JP6831338B2 - 可聴インジケータ - Google Patents
可聴インジケータ Download PDFInfo
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- JP6831338B2 JP6831338B2 JP2017562573A JP2017562573A JP6831338B2 JP 6831338 B2 JP6831338 B2 JP 6831338B2 JP 2017562573 A JP2017562573 A JP 2017562573A JP 2017562573 A JP2017562573 A JP 2017562573A JP 6831338 B2 JP6831338 B2 JP 6831338B2
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 230000005236 sound signal Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229940036220 synvisc Drugs 0.000 description 1
- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
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- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/3157—Means providing feedback signals when administration is completed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/43—General characteristics of the apparatus making noise when used correctly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
ここで、弾性力部材が第1の形態に達するまで1つまたはそれ以上の翼形状のセクションが特定の角度周りに旋回したとき、弾性力部材は付勢状態から弛緩状態に変化する。
1.1、101.1、201.1、301.1、401.1、501.1、601.1
駆動サブアセンブリ
2 ケース
2.1 前方ケース
2.2、102.2、202.2、302.2、402.2、502.2、602.2
後方ケース
502.2.1 支持突出部
602.2.1 カンチレバービーム
2.15 径方向止め具
3 薬剤容器、シリンジ
4、104、404、504 針
5 保護ニードルシース
6 ストッパ
7、307、407、507 ニードルシュラウド
7.6 アパーチャ
307.7 支持リブ
407.8 ロックリブ
507.9 作動リブ
8 シュラウドばね
9、109、409、509 駆動ばね
10、110、210、310、410、510、610 プランジャ
10.1、110.1、210.1、310.1、410.1、510.1 近位プランジャセクション
10.2、110.2、210.2、310.2、410.2、510.2 遠位プランジャセクション
11 キャップ
11.1 グリップ機能
11.2 グリップ要素
11.3 コンプライアントビーム
11.4 リブ
12 プランジャ解放機構
13、113、213、313、413、513、613 可聴インジケータ
13.1、113.1、213.1、313.1、413.1、513.1、613.1 弾性力部材
13.1.1 遠位方向を向く端部
13.1.2 近位方向を向く端部
13.2、113.2、213.2、313.2、413.2、513.2、613.2 長手方向曲げ部
13.3 タブ
113.3 近位ばねセクション
113.4 遠位ばねセクション
113.5 交差曲げ部
213.3 よじれ先端
313.3、413.3、513.3 近位ばねセクション
313.4、413.4 中間ばねセクション
313.5、413.5 遠位ばねセクション
313.5.1 フック状の突起
313.6、413.6 第1の交差曲げ部
313.7、413.7 第2の交差曲げ部
513.4 遠位ばねセクション
513.5 交差曲げ部
613.3 よじれ先端
14 シュラウドロック機構
15.1、115.1、215.1、315.1、415.1、515.1、615.1 支持アーム
215.1.1 長手方向凹部
315.1.1 案内凹部
315.1.2、415.2.1 ロックタブ
415.2 固定要素
615.1.1 長手方向凹部
15.2 可撓性アーム
15.2.1 突起
16 キャリア
418 カラー
418.1 カラー傾斜部
A、A100、A200、A300、A400、A500、A600 軸
C 力−曲げ曲線
L、L100、L200、L300、L400、L500、L600 長手方向軸
M 薬剤
S1 弛緩状態
S2 付勢状態
x 横座標
y 縦座標
x1、y2 座標
x2、y1 座標
Claims (16)
- 薬物送達デバイス(1、101、201、301、401、501、601)で使用するための可聴インジケータ(13、113、213、313、413、513、613)であって、2つ以上の異なる形態を有する2つ以上の状態(S1、S2)にあるように構成された双安定弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)を含み、
ここで、弛緩状態(S1)では、弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)は第1の形態で弛緩しており、
付勢状態(S2)では、弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)は第1の形態とは異なる第2の形態でエネルギーを蓄えるように付勢されており、
弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)は、第2の形態から第1の形態への遷移に起因して付勢状態(S2)から弛緩状態(S1)に変化するときに、蓄えられたエネルギーを解放して可聴シグナルを生成し、ここで、弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)は、プランジャ(10、110、210、310、410、510、610)の動きによって付勢状態(S2)から変化する、前記可聴インジケータ。 - 弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)は、薬剤送達工程の終わりに、遠位位置に向かうプランジャ(10、110、210、310、410、510、610)の動きによって付勢状態(S2)から弛緩状態(S1)に変化することを特徴とする、請求項1に記載の可聴インジケータ(13、113、213、313、413、513、613)。
- 弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)は、長手方向軸(L〜L600)を有する板ばねを含み、弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)は、長手方向軸(L〜L600)周りに特定の角度だけ曲げられて、2つの傾斜した翼
形状のセクションが形成されることを特徴とする、請求項1または2に記載の可聴インジケータ(13、113、213、313、413、513、613)。 - 板ばねは、長円形の形状を有することを特徴とする、請求項3に記載の可聴インジケータ(13、113、213、313、413、513、613)。
- 板ばねは、矩形の形状、方形の形状を有することを特徴とする、請求項3に記載の可聴インジケータ(13、113、213、313、413、513、613)。
- 双安定弾性力部材(313.1、413.1、513.1)は、弛緩状態(S1)への遷移を防止するために、付勢状態(S2)において支持部材(307.7、502.2.1、418)によって支持されていることを特徴とする、請求項1〜5のいずれか1項に記載の可聴インジケータ(13、113、213、313、413、513)。
- 弾性力部材(313.1、413.1)は、薬物送達デバイス(301、401)が初期状態にあるときに支持され、
弾性力部材(313.1、413.1)は、薬物送達デバイス(301、401)が準備完了状態にあるときに支持されないこと、
または、弾性力部材(513.1)は、薬物送達デバイス(501)が初期状態および準備完了状態にあるときに支持され、弾性力部材(513.1)の近位ばねセクション(513.3)が、後方ケース(502.2)に配置された支持突出部(502.2.1)によって支持されること、または、弾性力部材(113.1、213.1)は、付勢状態(S2)において支持されないこと、を特徴とする、請求項6に記載の可聴インジケータ(313、413)。 - 弾性力部材(113.1、313.1、413.1)は、プランジャ(10、110、210、310、410、510、610)の近位部分の近位プランジャセクション(110.1、310.1、410.1)が弾性力部材(113.1、313.1、413.1)の遠位部分の遠位セクション(113.4、313.5、413.5)に当接したときに、付勢状態(S2)から弛緩状態(S1)に遷移し、
弾性力部材(113.1、313.1、413.1)が付勢状態(S2)にあるときに、弾性力部材(113.1、313.1、413.1)の遠位セクション(113.4、313.5、413.5)は、弾性力部材(113.1、313.1、413.1)の中間セクション(313.4、413.4)に対して、または弾性力部材(113.1、313.1、413.1)の近位セクション(113.3)に対して、長手方向軸(L100、L300、L400)に垂直な軸(A100、A300、A400)周りに曲げられていることを特徴とする、請求項7に記載の可聴インジケータ(113、313、413)。 - 薬物送達デバイス(1、101、201、301、401、501、601)の針(4)がニードルシュラウド(307)によって覆われる第1の位置と針(4)が露出される後退位置との間で移動可能であるニードルシュラウド(307)に配置された支持リブ(307.7)によって支持される遠位ばねセクション(313.5)に配置された突起(313.5.1)を特徴とする、請求項8に記載の可聴インジケータ(313)。
- プランジャ(410)に連結され、遠位ばねセクション(413.5)を支持するように適用されたカラー(418)を特徴とする、請求項8に記載の可聴インジケータ(413)。
- 弾性力部材(513.1)は、ニードルシュラウド(507)の作動リブ(507.9
)が、近位ばねセクション(513.3)に当接したときに、付勢状態(S2)から弛緩状態(S1)に変化し、
弾性力部材(513.1)が付勢状態(S2)にあるときに、近位ばねセクション(513.3)は、遠位ばねセクション(513.4)に対して、長手方向軸(L500)に垂直な軸(A500)周りに曲げられていることを特徴とする、請求項10に記載の可聴インジケータ(513)。 - 弾性力部材(213.1)はよじれ先端(213.3)を含み、
近位プランジャセクション(210.1)がよじれ先端(213.3)に当接したときに、弾性力部材(213.1)は、付勢状態(S2)から弛緩状態(S1)に変化することを特徴とする、請求項4または9に記載の可聴インジケータ(213)。 - 弾性力部材(13.1)は、後方ケース(2.2)に配置された可撓性アーム(15)の支持によって付勢状態(S2)で静止しており、
可撓性アーム(15.1)は、プランジャ(10)の外周によって付勢され、可撓性アーム(15.1)が解放されたときに、弾性力部材(13.1)が付勢状態(S2)から弛緩状態(S1)に変化すること、または、弾性力部材(613.1)は、後方ケース(602.2)に配置されたカンチレバービーム(602.2.1)の支持によって付勢状態(S2)で静止しており、カンチレバービーム(602.2.1)は、プランジャ(610)の外周によって付勢され、カンチレバービーム(602.2.1)が解放されたときに、弾性力部材(613.1)が付勢状態(S2)から弛緩状態(S1)に変化すること、を特徴とする、請求項2〜12のいずれか1項に記載の可聴インジケータ(13)。 - 少なくとも100dBの音量を有する可聴シグナルを生成することができる、請求項1〜13のいずれか1項に記載の可聴インジケータ(13)。
- 弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)は、1つまたはそれ以上の翼形状のセクションの1つまたはそれ以上の外縁部もしくは中央領域にエネルギーを蓄えるように適用された1つまたはそれ以上の翼形状のセクションを含む板ばねを含み、
弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)が第1の形態に達するまで1つまたはそれ以上の翼形状のセクションが特定の角度周りに旋回したとき、弾性力部材(13.1、113.1、213.1、313.1、413.1、513.1、613.1)が付勢状態(S2)から弛緩状態(S1)に変化することを特徴とする、薬剤送達の完了を示すように適用された、請求項1〜14のいずれか1項に記載の可聴インジケータ(13、113、213、313、413、513、613)。 - 薬物送達デバイス(1、101、201、301、401、501、601)であって、請求項1〜15のいずれか1項に記載の可聴インジケータ(13、113、213、313、413、513、613)を含む前記薬物送達デバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15170584 | 2015-06-03 | ||
EP15170584.5 | 2015-06-03 | ||
PCT/EP2016/062450 WO2016193344A1 (en) | 2015-06-03 | 2016-06-02 | Audible indicator |
Publications (3)
Publication Number | Publication Date |
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JP2018516681A JP2018516681A (ja) | 2018-06-28 |
JP2018516681A5 JP2018516681A5 (ja) | 2019-06-20 |
JP6831338B2 true JP6831338B2 (ja) | 2021-02-17 |
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AR (1) | AR104869A1 (ja) |
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IL (1) | IL256018A (ja) |
MX (1) | MX2017015501A (ja) |
RU (1) | RU2017142691A (ja) |
TW (1) | TW201709940A (ja) |
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Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2532270B (en) * | 2014-11-14 | 2017-05-10 | Ge Aviat Systems Ltd | An aircraft assembly with load and position indicator |
TW201709940A (zh) | 2015-06-03 | 2017-03-16 | 賽諾菲阿凡提斯德意志有限公司 | 聲響指示器(一) |
TW201707737A (zh) | 2015-06-03 | 2017-03-01 | 賽諾菲阿凡提斯德意志有限公司 | 藥物輸送裝置(一) |
TW201711713A (zh) | 2015-06-03 | 2017-04-01 | 賽諾菲阿凡提斯德意志有限公司 | 藥物輸送裝置(五) |
TW201709941A (zh) | 2015-06-03 | 2017-03-16 | 賽諾菲阿凡提斯德意志有限公司 | 聲響指示器(二) |
US10967128B2 (en) | 2016-07-14 | 2021-04-06 | Shl Medical Ag | Administration mechanism for a medicament delivery device |
JP7257319B2 (ja) * | 2016-08-26 | 2023-04-13 | サノフィ-アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 可聴インジケータ |
JP1629609S (ja) | 2017-10-25 | 2019-04-15 | ||
JP7258876B2 (ja) * | 2017-11-03 | 2023-04-17 | サノフイ | 薬物送達デバイス |
US11654246B2 (en) | 2017-11-03 | 2023-05-23 | Sanofi | Drug delivery device |
USD908868S1 (en) * | 2018-05-16 | 2021-01-26 | Sanofi | Injection device |
USD866751S1 (en) * | 2018-05-22 | 2019-11-12 | Sanofi | Injection device |
CN111422346B (zh) * | 2019-01-09 | 2021-09-21 | 浙江工业大学 | 一种基于多稳态特性的可折叠无人机机翼 |
EP3930790A1 (en) * | 2019-02-26 | 2022-01-05 | Becton Dickinson France | Auto-injector with audio indicator |
WO2022135947A1 (en) * | 2020-12-24 | 2022-06-30 | Shl Medical Ag | Medicament delivery device |
CN117651577A (zh) * | 2021-06-02 | 2024-03-05 | 赛诺菲 | 药物递送装置、柱塞杆、柱塞杆组、用于组装药物递送装置的方法及药物递送装置组 |
WO2024094705A1 (en) | 2022-10-31 | 2024-05-10 | Sanofi | Drug delivery device having a two-part user indicator |
WO2024094703A1 (en) | 2022-10-31 | 2024-05-10 | Sanofi | Plunger for expelling a drug, drug delivery device, rear sub-assembly and corresponding methods |
WO2024094701A1 (en) | 2022-10-31 | 2024-05-10 | Sanofi | Assembly for a drug delivery device |
WO2024094699A1 (en) | 2022-10-31 | 2024-05-10 | Sanofi | Container holder and drug delivery device comprising the container holder |
WO2024094704A1 (en) | 2022-10-31 | 2024-05-10 | Sanofi | Arrangement for a drug delivery device, drug delivery device and method for assembly |
WO2024094698A1 (en) | 2022-10-31 | 2024-05-10 | Sanofi | Front sub-assembly for a drug delivery device |
WO2024094702A1 (en) | 2022-10-31 | 2024-05-10 | Sanofi | Device body for a drug delivery device, assembly for a drug delivery device and drug delivery device |
WO2024094707A1 (en) | 2022-10-31 | 2024-05-10 | Sanofi | Drug delivery device with feedback element and method for providing a user of a drug delivery device feedback regarding a dose dispensing process |
WO2024094706A1 (en) | 2022-10-31 | 2024-05-10 | Sanofi | Audible indicator, indicator holder and method of assembling an audible indicator |
WO2024094700A1 (en) | 2022-10-31 | 2024-05-10 | Sanofi | Method for assembling an assembly for a drug delivery device and drug delivery device. |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE7833454U1 (de) * | 1978-11-10 | 1979-05-10 | Fohlmeister, Claus, 2000 Hamburg | Spielzeug |
US4693711A (en) * | 1981-12-22 | 1987-09-15 | Bremer Roger E | Long-life biomedical transcutaneous drug application device and method of transcutaneous application of drugs |
US4629454A (en) | 1985-03-29 | 1986-12-16 | Grier Dale C | Hypodermic syringe |
DE3638984C3 (de) | 1986-11-14 | 1993-11-18 | Haselmeier Wilhelm Fa | Injektionsgerät |
US4810249A (en) * | 1987-03-12 | 1989-03-07 | Habley Medical Technology Corp. | Linear and Vernier-type syringe |
US5127906A (en) | 1989-04-28 | 1992-07-07 | Flp Enterprises, Inc. | Non-reusable syringe |
DE3935672A1 (de) | 1989-05-20 | 1990-11-22 | Dirk Breimeyer | Durchflussmessgeraet |
CA1325149C (en) | 1989-08-31 | 1993-12-14 | Gavin Mcgregor | Variable intensity remote controlled needleless injector |
US5271527A (en) * | 1992-04-02 | 1993-12-21 | Habley Medical Technology Corporation | Reusable pharmaceutical dispenser with full stroke indicator |
US5391157A (en) | 1992-10-20 | 1995-02-21 | Eli Lilly And Company | End of dose indicator |
CA2445511C (en) | 2001-05-16 | 2010-03-16 | Eli Lilly And Company | Medication injector apparatus with drive assembly that facilitates reset |
US8932264B2 (en) * | 2003-08-11 | 2015-01-13 | Becton, Dickinson And Company | Medication delivery pen assembly with needle locking safety shield |
FR2861995A1 (fr) | 2003-11-10 | 2005-05-13 | Mb Innovation | Dispositif a usage unique de pulverisation d'un fluide medicamenteux |
RU2401134C2 (ru) | 2005-01-25 | 2010-10-10 | Ново Нордиск А/С | Инъекционное устройство с механизмом обратной связи для сообщения о завершении введения дозы препарата |
US20070088248A1 (en) * | 2005-09-02 | 2007-04-19 | Iomai Corporation | Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof |
US7611495B1 (en) | 2005-10-07 | 2009-11-03 | Gianturco Michael C | Device for manually controlling delivery rate of a hypodermic syringe and syringe having same |
KR20090038854A (ko) * | 2006-05-19 | 2009-04-21 | 옥시밴드 테크놀러지스 인크. | 세포조직 치료 장치를 위한 가스 및 증기 전달 증진 시스템및 방법 |
US10188787B2 (en) | 2007-12-31 | 2019-01-29 | Deka Products Limited Partnership | Apparatus, system and method for fluid delivery |
US20090248085A1 (en) * | 2008-03-31 | 2009-10-01 | Cochlear Limited | Tissue injection fixation system for a prosthetic device |
CN201243374Y (zh) | 2008-07-02 | 2009-05-20 | 东莞市三正华声电子科技有限公司 | 耳机音量调节控制装置 |
WO2010035059A1 (en) | 2008-09-29 | 2010-04-01 | Becton Dickinson France | Automatic injection device with audible indicator of completed injection |
CN102209564B (zh) | 2008-09-29 | 2014-06-25 | 贝克顿迪金森法国公司 | 带有完成输送声响指示的注射装置 |
US20110105952A1 (en) * | 2009-10-30 | 2011-05-05 | Seventh Sense Biosystems, Inc. | Relatively small devices applied to the skin, modular systems, and methods of use thereof |
EP3278822B1 (en) | 2009-12-23 | 2021-05-05 | Becton, Dickinson and Company | Monodose nasal drug delivery device |
SG183127A1 (en) | 2010-02-01 | 2012-09-27 | Sanofi Aventis Deutschland | Cartridge holder, drug delivery device and method for securing a cartridge in a cartridge holder |
WO2011123024A1 (en) | 2010-03-31 | 2011-10-06 | Shl Group Ab | Medicament delivery device comprising feedback signalling means |
EP2605814B1 (en) | 2010-08-19 | 2018-04-18 | Novo Nordisk A/S | Medical auto-injection device for manual needle insertion having needle shield, damping mechanism and audible and tactile feedback |
EP2489387A1 (en) * | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
GB2488578B (en) | 2011-03-02 | 2017-05-24 | Owen Mumford Ltd | Injection device |
GB2488579A (en) | 2011-03-02 | 2012-09-05 | Owen Mumford Ltd | Autoinjector with "injection complete" indicator |
US9131900B2 (en) * | 2011-07-11 | 2015-09-15 | Covidien Lp | Force regulating device applicators |
US20130090605A1 (en) | 2011-09-29 | 2013-04-11 | Animas Corporation | Tunable mechanical injection device for medication |
EP2583707A1 (en) * | 2011-10-21 | 2013-04-24 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
CN104519929B (zh) | 2012-07-06 | 2017-03-22 | 卡贝欧洲有限公司 | 药物输送装置 |
EP2727617A1 (en) | 2012-11-06 | 2014-05-07 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
EP3881880A1 (en) | 2013-03-13 | 2021-09-22 | Sanofi-Aventis Deutschland GmbH | Assembly for a drug delivery device comprising a feedback feature |
CA2903484C (en) | 2013-03-13 | 2019-01-08 | Antares Pharma, Inc. | Push button safety injector |
EP2968786B1 (en) | 2013-03-13 | 2020-09-23 | Sanofi-Aventis Deutschland GmbH | Assembly for a drug delivery device comprising a feedback feature |
US20140276568A1 (en) | 2013-03-15 | 2014-09-18 | Morris Elijah Worden | Systems and methods for dampening friction in an autoinjector device |
EP2781230B1 (de) | 2013-03-22 | 2019-08-21 | TecPharma Licensing AG | Substanzabgabevorrichtung mit Signalvorrichtung |
EP2823839A1 (en) | 2013-07-09 | 2015-01-14 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
EP2868338A1 (en) | 2013-10-31 | 2015-05-06 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device |
TW201709940A (zh) | 2015-06-03 | 2017-03-16 | 賽諾菲阿凡提斯德意志有限公司 | 聲響指示器(一) |
TW201707737A (zh) | 2015-06-03 | 2017-03-01 | 賽諾菲阿凡提斯德意志有限公司 | 藥物輸送裝置(一) |
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2016
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- 2016-06-02 AR ARP160101623A patent/AR104869A1/es unknown
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US20180154078A1 (en) | 2018-06-07 |
WO2016193344A1 (en) | 2016-12-08 |
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HK1247874A1 (zh) | 2018-10-05 |
MX2017015501A (es) | 2018-02-21 |
AR104869A1 (es) | 2017-08-23 |
US10926032B2 (en) | 2021-02-23 |
DK3302631T3 (da) | 2022-06-20 |
CN107683157A (zh) | 2018-02-09 |
EP3302631B1 (en) | 2022-03-30 |
TW201709940A (zh) | 2017-03-16 |
IL256018A (en) | 2018-01-31 |
EP3302631A1 (en) | 2018-04-11 |
KR20180015675A (ko) | 2018-02-13 |
AU2016269696A1 (en) | 2018-01-18 |
RU2017142691A (ru) | 2019-07-09 |
JP2018516681A (ja) | 2018-06-28 |
CN107683157B (zh) | 2021-05-04 |
BR112017025750A2 (pt) | 2018-08-14 |
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