ES2883347T3 - Composiciones y procedimientos para atenuar y prevenir la inflamación intestinal debida a la presencia de antígenos alimentarios peptídicos en un intestino - Google Patents

Composiciones y procedimientos para atenuar y prevenir la inflamación intestinal debida a la presencia de antígenos alimentarios peptídicos en un intestino Download PDF

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Publication number
ES2883347T3
ES2883347T3 ES15809878T ES15809878T ES2883347T3 ES 2883347 T3 ES2883347 T3 ES 2883347T3 ES 15809878 T ES15809878 T ES 15809878T ES 15809878 T ES15809878 T ES 15809878T ES 2883347 T3 ES2883347 T3 ES 2883347T3
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Prior art keywords
nepentesin
neprosin
nepenthes
protein
variant
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Active
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ES15809878T
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English (en)
Spanish (es)
Inventor
David Schriemer
Martial Rey
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Codexis Inc
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Codexis Inc
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Publication of ES2883347T3 publication Critical patent/ES2883347T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23012—Nepenthesin (3.4.23.12)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
ES15809878T 2014-06-16 2015-06-16 Composiciones y procedimientos para atenuar y prevenir la inflamación intestinal debida a la presencia de antígenos alimentarios peptídicos en un intestino Active ES2883347T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462012865P 2014-06-16 2014-06-16
US201562118396P 2015-02-19 2015-02-19
PCT/CA2015/000389 WO2015192211A1 (en) 2014-06-16 2015-06-16 Compositions and methods for treating gluten intolerance and disorders arising therefrom

Publications (1)

Publication Number Publication Date
ES2883347T3 true ES2883347T3 (es) 2021-12-07

Family

ID=54934596

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15809878T Active ES2883347T3 (es) 2014-06-16 2015-06-16 Composiciones y procedimientos para atenuar y prevenir la inflamación intestinal debida a la presencia de antígenos alimentarios peptídicos en un intestino

Country Status (8)

Country Link
US (3) US20160022785A1 (enExample)
EP (2) EP3220946B1 (enExample)
JP (2) JP6829077B2 (enExample)
CN (2) CN113827708A (enExample)
DK (1) DK3220946T3 (enExample)
ES (1) ES2883347T3 (enExample)
SI (1) SI3220946T1 (enExample)
WO (1) WO2015192211A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025062056A1 (es) 2023-09-22 2025-03-27 Consejo Superior De Investigaciones Científicas (Csic) Proteína degradadora de gluten y usos de la misma

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2883347T3 (es) * 2014-06-16 2021-12-07 Codexis Inc Composiciones y procedimientos para atenuar y prevenir la inflamación intestinal debida a la presencia de antígenos alimentarios peptídicos en un intestino
US10857214B2 (en) 2015-12-16 2020-12-08 Codexis, Inc. Compositions and methods for treating gluten intolerance and disorders arising therefrom
CN108504615B (zh) * 2018-03-30 2020-12-29 江南大学 一种产酸性蛋白酶的重组菌及其应用
US20250064903A1 (en) * 2020-10-30 2025-02-27 University Of Washington Compositions and methods for treating celiac sprue disease
JP2025518476A (ja) * 2022-05-10 2025-06-17 コデクシス， インコーポレイテッド 組換えネプロシンポリペプチドおよび発現の方法
CN115336666A (zh) * 2022-07-05 2022-11-15 熊子奕 猪笼草捕虫囊蛋白酶降低乳清蛋白致敏性的应用及方法

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JPH1149697A (ja) 1997-08-01 1999-02-23 Nisshin Flour Milling Co Ltd ストレス抑制剤及びストレス抑制用食品
FI980410A0 (fi) 1998-02-23 1998-02-23 Tapio Raivio Termoset
JP2002503699A (ja) * 1998-02-23 2002-02-05 カルニボーラ・フォルシュングス−ゲーエムベーハー プロテインキナーゼの阻害を目的とする食肉植物の圧搾汁、消化液または抽出物の使用
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025062056A1 (es) 2023-09-22 2025-03-27 Consejo Superior De Investigaciones Científicas (Csic) Proteína degradadora de gluten y usos de la misma

Also Published As

Publication number Publication date
US20190022194A1 (en) 2019-01-24
CN106794228B (zh) 2021-09-03
JP2021073236A (ja) 2021-05-13
JP2017519763A (ja) 2017-07-20
US20160022785A1 (en) 2016-01-28
EP3943104A1 (en) 2022-01-26
US20210220451A1 (en) 2021-07-22
US10960059B2 (en) 2021-03-30
EP3220946A4 (en) 2018-08-15
CN106794228A (zh) 2017-05-31
EP3220946B1 (en) 2021-06-09
WO2015192211A1 (en) 2015-12-23
EP3220946A1 (en) 2017-09-27
JP6829077B2 (ja) 2021-02-10
JP7369893B2 (ja) 2023-10-27
US11723960B2 (en) 2023-08-15
SI3220946T1 (sl) 2021-11-30
CN113827708A (zh) 2021-12-24
DK3220946T3 (da) 2021-08-02
WO2015192211A9 (en) 2016-02-25

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