JP6841997B1 - Polishing equipment for pharmaceutical intermediates - Google Patents

Polishing equipment for pharmaceutical intermediates Download PDF

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JP6841997B1
JP6841997B1 JP2020025602A JP2020025602A JP6841997B1 JP 6841997 B1 JP6841997 B1 JP 6841997B1 JP 2020025602 A JP2020025602 A JP 2020025602A JP 2020025602 A JP2020025602 A JP 2020025602A JP 6841997 B1 JP6841997 B1 JP 6841997B1
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crushing
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proportional control
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JP2021070021A (en
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毛春亮
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青島開運安豊智能科技有限公司
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C21/00Disintegrating plant with or without drying of the material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00Other disintegrating devices or methods
    • B02C19/10Mills in which a friction block is towed along the surface of a cylindrical or annular member
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C23/00Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
    • B02C23/08Separating or sorting of material, associated with crushing or disintegrating
    • B02C23/16Separating or sorting of material, associated with crushing or disintegrating with separator defining termination of crushing or disintegrating zone, e.g. screen denying egress of oversize material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C4/00Crushing or disintegrating by roller mills
    • B02C4/02Crushing or disintegrating by roller mills with two or more rollers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C4/00Crushing or disintegrating by roller mills
    • B02C4/28Details
    • B02C4/42Driving mechanisms; Roller speed control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C23/00Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
    • B02C23/08Separating or sorting of material, associated with crushing or disintegrating
    • B02C23/16Separating or sorting of material, associated with crushing or disintegrating with separator defining termination of crushing or disintegrating zone, e.g. screen denying egress of oversize material
    • B02C2023/165Screen denying egress of oversize material

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  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Crushing And Grinding (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Disintegrating Or Milling (AREA)

Abstract

【課題】本発明は医薬中間体の研磨装置を開示した。【解決手段】本体を含み、前記本体の中には粉砕空間が設置され、前記粉砕空間の中には粉砕装置が設置され、前記粉砕装置は前後対称で回転できる粉砕車を含み、研磨待ちの医薬品を前記粉砕空間の中に置き、前記粉砕車の回転により薬品が研磨され、前記粉砕空間の下側には回転空間が設置され、前記回転空間の中には回転ブロックが回転可能に取り付けられ、前記回転ブロックの中には比例制御装置が設置され、前記比例制御装置は四つの分離できる研磨ブロックを含み、前記研磨ブロックにより一つの完全なる円弧面が形成され、前記比例制御装置の下側には四つの連結装置が環状に配列されている。【選択図】図1PROBLEM TO BE SOLVED: To disclose a polishing apparatus for a pharmaceutical intermediate. SOLUTION: The main body is included, a crushing space is installed in the main body, a crushing device is installed in the crushing space, and the crushing device includes a crushing wheel that can rotate symmetrically in the front-rear direction and is waiting for polishing. The medicine is placed in the crushing space, the medicine is polished by the rotation of the crushing wheel, a rotating space is installed under the crushing space, and a rotating block is rotatably attached in the rotating space. , The proportional control device is installed in the rotary block, the proportional control device includes four separable polishing blocks, and the polishing blocks form one perfect arcuate surface, which is below the proportional control device. Four coupling devices are arranged in a ring shape. [Selection diagram] Fig. 1

Description

本願発明は医薬技術分野に関わり、具体的には医薬中間体の研磨装置である。 The present invention relates to the field of pharmaceutical technology, and specifically is a polishing device for pharmaceutical intermediates.

従来の生物医薬品に対する研磨装置は相対位置に設置されて回転できる研磨車の回転により研磨を実現するのであり、相対位置に設置された研磨車は研磨できる範囲が狭いし、研磨車の長さにも制限されるため、一回の研磨量が少なく、また研磨の時間が研磨車の直径に制限られ、研磨車の直径が短ければ短いほど、医薬品と研磨車との接触する時間が小さくなり、そのため、研磨が不十分となり、研磨の効率も良くない。本出願は上記の問題を解決できる装置を開示する。 The conventional polishing device for biopharmaceuticals realizes polishing by the rotation of a polishing wheel that can be rotated by being installed in a relative position, and the polishing wheel installed in a relative position has a narrow range of polishing and the length of the polishing wheel. Because the amount of polishing at one time is small, the polishing time is limited to the diameter of the polishing wheel, and the shorter the diameter of the polishing wheel, the shorter the contact time between the medicine and the polishing wheel. Therefore, polishing becomes insufficient and polishing efficiency is not good. This application discloses a device capable of solving the above problems.

中国特許出願公開第107008533号明細書Chinese Patent Application Publication No. 107008533

技術問題:
従来の医薬品研磨装置は研磨が不十分で、研磨効率が低い。
Technical problem:
Conventional pharmaceutical polishing equipment has insufficient polishing and low polishing efficiency.

上記の問題を解決するため、本出願には医薬中間体の研磨装置を設計した。医薬中間体の研磨装置であって、本体を含み、前記本体の中には粉砕空間が設置され、前記粉砕空間の中には粉砕装置が設置され、前記粉砕装置は前後対称で回転できる粉砕車を含み、研磨待ちの医薬品を前記粉砕空間の中に置き、前記粉砕車の回転により薬品が研磨され、前記粉砕空間の下側には回転空間が設置され、前記回転空間の中には回転ブロックが回転可能に取り付けられ、前記回転ブロックの中には比例制御装置が設置され、前記比例制御装置は四つの分離できる研磨ブロックを含み、前記研磨ブロックにより一つの完全なる円弧面が形成され、前記比例制御装置の下側には四つの連結装置が環状に配列され、前記連結装置はスライドできる十六個の連結スライダを含み、前記回転空間の外側には研磨空間が前記回転空間と連通するように設置され、前記研磨空間の中には環状である研磨筒が回転可能に設置され、前記研磨筒は外面に歯が形成され、前記比例制御装置によって前記研磨筒と前記研磨ブロックとの距離を所要の研磨精度により調節することができ、前記研磨ブロックと前記研磨筒との距離が縮める時、隣接する前記研磨ブロックが分離して隙間を生み出し、こうして前記連結装置が作動して前記連結スライダを隣接する前記研磨ブロックの間の隙間に埋めることで、医薬品を前記研磨空間の中で継続的に研磨でき、前記研磨筒の下端面にはフィルターが固定的に設置され、研磨完了後の医薬品は前記フィルターにより濾過され、前記研磨空間の左側には駆動装置が設置され、前記駆動装置は前記粉砕装置の作動、前記研磨筒及び前記回転ブロックの回転に動力を提供し、前記研磨空間の下側には逆円錐形である流通空間が設置され、前記本体の下端面には前記流通空間と連通した医薬品送り出し口が設置されている。 In order to solve the above problems, a polishing device for pharmaceutical intermediates was designed in this application. A polishing device for a pharmaceutical intermediate, including a main body, a crushing space is installed in the main body, a crushing device is installed in the crushing space, and the crushing device can rotate symmetrically in the front-rear direction. A medicine awaiting polishing is placed in the crushing space, the medicine is polished by the rotation of the crushing wheel, a rotating space is installed under the crushing space, and a rotating block is provided in the rotating space. Is rotatably mounted, a proportional control device is installed within the rotating block, the proportional control device includes four separable polishing blocks, the polishing blocks forming one perfect arc surface, said. Under the proportional control device, four connecting devices are arranged in an annular shape, the connecting device includes 16 sliding connecting sliders , and the polishing space communicates with the rotating space outside the rotating space. In the polishing space, an annular polishing cylinder is rotatably installed, teeth are formed on the outer surface of the polishing cylinder, and the distance between the polishing cylinder and the polishing block is determined by the proportional control device. It can be adjusted according to the required polishing accuracy, and when the distance between the polishing block and the polishing cylinder is shortened, the adjacent polishing blocks are separated to create a gap, and thus the connecting device is activated to operate the connecting slider. By filling the gap between the adjacent polishing blocks, the medicine can be continuously polished in the polishing space, a filter is fixedly installed on the lower end surface of the polishing cylinder, and the medicine after polishing is completed. Filtered by the filter, a drive is installed on the left side of the polishing space, which powers the operation of the crusher, the rotation of the polishing cylinder and the rotating block, and the lower side of the polishing space. Is provided with an inverted conical distribution space, and a drug delivery port communicating with the distribution space is installed on the lower end surface of the main body.

好ましくは、前記本体の下端面の四つの角には四つの支持柱が固定的に取り付けられ、四つの前記支持柱は前記本体を安定させるための支持作用を果たす。 Preferably, four support columns are fixedly attached to the four corners of the lower end surface of the main body, and the four support columns perform a supporting action for stabilizing the main body.

好ましくは、前記回転ブロックの上端面には螺旋溝が形成され、前記螺旋溝の内径は内部から外部へ順に短くなり、前記螺旋溝の深さは医薬品の厚さの二分の一より小さく、以上により、前記粉砕車と前記回転ブロックが逆転する時、医薬品を粉砕でき、前記回転ブロックの回転とともに、医薬品が連動して前記螺旋溝に沿って外側へ前記研磨空間の中に送られ、こうして前記螺旋溝の内径は小さくなり、医薬品を効率よく砕くことができる。 Preferably, a spiral groove is formed on the upper end surface of the rotating block, the inner diameter of the spiral groove is gradually shortened from the inside to the outside, and the depth of the spiral groove is less than half the thickness of the pharmaceutical product. When the crushing wheel and the rotating block are reversed, the medicine can be crushed, and with the rotation of the rotating block, the medicine is interlocked and sent outward along the spiral groove into the polishing space, and thus the said. The inner diameter of the spiral groove is reduced, and the drug can be efficiently crushed.

前記粉砕装置は砕きブロックを含み、前記砕きブロックは砕き回転軸により前記粉砕空間の中に回転可能に取り付けられ、前記砕き回転軸の下端と前記回転ブロックの上端面とが回転可能に連結され、前記砕きブロックの中には上下に貫通した貫通空間が設置され、前後の前記粉砕車が前記貫通空間内に回転可能に取り付けられ、前記粉砕空間の上側には前記粉砕空間と外部空間とを連通する左右対称である医薬品入れ口が設置され、前記医薬品入れ口と前記貫通空間とが連通しており、前記医薬品入れ口を介して前記粉砕空間に医薬品を入れ、前記砕きブロック及び前記粉砕車の回転により医薬品を砕く。 The crushing device includes a crushing block, the crushing block is rotatably mounted in the crushing space by a crushing rotary shaft, and a lower end of the crushing rotary shaft and an upper end surface of the rotary block are rotatably connected. A penetrating space penetrating vertically is installed in the crushing block, the front and rear crushing wheels are rotatably mounted in the penetrating space, and the crushing space and the external space are communicated above the crushing space. A symmetrical drug inlet is installed, the drug inlet and the penetrating space communicate with each other, and the drug is put into the crushing space through the drug inlet, and the crushing block and the crushing wheel are used. Crush the medicine by rotation.

前記比例制御装置は比例制御空間を含み、前記比例制御空間の上端壁の中には比例制御モーターが固定的に設置され、前記比例制御モーターの下端には動力軸が伝動可能に取り付けられ、前記動力軸には比例制御回転ブロックが固定的に設置され、前記比例制御回転ブロックの中には四つの凹溝が環状に配列され、前記凹溝の中には比例制御スライド棒が前記凹溝と当接するよう設置され、前記比例制御スライド棒はさらに前記凹溝の中にスライドできるように設置され、前記比例制御スライド棒において前記動力軸から離れた一端が前記研磨空間の中に伸び、かつ対応する前記研磨ブロックと固定的に取り付けられ、前記比例制御スライド棒の上端面には復帰バネが取り付けられ、前記比例制御回転ブロックが回転すると、前記比例制御スライド棒を押して外側に移動させ、そして前記研磨ブロックは連動して外側へ前記研磨筒との距離を縮み、こうして研磨をより細かくする。 The proportional control device includes a proportional control space, a proportional control motor is fixedly installed in the upper end wall of the proportional control space, and a power shaft is movably attached to the lower end of the proportional control motor. A proportional control rotation block is fixedly installed on the power shaft, four concave grooves are arranged in an annular shape in the proportional control rotation block, and a proportional control slide rod is provided with the concave groove in the concave groove. The proportional control slide rod is installed so as to abut, and the proportional control slide rod is further installed so as to be slidable in the concave groove, and one end of the proportional control slide rod separated from the power shaft extends into the polishing space and corresponds to it. A return spring is attached to the upper end surface of the proportional control slide rod, and when the proportional control rotation block rotates, the proportional control slide rod is pushed to move outward, and the proportional control slide rod is moved outward. The polishing block interlocks to reduce the distance from the polishing cylinder to the outside, thus making the polishing finer.

前記連結装置は環状に配列した四つの伸縮空間を含み、前記連結スライダにおいて配列中心に近接した一端が前記伸縮空間の中にスライド可能に取り付けられ、また前記連結スライダの上端面にはスライドガイドブロックが固定的に設置され、前記伸縮空間の上端壁の中には十六個のスライドガイド溝が前記伸縮空間と連通するように形成され、前記スライドガイドブロックと前記スライドガイド溝とがスライド可能に連結され、前記連結スライダの中には引き溝の中には押し棒がスライド可能に設置され、前記押し棒において配列中心から離れた一端と前記引き溝とは圧力バネによって連結され、前記伸縮空間の下側には押し空間が前記伸縮空間と連通するように設置され、前記押し棒の下端が前記押し空間の中に伸びており、四つの前記押し空間の配列中心には伝動空間が設置され、前記伝動空間と前記押し空間とがスライド溝により連通され、前記スライド溝の中には押し板がスライド可能に設置され、前記押し板の中には親ネジがネジ山により取り付けられ、前記親ネジにおいて配列中心に近接する一端が前記伝動空間の中に伸びており、また前記親ネジにおいて配列中心に近接する一端には従動傘歯車が固定的に設置され、四つの従動傘歯車が互いに離れており、また四つの前記従動傘歯車の上端に主動傘歯車が共同で噛み合っており、前記主動傘歯車と前記動力軸の下端とが固定的に連結され、前記比例制御モーターが作動して前記主動傘歯車を駆動して回転させ、そして前記親ネジが駆動されて回転し、前記押し板が移動して前記押し棒を押し動かして移動させ、さらに前記連結スライダを外側へ移動させて前記研磨ブロックの間の隙間を埋め、他の前記連結スライダが前記研磨ブロックの妨害により移動できなく、こうして前記圧力バネが圧縮される。 The connecting device includes four expansion and contraction spaces arranged in an annular shape, one end of the connection slider close to the center of the arrangement is slidably mounted in the expansion and contraction space, and a slide guide block is attached to the upper end surface of the connection slider. Is fixedly installed, and 16 slide guide grooves are formed in the upper end wall of the expansion and contraction space so as to communicate with the expansion and contraction space, so that the slide guide block and the slide guide groove can slide. A push rod is slidably installed in the pull groove in the connection slider, and one end of the push rod away from the center of the arrangement and the pull groove are connected by a pressure spring to form the expansion and contraction space. A push space is installed on the lower side so as to communicate with the expansion and contraction space, the lower end of the push rod extends into the push space, and a transmission space is installed at the center of the arrangement of the four push spaces. The transmission space and the push space are communicated with each other by a slide groove, a push plate is slidably installed in the slide groove, and a master screw is attached in the push plate by a screw thread. One end of the screw close to the center of the arrangement extends into the transmission space, and a driven umbrella gear is fixedly installed at one end of the master screw close to the center of the arrangement, and the four driven umbrella gears are separated from each other. The driving umbrella gear is jointly meshed with the upper ends of the four driven umbrella gears, the driving umbrella gear and the lower end of the power shaft are fixedly connected, and the proportional control motor is operated to operate the proportional control motor. The main screw is driven to rotate, and the base screw is driven to rotate, the push plate moves to push and move the push rod, and the connecting slider is further moved to the outside to perform the polishing. The gap between the blocks is filled and the other connecting sliders cannot move due to the interference of the polishing block, thus compressing the pressure spring.

好ましくは、前記連結スライダの幅は内部から外部へと段々長くなって弧状を形成し、前記スライドガイド溝の方向が前記連結スライダの中心線と対応し、前記連結スライダは各自の中心線に沿って前記研磨筒へ移動でき、こうして隣接した前記研磨ブロックの間の隙間を埋める。 Preferably, the width of the connecting slider gradually increases from the inside to the outside to form an arc, the direction of the slide guide groove corresponds to the center line of the connecting slider, and the connecting slider is along its own center line. Can be moved to the polishing cylinder, thus filling the gap between adjacent polishing blocks.

好ましくは、前記回転ブロックの中には四つの伸縮溝が環状に配列され、前記伸縮溝の中には伸縮軸がスライド可能に取り付けられ、前記伸縮軸と前記伸縮軸に対応した前記研磨ブロックの中心部とが固定的に連結され、こうして前記研磨ブロックの伸縮方向を固定できる。 Preferably, four telescopic grooves are arranged in an annular shape in the rotating block, and a telescopic shaft is slidably mounted in the telescopic groove, and the telescopic shaft and the polishing block corresponding to the telescopic shaft are provided. The central portion is fixedly connected, and thus the expansion / contraction direction of the polishing block can be fixed.

前記駆動装置は駆動溝を含み、前記駆動溝の中には連結軸により回転歯車が回転可能に取り付けられ、前記回転歯車と前記研磨筒の外面とが噛み合っており、前記連結軸の上端と前記砕き回転軸とがタイミングベルトにより伝動可能に連結され、前記駆動溝の下側には駆動空間が前記駆動溝と連通するように設置され、前記連結軸の下端が前記駆動空間の中に伸びており、また前記連結軸の下端には第一傘歯車が固定的に設置され、前記第一傘歯車の左側には第二傘歯車が噛み合っており、前記第二傘歯車の中心部には駆動軸が固定的に設置され、前記駆動軸の左端が前記駆動空間の左端壁に取り付けられた駆動モーターに伝動可能に連結され、前記回転ブロックの下側には転向空間が設置され、前記駆動軸の右端が前記転向空間の中に伸びており、また前記駆動軸の右端には第三傘歯車が固定的に設置され、前記第三傘歯車の上側には第四傘歯車が噛み合っており、前記第四傘歯車の中心部には回転軸が固定的に設置され、前記回転軸と前記回転ブロックとが固定的に連結され、
前記駆動モーターが作動して前記回転ブロック及び前記砕き回転軸を駆動して回転させることにより、前記砕きブロックと、前記粉砕車と、前記研磨筒と、前記回転ブロックとが同期に回転する。
The drive device includes a drive groove, and a rotary gear is rotatably mounted in the drive groove by a connecting shaft, and the rotary gear and the outer surface of the polishing cylinder are engaged with each other, and the upper end of the connecting shaft and the said The crushing rotary shaft is movably connected by a timing belt, a drive space is installed below the drive groove so as to communicate with the drive groove, and the lower end of the connecting shaft extends into the drive space. A first bevel gear is fixedly installed at the lower end of the connecting shaft, a second bevel gear is meshed on the left side of the first bevel gear, and a drive is provided at the center of the second bevel gear. The shaft is fixedly installed, the left end of the drive shaft is movably connected to a drive motor attached to the left end wall of the drive space, a turning space is installed under the rotating block, and the drive shaft is installed. The right end of the gear extends into the turning space, the third bevel gear is fixedly installed at the right end of the drive shaft, and the fourth bevel gear is meshed with the upper side of the third bevel gear. A rotating shaft is fixedly installed at the center of the fourth bevel gear, and the rotating shaft and the rotating block are fixedly connected to each other.
By operating the drive motor to drive and rotate the rotating block and the crushing rotary shaft, the crushing block, the crushing wheel, the polishing cylinder, and the rotating block rotate synchronously.

本願発明の効果は:本願発明は粉砕車の回転と螺旋溝の協働により医薬品を粉砕してから研磨空間に送り、分離可能な四つの研磨ブロックは伸縮することで研磨筒との距離を調節でき、即ち研磨完了後の医薬品粒子の大きさを調節でき、また研磨ブロックの間の隙間は連結装置の連結スライダにより埋められ、研磨の連続性と完全性を保障し、研磨の効率を高め、本願発明は研磨精度を調節でき、適用範囲が広い、また構成も操作も簡単である。 The effect of the present invention is: In the present invention, the medicine is crushed by the cooperation of the rotation of the crushing wheel and the spiral groove and then sent to the polishing space, and the four separable polishing blocks expand and contract to adjust the distance to the polishing cylinder. Yes, that is, the size of the pharmaceutical particles after polishing can be adjusted, and the gap between the polishing blocks is filled by the connecting slider of the connecting device, ensuring the continuity and completeness of polishing, increasing the efficiency of polishing, and increasing the efficiency of polishing. The invention of the present application has an adjustable polishing accuracy, a wide range of application, and a simple configuration and operation.

下記に図1〜6をあわせて本発明について詳しく説明し、便利に説明するために、下記の方向を以下のように規定する:図1は本発明装置の正面図であり、本願に記載の各方向が、図1と同じ向きに装置を見た際の方向である。 In order to explain the present invention in detail with reference to FIGS. 1 to 6 below and to explain the present invention in a convenient manner, the following directions are defined as follows: FIG. 1 is a front view of the apparatus of the present invention and is described in the present application. Each direction is the direction when the device is viewed in the same direction as in FIG.

図1は本願発明の全体構成概略図FIG. 1 is a schematic diagram of the overall configuration of the present invention. 図2は図1の「A―A」方向の構成概略図FIG. 2 is a schematic configuration diagram in the “AA” direction of FIG. 図3は図1の「B」を拡大した構成概略図FIG. 3 is an enlarged configuration schematic view of “B” in FIG. 図4は図3の「C―C」方向の構成概略図FIG. 4 is a schematic configuration diagram in the “CC” direction of FIG. 図5は図3の「D―D」方向の構成概略図FIG. 5 is a schematic configuration diagram in the “DD” direction of FIG. 図6は図3の「E―E」方向の構成概略図FIG. 6 is a schematic configuration diagram in the “EE” direction of FIG.

本願発明は医薬中間体の研磨装置であり、主に医薬品の粉砕作業に使用され、以下、本願発明の附図に合わせてさらなる説明を行う。 The present invention is a polishing device for pharmaceutical intermediates, and is mainly used for crushing pharmaceuticals. Hereinafter, further description will be given with reference to the accompanying drawings of the present invention.

本願発明に記載の医薬中間体の研磨装置は、本体10を含み、前記本体10の中には粉砕空間12が設置され、前記粉砕空間12の中には粉砕装置601が設置され、前記粉砕装置601は前後対称で回転できる粉砕車16を含み、研磨待ちの医薬品を前記粉砕空間12の中に置き、前記粉砕車16の回転により薬品が研磨され、前記粉砕空間12の下側には回転空間30が設置され、前記回転空間30の中には回転ブロック31が回転可能に取り付けられ、前記回転ブロック31の中には比例制御装置602が設置され、前記比例制御装置602は四つの分離できる研磨ブロック40を含み、前記研磨ブロック40により一つの完全なる円弧面が形成され、前記比例制御装置602の下側には四つの連結装置603が環状に配列され、前記連結装置603はスライドできる十六個の連結スライダ45を含み、前記回転空間30の外側には研磨空間28が前記回転空間30と連通するように設置され、前記研磨空間28の中には環状である研磨筒27が回転可能に設置され、前記研磨筒27は外面に歯が形成され、前記比例制御装置602によって前記研磨筒27と前記研磨ブロック40との距離を所要の研磨精度により調節することができ、前記研磨ブロック40と前記研磨筒27との距離が縮める時、隣接する前記研磨ブロック40が分離して隙間を生み出し、こうして前記連結装置603が作動して前記連結スライダ45を隣接する前記研磨ブロック40の間の隙間に埋めることで、医薬品を前記研磨空間28の中で継続的に研磨でき、前記研磨筒27の下端面にはフィルター29が固定的に設置され、研磨完了後の医薬品は前記フィルター29により濾過され、前記研磨空間28の左側には駆動装置604が設置され、前記駆動装置604は前記粉砕装置601の作動、前記研磨筒27及び前記回転ブロック31の回転に動力を提供し、前記研磨空間28の下側には逆円錐形である流通空間63が設置され、前記本体10の下端面には前記流通空間63と連通した医薬品送り出し口80が設置されている。 The pharmaceutical intermediate polishing device according to the present invention includes a main body 10, a crushing space 12 is installed in the main body 10, and a crushing device 601 is installed in the crushing space 12, and the crushing device is installed. 601 includes a crushing wheel 16 that can rotate symmetrically in the front-rear direction, a medicine waiting to be polished is placed in the crushing space 12, the chemical is polished by the rotation of the crushing wheel 16, and a rotating space is below the crushing space 12. 30 is installed, a rotating block 31 is rotatably mounted in the rotating space 30, a proportional control device 602 is installed in the rotating block 31, and the proportional control device 602 has four separable polishings. A perfect arc surface is formed by the polishing block 40 including the block 40, four connecting devices 603 are arranged in an annular shape under the proportional control device 602, and the connecting device 603 is slidable. A polishing space 28 is installed outside the rotating space 30 so as to communicate with the rotating space 30, and an annular polishing cylinder 27 can be rotated in the polishing space 28. The polishing cylinder 27 is installed, and teeth are formed on the outer surface of the polishing cylinder 27, and the distance between the polishing cylinder 27 and the polishing block 40 can be adjusted by the proportional control device 602 with a required polishing accuracy. When the distance from the polishing cylinder 27 is shortened, the adjacent polishing blocks 40 are separated to create a gap, and thus the connecting device 603 is activated to move the connecting slider 45 into the gap between the adjacent polishing blocks 40. By filling, the medicine can be continuously polished in the polishing space 28, a filter 29 is fixedly installed on the lower end surface of the polishing cylinder 27, and the medicine after polishing is filtered by the filter 29. A drive device 604 is installed on the left side of the polishing space 28, and the drive device 604 provides power for the operation of the crushing device 601 and the rotation of the polishing cylinder 27 and the rotating block 31, and under the polishing space 28. A distribution space 63 having an inverted conical shape is installed on the side, and a drug delivery port 80 communicating with the distribution space 63 is installed on the lower end surface of the main body 10.

有益なように、前記本体10の下端面の四つの角には四つの支持柱11が固定的に取り付けられ、四つの前記支持柱11は前記本体10を安定させるための支持作用を果たす。 As a benefit, four support columns 11 are fixedly attached to the four corners of the lower end surface of the main body 10, and the four support columns 11 serve a support action for stabilizing the main body 10.

有益なように、前記回転ブロック31の上端面には螺旋溝32が形成され、前記螺旋溝32の内径は内部から外部へ順に短くなり、前記螺旋溝32の深さは医薬品の厚さの二分の一より小さく、以上により、前記粉砕車16と前記回転ブロック31が逆転する時、医薬品を粉砕でき、前記回転ブロック31の回転とともに、医薬品が連動して前記螺旋溝32に沿って外側へ前記研磨空間28の中に送られ、こうして前記螺旋溝32の内径は小さくなり、医薬品を効率よく砕くことができる。 Beneficially, a spiral groove 32 is formed on the upper end surface of the rotating block 31, the inner diameter of the spiral groove 32 is gradually shortened from the inside to the outside, and the depth of the spiral groove 32 is half the thickness of the pharmaceutical product. When the crushing wheel 16 and the rotating block 31 are reversed, the medicine can be crushed, and the medicine is interlocked with the rotation of the rotating block 31 to the outside along the spiral groove 32. It is sent into the polishing space 28, and thus the inner diameter of the spiral groove 32 is reduced, so that the pharmaceutical product can be efficiently crushed.

前記粉砕装置601は砕きブロック13を含み、前記砕きブロック13は砕き回転軸14により前記粉砕空間12の中に回転可能に取り付けられ、前記砕き回転軸14の下端と前記回転ブロック31の上端面とが回転可能に連結され、前記砕きブロック13の中には上下に貫通した貫通空間15が設置され、前後の前記粉砕車16が前記貫通空間15内に回転可能に取り付けられ、前記粉砕空間12の上側には前記粉砕空間12と外部空間とを連通する左右対称である医薬品入れ口17が設置され、前記医薬品入れ口17と前記貫通空間15とが連通しており、前記医薬品入れ口17を介して前記粉砕空間12に医薬品を入れ、前記砕きブロック13及び前記粉砕車16の回転により医薬品を砕く。 The crushing device 601 includes a crushing block 13, and the crushing block 13 is rotatably mounted in the crushing space 12 by a crushing rotating shaft 14, and a lower end surface of the crushing rotating shaft 14 and an upper end surface of the rotating block 31. Are rotatably connected, a penetrating space 15 penetrating vertically is installed in the crushing block 13, and the front and rear crushing wheels 16 are rotatably mounted in the penetrating space 15, and the crushing space 12 On the upper side, a symmetrical drug inlet 17 that communicates the crushing space 12 and the external space is installed, and the drug inlet 17 and the penetrating space 15 communicate with each other through the drug inlet 17. The medicine is put into the crushing space 12, and the medicine is crushed by the rotation of the crushing block 13 and the crushing wheel 16.

前記比例制御装置602は比例制御空間33を含み、前記比例制御空間33の上端壁の中には比例制御モーター34が固定的に設置され、前記比例制御モーター34の下端には動力軸35が伝動可能に取り付けられ、前記動力軸35には比例制御回転ブロック36が固定的に設置され、前記比例制御回転ブロック36の中には四つの凹溝37が環状に配列され、前記凹溝37の中には比例制御スライド棒38が前記凹溝37と当接するよう設置され、前記比例制御スライド棒38はさらに前記凹溝37の中にスライドできるように設置され、前記比例制御スライド棒38において前記動力軸35から離れた一端が前記研磨空間28の中に伸び、かつ対応する前記研磨ブロック40と固定的に取り付けられ、前記比例制御スライド棒38の上端面には復帰バネ39が取り付けられ、前記比例制御回転ブロック36が回転すると、前記比例制御スライド棒38を押して外側に移動させ、そして前記研磨ブロック40は連動して外側へ前記研磨筒27との距離を縮み、こうして研磨をより細かくする。 The proportional control device 602 includes a proportional control space 33, a proportional control motor 34 is fixedly installed in the upper end wall of the proportional control space 33, and a power shaft 35 is transmitted to the lower end of the proportional control motor 34. Proportional control rotation block 36 is fixedly installed on the power shaft 35, and four recessed grooves 37 are arranged in an annular shape in the proportional control rotation block 36, and the inside of the recessed groove 37. The proportional control slide rod 38 is installed so as to come into contact with the concave groove 37, and the proportional control slide rod 38 is further installed so as to be slidable in the concave groove 37. One end away from the shaft 35 extends into the polishing space 28 and is fixedly attached to the corresponding polishing block 40, and a return spring 39 is attached to the upper end surface of the proportional control slide rod 38 to form the proportionality. When the control rotation block 36 rotates, the proportional control slide rod 38 is pushed to move outward, and the polishing block 40 interlocks to reduce the distance from the polishing cylinder 27 to the outside, thus making the polishing finer.

前記連結装置603は環状に配列した四つの伸縮空間43を含み、前記連結スライダ45において配列中心に近接した一端が前記伸縮空間43の中にスライド可能に取り付けられ、また前記連結スライダ45の上端面にはスライドガイドブロック44が固定的に設置され、前記伸縮空間43の上端壁の中には十六個のスライドガイド溝61が前記伸縮空間43と連通するように形成され、前記スライドガイドブロック44と前記スライドガイド溝61とがスライド可能に連結され、前記連結スライダ45の中には引き溝49の中には押し棒51がスライド可能に設置され、前記押し棒51において配列中心から離れた一端と前記引き溝49とは圧力バネ50によって連結され、前記伸縮空間43の下側には押し空間48が前記伸縮空間43と連通するように設置され、前記押し棒51の下端が前記押し空間48の中に伸びており、四つの前記押し空間48の配列中心には伝動空間56が設置され、前記伝動空間56と前記押し空間48とがスライド溝53により連通され、前記スライド溝53の中には押し板52がスライド可能に設置され、前記押し板52の中には親ネジ54がネジ山により取り付けられ、前記親ネジ54において配列中心に近接する一端が前記伝動空間56の中に伸びており、また前記親ネジ54において配列中心に近接する一端には従動傘歯車55が固定的に設置され、四つの従動傘歯車55が互いに離れており、また四つの前記従動傘歯車55の上端に主動傘歯車が共同で噛み合っており、前記主動傘歯車64と前記動力軸35の下端とが固定的に連結され、前記比例制御モーター34が作動して前記主動傘歯車64を駆動して回転させ、そして前記親ネジ54が駆動されて回転し、前記押し板52が移動して前記押し棒51を押し動かして移動させ、さらに前記連結スライダ45を外側へ移動させて前記研磨ブロック40の間の隙間を埋め、他の前記連結スライダ45が前記研磨ブロック40の妨害により移動できなく、こうして前記圧力バネ50が圧縮される。 The connecting device 603 includes four expansion and contraction spaces 43 arranged in an annular shape, one end of the connection slider 45 close to the center of the arrangement is slidably mounted in the expansion and contraction space 43, and an upper end surface of the connection slider 45 is provided. A slide guide block 44 is fixedly installed in the room, and 16 slide guide grooves 61 are formed in the upper end wall of the expansion and contraction space 43 so as to communicate with the expansion and contraction space 43. And the slide guide groove 61 are slidably connected, and a push rod 51 is slidably installed in the pull groove 49 in the connection slider 45, and one end of the push rod 51 away from the center of the arrangement. And the pull groove 49 are connected by a pressure spring 50, a push space 48 is installed under the expansion and contraction space 43 so as to communicate with the expansion and contraction space 43, and the lower end of the push rod 51 is the push space 48. A transmission space 56 is installed at the center of the arrangement of the four push spaces 48, and the transmission space 56 and the push space 48 are communicated with each other by the slide groove 53, and the inside of the slide groove 53. The push plate 52 is slidably installed, a base screw 54 is attached to the push plate 52 by a screw thread, and one end of the base screw 54 close to the center of the arrangement extends into the transmission space 56. A driven cap gear 55 is fixedly installed at one end of the master screw 54 near the center of the arrangement, the four driven cap gears 55 are separated from each other, and the four driven cap gears 55 are located at the upper ends of the four driven cap gears 55. The driving umbrella gears are jointly meshed with each other, the driving umbrella gear 64 and the lower end of the power shaft 35 are fixedly connected, and the proportional control motor 34 operates to drive and rotate the driving umbrella gear 64. Then, the base screw 54 is driven and rotated, the push plate 52 moves to push and move the push rod 51, and further moves the connecting slider 45 to the outside to move between the polishing blocks 40. The gap is filled and the other connecting slider 45 cannot move due to the interference of the polishing block 40, thus compressing the pressure spring 50.

有益なように、前記連結スライダ45の幅は内部から外部へと段々長くなって弧状を形成し、前記スライドガイド溝61の方向が前記連結スライダ45の中心線と対応し、前記連結スライダ45は各自の中心線に沿って前記研磨筒27へ移動でき、こうして隣接した前記研磨ブロック40の間の隙間を埋める。 To be beneficial, the width of the connecting slider 45 gradually increases from the inside to the outside to form an arc, the direction of the slide guide groove 61 corresponds to the center line of the connecting slider 45, and the connecting slider 45 They can move to the polishing cylinder 27 along their own center line, thus filling the gap between the adjacent polishing blocks 40.

有益なように、前記回転ブロック31の中には四つの伸縮溝42が環状に配列され、前記伸縮溝42の中には伸縮軸41がスライド可能に取り付けられ、前記伸縮軸41と前記伸縮軸41に対応した前記研磨ブロック40の中心部とが固定的に連結され、こうして前記研磨ブロック40の伸縮方向を固定できる。 For convenience, four telescopic grooves 42 are arranged in an annular shape in the rotating block 31, and a telescopic shaft 41 is slidably mounted in the telescopic groove 42, and the telescopic shaft 41 and the telescopic shaft are slidably mounted. The central portion of the polishing block 40 corresponding to 41 is fixedly connected, and thus the expansion / contraction direction of the polishing block 40 can be fixed.

前記駆動装置604は駆動溝21を含み、前記駆動溝21の中には連結軸20により回転歯車22が回転可能に取り付けられ、前記回転歯車22と前記研磨筒27の外面とが噛み合っており、前記連結軸20の上端と前記砕き回転軸14とがタイミングベルト19により伝動可能に連結され、前記駆動溝21の下側には駆動空間26が前記駆動溝21と連通するように設置され、前記連結軸20の下端が前記駆動空間26の中に伸びており、また前記連結軸20の下端には第一傘歯車23が固定的に設置され、前記第一傘歯車23の左側には第二傘歯車25が噛み合っており、前記第二傘歯車25の中心部には駆動軸62が固定的に設置され、前記駆動軸62の左端が前記駆動空間26の左端壁に取り付けられた駆動モーター24に伝動可能に連結され、前記回転ブロック31の下側には転向空間57が設置され、前記駆動軸62の右端が前記転向空間57の中に伸びており、また前記駆動軸62の右端には第三傘歯車60が固定的に設置され、前記第三傘歯車60の上側には第四傘歯車58が噛み合っており、前記第四傘歯車58の中心部には回転軸59が固定的に設置され、前記回転軸59と前記回転ブロック31とが固定的に連結され、前記駆動モーター24が作動して前記回転ブロック31及び前記砕き回転軸14を駆動して回転させることにより、前記砕きブロック13と、前記粉砕車16と、前記研磨筒27と、前記回転ブロック31とが同期に回転する。 The drive device 604 includes a drive groove 21, and a rotary gear 22 is rotatably attached to the drive groove 21 by a connecting shaft 20, and the rotary gear 22 and the outer surface of the polishing cylinder 27 are engaged with each other. The upper end of the connecting shaft 20 and the crushing rotary shaft 14 are communicably connected by a timing belt 19, and a drive space 26 is installed below the drive groove 21 so as to communicate with the drive groove 21. The lower end of the connecting shaft 20 extends into the drive space 26, the first bevel gear 23 is fixedly installed at the lower end of the connecting shaft 20, and the second is on the left side of the first bevel gear 23. The bevel gear 25 is meshed with each other, a drive shaft 62 is fixedly installed at the center of the second bead gear 25, and the left end of the drive shaft 62 is attached to the left end wall of the drive space 26. A turning space 57 is installed under the rotating block 31, the right end of the drive shaft 62 extends into the turning space 57, and the right end of the drive shaft 62 The third bevel gear 60 is fixedly installed, the fourth bevel gear 58 is meshed on the upper side of the third bead gear 60, and the rotating shaft 59 is fixedly mounted on the central portion of the fourth bead gear 58. The crushing block is installed, the rotary shaft 59 and the rotary block 31 are fixedly connected, and the drive motor 24 operates to drive and rotate the rotary block 31 and the crushing rotary shaft 14. 13, the crushing wheel 16, the polishing cylinder 27, and the rotating block 31 rotate in synchronization with each other.

附図1〜6に合わせて本願発明の使用方法を詳しく説明する。 The method of using the present invention will be described in detail with reference to FIGS. 1 to 6.

初期において、四つの研磨ブロック40が密着しており、研磨ブロック40と研磨筒27との間の隙間が最大であるため、研磨後の粒子も最大であり、連結スライダ45が研磨ブロック40内に位置して包まれており、圧力バネ50が自由状態にある。 In the initial stage, the four polishing blocks 40 are in close contact with each other, and the gap between the polishing block 40 and the polishing cylinder 27 is the largest. Therefore, the particles after polishing are also the largest, and the connecting slider 45 is placed in the polishing block 40. Positioned and wrapped, the pressure spring 50 is free.

使用時、所要の研磨精度により研磨ブロック40と研磨筒27との距離を調節し、比例制御モーター34を作動させ、動力軸35が駆動されて回転し、そして比例制御ブロック36が回転し、比例制御スライド棒38を押し動かして動力軸35から離れるように移動させ、研磨ブロック40を外側へ移動させて研磨筒27との間の距離を縮み、この時、研磨ブロック40の間には隙間が生じ、動力軸35が回転すると同時に主動傘歯車64を回転させ、こうして従動傘歯車55が親ネジ54を回転させることで、押し板52を主動傘歯車64から離れるように移動させ、押し板52が押し棒51を押して外側に移動させ、隣接した研磨ブロック40の隙間に位置する連結スライダ45が外側に移動して研磨ブロック40の外弧面と接触し、研磨ブロック40の内側に位置する連結スライダ45が研磨ブロック40の妨害を受けて移動できなく、こうして圧力バネ50が圧縮され、ここで、隙間の調節を完成し、
研磨時、駆動モーター24が作動して駆動軸62を駆動して回転させ、回転歯車22が回転して研磨筒27を駆動して回転させ、タイミングベルト19により砕き回転軸14が同時に回転し、そして砕きブロック13が粉砕車16を回転させ、駆動軸62が回転すると同時に第三傘歯車60を回転させ、第四傘歯車58が回転ブロック31を回転させ、さらに連結スライダ45及び研磨ブロック40が同期に回転し、この時、研磨ブロック40の回転方向は研磨筒27の回転方向と反対であり、研磨待ちの医薬品を医薬品入れ口17を介して粉砕空間12の中に入れ、粉砕車16が回転して医薬品を砕き、砕かれた医薬品が螺旋溝32に沿って研磨空間28に入り、その後、研磨筒27と研磨ブロック40を逆転させて医薬品を研磨し、研磨された医薬品はフィルター29により濾過された後に、流通空間63の中に入り、そして医薬品送り出し口80により排出されて集められる。
At the time of use, the distance between the polishing block 40 and the polishing cylinder 27 is adjusted according to the required polishing accuracy, the proportional control motor 34 is operated, the power shaft 35 is driven and rotated, and the proportional control block 36 is rotated and proportional. The control slide rod 38 is pushed and moved to move away from the power shaft 35, and the polishing block 40 is moved outward to reduce the distance between the polishing block 27 and the polishing cylinder 27. At this time, there is a gap between the polishing blocks 40. As a result, the driving umbrella gear 64 is rotated at the same time as the power shaft 35 is rotated, and thus the driven umbrella gear 55 rotates the master screw 54 to move the push plate 52 away from the driving umbrella gear 64, and the push plate 52. Pushes the push rod 51 to move it outward, and the connecting slider 45 located in the gap between the adjacent polishing blocks 40 moves outward to come into contact with the outer arc surface of the polishing block 40, and the connection located inside the polishing block 40. The slider 45 cannot move due to the interference of the polishing block 40, and thus the pressure spring 50 is compressed, where the clearance adjustment is completed.
At the time of polishing, the drive motor 24 operates to drive and rotate the drive shaft 62, the rotary gear 22 rotates to drive and rotate the polishing cylinder 27, and the timing belt 19 causes the crushing rotary shaft 14 to rotate at the same time. Then, the crushing block 13 rotates the crushing wheel 16, the drive shaft 62 rotates, and at the same time, the third umbrella gear 60 rotates, the fourth umbrella gear 58 rotates the rotating block 31, and the connecting slider 45 and the polishing block 40 rotate. It rotates synchronously, and at this time, the rotation direction of the polishing block 40 is opposite to the rotation direction of the polishing cylinder 27, and the medicine waiting to be polished is put into the crushing space 12 through the medicine inlet 17, and the crushing wheel 16 Rotate to crush the drug, the crushed drug enters the polishing space 28 along the spiral groove 32, then the polishing cylinder 27 and the polishing block 40 are reversed to polish the drug, and the polished drug is filtered by the filter 29. After being filtered, it enters the distribution space 63 and is discharged and collected by the drug delivery port 80.

上記の方式により、当業者は本願発明の範囲内で作業状況に応じて様々の改変を加えられる。


According to the above method, those skilled in the art can make various modifications according to the working situation within the scope of the present invention.


Claims (4)

医薬中間体の研磨装置であって、本体を含み、
前記本体の中には粉砕空間が設置され、前記粉砕空間の中には粉砕装置が設置され、前記粉砕装置は前後対称で回転できる粉砕車を含み、研磨待ちの医薬品を前記粉砕空間の中に置き、前記粉砕車の回転により薬品が研磨され、前記粉砕空間の下側には回転空間が設置され、前記回転空間の中には回転ブロックが回転可能に取り付けられ、前記回転ブロックの中には比例制御装置が設置され、前記比例制御装置は四つの分離できる研磨ブロックを含み、前記研磨ブロックにより一つの完全なる円弧面が形成され、前記比例制御装置の下側には四つの連結装置が環状に配列され、前記連結装置はスライドできる十六個の連結スライダを含み、前記回転空間の外側には研磨空間が前記回転空間と連通するように設置され、前記研磨空間の中には環状である研磨筒が回転可能に設置され、前記研磨筒は外面に歯が形成され、前記比例制御装置によって前記研磨筒と前記研磨ブロックとの距離を所要の研磨精度により調節することができ、前記研磨ブロックと前記研磨筒との距離が縮める時、隣接する前記研磨ブロックが分離して隙間を生み出し、こうして前記連結装置が作動して前記連結スライダを隣接する前記研磨ブロックの間の隙間に埋めることで、医薬品を前記研磨空間の中で継続的に研磨でき、
前記研磨筒の下端面にはフィルターが固定的に設置され、研磨完了後の医薬品は前記フィルターにより濾過され、前記研磨空間の左側には駆動装置が設置され、前記駆動装置は前記粉砕装置の作動、前記研磨筒及び前記回転ブロックの回転に動力を提供し、前記研磨空間の下側には逆円錐形である流通空間が設置され、前記本体の下端面には前記流通空間と連通した医薬品送り出し口が設置され、
前記本体の下端面の四つの角には四つの支持柱が固定的に取り付けられ、
前記回転ブロックの上端面には螺旋溝が形成され、前記螺旋溝の内径は内部から外部へ順に短くなり、前記螺旋溝の深さは医薬品の厚さの二分の一より小さく、
前記粉砕装置は砕きブロックを含み、
前記砕きブロックは砕き回転軸により前記粉砕空間の中に回転可能に取り付けられ、前記砕き回転軸の下端と前記回転ブロックの上端面とが回転可能に連結され、前記砕きブロックの中には上下に貫通した貫通空間が設置され、前後の前記粉砕車が前記貫通空間内に回転可能に取り付けられ、前記粉砕空間の上側には前記粉砕空間と外部空間とを連通する左右対称である医薬品入れ口が設置され、前記医薬品入れ口と前記貫通空間とが連通し、
前記比例制御装置は比例制御空間を含み、
前記比例制御空間の上端壁の中には比例制御モーターが固定的に設置され、前記比例制御モーターの下端には動力軸が伝動可能に取り付けられ、前記動力軸には比例制御回転ブロックが固定的に設置され、前記比例制御回転ブロックの中には四つの凹溝が環状に配列され、前記凹溝の中には比例制御スライド棒が前記凹溝と当接するよう設置され、前記比例制御スライド棒はさらに前記凹溝の中にスライドできるように設置され、前記比例制御スライド棒において前記動力軸から離れた一端が前記研磨空間の中に伸び、かつ対応する前記研磨ブロックと固定的に取り付けられ、前記比例制御スライド棒の上端面には復帰バネが取り付けられ、
前記連結装置は環状に配列した四つの伸縮空間を含み、
前記連結スライダにおいて配列中心に近接した一端が前記伸縮空間の中にスライド可能に取り付けられ、また前記連結スライダの上端面にはスライドガイドブロックが固定的に設置され、前記伸縮空間の上端壁の中には十六個のスライドガイド溝が前記伸縮空間と連通するように形成され、前記スライドガイドブロックと前記スライドガイド溝とがスライド可能に連結され、前記連結スライダの中には引き溝の中には押し棒がスライド可能に設置され、前記押し棒において配列中心から離れた一端と前記引き溝とは圧力バネによって連結され、
前記伸縮空間の下側には押し空間が前記伸縮空間と連通するように設置され、前記押し棒の下端が前記押し空間の中に伸びており、四つの前記押し空間の配列中心には伝動空間が設置され、前記伝動空間と前記押し空間とがスライド溝により連通され、前記スライド溝の中には押し板がスライド可能に設置され、前記押し板の中には親ネジがネジ山により取り付けられ、前記親ネジにおいて配列中心に近接する一端が前記伝動空間の中に伸びており、また前記親ネジにおいて配列中心に近接する一端には従動傘歯車が固定的に設置され、四つの従動傘歯車が互いに離れており、また四つの前記従動傘歯車の上端に主動傘歯車が共同で噛み合っており、前記主動傘歯車と前記動力軸の下端とが固定的に連結され、
前記比例制御モーターが作動して前記主動傘歯車を駆動して回転させ、そして前記親ネジが駆動されて回転し、前記押し板が移動して前記押し棒を押し動かして移動させ、さらに前記連結スライダを外側へ移動させて前記研磨ブロックの間の隙間を埋め、他の前記連結スライダが前記研磨ブロックの妨害により移動できなく、こうして前記圧力バネが圧縮されることを特徴とする医薬中間体の研磨装置
A polishing device for pharmaceutical intermediates, including the main body
A crushing space is installed in the main body, a crushing device is installed in the crushing space, and the crushing device includes a crushing wheel that can rotate symmetrically in the front-rear direction, and a medicine waiting for polishing is placed in the crushing space. The chemicals are polished by the rotation of the crushing wheel, a rotating space is installed under the crushing space, a rotating block is rotatably attached in the rotating space, and the rotating block is inside the rotating block. A proportional control device is installed, the proportional control device includes four separable polishing blocks, the polishing blocks form one perfect arcuate surface, and four coupling devices are annular under the proportional control device. The connecting device includes 16 sliding connecting sliders , and the polishing space is installed outside the rotating space so as to communicate with the rotating space, and is annular in the polishing space. The polishing cylinder is rotatably installed, teeth are formed on the outer surface of the polishing cylinder, and the distance between the polishing cylinder and the polishing block can be adjusted by the proportional control device according to the required polishing accuracy. When the distance between the polishing cylinder and the polishing cylinder is shortened, the adjacent polishing blocks are separated to create a gap, and thus the connecting device is activated to fill the connecting slider in the gap between the adjacent polishing blocks. The medicine can be continuously polished in the polishing space,
A filter is fixedly installed on the lower end surface of the polishing cylinder, the medicine after polishing is filtered by the filter, a driving device is installed on the left side of the polishing space, and the driving device operates the crushing device. A distribution space having an inverted conical shape is installed under the polishing space to provide power for the rotation of the polishing cylinder and the rotating block, and a medicine delivery space communicating with the distribution space is provided on the lower end surface of the main body. The mouth is installed,
Four support columns are fixedly attached to the four corners of the lower end surface of the main body.
A spiral groove is formed on the upper end surface of the rotating block, the inner diameter of the spiral groove is gradually shortened from the inside to the outside, and the depth of the spiral groove is smaller than half the thickness of the pharmaceutical product.
The crusher includes a crushing block
The crushing block is rotatably attached in the crushing space by a crushing rotation shaft, and the lower end of the crushing rotation shaft and the upper end surface of the rotation block are rotatably connected to each other, and the crushing block is moved up and down in the crushing block. A penetrating space is installed, the front and rear crushing wheels are rotatably mounted in the penetrating space, and above the crushing space, there is a symmetrical drug inlet that communicates the crushing space and the external space. It is installed, and the medicine inlet and the penetration space communicate with each other.
The proportional control device includes a proportional control space.
A proportional control motor is fixedly installed in the upper end wall of the proportional control space, a power shaft is movably attached to the lower end of the proportional control motor, and a proportional control rotation block is fixed to the power shaft. In the proportional control rotation block, four concave grooves are arranged in an annular shape, and in the concave groove, a proportional control slide rod is installed so as to abut the concave groove, and the proportional control slide rod is installed. Is further installed so that it can slide in the recessed groove, and one end of the proportional control slide rod away from the power shaft extends into the polishing space and is fixedly attached to the corresponding polishing block. A return spring is attached to the upper end surface of the proportional control slide rod.
The coupling device includes four expansion and contraction spaces arranged in a ring.
One end of the connecting slider close to the center of the arrangement is slidably mounted in the expansion and contraction space, and a slide guide block is fixedly installed on the upper end surface of the connection slider in the upper end wall of the expansion and contraction space. 16 slide guide grooves are formed so as to communicate with the expansion and contraction space, the slide guide block and the slide guide groove are slidably connected, and the connecting slider is contained in a pull groove. The push rod is slidably installed, and one end of the push rod away from the center of the arrangement and the pull groove are connected by a pressure spring.
A push space is installed below the telescopic space so as to communicate with the telescopic space, the lower end of the push rod extends into the push space, and a transmission space is located at the center of arrangement of the four push spaces. Is installed, the transmission space and the push space are communicated by a slide groove, a push plate is slidably installed in the slide groove, and a master screw is attached in the push plate by a screw thread. , One end of the master screw close to the center of the arrangement extends into the transmission space, and one end of the master screw close to the center of the arrangement is fixedly installed with a driven bevel gear, and four driven bead gears. Are separated from each other, and the main gears are jointly meshed with the upper ends of the four driven gears, and the main gears and the lower ends of the power shaft are fixedly connected to each other.
The proportional control motor operates to drive and rotate the main bevel gear, and the base screw is driven to rotate, the push plate moves to push and move the push rod, and further, the connection. A pharmaceutical intermediate of a pharmaceutical intermediate characterized in that the slider is moved outward to fill the gap between the polishing blocks so that the other connecting sliders cannot move due to interference of the polishing block and thus the pressure spring is compressed. Polishing equipment .
前記連結スライダの幅は内部から外部へと段々長くなって弧状を形成し、前記スライドガイド溝の方向が前記連結スライダの中心線と対応することを特徴とする請求項1に記載の医薬中間体の研磨装置。 The pharmaceutical intermediate according to claim 1 , wherein the width of the connecting slider gradually increases from the inside to the outside to form an arc shape, and the direction of the slide guide groove corresponds to the center line of the connecting slider. Polishing equipment. 前記回転ブロックの中には四つの伸縮溝が環状に配列され、前記伸縮溝の中には伸縮軸がスライド可能に取り付けられ、前記伸縮軸と前記伸縮軸に対応した前記研磨ブロックの中心部とが固定的に連結されていることを特徴とする請求項1に記載の医薬中間体の研磨装置。 Four telescopic grooves are arranged in an annular shape in the rotating block, and a telescopic shaft is slidably mounted in the telescopic groove, and the telescopic shaft and the central portion of the polishing block corresponding to the telescopic shaft are formed. The pharmaceutical intermediate polishing apparatus according to claim 1 , wherein the above-mentioned is fixedly connected. 前記駆動装置は駆動溝を含み、
前記駆動溝の中には連結軸により回転歯車が回転可能に取り付けられ、前記回転歯車と前記研磨筒の外面とが噛み合っており、前記連結軸の上端と前記砕き回転軸とがタイミングベルトにより伝動可能に連結され、前記駆動溝の下側には駆動空間が前記駆動溝と連通するように設置され、前記連結軸の下端が前記駆動空間の中に伸びており、また前記連結軸の下端には第一傘歯車が固定的に設置され、前記第一傘歯車の左側には第二傘歯車が噛み合っており、前記第二傘歯車の中心部には駆動軸が固定的に設置され、前記駆動軸の左端が前記駆動空間の左端壁に取り付けられた駆動モーターに伝動可能に連結され、前記回転ブロックの下側には転向空間が設置され、前記駆動軸の右端が前記転向空間の中に伸びており、また前記駆動軸の右端には第三傘歯車が固定的に設置され、前記第三傘歯車の上側には第四傘歯車が噛み合っており、前記第四傘歯車の中心部には回転軸が固定的に設置され、前記回転軸と前記回転ブロックとが固定的に連結されていることを特徴とする請求項1に記載の医薬中間体の研磨装置。
The drive device includes a drive groove and includes a drive groove.
A rotary gear is rotatably mounted in the drive groove by a connecting shaft, the rotary gear and the outer surface of the polishing cylinder are engaged, and the upper end of the connecting shaft and the crushing rotary shaft are transmitted by a timing belt. It is possibly connected, and a drive space is installed below the drive groove so as to communicate with the drive groove, the lower end of the connecting shaft extends into the drive space, and the lower end of the connecting shaft extends to the lower end of the connecting shaft. The first bevel gear is fixedly installed, the second bead gear is meshed on the left side of the first bead gear, and the drive shaft is fixedly installed at the center of the second bead gear. The left end of the drive shaft is movably connected to a drive motor attached to the left end wall of the drive space, a turning space is installed under the rotating block, and the right end of the drive shaft is in the turning space. The third umbrella gear is fixedly installed at the right end of the drive shaft, and the fourth umbrella gear is meshed on the upper side of the third umbrella gear, and is located at the center of the fourth umbrella gear. The pharmaceutical intermediate polishing apparatus according to claim 1, wherein the rotating shaft is fixedly installed, and the rotating shaft and the rotating block are fixedly connected to each other.
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CN114377803A (en) * 2022-01-12 2022-04-22 杨振宙 Crushing equipment of broken wall of traditional chinese medicine
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