JP6829077B2 - グルテン不耐症及びそれから生じる障害を治療するための組成物及び方法 - Google Patents

グルテン不耐症及びそれから生じる障害を治療するための組成物及び方法 Download PDF

Info

Publication number
JP6829077B2
JP6829077B2 JP2016573565A JP2016573565A JP6829077B2 JP 6829077 B2 JP6829077 B2 JP 6829077B2 JP 2016573565 A JP2016573565 A JP 2016573565A JP 2016573565 A JP2016573565 A JP 2016573565A JP 6829077 B2 JP6829077 B2 JP 6829077B2
Authority
JP
Japan
Prior art keywords
nepenthesin
nepenthes
neprocin
protein
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016573565A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017519763A5 (enExample
JP2017519763A (ja
Inventor
シュリーマー，デービッド
レイ，マーシャル
Original Assignee
ネプエトゥクス，エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ネプエトゥクス，エルエルシー filed Critical ネプエトゥクス，エルエルシー
Publication of JP2017519763A publication Critical patent/JP2017519763A/ja
Publication of JP2017519763A5 publication Critical patent/JP2017519763A5/ja
Priority to JP2021007953A priority Critical patent/JP7369893B2/ja
Application granted granted Critical
Publication of JP6829077B2 publication Critical patent/JP6829077B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23012—Nepenthesin (3.4.23.12)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2016573565A 2014-06-16 2015-06-16 グルテン不耐症及びそれから生じる障害を治療するための組成物及び方法 Active JP6829077B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021007953A JP7369893B2 (ja) 2014-06-16 2021-01-21 グルテン不耐症及びそれから生じる障害を治療するための組成物及び方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462012865P 2014-06-16 2014-06-16
US62/012,865 2014-06-16
US201562118396P 2015-02-19 2015-02-19
US62/118,396 2015-02-19
PCT/CA2015/000389 WO2015192211A1 (en) 2014-06-16 2015-06-16 Compositions and methods for treating gluten intolerance and disorders arising therefrom

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021007953A Division JP7369893B2 (ja) 2014-06-16 2021-01-21 グルテン不耐症及びそれから生じる障害を治療するための組成物及び方法

Publications (3)

Publication Number Publication Date
JP2017519763A JP2017519763A (ja) 2017-07-20
JP2017519763A5 JP2017519763A5 (enExample) 2018-07-26
JP6829077B2 true JP6829077B2 (ja) 2021-02-10

Family

ID=54934596

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016573565A Active JP6829077B2 (ja) 2014-06-16 2015-06-16 グルテン不耐症及びそれから生じる障害を治療するための組成物及び方法
JP2021007953A Active JP7369893B2 (ja) 2014-06-16 2021-01-21 グルテン不耐症及びそれから生じる障害を治療するための組成物及び方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021007953A Active JP7369893B2 (ja) 2014-06-16 2021-01-21 グルテン不耐症及びそれから生じる障害を治療するための組成物及び方法

Country Status (8)

Country Link
US (3) US20160022785A1 (enExample)
EP (2) EP3220946B1 (enExample)
JP (2) JP6829077B2 (enExample)
CN (2) CN113827708A (enExample)
DK (1) DK3220946T3 (enExample)
ES (1) ES2883347T3 (enExample)
SI (1) SI3220946T1 (enExample)
WO (1) WO2015192211A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3220946B1 (en) 2014-06-16 2021-06-09 Codexis, Inc. Compositions and methods for attenuating and preventing intestinal inflammation due to the presence of peptidic food antigens in an intestine
WO2017106798A2 (en) * 2015-12-16 2017-06-22 Nepetx, Llc Compositions and methods for treating gluten intolerance and disorders arising therefrom
CN108504615B (zh) * 2018-03-30 2020-12-29 江南大学 一种产酸性蛋白酶的重组菌及其应用
CA3257140A1 (en) * 2022-05-10 2023-11-16 Codexis Inc RECOMMENDED NEPROSIN POLYPEPTIDES AND EXPRESSION METHODS
CN115336666A (zh) * 2022-07-05 2022-11-15 熊子奕 猪笼草捕虫囊蛋白酶降低乳清蛋白致敏性的应用及方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK81193D0 (da) 1993-07-06 1993-07-06 Novo Nordisk As Enzym
JP3767831B2 (ja) 1995-06-14 2006-04-19 木村 健 ヘリコバクター・ピロリ除菌用組成物
JPH1149697A (ja) 1997-08-01 1999-02-23 Nisshin Flour Milling Co Ltd ストレス抑制剤及びストレス抑制用食品
FI980410A0 (fi) 1998-02-23 1998-02-23 Tapio Raivio Termoset
DE19980245D2 (de) * 1998-02-23 2001-05-10 Keller Helmut Verwendung eines Preßsaftes, Verdauungssaftes oder Extraktes von fleischfressenden Pflanzen zur Hemmung von Proteinkinasen
JP2003533335A (ja) 2000-05-22 2003-11-11 オーバス メディカル テクノロジーズ インク． 自己拡張形ステント
EP2364718B1 (en) 2002-02-14 2016-07-06 The Board of Trustees of the Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
US7320788B2 (en) * 2002-02-14 2008-01-22 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for Celiac Sprue
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
JP4415244B2 (ja) 2003-02-21 2010-02-17 グリコ栄養食品株式会社 小麦蛋白質にプロテアーゼを限定的に作用させて得られる食品素材
WO2005049097A2 (en) 2003-11-13 2005-06-02 Jerome Canady Bipolar surgical forceps with argon plasma coagulation capability
CN100384442C (zh) * 2004-01-13 2008-04-30 吴琼汉 一种中草药制剂及其制备方法和应用
US7628985B2 (en) 2004-04-26 2009-12-08 The Board Of Regents Of The Leland Stanford Junior University Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis
US20060095096A1 (en) 2004-09-09 2006-05-04 Debenedictis Leonard C Interchangeable tips for medical laser treatments and methods for using same
WO2006096527A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Nucleic acids and proteins and methods for making and using them
WO2007044906A2 (en) 2005-10-11 2007-04-19 Alvine Pharmaceuticals, Inc. Compositions and methods for enhanced gastrointestinal stability of oligopeptides and polypeptides
CA2644273A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
US20080115411A1 (en) 2006-11-16 2008-05-22 Ramsey Philip W Weed control system
US7645977B2 (en) 2006-11-17 2010-01-12 New Visual Media Group, L.L.C. Low cost dynamic insulated glazing unit
EP2090630B1 (en) 2006-12-04 2019-06-05 Mitsubishi Gas Chemical Company, Inc. Method for bonding resin materials containing oxymethylene polymer and structures
WO2008115411A1 (en) 2007-03-16 2008-09-25 The Board Of Trustees Of The Leland Stanford Junior University Combination enzyme therapy for digestion of dietary gluten
US8148105B2 (en) 2007-03-16 2012-04-03 The Board Of Trustees Of The Leland Stanford Junior University Scaleable manufacturing process for cysteine endoprotease B, isoform 2
EP2229404A4 (en) 2007-12-10 2011-03-09 Univ Leland Stanford Junior ENZYMATIC POLYTHERAPY FOR GASTRIC DIGESTION OF FOOD GLUTEN IN PATIENTS WITH CELIAC DISEASE
EP2100900A1 (en) 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates
CA2733514C (en) 2008-08-21 2017-10-24 Alvine Pharmaceuticals, Inc. Formulation for oral administration of proteins
WO2010042203A1 (en) 2008-10-10 2010-04-15 Alvine Pharmaceuticals, Inc. Dosage forms that facilitate rapid activation of zymogen
CN101732504A (zh) * 2010-01-06 2010-06-16 宋晓翠 猪笼草和艾蒿、香蒲草制成的妇科药物及其制备方法
CN102858795A (zh) 2010-02-02 2013-01-02 天野酶制品美国有限公司 蛋白酶针对谷蛋白不耐受的用途
AU2011238586A1 (en) 2010-03-30 2012-11-08 Alvine Pharmaceuticals, Inc. Proteases for degrading gluten
US9598684B2 (en) 2010-07-07 2017-03-21 Trustees Of Boston University Rothia species gluten-degrading enzymes and uses thereof
US9023345B2 (en) 2011-03-01 2015-05-05 Novus International, Inc. Methods for improving gut health
US9168308B2 (en) * 2011-04-22 2015-10-27 Paul Joseph FAERSTEIN Compositions and methods for nutritional supplementation
US9005610B2 (en) 2012-11-21 2015-04-14 Nepetx, Llc Treatment of gluten intolerance and related conditions
US8837173B2 (en) 2013-01-02 2014-09-16 Chicony Power Technology Co., Ltd DC to DC power converting device
EP2948170B1 (en) 2013-01-23 2020-08-19 Alvine Pharmaceuticals, Inc. Pharmaceutical compositions for treating celiac disease and gluten intolerance
EP3220946B1 (en) 2014-06-16 2021-06-09 Codexis, Inc. Compositions and methods for attenuating and preventing intestinal inflammation due to the presence of peptidic food antigens in an intestine
WO2017106798A2 (en) 2015-12-16 2017-06-22 Nepetx, Llc Compositions and methods for treating gluten intolerance and disorders arising therefrom

Also Published As

Publication number Publication date
EP3220946A1 (en) 2017-09-27
CN106794228A (zh) 2017-05-31
JP2017519763A (ja) 2017-07-20
EP3220946A4 (en) 2018-08-15
JP2021073236A (ja) 2021-05-13
US20210220451A1 (en) 2021-07-22
JP7369893B2 (ja) 2023-10-27
US20160022785A1 (en) 2016-01-28
CN106794228B (zh) 2021-09-03
EP3220946B1 (en) 2021-06-09
SI3220946T1 (sl) 2021-11-30
WO2015192211A9 (en) 2016-02-25
DK3220946T3 (da) 2021-08-02
EP3943104A1 (en) 2022-01-26
US20190022194A1 (en) 2019-01-24
ES2883347T3 (es) 2021-12-07
CN113827708A (zh) 2021-12-24
US11723960B2 (en) 2023-08-15
WO2015192211A1 (en) 2015-12-23
US10960059B2 (en) 2021-03-30

Similar Documents

Publication Publication Date Title
JP7369893B2 (ja) グルテン不耐症及びそれから生じる障害を治療するための組成物及び方法
RU2370279C2 (ru) Применение пролинспецифичных эндопротеаз для гидролиза пептидов и белков
US9598684B2 (en) Rothia species gluten-degrading enzymes and uses thereof
JP2012092125A (ja) 食品中のグルテンを低下させるためのプロテアーゼ混合物
JP6412876B2 (ja) グルテン不耐症および関連する状態の治療
US11701411B2 (en) Compositions and methods for treating gluten intolerance and disorders arising therefrom
CN1331250A (zh) 对幽门螺杆菌定居具有抑制活性的糖蛋白
JP6862627B2 (ja) 自然免疫応答疾患を治療するための医薬および方法
JP6502269B2 (ja) グルテン不耐症および関連する状態の治療
CN102365112A (zh) 治疗谷蛋白不耐受的组合物及其应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170223

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180614

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180614

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190702

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190910

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20191129

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200106

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200310

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200608

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20201013

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201021

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201027

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20201124

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201208

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201222

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210121

R150 Certificate of patent or registration of utility model

Ref document number: 6829077

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250