JP6846429B2 - ヒトβ−２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ - Google Patents

ヒトβ−２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ Download PDF

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JP6846429B2
JP6846429B2 JP2018533097A JP2018533097A JP6846429B2 JP 6846429 B2 JP6846429 B2 JP 6846429B2 JP 2018533097 A JP2018533097 A JP 2018533097A JP 2018533097 A JP2018533097 A JP 2018533097A JP 6846429 B2 JP6846429 B2 JP 6846429B2
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meganuclease
cells
sequence
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JP2018538000A (ja
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バートセビッチ，ビクター
ファム，クリスティーナ
マーティン，アーロン
ジャンツ，デレック
スミス，ジェームス，ジェファーソン
ニコルソン，マイケル，ジー．
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プレシジョン バイオサイエンシズ，インク．
プレシジョン バイオサイエンシズ，インク．
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    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Developmental Biology & Embryology (AREA)
JP2018533097A 2015-12-23 2016-12-22 ヒトβ−２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ Active JP6846429B2 (ja)

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JP2021031458A JP7203873B2 (ja) 2015-12-23 2021-03-01 ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ
JP2022209145A JP2023052095A (ja) 2015-12-23 2022-12-27 ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ

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US201562387318P 2015-12-23 2015-12-23
US62/387,318 2015-12-23
US201662416513P 2016-11-02 2016-11-02
US62/416,513 2016-11-02
PCT/US2016/068289 WO2017112859A1 (en) 2015-12-23 2016-12-22 Engineered meganucleases with recognition sequences found in the human beta-2 microglobulin gene

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JP2018538000A JP2018538000A (ja) 2018-12-27
JP2018538000A5 JP2018538000A5 (OSRAM) 2020-02-06
JP6846429B2 true JP6846429B2 (ja) 2021-03-24

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JP2021031458A Active JP7203873B2 (ja) 2015-12-23 2021-03-01 ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ
JP2022209145A Pending JP2023052095A (ja) 2015-12-23 2022-12-27 ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ

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JP2022209145A Pending JP2023052095A (ja) 2015-12-23 2022-12-27 ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ

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US (3) US20190017075A1 (OSRAM)
EP (2) EP3394253B1 (OSRAM)
JP (3) JP6846429B2 (OSRAM)
AU (2) AU2016379393B2 (OSRAM)
CA (1) CA3009637A1 (OSRAM)
ES (1) ES2901000T3 (OSRAM)
WO (1) WO2017112859A1 (OSRAM)

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JP2021101704A (ja) * 2015-12-23 2021-07-15 プレシジョン バイオサイエンシズ，インク． ヒトβ−２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ

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JP6816133B2 (ja) 2015-10-05 2021-01-20 プレシジョン バイオサイエンシズ，インク． 改変ヒトｔ細胞受容体アルファ定常領域遺伝子を含む遺伝子改変細胞
EP4234691A3 (en) * 2016-10-14 2023-10-18 Precision Biosciences, Inc. Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome
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CN116200342A (zh) 2019-04-03 2023-06-02 精密生物科学公司 包含microRNA适应的shRNA（shRNAmiR）的遗传修饰的免疫细胞
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Publication number Priority date Publication date Assignee Title
JP2021101704A (ja) * 2015-12-23 2021-07-15 プレシジョン バイオサイエンシズ，インク． ヒトβ−２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ
JP7203873B2 (ja) 2015-12-23 2023-01-13 プレシジョン バイオサイエンシズ，インク． ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ

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US20210032664A1 (en) 2021-02-04
EP3988655A3 (en) 2022-08-03
AU2023202035A1 (en) 2023-04-27
EP3394253B1 (en) 2021-09-01
AU2016379393B2 (en) 2023-01-05
AU2016379393A1 (en) 2018-07-12
JP2023052095A (ja) 2023-04-11
JP2018538000A (ja) 2018-12-27
CA3009637A1 (en) 2017-06-29
US20240052373A1 (en) 2024-02-15
JP7203873B2 (ja) 2023-01-13
EP3988655A2 (en) 2022-04-27
EP3394253A1 (en) 2018-10-31
ES2901000T3 (es) 2022-03-21
WO2017112859A1 (en) 2017-06-29
JP2021101704A (ja) 2021-07-15
US20190017075A1 (en) 2019-01-17

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