JP6843616B2 - アモルファステコビリマット調製 - Google Patents

アモルファステコビリマット調製 Download PDF

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Publication number
JP6843616B2
JP6843616B2 JP2016526997A JP2016526997A JP6843616B2 JP 6843616 B2 JP6843616 B2 JP 6843616B2 JP 2016526997 A JP2016526997 A JP 2016526997A JP 2016526997 A JP2016526997 A JP 2016526997A JP 6843616 B2 JP6843616 B2 JP 6843616B2
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Prior art keywords
amorphous
octahydro
isoindole
dioxo
trifluoromethyl
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JP2016526997A
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English (en)
Japanese (ja)
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JP2016527229A5 (https=
JP2016527229A (ja
Inventor
シャンタクマール・アール・チャヴァナギマット
エヌ・ケー・ピーター・サミュエル
ジョセフ・パズ
イン・タン
デニス・イー・フルビー
Original Assignee
シガ・テクノロジーズ・インコーポレーテッド
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Priority to JP2020195121A priority Critical patent/JP7681393B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C07D209/76—4,7-Endo-alkylene-iso-indoles with oxygen atoms in positions 1 and 3

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016526997A 2013-07-19 2014-07-11 アモルファステコビリマット調製 Active JP6843616B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020195121A JP7681393B2 (ja) 2013-07-19 2020-11-25 アモルファステコビリマット調製

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361856240P 2013-07-19 2013-07-19
US61/856,240 2013-07-19
PCT/US2014/046340 WO2015009566A1 (en) 2013-07-19 2014-07-11 Amorphous tecovirimat preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020195121A Division JP7681393B2 (ja) 2013-07-19 2020-11-25 アモルファステコビリマット調製

Publications (3)

Publication Number Publication Date
JP2016527229A JP2016527229A (ja) 2016-09-08
JP2016527229A5 JP2016527229A5 (https=) 2017-08-24
JP6843616B2 true JP6843616B2 (ja) 2021-03-17

Family

ID=52346653

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016526997A Active JP6843616B2 (ja) 2013-07-19 2014-07-11 アモルファステコビリマット調製
JP2020195121A Active JP7681393B2 (ja) 2013-07-19 2020-11-25 アモルファステコビリマット調製
JP2023065084A Pending JP2023080234A (ja) 2013-07-19 2023-04-12 アモルファステコビリマット調製

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020195121A Active JP7681393B2 (ja) 2013-07-19 2020-11-25 アモルファステコビリマット調製
JP2023065084A Pending JP2023080234A (ja) 2013-07-19 2023-04-12 アモルファステコビリマット調製

Country Status (8)

Country Link
US (3) US9670158B2 (https=)
EP (2) EP3763702B1 (https=)
JP (3) JP6843616B2 (https=)
CN (2) CN111635353A (https=)
AU (1) AU2014290333B2 (https=)
CA (3) CA3246369A1 (https=)
IL (1) IL242331B (https=)
WO (1) WO2015009566A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015009566A1 (en) * 2013-07-19 2015-01-22 Siga Technologies, Inc. Amorphous tecovirimat preparation
CN107126419B (zh) * 2016-02-26 2020-06-19 石药集团中诺药业（石家庄）有限公司 一种奥贝胆酸片剂及其制备方法
CN112955130A (zh) * 2018-10-30 2021-06-11 佩洛通治疗公司 包含取代茚满的固体分散体和药物组合物及其制备和使用方法
CN115141136B (zh) * 2021-03-31 2023-06-20 中国人民解放军军事科学院军事医学研究院 特考韦瑞药的共晶及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011184A1 (es) 2000-03-16 2001-11-15 Pfizer Prod Inc Composiciones farmaceuticas de inhibidores de la glucogeno-fosforilasa
US6596771B2 (en) 2001-01-12 2003-07-22 Schering Corporation Drugs for treating viral infections
US6433016B1 (en) 2001-01-12 2002-08-13 Vassil Stefanov Georgiev Drugs for treating viral infections
US7687641B2 (en) 2003-06-20 2010-03-30 Siga Technologies, Inc. Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
EP1638938B1 (en) * 2003-06-20 2017-04-12 Siga Technologies Inc. Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US8642577B2 (en) * 2005-04-08 2014-02-04 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
JP2010526848A (ja) * 2007-05-11 2010-08-05 エフ．ホフマン−ラ ロシュ アーゲー 難溶性薬物用の医薬組成物
JP6018041B2 (ja) 2010-03-23 2016-11-02 シガ・テクノロジーズ・インコーポレーテッド Ｓｔ−２４６の多形型および調製方法
BR112012031516A2 (pt) * 2010-06-09 2016-11-08 Abbott Lab dispersões sólidas contendo inibidores de quinase
GB201103837D0 (en) * 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
US8591944B2 (en) * 2011-03-08 2013-11-26 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
WO2013056108A2 (en) * 2011-10-14 2013-04-18 Array Biopharma Inc. Solid dispersion
JP2013103899A (ja) * 2011-11-11 2013-05-30 Fuji Chem Ind Co Ltd 難溶性薬物の新規な固体分散体
CN102406617B (zh) * 2011-11-30 2013-08-28 中国人民解放军军事医学科学院生物工程研究所 一种替韦立马干混悬剂及其制备方法
WO2015009566A1 (en) 2013-07-19 2015-01-22 Siga Technologies, Inc. Amorphous tecovirimat preparation

Also Published As

Publication number Publication date
EP3021836A1 (en) 2016-05-25
EP3763702B1 (en) 2023-12-13
CA3246369A1 (en) 2025-10-30
EP3021836B1 (en) 2020-10-07
WO2015009566A1 (en) 2015-01-22
WO2015009566A8 (en) 2015-12-10
CA3128535A1 (en) 2015-01-22
CA3128535C (en) 2024-10-15
CN111635353A (zh) 2020-09-08
US9889119B2 (en) 2018-02-13
US20170224661A1 (en) 2017-08-10
AU2014290333B2 (en) 2018-11-08
JP7681393B2 (ja) 2025-05-22
EP3021836A4 (en) 2016-12-07
JP2016527229A (ja) 2016-09-08
JP2021028336A (ja) 2021-02-25
CN105307636A (zh) 2016-02-03
US20180125819A1 (en) 2018-05-10
CA2917199A1 (en) 2015-01-22
CA2917199C (en) 2021-08-31
AU2014290333A1 (en) 2015-12-03
EP3763702A1 (en) 2021-01-13
JP2023080234A (ja) 2023-06-08
US9670158B2 (en) 2017-06-06
US20160152565A1 (en) 2016-06-02
IL242331B (en) 2021-02-28
US10045963B2 (en) 2018-08-14

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