP2018518629A JP2018518629A JP6853819B2 JP 6853819 B2 JP6853819 B2 JP 6853819B2 JP 2018518629 A JP2018518629 A JP 2018518629A JP 2018518629 A JP2018518629 A JP 2018518629A JP 6853819 B2 JP6853819 B2 JP 6853819B2
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JP2018535949A (ja
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チャン、シャオフー
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スーチョウ ユンシュアン イーヤオ カジ ヨウシェン ゴンス
スーチョウ ユンシュアン イーヤオ カジ ヨウシェン ゴンス
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Priority claimed from CN201510645986.2A external-priority patent/CN105254613A/zh
Priority claimed from CN201610670828.7A external-priority patent/CN107759584B/zh
Priority claimed from CN201610850358.2A external-priority patent/CN107286136B/zh
Priority claimed from CN201610850357.8A external-priority patent/CN107286135B/zh
Application filed by スーチョウ ユンシュアン イーヤオ カジ ヨウシェン ゴンス, スーチョウ ユンシュアン イーヤオ カジ ヨウシェン ゴンス filed Critical スーチョウ ユンシュアン イーヤオ カジ ヨウシェン ゴンス
Priority claimed from PCT/US2016/055851 external-priority patent/WO2017062688A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2018518629A 2015-10-08 2016-10-06 Ｗｎｔシグナル伝達経路阻害剤およびその治療用途 Active JP6853819B2 (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
CN201510645986.2A CN105254613A (zh) 2015-10-08 2015-10-08 具有Wnt信号通路抑制活性的杂环化合物及其应用
CN201510645986.2 2015-10-08
CN201610195733 2016-03-31
CN201610195731.5 2016-03-31
CN201610195733.4 2016-03-31
CN201610195731 2016-03-31
CN201610670828.7 2016-08-16
CN201610670828.7A CN107759584B (zh) 2016-08-16 2016-08-16 一种具有Wnt信号通路抑制活性的氨基五元杂环化合物及其应用
CN201610850360.XA CN106565673B (zh) 2015-10-08 2016-09-26 具有Wnt信号通路抑制活性的5-氟嘧啶杂环化合物及其应用
CN201610850357.8 2016-09-26
CN201610850358.2A CN107286136B (zh) 2016-03-31 2016-09-26 一种3-氟吡啶杂环化合物及其应用
CN201610850360.X 2016-09-26
CN201610850357.8A CN107286135B (zh) 2016-03-31 2016-09-26 一种具有Wnt信号通路抑制活性的杂环化合物及其应用
CN201610850358.2 2016-09-26
PCT/US2016/055851 WO2017062688A1 (en) 2015-10-08 2016-10-06 Wnt signaling pathway inhibitors and therapeutic applications thereof

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JP2018535949A5 JP2018535949A5 (https=) 2019-11-14
JP6853819B2 true JP6853819B2 (ja) 2021-03-31

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US (2) US10450300B2 (https=)
EP (1) EP3359154B1 (https=)
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WO2021136803A1 (en) 2020-01-02 2021-07-08 Helmholtz-Zentrum für Infektionsforschung GmbH NEW PqsR INVERSE AGONISTS
WO2021136805A1 (en) * 2020-01-02 2021-07-08 Helmholtz-Zentrum für Infektionsforschung GmbH NOVEL PqsR INVERSE AGONISTS
CN112612873B (zh) * 2020-12-25 2023-07-07 上海德拓信息技术股份有限公司 一种基于nlp技术的集中性事件挖掘方法
EP4382519A4 (en) * 2021-08-27 2024-12-04 Adlai Nortye Biopharma Co., Ltd. CYCLIN K DEGRADING AGENT
WO2025143733A1 (ko) * 2023-12-26 2025-07-03 (주)아이젠사이언스 신규한 유비퀴틴 특이적 펩티드 분해효소 1 저해제

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UY32055A (es) 2008-08-19 2010-03-26 Astrazeneca Ab Derivados sustituidos de la 5-Halo-N2-[sustituido](1-metil-1H-imidazol-4-il)pirimidin-2,-diamina y sus sales farmacéuticamente aceptables, procesos de preparación, composiciones y aplicaciones.
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US20180244651A1 (en) 2018-08-30
KR20180061363A (ko) 2018-06-07
US10450300B2 (en) 2019-10-22
US20200048223A1 (en) 2020-02-13
JP2018535949A (ja) 2018-12-06
EP3359154B1 (en) 2021-05-26
KR102698411B1 (ko) 2024-08-26
EP3359154A1 (en) 2018-08-15
EP3359154A4 (en) 2019-05-15

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