JP6847828B2 - 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用 - Google Patents

新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用 Download PDF

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JP6847828B2
JP6847828B2 JP2017508102A JP2017508102A JP6847828B2 JP 6847828 B2 JP6847828 B2 JP 6847828B2 JP 2017508102 A JP2017508102 A JP 2017508102A JP 2017508102 A JP2017508102 A JP 2017508102A JP 6847828 B2 JP6847828 B2 JP 6847828B2
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shk
analog
seq
amino acid
analog according
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JP2017525357A (ja
JP2017525357A5 (https=
Inventor
レイモンド エス ノートン
レイモンド エス ノートン
シー チエ チャン
シー チエ チャン
マイケル ダブリュー ペニントン
マイケル ダブリュー ペニントン
クリスティン ビートン
クリスティン ビートン
ブライアン ジェイ． スミス
ブライアン ジェイ． スミス
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Peptides International Inc
Baylor College of Medicine
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Peptides International Inc
Baylor College of Medicine
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Priority to JP2020081545A priority Critical patent/JP6953579B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
JP2017508102A 2014-08-15 2015-08-14 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用 Active JP6847828B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020081545A JP6953579B2 (ja) 2014-08-15 2020-05-01 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2014903189A AU2014903189A0 (en) 2014-08-15 Novel potassium channel blockers
AU2014903189 2014-08-15
PCT/AU2015/000487 WO2016023072A1 (en) 2014-08-15 2015-08-14 Novel potassium channel blockers and use thereof in the treatment of autoimmune diseases

Related Child Applications (1)

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JP2020081545A Division JP6953579B2 (ja) 2014-08-15 2020-05-01 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用

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JP2017525357A JP2017525357A (ja) 2017-09-07
JP2017525357A5 JP2017525357A5 (https=) 2018-09-20
JP6847828B2 true JP6847828B2 (ja) 2021-03-24

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JP2020081545A Active JP6953579B2 (ja) 2014-08-15 2020-05-01 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用

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Country Link
US (1) US10246496B2 (https=)
EP (1) EP3180365B1 (https=)
JP (2) JP6847828B2 (https=)
AU (1) AU2015303825B2 (https=)
WO (1) WO2016023072A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020127419A (ja) * 2014-08-15 2020-08-27 モナッシュ ユニバーシティ 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用
KR102533290B1 (ko) * 2022-04-14 2023-05-16 한국해양과학기술원 전압개폐 칼륨이온채널 억제 활성능을 갖는 펩타이드
KR102553070B1 (ko) * 2022-06-16 2023-07-07 한국해양과학기술원 전압개폐 칼륨이온채널 억제 활성능을 갖는 작은상자해파리 기원 펩타이드

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2474316B1 (en) * 2004-10-07 2016-04-06 The Regents of The University of California Analogs of shk toxin and their uses in selective inhibition of kv1.3 potassium channels
PE20081140A1 (es) * 2006-10-25 2008-09-22 Amgen Inc Agentes terapeuticos a base de peptidos derivados de toxinas
CN101796069B (zh) * 2007-05-14 2014-02-19 墨西哥国立自治大学 Vm23和Vm24，两种以高选择性阻断人类T淋巴细胞钾通道(Kv1.3亚型)并降低大鼠的体内DTH反应的蝎子肽
EP2408814B1 (en) * 2009-03-20 2018-11-21 Amgen Inc. Carrier immunoglobulins and uses thereof
WO2012170392A2 (en) * 2011-06-06 2012-12-13 Kineta One, Llc Shk-based pharmaceutical compositions and methods of manufacturing and using the same
RS57422B1 (sr) * 2013-01-25 2018-09-28 Janssen Biotech Inc Antagonisti kv1.3 i postupci za upotrebu
JP6847828B2 (ja) * 2014-08-15 2021-03-24 モナッシュ ユニバーシティ 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020127419A (ja) * 2014-08-15 2020-08-27 モナッシュ ユニバーシティ 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用
KR102533290B1 (ko) * 2022-04-14 2023-05-16 한국해양과학기술원 전압개폐 칼륨이온채널 억제 활성능을 갖는 펩타이드
KR102553070B1 (ko) * 2022-06-16 2023-07-07 한국해양과학기술원 전압개폐 칼륨이온채널 억제 활성능을 갖는 작은상자해파리 기원 펩타이드

Also Published As

Publication number Publication date
WO2016023072A1 (en) 2016-02-18
US10246496B2 (en) 2019-04-02
EP3180365A1 (en) 2017-06-21
EP3180365A4 (en) 2018-01-17
JP2017525357A (ja) 2017-09-07
EP3180365B1 (en) 2021-08-18
JP2020127419A (ja) 2020-08-27
JP6953579B2 (ja) 2021-10-27
US20170362286A1 (en) 2017-12-21
AU2015303825B2 (en) 2021-01-14
AU2015303825A1 (en) 2017-03-23

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