IL242331B - Preparation of Amorphous Taquirimate - Google Patents
Preparation of Amorphous TaquirimateInfo
- Publication number
- IL242331B IL242331B IL242331A IL24233115A IL242331B IL 242331 B IL242331 B IL 242331B IL 242331 A IL242331 A IL 242331A IL 24233115 A IL24233115 A IL 24233115A IL 242331 B IL242331 B IL 242331B
- Authority
- IL
- Israel
- Prior art keywords
- tecovirimat
- amorphous
- preparation
- tecovirimat preparation
- amorphous tecovirimat
- Prior art date
Links
- CSKDFZIMJXRJGH-VWLPUNTISA-N tecovirimat Chemical compound C1=CC(C(F)(F)F)=CC=C1C(=O)NN1C(=O)[C@@H]([C@@H]2[C@H]3C[C@H]3[C@H]3C=C2)[C@@H]3C1=O CSKDFZIMJXRJGH-VWLPUNTISA-N 0.000 title 1
- 229950009384 tecovirimat Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/72—4,7-Endo-alkylene-iso-indoles
- C07D209/76—4,7-Endo-alkylene-iso-indoles with oxygen atoms in positions 1 and 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361856240P | 2013-07-19 | 2013-07-19 | |
| PCT/US2014/046340 WO2015009566A1 (en) | 2013-07-19 | 2014-07-11 | Amorphous tecovirimat preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL242331B true IL242331B (en) | 2021-02-28 |
Family
ID=52346653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL242331A IL242331B (en) | 2013-07-19 | 2015-10-29 | Preparation of Amorphous Taquirimate |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9670158B2 (https=) |
| EP (2) | EP3763702B1 (https=) |
| JP (3) | JP6843616B2 (https=) |
| CN (2) | CN111635353A (https=) |
| AU (1) | AU2014290333B2 (https=) |
| CA (3) | CA3246369A1 (https=) |
| IL (1) | IL242331B (https=) |
| WO (1) | WO2015009566A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015009566A1 (en) * | 2013-07-19 | 2015-01-22 | Siga Technologies, Inc. | Amorphous tecovirimat preparation |
| CN107126419B (zh) * | 2016-02-26 | 2020-06-19 | 石药集团中诺药业（石家庄）有限公司 | 一种奥贝胆酸片剂及其制备方法 |
| CN112955130A (zh) * | 2018-10-30 | 2021-06-11 | 佩洛通治疗公司 | 包含取代茚满的固体分散体和药物组合物及其制备和使用方法 |
| CN115141136B (zh) * | 2021-03-31 | 2023-06-20 | 中国人民解放军军事科学院军事医学研究院 | 特考韦瑞药的共晶及其制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20011184A1 (es) | 2000-03-16 | 2001-11-15 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la glucogeno-fosforilasa |
| US6596771B2 (en) | 2001-01-12 | 2003-07-22 | Schering Corporation | Drugs for treating viral infections |
| US6433016B1 (en) | 2001-01-12 | 2002-08-13 | Vassil Stefanov Georgiev | Drugs for treating viral infections |
| US7687641B2 (en) | 2003-06-20 | 2010-03-30 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| EP1638938B1 (en) * | 2003-06-20 | 2017-04-12 | Siga Technologies Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US8642577B2 (en) * | 2005-04-08 | 2014-02-04 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
| JP2010526848A (ja) * | 2007-05-11 | 2010-08-05 | エフ．ホフマン−ラ ロシュ アーゲー | 難溶性薬物用の医薬組成物 |
| JP6018041B2 (ja) | 2010-03-23 | 2016-11-02 | シガ・テクノロジーズ・インコーポレーテッド | Ｓｔ−２４６の多形型および調製方法 |
| BR112012031516A2 (pt) * | 2010-06-09 | 2016-11-08 | Abbott Lab | dispersões sólidas contendo inibidores de quinase |
| GB201103837D0 (en) * | 2011-03-07 | 2011-04-20 | Oxagen Ltd | Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid |
| US8591944B2 (en) * | 2011-03-08 | 2013-11-26 | Zalicus Pharmaceuticals Ltd. | Solid dispersion formulations and methods of use thereof |
| WO2013056108A2 (en) * | 2011-10-14 | 2013-04-18 | Array Biopharma Inc. | Solid dispersion |
| JP2013103899A (ja) * | 2011-11-11 | 2013-05-30 | Fuji Chem Ind Co Ltd | 難溶性薬物の新規な固体分散体 |
| CN102406617B (zh) * | 2011-11-30 | 2013-08-28 | 中国人民解放军军事医学科学院生物工程研究所 | 一种替韦立马干混悬剂及其制备方法 |
| WO2015009566A1 (en) | 2013-07-19 | 2015-01-22 | Siga Technologies, Inc. | Amorphous tecovirimat preparation |
-
2014
- 2014-07-11 WO PCT/US2014/046340 patent/WO2015009566A1/en not_active Ceased
- 2014-07-11 CA CA3246369A patent/CA3246369A1/en active Pending
- 2014-07-11 CA CA3128535A patent/CA3128535C/en active Active
- 2014-07-11 CA CA2917199A patent/CA2917199C/en active Active
- 2014-07-11 CN CN202010516675.7A patent/CN111635353A/zh active Pending
- 2014-07-11 EP EP20190932.2A patent/EP3763702B1/en active Active
- 2014-07-11 AU AU2014290333A patent/AU2014290333B2/en active Active
- 2014-07-11 JP JP2016526997A patent/JP6843616B2/ja active Active
- 2014-07-11 EP EP14825621.7A patent/EP3021836B1/en active Active
- 2014-07-11 CN CN201480026785.8A patent/CN105307636A/zh active Pending
- 2014-07-11 US US14/903,083 patent/US9670158B2/en active Active
-
2015
- 2015-10-29 IL IL242331A patent/IL242331B/en active IP Right Grant
-
2017
- 2017-04-27 US US15/498,787 patent/US9889119B2/en active Active
-
2018
- 2018-01-02 US US15/860,262 patent/US10045963B2/en active Active
-
2020
- 2020-11-25 JP JP2020195121A patent/JP7681393B2/ja active Active
-
2023
- 2023-04-12 JP JP2023065084A patent/JP2023080234A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3021836A1 (en) | 2016-05-25 |
| EP3763702B1 (en) | 2023-12-13 |
| CA3246369A1 (en) | 2025-10-30 |
| EP3021836B1 (en) | 2020-10-07 |
| WO2015009566A1 (en) | 2015-01-22 |
| WO2015009566A8 (en) | 2015-12-10 |
| CA3128535A1 (en) | 2015-01-22 |
| JP6843616B2 (ja) | 2021-03-17 |
| CA3128535C (en) | 2024-10-15 |
| CN111635353A (zh) | 2020-09-08 |
| US9889119B2 (en) | 2018-02-13 |
| US20170224661A1 (en) | 2017-08-10 |
| AU2014290333B2 (en) | 2018-11-08 |
| JP7681393B2 (ja) | 2025-05-22 |
| EP3021836A4 (en) | 2016-12-07 |
| JP2016527229A (ja) | 2016-09-08 |
| JP2021028336A (ja) | 2021-02-25 |
| CN105307636A (zh) | 2016-02-03 |
| US20180125819A1 (en) | 2018-05-10 |
| CA2917199A1 (en) | 2015-01-22 |
| CA2917199C (en) | 2021-08-31 |
| AU2014290333A1 (en) | 2015-12-03 |
| EP3763702A1 (en) | 2021-01-13 |
| JP2023080234A (ja) | 2023-06-08 |
| US9670158B2 (en) | 2017-06-06 |
| US20160152565A1 (en) | 2016-06-02 |
| US10045963B2 (en) | 2018-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |