ES2883347T3 - Composiciones y procedimientos para atenuar y prevenir la inflamación intestinal debida a la presencia de antígenos alimentarios peptídicos en un intestino - Google Patents

Composiciones y procedimientos para atenuar y prevenir la inflamación intestinal debida a la presencia de antígenos alimentarios peptídicos en un intestino Download PDF

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Publication number
ES2883347T3
ES2883347T3 ES15809878T ES15809878T ES2883347T3 ES 2883347 T3 ES2883347 T3 ES 2883347T3 ES 15809878 T ES15809878 T ES 15809878T ES 15809878 T ES15809878 T ES 15809878T ES 2883347 T3 ES2883347 T3 ES 2883347T3
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Spain
Prior art keywords
nepentesin
neprosin
nepenthes
protein
variant
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Active
Application number
ES15809878T
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English (en)
Spanish (es)
Inventor
David Schriemer
Martial Rey
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Codexis Inc
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Codexis Inc
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Publication of ES2883347T3 publication Critical patent/ES2883347T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23012—Nepenthesin (3.4.23.12)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
ES15809878T 2014-06-16 2015-06-16 Composiciones y procedimientos para atenuar y prevenir la inflamación intestinal debida a la presencia de antígenos alimentarios peptídicos en un intestino Active ES2883347T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462012865P 2014-06-16 2014-06-16
US201562118396P 2015-02-19 2015-02-19
PCT/CA2015/000389 WO2015192211A1 (en) 2014-06-16 2015-06-16 Compositions and methods for treating gluten intolerance and disorders arising therefrom

Publications (1)

Publication Number Publication Date
ES2883347T3 true ES2883347T3 (es) 2021-12-07

Family

ID=54934596

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15809878T Active ES2883347T3 (es) 2014-06-16 2015-06-16 Composiciones y procedimientos para atenuar y prevenir la inflamación intestinal debida a la presencia de antígenos alimentarios peptídicos en un intestino

Country Status (8)

Country Link
US (3) US20160022785A1 (enExample)
EP (2) EP3943104A1 (enExample)
JP (2) JP6829077B2 (enExample)
CN (2) CN113827708A (enExample)
DK (1) DK3220946T3 (enExample)
ES (1) ES2883347T3 (enExample)
SI (1) SI3220946T1 (enExample)
WO (1) WO2015192211A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160022785A1 (en) 2014-06-16 2016-01-28 Nepetx, Llc Compositions and methods for treating gluten intolerance and disorders arising therefrom
JP2019504011A (ja) 2015-12-16 2019-02-14 ネプエトゥクス，エルエルシー グルテン不耐症およびそれにより発生する障害を治療するための組成物および方法
CN108504615B (zh) * 2018-03-30 2020-12-29 江南大学 一种产酸性蛋白酶的重组菌及其应用
EP4522200A2 (en) * 2022-05-10 2025-03-19 Codexis, Inc. Recombinant neprosin polypeptides and methods of expression
CN115336666A (zh) * 2022-07-05 2022-11-15 熊子奕 猪笼草捕虫囊蛋白酶降低乳清蛋白致敏性的应用及方法

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JP3767831B2 (ja) 1995-06-14 2006-04-19 木村 健 ヘリコバクター・ピロリ除菌用組成物
JPH1149697A (ja) 1997-08-01 1999-02-23 Nisshin Flour Milling Co Ltd ストレス抑制剤及びストレス抑制用食品
DE19980245D2 (de) 1998-02-23 2001-05-10 Keller Helmut Verwendung eines Preßsaftes, Verdauungssaftes oder Extraktes von fleischfressenden Pflanzen zur Hemmung von Proteinkinasen
FI980410A0 (fi) 1998-02-23 1998-02-23 Tapio Raivio Termoset
US7169175B2 (en) 2000-05-22 2007-01-30 Orbusneich Medical, Inc. Self-expanding stent
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US7320788B2 (en) * 2002-02-14 2008-01-22 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for Celiac Sprue
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JP4415244B2 (ja) 2003-02-21 2010-02-17 グリコ栄養食品株式会社 小麦蛋白質にプロテアーゼを限定的に作用させて得られる食品素材
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US7628985B2 (en) 2004-04-26 2009-12-08 The Board Of Regents Of The Leland Stanford Junior University Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis
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Also Published As

Publication number Publication date
DK3220946T3 (da) 2021-08-02
EP3220946A1 (en) 2017-09-27
JP7369893B2 (ja) 2023-10-27
US10960059B2 (en) 2021-03-30
SI3220946T1 (sl) 2021-11-30
JP2017519763A (ja) 2017-07-20
EP3943104A1 (en) 2022-01-26
US20210220451A1 (en) 2021-07-22
EP3220946A4 (en) 2018-08-15
JP6829077B2 (ja) 2021-02-10
WO2015192211A1 (en) 2015-12-23
CN106794228B (zh) 2021-09-03
US20160022785A1 (en) 2016-01-28
US20190022194A1 (en) 2019-01-24
WO2015192211A9 (en) 2016-02-25
CN106794228A (zh) 2017-05-31
CN113827708A (zh) 2021-12-24
EP3220946B1 (en) 2021-06-09
US11723960B2 (en) 2023-08-15
JP2021073236A (ja) 2021-05-13

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