JP6822970B2 - 耐擦り傷性かつ帯電防止性のコーティングを有するシクロオレフィンポリマー容器 - Google Patents
耐擦り傷性かつ帯電防止性のコーティングを有するシクロオレフィンポリマー容器 Download PDFInfo
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- JP6822970B2 JP6822970B2 JP2017544764A JP2017544764A JP6822970B2 JP 6822970 B2 JP6822970 B2 JP 6822970B2 JP 2017544764 A JP2017544764 A JP 2017544764A JP 2017544764 A JP2017544764 A JP 2017544764A JP 6822970 B2 JP6822970 B2 JP 6822970B2
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- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229940057739 vivitrol Drugs 0.000 description 1
- 229940053867 xeloda Drugs 0.000 description 1
- 229940002552 xenical Drugs 0.000 description 1
- 229940018272 xeomin Drugs 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 229940098506 zemuron Drugs 0.000 description 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
- 229940049909 zingo Drugs 0.000 description 1
- 150000003754 zirconium Chemical class 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- 229940107931 zovirax Drugs 0.000 description 1
- 229940079008 zymaxid Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/065—Rigid ampoules, e.g. glass ampoules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D145/00—Coating compositions based on homopolymers or copolymers of compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic or in a heterocyclic system; Coating compositions based on derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
- A61J1/1425—Snap-fit type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0233—Conductive materials, e.g. antistatic coatings for spark prevention
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F32/00—Homopolymers and copolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system
- C08F32/02—Homopolymers and copolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having no condensed rings
- C08F32/04—Homopolymers and copolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having no condensed rings having one carbon-to-carbon double bond
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
- G01N23/227—Measuring photoelectric effect, e.g. photoelectron emission microscopy [PEEM]
- G01N23/2273—Measuring photoelectron spectrum, e.g. electron spectroscopy for chemical analysis [ESCA] or X-ray photoelectron spectroscopy [XPS]
Description
Ablavar(ガドホスベセット三ナトリウム注射薬);アバレリックスデポ;アボボツリナムトキシンA注射薬(ディスポート);ABT−263;ABT−869;ABX−EFG;Accretropin(ソマトロピン注射薬);Acetadote(アセチルシステイン注射薬);Acetazolamide注射薬(アセタゾラミド注射薬);アセチルシステイン注射薬(Acetadote);アクテムラ(トシリズマブ注射薬);Acthrel(注射用のコルチコレリンオーバイントリフルテート);Actummune;Activase;注射用アシクロビル(Zovirax注射薬);Adacel;アダリムマブ;アデノスキャン(アデノシン注射薬);アデノシン注射薬(アデノスキャン);Adrenaclick;AdreView(静脈用のヨーベングアンI 123注射薬);Afluria;Ak−Fluor(フルオレセイン注射薬);アウドラザイム(ラロニダーゼ);アルグルセラーゼ注射薬(Ceredase);アルケラン注射薬(メルファランHcl注射薬);注射用アロプリノールナトリウム(Aloprim);Aloprim(注射用アロプリノールナトリウム);アルプロスタジル;Alsuma(スマトリプタン注射薬);ALTU−238;アミノ酸注射薬;Aminosyn;アピドラ;アプレミラスト;注射用アルプロスタジルデュアルチャンバーシステム(Caverject Impulse);AMG009;AMG076;AMG102;AMG108;AMG114;AMG162;AMG220;AMG221;AMG222;AMG223;AMG317;AMG379;AMG386;AMG403;AMG477;AMG479;AMG517;AMG531;AMG557;AMG623;AMG655;AMG706;AMG714;AMG745;AMG785;AMG811;AMG827;AMG837;AMG853;AMG951;Amiodarone HCl注射薬(アミオダロンHCl注射薬);アモバルビタールナトリウム注射薬(アミタールナトリウム);アミタールナトリウム(アモバルビタールナトリウム注射薬);Anakinra;抗−Aベータ;抗−ベータ7;抗−ベータ20;抗−CD4;抗−CD20;抗−CD40;抗−IFNアルファ;抗−IL13;抗−OX40L;抗−oxLDS;抗−NGF;抗−NRPl;アリクストラ;Amphadase(ヒアルロニダーゼ注射薬);Ammonul(フェニル酢酸ナトリウム及び安息香酸ナトリウムの注射薬);Anaprox;Anzemet注射薬(メシル酸ドラセトロン注射薬);アピドラ(インスリングルリジン[rDNA由来]注射薬);Apomab;Aranesp(ダルベポエチンアルファ);Argatroban(アルガトロバン注射薬);アルギニン塩酸塩注射薬(R−Gene10);アリストコート;アリストスパン;三酸化ヒ素注射薬(Trisenox);Articane HCl及びエピネフリン注射薬(セプトカイン);アーゼラ(オファツムマブ注射薬);Asclera(ポリドカノール注射薬);Ataluren;Ataluren−DMD;アテノロール注射薬(テノーミンI.V.注射薬);Atracurium Besylate注射薬(アトラクリウムベシル酸塩注射薬);アバスチン;アザクタム注射薬(アズトレオナム注射薬);アジスロマイシン(Zithromax注射薬);アズトレオナム注射薬(Azactam注射薬);バクロフェン注射薬(Lioresal髄注);静菌水(注射用静菌水);バクロフェン注射薬(Lioresal髄注);Bal in Oilアンプル(ジメルカプロール注射薬);BayHepB;BayTet;ベナドリル;ベンダムスチン塩酸塩注射薬(Treanda);メシル酸ベンズトロピン注射薬(Cogentin);ベタメタゾン懸濁注射液(Celestone Soluspan);ベキサール;バイシリンC−R900/300(ペニシリンGベンザチン及びペニシリンGプロカイン注射薬);ブレノキサン(ブレオマイシン硫酸塩注射薬);ブレオマイシン硫酸塩注射薬(ブレノキサン);Boniva注射薬(イバンドロネートナトリウム注射薬);ボトックス化粧品(注射用OnabotulinumtoxinA);BR3−FC;Bravelle(ウロホリトロピン注射薬);ブレチリウム(ブレチリウムトシレート注射薬);ブレビタールナトリウム(注射用メトヘキシタールナトリウム);Brethine;Briobacept;BTT−1023;ブピバカインHCl;バイエッタ;Ca−DTPA(ペンテト酸カルシウム三ナトリウム注射薬);カバジタキセル注射薬(ジェブタナ);カフェインアルカロイド(カフェイン及び安息香酸ナトリウム注射薬);カルシジェックス注射薬(Calcitrol);Calcitrol(カルシジェックス注射薬);塩化カルシウム(塩化カルシウム注射薬10%);カルシウム二ナトリウムベルセネート(エデト酸カルシウム二ナトリウム注射薬);Campath(Altemtuzumab);Camptosar注射薬(イリノテカン塩酸塩);カナキヌマブ注射薬(イラリス);カパスタット硫酸塩(注射用カプレオマイシン;注射用カプレオマイシン(カパスタット硫酸塩);Cardiolite(注射用テクネチウムTc99セスタミビ調製キット);Carticel;Cathflo;注射用セファゾリン及びブドウ糖(セファゾリン注射薬);セフェピム塩酸塩;セフォタキシム;セフトリアキソン;セレザイム;カルニトール注射薬;カバージェクト;Celestone Soluspan;Celsior;セレビックス(ホスフェニトインナトリウム注射薬);セレデース(アルグルセラーゼ注射薬);Ceretec(テクネチウムTc99mエキサメタジム注射薬);セルトリズマブ;CF−101;クロラムフェニコールコハク酸ナトリウム(クロラムフェニコールコハク酸ナトリウム注射薬);クロラムフェニコールコハク酸ナトリウム注射薬(クロラムフェニコールコハク酸ナトリウム);コレスタゲル(コレセベラムHCL);絨毛性ゴナドトロピンアルファ注射薬(Ovidrel);シムジア;シスプラチン(シスプラチン注射薬);クロラール(クロファラビン注射薬);クエン酸クロミフィン;クロニジン注射薬(Duraclon);コゲンチン(メシル酸ベンズトロピン注射薬);コリスチメタート注射薬(Coly−Mycin M);Coly−Mycin M(コリスチメタート注射薬);Compath;コニバプタンHcl注射薬(バプリゾール);注射用結合型エストロゲン(プレマリン注射薬);コパキソン;注射用コルチコレリンオーバイントリフルテート(Acthrel);コルベルト(フマル酸イブチリド注射薬);キュビシン(ダプトマイシン注射薬);CF−101;シアノキット(注射用ヒドロキソコバラミン);シタラビンリポソーム注射薬(デポサイト);シアノコバラミン;サイトベン(ガンシクロビル);D.H.E.45;ダセツズマブ;ダコゲン(デシタビン注射薬);ダルテパリン;ダントリウムIV(注射用ダントロレンナトリウム);注射用ダントロレンナトリウム(ダントリウムIV);ダプトマイシン注射薬(キュビシン);ダルベポエチンアルファ;DDAVP注射薬(デスモプレシン酢酸塩注射薬);Decavax;デシタビン注射薬(ダコゲン);無水アルコール(無水アルコール注射薬);デノスマブ注射薬(プロリア);デラテストリル;デルエストロゲン;デルテパリンナトリウム;デパコン(バルプロ酸ナトリウム注射薬);デポメドロール(酢酸メチルプレドニゾロン懸濁注射液);デポサイト(シタラビンリポソーム注射薬);デポデュール(モルヒネ硫酸塩XRリポソーム注射薬;デスモプレシン酢酸塩注射薬(DDAVP注射薬);デポ−エストラジオール;デポ−プロベラ104mg/ml;デポ−プロベラ150mg/ml;デポ−テストステロン;注射用デキスラゾキサン、静注のみ(Totect);ブドウ糖/電解質;ブドウ糖及び塩化ナトリウム注射薬(0.9%の塩化ナトリウム中5%のブドウ糖);ブドウ糖;ジアゼパム注射薬(ジアゼパム注射薬);ジゴキシン注射薬(ラノキシン注射薬);ジラウジッド−HP(ヒドロモルホン塩酸塩注射薬);ジメルカプロール注射薬(Bal in Oil アンプル);ジフェンヒドラミン注射薬(ベナドリル注射薬);ジピリダモール注射薬(Dipyridamole注射薬);DMOAD;注射用ドセタキセル(タキソテール);メシル酸ドラセトロン注射薬(アンゼメット注射薬);ドリバックス(注射用ドリペネム);注射用ドリペネム(ドリバックス);ドキセルカルシフェロール注射薬(ヘクトロール注射薬);ドキシル(ドキソルビシンHclリポソーム注射薬);ドキソルビシンHclリポソーム注射薬(ドキシル);Duraclon(クロニジン注射薬);Duramorph(モルヒネ注射薬);ディスポート(アボボツリナムトキシンA注射薬);エカランチド注射薬(Kalbitor);EC−ナプロシン(ナプロキセン);エデト酸カルシウム二ナトリウム注射薬(カルシウム二ナトリウムベルセネート);Edex(注射用アルプロスタジル);Engerix;エドロホニウム注射薬(Enlon);エリグルスタット酒石酸塩;エロキサチン(オキサリプラチン注射薬;Emend注射薬(フォサプレピタントジメグルミン注射薬);エナラプリラット注射薬(Enalaprilat注射薬);Enlon(エドロホニウム注射薬);エノキサパリンナトリウム注射薬(ラブノックス);エオビスト(ガドキセト酸二ナトリウム注射薬);エンブレル(エタネルセプト);エノキサパリン;Epicel;エピネフェリン;エピペン;エピペンJr.;エピラツズマブ;アービタックス;エルタペネム注射薬(Invanz);エリスロポエテン;必須アミノ酸注射薬(Nephramine);シピオン酸エストラジオール;吉草酸エストラジオール;エタネルセプト;エキセナチド注射薬(バイエッタ);エボルトラ;ファブラザイム(アダルシダーゼベータ);ファモチジン注射薬;FDG(フルデオキシグルコースF18注射薬);Feraheme(フェルモキシトール注射薬);フェリデックスI.V.(フェルモキシデスの注射用液);Fertinex;フェルモキシデスの注射用液(フェリデックスI.V.);フェルモキシトール注射薬(フェラヘム);フラジール注射薬(メトロニダゾール注射薬);フルアリックス;フルダラ(リン酸フルダラビン);フルデオキシグルコースF18注射薬(FDG);フルオレセイン注射薬(Ak−Fluor);フォリスチムAQカートリッジ(フォリトロピンベータ注射薬);フォリトロピンアルファ注射薬(ゴナール−f RFF);フォリトロピンベータ注射薬(フォリスチムAQカートリッジ);Folotyn(静注用プララトレキサート溶液);フォンダパリヌクス;フォルテオ(テリパラチド(rDNA由来)注射薬);Fostamatinib;フォサプレピタントジメグルミン注射薬(イメンド注射薬);ホスカルネットナトリウム注射薬(ホスカビル);ホスカビル(ホスカルネットナトリウム注射薬);ホスフェニトインナトリウム注射薬(Cerebyx);ホスプロポフォール二ナトリウム注射薬(Lusedra);フラグミン;フゼオン(エンフビルチド);GA101;ガドベン酸メグルミン注射薬(Multihance);ガドホスベセット三ナトリウム注射薬(Ablavar);ガドテリドール注射薬溶液(プロハンス);カドベルセタミド注射薬(OptiMARK);ガドキセト酸二ナトリウム(Eovist);ガニレリクス(ガニレリクス酢酸塩注射薬);ガーダシル;GC1008;GDFD;注射用ゲムツズマブオゾガマイシン(マイロターグ);ジェノトロピン;ゲンタマイシン注射薬;GENZ−112638;ゴリムマブ注射薬(シンポニー注射薬);ゴナール−f RFF(フォリトロピンアルファ注射薬);グラニセトロン塩酸塩(カイトリル注射薬);ゲンタマイシン硫酸塩;グラチラマー酢酸塩;グ
ルカゲン;グルカゴン;HAE1;Haldol(ハロペリドール注射薬);Havrix;Hectorol注射薬(ドキセルカルシフェロール注射薬);ヘッジホッグ経路阻害薬;へパリン;ハーセプチン;hG−CSF;ヒューマログ;ヒト成長ホルモン;ヒューマトロープ;HuMax;Humegon;ヒュミラ;ヒューマリン;イバンドロネートナトリウム注射薬(Boniva注射薬);イブプロフェンリシン注射薬(NeoProfen);フマル酸イブチリド注射薬(コルベルト);イダマイシンPFS(イダルビシン塩酸塩注射薬);イダルビシン塩酸塩注射薬(イダマイシンPFS);イラリス(カナキヌマブ注射薬);注射用イミペネム及びシラスタチン(プリマキシンI.V.);イミトレックス;注射用インコボツリナムトキシンA(ゼオミン);Increlex(メカセルミン[rDNA由来]注射薬);インドシンIV(インドメタシン注射薬);インドメタシン注射薬(インドシンIV);Infanrix;イノヘップ;インスリン;インスリンアスパルト[rDNA由来]注射薬(ノボログ);インスリングラルギン[rDNA由来]注射薬(ランタス);インスリングルリシン[rDNA由来]注射薬(アピドラ);インターフェロンアルファ−2b、注射用遺伝子組換え型(イントロンA);イントロンA(インターフェロンアルファ−2b、注射用遺伝子組換え型);インバンズ(エルタペネム注射薬);Invega Sustenna(パリペリドンパルミチン酸エステル徐放性懸濁注射液);インビラーゼ(サキナビルメシル酸塩);ヨーベングアンI 123静注用注射薬(AdreView);イオプロミド注射薬(Ultravist);イオベルソール注射薬(オプチレイ注射薬);Iplex(メカセルミンリンファバート[rDNA由来]注射薬);Iprivask;イリノテカン塩酸塩(Camptosar注射薬);含糖酸化鉄注射薬(ヴェノファー);Istodax(注射用ロミデプシン);イトラコナゾール注射薬(スポラノックス注射薬);ジェブタナ(カバジタキセル注射薬);Jonexa;Kalbitor(エカランチド注射薬);KCL in D5NS(5%のブドウ糖と塩化ナトリウムの中に塩化カリウムが入った注射薬);KCL in D5W;KCL in NS;ケナログ10注射薬(トリアムシノロンアセトニド懸濁注射液);ケピバンス(パリフェルミン);ケプラ注射薬(レベチラセタム);ケラチノサイト;KFG;キナーゼ阻害薬;Kineret(アナキンラ);Kinlytic(ウロキナーゼ注射薬);Kinrix;クロノピン(クロナゼパム);カイトリル注射薬(グラニセトロン塩酸塩);ラコサミド錠及び注射薬(ビンパット);乳酸リンゲル液;ラノキシン注射薬(ジゴキシン注射薬);注射用ランソプラゾール(プレバシドI.V.);ランタス;ロイコボリンカルシウム(ロイコボリンカルシウム注射薬);レンテ(L);レプチン;レベミル;リューカインサルグラモスチム;ロイプロリド酢酸塩;レボチロキシン;レベチラセタム(ケプラ注射薬);ラブノックス;レボカルニチン注射薬(Carnitor注射薬);レキスキャン(レガデノソン注射薬);リオレサール髄注(バクロフェン注射薬);リラグルチド[rDNA]注射薬(ビクトーザ);ラブノックス(エノキサパリンナトリウム注射薬);ルセンティス(ラニビズマブ注射薬);Lumizyme;ルプロン(ロイプロリド酢酸塩注射薬);Lusedra(ホスプロポフォール二ナトリウム注射薬);Maci;マグネシウム硫酸塩(マグネシウム硫酸塩注射薬);マンニトール注射薬(マンニトールIV);マーカイン(ブピバカイン塩酸塩及びエピネフリン注射薬);マキシピーム(注射用セフェピム塩酸塩);テクネチウム注射薬のMDP多用量キット(テクネチウムTc99mメドロナート注射薬);メカセルミン[rDNA由来]注射薬(Increlex);メカセルミンリンファバート[rDNA由来]注射薬(Iplex);メルファランHcl注射薬(アルケラン注射薬);メトトレキサート;メナクトラ;Menopur(メノトロピンス注射薬);注射用メノトロピンス(Repronex);注射用メトヘキシタールナトリウム(ブレビタールナトリウム);メチルドーパート塩酸塩注射薬、溶液(メチルドーパートHcl);メチレンブルー(メチレンブルー注射薬);酢酸メチルプレドニゾロン懸濁注射液(デポメドロール);MetMab;メトクロプラミド注射薬(Reglan注射薬);メトロジン(注射用ウロホリトロピン);メトロニダゾール注射薬(フラジール注射薬);ミアカルシン;ミダゾラム(ミダゾラム注射薬);ミンパラ(シナカレト);ミノシン注射薬(ミノサイクリン注射薬);ミノサイクリン注射薬(ミノシン注射薬);ミポメルセン;ミトキサントロン注射用濃縮液(ノバントロン);モルヒネ注射薬(Duramorph);モルヒネ硫酸塩XRリポソーム注射薬(デポデュール);モルイン酸ナトリウム(モルイン酸ナトリウム注射薬);モテサニブ;モゾビル(プレリキサフォル注射薬);Multihance(ガドベン酸メグルミン注射薬);複合電解質及びブドウ糖注射薬;複合電解質注射薬;マイロターグ(注射用ゲムツズマブオゾガマイシン);マイオザイム(アルグルコシダーゼアルファ);ナフシリン注射薬(ナフシリンナトリウム);ナフシリンナトリウム(ナフシリン注射薬);ナルトレキソンXR注射薬(ビビトロル);ナプロシン(ナプロキセン);NeoProfen(イブプロフェンリシン注射薬);デカン酸ナンドロール;ネオスチグミンメチル硫酸塩(ネオスチグミンメチル硫酸塩注射薬);NEO−GAA;NeoTect(テクネチウムTc99mデプレオチド注射薬);Nephramine(必須アミノ酸注射薬);Neulasta(ペグフィルグラスチム);Neupogen(フィルグラスチム);ノボリン;ノボログ;NeoRecormon;Neutrexin(グルコン酸トリメトレキサート注射薬);NPH(N);Nexterone(アミオダロンHCl注射薬);ノルディトロピン(ソマトロピン注射薬);生理食塩水(塩化ナトリウム注射薬);ノバントロン(ミトキサントロン注射用濃縮液);ノボリン70/30イノレット(70%NPH、ヒトインスリンイソフェン懸濁液及び30%レギュラー、ヒトインスリン注射薬);ノボログ(インスリンアスパルト[rDNA由来]注射薬);Nplate(ロミプロスチム);ニュートロピン(注射用ソマトロピン(rDNA由来));ニュートロピンAQ;ニュートロピンデポ(注射用ソマトロピン(rDNA由来));オクトレオチド酢酸塩注射薬(サンドスタチンLAR);オクレリズマブ;オファツムマブ注射薬(アーゼラ);徐放性オランザピン懸濁注射液(Zyprexa Relprevv);オムニターグ;オムニトロープ(ソマトロピン[rDNA由来]注射薬);オンダンセトロン塩酸塩注射薬(ゾフラン注射薬);OptiMARK(カドベルセタミド注射薬);オプチレイ注射薬(イオベルソール注射薬);オレンシア;Aviva中のOsmitrol注射薬(Avivaプラスチック容器中のマンニトール注射薬);Viaflex中のOsmitrol注射薬(Viaflexプラスチック容器中のマンニトール注射薬);オステオプロテグリン;Ovidrel(絨毛性ゴナドトロピンアルファ注射薬);オキサシリン(注射用オキサシリン);オキサリプラチン注射薬(エロキサチン);オキシトシン注射薬(ピトシン);パリペリドンパルミチン酸エステル徐放性懸濁注射液(Invega Sustenna);パミドロン酸二ナトリウム注射薬(パミドロン酸二ナトリウム注射薬);静注用パニツムマブ(ベクティビックス);パパベリン塩酸塩注射薬(パパベリン注射薬);パパベリン注射薬(パパベリン塩酸塩注射薬);副甲状腺ホルモン;パリカルシトール注射薬フリップトップ型バイアル(Zemplar注射薬);PARP阻害薬;Pediarix;ペグイントロン;ペグインターフェロン;ペグフィルグラスチム;ペニシリンGベンザチン及びペニシリンGプロカイン;ペンテト酸カルシウム三ナトリウム注射薬(Ca−DTPA);ペンテト酸亜鉛三ナトリウム注射薬(Zn−DTPA);ペプシド注射薬(ファモチジン注射薬);Pergonal;ペルツズマブ;メシル酸フェントールアミン(注射用メシル酸フェントールアミン);サリチル酸フィゾスチグミン(サリチル酸フィゾスチグミン(注射薬));サリチル酸フィゾスチグミン(注射薬)(サリチル酸フィゾスチグミン);ピペラシリン及びタゾバクタム注射薬(ゾシン);ピトシン(オキシトシン注射薬);Plasma−Lyte 148(複合電解質注射薬);Plasma−Lyte 56及びブドウ糖(Viaflexプラスチック容器中の複合電解質及びブドウ糖注射薬);PlasmaLyte;プレリキサフォル注射薬(モゾビル);ポリドカノール注射薬(Asclera);塩化カリウム;静注用プララトレキサート溶液(フォロチン);酢酸プラムリンタイド注射薬(Symlin);プレマリン注射薬(注射用結合型エストロゲン);注射用テクネチウムTc99セスタミビ調製キット(カーディオライト);プレバシドI.V.(注射用ランソプラゾール);プリマキシンI.V.(注射用イミペネム及びシラスタチン);Prochymal;プロクリット;黄体ホルモン;プロハンス(ガドテリドール注射薬溶液);プロリア(デノスマブ注射薬);プロメタジンHCl注射薬(プロメタジン塩酸塩注射薬);プロプラノロール塩酸塩注射薬(Propranolol塩酸塩注射薬);グルコン酸キニジン注射薬(キニジン注射薬);キニジン注射薬(グルコン酸キニジン注射薬);R−Gene 10(アルギニン塩酸塩注射薬);ラニビズマブ注射薬(ルセンティス);ラニチジン塩酸塩注射薬(ザンタック注射薬);ラプティバ;リクラスト(ゾレドロン酸注射薬);Recombivarix HB;レガデノソン注射薬(レキスキャン);Reglan注射薬(メトクロプラミド注射薬);レミケード;レナジェル;Renvela(セベラマー炭酸塩);Repronex(注射用メノトロピンス);レトロビルIV(ジドブジン注射薬);rhApo2L/TRAIL;リンゲル及び5%ブドウ糖注射薬(ブドウ糖含有リンゲル液);リンゲル注射薬(リンゲル液);リツキサン;リツキシマブ;ロセフィン(セフトリアキソン);ロクロニウム臭化物注射薬(ゼムロン);ロフェロン−A(インターフェロンアルファ−2a);Romazicon(フルマゼニル);注射用ロミデプシン(Istodax);サイゼン(ソマトロピン注射薬);サンドスタチンLAR(オクトレオチド酢酸塩注射薬);スクレロスチンAb;センシパー(シナカルセト);Sensorcaine(ブピバカインHCl注射薬);セプトカイン(アルチカインHCl及びエピネフリン注射薬);Serostim LQ(ソマトロピン(rDNA由来)注射薬);シンポニー注射薬(ゴリムマブ注射薬);酢酸ナトリウム(酢酸ナトリウム注射薬);炭酸水素ナトリウム(炭酸水素ナトリウム5%注射薬);乳酸ナトリウム(AVIVA中の乳酸ナトリウム注射薬);フェニル酢酸ナトリウム及び安息香酸ナトリウム注射薬(Ammonul);注射用ソマトロピン(rDNA由来)(ニュートロピン);スポラノックス注射薬(イトラコナゾール注射薬);ステラーラ注射薬(ウステキヌマブ);Stemgen;スフェンタ(クエン酸スフェンタニル注射薬);クエン酸スフェンタニル注射薬(スフェンタ);Sumavel;スマトリプタン注射薬(Alsuma);Symlin;Symlin Pen;全身性ヘッジホッグ拮抗薬;シンビスク−ワン(Hylan G−F 20単回関節内注射薬);タルセバ;タキソテール(注射用ドセタキセル);テクネチウムTc99m;注射用テラバンシン(ヴィバティブ);テムシロリムス注射薬(トーリセル);テノーミンI.V.注射薬(アテノロール注射薬);テリパラチド(rDNA由来)注射薬(フォルテオ);テストステロンシピオネー
ト;テストステロンエナント酸エステル;テストステロンプロピオン酸エステル;Tev−Tropin(ソマトロピン、rDNA由来、注射用);tgAAC94;塩化タリウム;テオフィリン;チオテパ(チオテパ注射薬);サイモグロブリン(抗胸腺細胞免疫グロブリン(ウサギ);タイロゲン(注射用チロトロピンアルファ);チカルシリンジナトリウム及びクラブラン酸カリウムギャラクシー(チメンチン注射薬);Tigan注射薬(注射用トリメトベンズアミド塩酸塩);チメンチン注射薬(チカルシリンジナトリウム及びクラブラン酸カリウムギャラクシー);TNKase;トブラマイシン注射薬(トブラマイシン注射薬);トシリズマブ注射薬(アクテムラ);トーリセル(テムシロリムス注射薬);Totect(注射用デキスラゾキサン、静注のみ);トラスツズマブ−DM1;Travasol(アミノ酸(注射薬));トレアンダ(ベンダムスチン塩酸塩注射薬);トレルスター(懸濁注射液用トリプトレリンパモエート);トリアムシノロンアセトニド;トリアムシノロンジアセテート;トリアムシノロンヘキサアセトニド懸濁注射液(アリストスパン注射薬20mg);Triesence(トリアムシノロンアセトニド懸濁注射液);注射用トリメトベンズアミド塩酸塩(Tigan注射薬);グルコン酸トリメトレキサート注射薬(Neutrexin);懸濁注射液用トリプトレリンパモエート(トレルスター);Twinject;Trivaris(トリアムシノロンアセトニド懸濁注射液;トリセノックス(三酸化ヒ素注射薬);Twinrix;Typhoid Vi;Ultravist(イオプロミド注射薬);注射用ウロホリトロピン(Metrodin);ウロキナーゼ注射薬(Kinlytic);ウステキヌマブ(ステラーラ注射薬);ウルトラレンテ(U);バリウム(ジアゼパム);バルプロ酸ナトリウム注射薬(Depacon);Valtropin(ソマトロピン注射薬);バンコマイシン塩酸塩(バンコマイシン塩酸塩注射薬);バンコマイシン塩酸塩注射薬(バンコマイシン塩酸塩);バプリゾール(コニバプタンHcl注射薬);VAQTA;バソビスト(ガドホスベセット三ナトリウム注射薬静注用);ベクティビックス(パニツムマブ注射薬静注用);ヴェノファー(含糖酸化鉄注射薬);ベルテポルフィン注射薬(ビスダイン);ヴィバティブ(注射用テラバンシン);ビクトーザ(リラグルチド[rDNA]注射薬);ビンパット(ラコサミド錠及び注射薬);ビンブラスチン硫酸塩(ビンブラスチン硫酸塩注射薬);Vincasar PFS(ビンクリスチン硫酸塩注射薬);ビクトーザ;ビンクリスチン硫酸塩(ビンクリスチン硫酸塩注射薬);ビスダイン(ベルテポルフィン注射薬);ビタミンB−12;ビビトロル(ナルトレキソンXR注射薬);ボルベン(塩化ナトリウム中のヒドロキシエチルデンプン注射薬);ゼローダ;ゼニカル(オルリスタット);Xeomin(注射用インコボツリナムトキシンA);ゾレア;ザンタック注射薬(ラニチジン塩酸塩注射薬);Zemplar注射薬(パリカルシトール注射薬フリップトップ型バイアル);Zemuron(ロクロニウム臭化物注射薬);ゼナパックス(ダクリズマブ);ゼバリン;ジドブジン注射薬(レトロビルIV);ジスロマック注射薬(アジスロマイシン);Zn−DTPA(ペンテト酸亜鉛三ナトリウム注射薬);ゾフラン注射薬(オンダンセトロン塩酸塩注射薬);Zingo;注射用ゾレドロン酸(ゾメタ);ゾレドロン酸注射薬(リクラスト);ゾメタ(注射用ゾレドロン酸);ゾシン(ピペラシリン及びタゾバクタム注射薬);Zyprexa Relprevv(徐放性オランザピン懸濁注射液)。
エビリファイ;AccuNeb(アルブテロール硫酸塩吸入液);Actidose Aqua(活性炭懸濁液);活性炭懸濁液(Actidose Aqua);アドベア;Agenerase経口液(アンプレナビル経口液);Akten(リドカイン塩酸塩眼科用ゲル);Alamast(ペミロラストカリウム点眼液);アルブミン(ヒト)5%溶液(ブミネート5%);アルブテロール硫酸塩吸入液;Alinia;Alocril;アルファガン;Alrex;オルベスコ;アンプレナビル経口液;Analpram−HC;アルフォルモテロール酒石酸塩吸入液(Brovana);アリストスパン注射薬20mg(トリアムシノロンヘキサアセトニド懸濁注射液);アサコール;アズマネックス;Astepro;Astepro(アゼラスチン塩酸塩点鼻薬);アトロベント点鼻薬(臭化イプラトロピウム点鼻薬);アトロベント点鼻薬.06;オーグメンチンES−600;Azasite(アジスロマイシン点眼液);アゼライン酸(フィナシアゲル);アゼラスチン塩酸塩点鼻薬(Astepro);Azelex(アゼライン酸クリーム);エイゾプト(ブリンゾラミド懸濁性点眼液);静菌生理食塩水;平衡塩;ベポタスチン;バクトロバン鼻腔用;バクトロバン;Beclovent;ベンザックW;Betimol;Betoptic S;Bepreve;ビマトプロスト点眼液;Bleph 10(スルファセタミドナトリウム点眼液10%);ブリンゾラミド懸濁点眼液(エイゾプト);ブロムフェナク点眼液(Xibrom);Bromhist;Brovana(アルフォルモテロール酒石酸塩吸入液);ブデソニド吸入用懸濁液(Pulmicort Respules);Cambia(経口液用ジクロフェナクカリウム);Capex;Carac;Carboxine−PSE;Carnitor;Cayston(吸入液用アズトレオナム);セルセプト;Centany;Cerumenex;Ciloxan点眼液(シプロフロキサシンHCL点眼液);Ciprodex;シプロフロキサシンHCL点眼液(Ciloxan点眼液);クレマスチンフマル酸塩シロップ(Clemastine Fumarateシロップ);CoLyte(PEG電解質溶液);Combiven;コムタン;Condylox;Cordran;Cortisporin懸濁性点眼液;Cortisporin耳科用懸濁液;クロモリンナトリウム吸入液(Intal Nebulizer溶液);クロモリンナトリウム点眼液(Opticrom);電解質含有結晶性アミノ酸溶液(Aminosyn電解質);Cutivate;Cuvposa(グリコピロレート経口液);シアノコバラミン(CaloMist点鼻薬);シクロスポリン経口液(Gengraf経口液);サイクロジル;Cysview(ヘキサミノレブリナート塩酸塩膀胱内用溶液);DermOticオイル(フルオシノロンアセトニドオイル点耳薬);デスモプレシン酢酸塩点鼻薬;DDAVP;Derma−Smoothe/FS;デキサメタゾンインテンソール;ダイアニール低カルシウム;ダイアニールPD;経口液用ジクロフェナクカリウム(Cambia);ジダノシン小児用粉末経口液用(ヴァイデックス);ディフェリン;ディランチン125(フェニトイン経口懸濁液);Ditropan;ドルゾラミド塩酸塩点眼液(トルソプト);ドルゾラミド塩酸塩−チモロールマレイン酸塩点眼液(コソプト);ドボネックススカルプ(カルシポトリエン溶液);ドキシサイクリンカルシウム経口懸濁液(ビブラマイシン経口用);Efudex;エラプレース(イデュルスルファーゼ溶液);Elestat(エピナスチンHCl点眼液);Elocon;エピナスチンHCl点眼液(Elestat);エピビルHBV;エポゲン(エポエチンアルファ);エリスロマイシン局所用液1.5%(Staticin);エチオドール(Ethiodized Oil);エトスクシミド経口液(ザロンチン経口液);オイラックス;Extraneal(イコデキストリン腹膜透析液);Felbatol;フェリデックスI.V.(フェルモキシデス注射用溶液);Flovent;フロキシン耳科用薬(オフロキサシン耳科用液);Flo−Pred(プレドニゾロン酢酸エステル経口懸濁液);Fluoplex;フルニソリド点鼻液(フルニソリド点鼻用スプレー.025%);フルオロメトロン懸濁性点眼液(FML);フルルビプロフェンナトリウム点眼液(Ocufen);FML;Foradil;フマル酸ホルモテロール吸入液(Perforomist);フォサマックス;フラダンチン(ニトロフラントイン経口懸濁液);フロキソン;ガンマガード液(静注用免疫グロブリン(ヒト)10%);ガントリシン(アセチルスルフイソキサゾール小児用懸濁液);ガチフロキサシン点眼液(Zymar);Gengraf経口液(シクロスポリン経口液);グリコピロレート経口液(Cuvposa);ハルシノニド局所用液(Halog溶液);Halog溶液(ハルシノニド局所用液);HEP−LOCK U/P(防腐剤無添加ヘパリンロックフラッシュ液);ヘパリンロックフラッシュ液(Hepflush10);ヘキサミノレブリネート塩酸塩膀胱内溶液(Cysview);酒石酸水素ヒドロコドン及びアセトアミノフェン経口液(Lortab Elixir);ヒドロキノン3%局所用液(Melquin−3局所用液);IAP拮抗薬;Isopto;臭化イプラトロピウム点鼻薬(アトロベント点鼻薬);イトラコナゾール経口液(スポラノックス経口液);ケトロラクトロメタミン点眼液(Acular LS);カレトラ;ラノキシン;レクシヴァ;デポ懸濁液用ロイプロリド酢酸塩(ルプロンデポ11.25mg);レボベタキソロール塩酸塩懸濁性点眼液(ベタキソン);レボカルニチン錠、経口液、無糖(Carnitor);レボフロキサシン点眼液0.5%(Quixin);リドカインHCl滅菌液(キシロカインMPF滅菌液);Lok Pak(ヘパリンロックフラッシュ液);Lorazepam Intensol;Lortab Elixir(酒石酸水素ヒドロコドン及びアセトアミノフェン経口液);Lotemax(エタボン酸ロテプレドノール懸濁点眼液);エタボン酸ロテプレドノール懸濁点眼液(Alrex);低カルシウム腹膜透析溶液(ダイアニール低カルシウム);ルミガン(緑内障用ビマトプロスト点眼液0.03%);ルプロンデポ11.25mg(デポ懸濁液用ロイプロリド酢酸塩);メゲストロール酢酸塩経口懸濁液(メゲストロール酢酸塩経口懸濁液);MEK阻害薬;Mepron;Mesnex;メスチノン;メサラミン注腸剤(Rowasa);Melquin−3局所用液(ヒドロキノン3%局所用液);MetMab;メチルドーパートHcl(メチルドーパート塩酸塩注射薬、溶液);Methylin経口液(メチルフェニデートHCl経口液5mg/5mL及び10mg/5mL);酢酸メチルプレドニゾロン懸濁注射液(デポメドロール);メチルフェニデートHCl経口液5mg/5mL及び10mg/5mL(Methylin経口液);コハク酸メチルプレドニゾロンナトリウム(ソルメドロール);メチプラノロール点眼液(Optipranolol);Migranal;Miochol−E(アセチルコリン塩化物眼内溶液);液体懸濁液用Micro−K(液体懸濁液用塩化カリウム徐放製剤);ミノシン(ミノサイクリン塩酸塩経口懸濁液);ナサコート;ネオマイシン硫酸塩及びポリミキシンB硫酸塩及びヒドロコルチゾン;ネパフェナク懸濁点眼液(ネバナック);ネバナック(ネパフェナク懸濁点眼液);ニトロフラントイン経口懸濁液(フラダンチン);Noxafil(ポサコナゾール経口懸濁液);ニスタチン(経口)(ニスタチン経口懸濁液);ニスタチン経口懸濁液(ニスタチン(経口));Ocufen(フルルビプロフェンナトリウム点眼液);オフロキサシン点眼液(オフロキサシン点眼液);オフロキサシン耳科用液(フロキシン耳科用薬);オロパタジン塩酸塩点眼液(Pataday);Opticrom(クロモリンナトリウム点眼液);Optipranolol(メチプラノロール点眼液);パタノール;Pediapred;PerioGard;フェニトイン経口懸濁液(ディランチン125);Phisohex;ポサコナゾール経口懸濁液(Noxafil);液体懸濁液用塩化カリウム徐放製剤(液体懸濁液用Micro−K);Pataday(オロパタジン塩酸塩点眼液);Patanase点鼻薬(オロパタジン塩酸塩点鼻薬);PEG電解質溶液(CoLyte);ペミロラストカリウム点眼液(Alamast);Penlac(シクロピロクス局所用液);PENNSAIDジクロフェナクナトリウム局所用液);Perforomist(フマル酸ホルモテロール吸入液);腹膜透析溶液;フェニレフリン塩酸塩点眼液(ネオシネフリン);ヨウ化ホスホリン(点眼液用ヨウ化エコチオフェート);ポドフィロックス(ポドフィロックス局所用液);Pred Forte(プレドニゾロン酢酸エステル懸濁点眼液);静注用プララトレキサート溶液(フォロチン);Pred Mild;プレドニゾンインテンソール;プレドニゾロン酢酸エステル懸濁性点眼液(Pred Forte);プレバシド;PrismaSol溶液(滅菌血液濾過血液透析濾過溶液);プロエアー;プログリセム;プロハンス(ガドテリドール注射薬溶液);プロパラカイン塩酸塩点眼液(Alcaine);プロパイン;パルミコート;プルモザイム;Quixin(レボフロキサシン点眼液0.5%);QVAR;ラパミューン;レベトール;Relacon−HC;ロタリックス(経口生ロタウイルスワクチン懸濁液);経口生ロタウイルスワクチン懸濁液(ロタリックス);Rowasa(メサラミン注腸剤);サブリル(ビガバトリン経口液);サクロシダーゼ経口液(Sucraid);サンディミュン;Sepra;Serevent Diskus;ソルコーテフ(ヒドロコルチゾンコハク酸エステルナトリウム);ソルメドロール(コハク酸メチルプレドニゾロンナトリウム);スピリーバ;スポラノックス経口液(イトラコナゾール経口液);Staticin(エリスロマイシン局所用液1.5%);スタレボ;Starlix;滅菌血液濾過血液透析濾過溶液(PrismaSol溶液);Stimate;スクラルファート(カラファート懸濁液);スルファセタミドナトリウム点眼液10%(Bleph 10);Synarel点鼻液(子宮内膜症用酢酸ナファレリン点鼻液);Taclonex Scalp(カルシポトリエン及びジプロピオン酸ベタメタゾン局所用懸濁液);タミフル;トービイ;TobraDex;Tobradex ST(トブラマイシン/デキサメサゾン懸濁性点眼液0.3%/0.05%);トブラマイシン/デキサメサゾン懸濁性点眼液0.3%/0.05%(Tobradex ST);チモロール;Timoptic;トラバタン Z;トレプロスチニル吸入液(Tyvaso);トルソプト(ドルゾラミド塩酸塩点眼液);Tyvaso(トレプロスチニル吸入液);ベントリン;ブイフェンド;ビブラマイシン経口用(ドキシサイクリンカルシウム経口懸濁液;ヴァイデックス(ジダノシン小児用粉末経口液用);ビガバトリン経口液(サブリル);Viokase;ビラセプト;ビラミューン;ビタミンK1(ビタミンK1の流体コロイド溶液);ボルタレン眼科用(ジクロフェナクナトリウム点眼液);ザロンチン経口液(エトスクシミド経口液);ザイアジェン;ザイボックス;Zymar(ガチフロキサシン点眼液);Zymaxid(ガチフロキサシン点眼液)。
5−アルファ−還元酵素阻害薬;5−アミノサリチル酸塩;5HT3受容体拮抗薬;アダマンタン抗ウイルス薬;副腎皮質ステロイド;副腎皮質ホルモン阻害薬;アドレナリン作動性気管支拡張薬;高血圧性緊急疾患用薬剤;肺高血圧症用薬剤;アルドステロン受容体拮抗薬;アルキル化剤;アルファ−アドレナリン受容体拮抗薬;アルファ−グルコシダーゼ阻害薬;代替薬;殺アメーバ剤;アミノグリコシド;アミノペニシリン;アミノサリチル酸塩;アミリン類似体;鎮痛配合剤;鎮痛薬;アンドロゲン及びアナボリックステロイド;アンジオテンシン変換酵素阻害薬;アンジオテンシンII阻害薬;肛門直腸製剤;食欲抑制剤;制酸剤;駆虫剤;抗血管原性眼科用剤;抗−CTLA−4モノクローナル抗体;抗感染症薬;抗アドレナリン作用薬、中枢作用型;抗アドレナリン作用薬、抹消作用型;抗アンドロゲン薬;抗狭心症薬;抗不整脈薬;抗喘息配合剤;抗生剤/抗腫瘍薬;抗コリン性制吐薬;抗コリン性抗パーキンソン薬;抗コリン性気管支拡張薬;抗コリン性変時薬;抗コリン作動薬/鎮痙薬;凝固防止剤;抗痙攣薬;抗うつ薬;抗糖尿病薬;抗糖尿病配合剤;止瀉薬;抗利尿ホルモン;解毒剤;制吐薬/抗暈眩薬;抗真菌薬;抗ゴナドトロピン薬;痛風治療薬;抗ヒスタミン薬;抗高脂血症剤;抗高脂血症配合剤;降圧配合剤;尿酸降下薬;抗マラリア薬;抗マラリア配合剤;抗マラリア薬キノリン;代謝拮抗薬;抗片頭痛薬;抗腫瘍解毒剤;抗腫瘍インターフェロン;抗腫瘍モノクローナル抗体;抗腫瘍薬;抗パーキンソン薬;抗血小板薬;抗緑膿菌ペニシリン;抗乾癬薬;抗精神病薬;抗リウマチ薬;防腐剤及び殺菌剤;抗甲状腺薬;抗毒素及び抗蛇毒素;抗結核薬;抗結核薬配合剤;鎮咳薬;抗ウイルス薬;抗ウイルス配合剤;抗ウイルスインターフェロン;抗不安薬、鎮静薬、及び催眠薬;アロマターゼ阻害薬;非定型抗精神病薬;アゾール抗真菌薬;細菌性ワクチン;バルビツール酸系抗痙攣薬;バルビツール酸塩;BCR−ABLチロシンキナーゼ阻害薬;ベンゾジアゼピン系抗痙攣薬;ベンゾジアゼピン;β−アドレナリン遮断薬;β−ラクタマーゼ阻害薬;胆汁酸抑制薬;生物製剤;ビスホスホネート;骨吸収阻害薬;気管支拡張薬配合剤;気管支拡張薬;カルシトニン;カルシウムチャネル遮断薬;カルバメート系抗痙攣薬;カルバペネム;炭酸脱水酵素阻害抗痙攣薬;炭酸脱水酵素阻害薬;心臓負荷薬;心選択性β遮断薬;心臓血管薬;カテコールアミン;CD20モノクローナル抗体;CD33モノクローナル抗体;CD52モノクローナル抗体;中枢神経系薬;セファロスポリン;耳垢水;キレート剤;ケモカイン受容体拮抗薬;クロライドチャネル活性化剤;コレステロール吸収阻害薬;コリン作動薬;コリン作動性筋刺激剤;コリンエステラーゼ阻害薬;中枢神経刺激薬;凝固調整剤;コロニー刺激因子;避妊薬;コルチコトロピン;クマリン及びインダンジオン;cox−2阻害薬;充血除去剤;皮膚用剤;診断用放射性医薬品;ジベンザゼピン抗痙攣薬;消化酵素;ジペプチジルペプチダーゼ4阻害薬;利尿剤;ドーパミン系抗パーキンソン薬;アルコール依存症に使用される薬剤;エキノカンジン;EGFR阻害薬;エストロゲン受容体拮抗薬;エストロゲン;去痰薬;第Xa因子阻害剤;脂肪酸誘導体抗痙攣薬;フィブリン酸誘導体;第1世代セファロスポリン;第4世代セファロスポリン;機能性腸疾患薬;胆石可溶化薬;γ−アミノ酪酸類似体;γ−アミノ酪酸再取り込み阻害薬;γ−アミノ酪酸トランスアミナーゼ阻害薬;胃腸薬;全身麻酔薬;尿生殖器管薬;GI刺激薬;グルココルチコイド;グルコース上昇剤;グリコペプチド抗生剤;糖タンパク質血小板阻害薬;グリシルサイクリン;ゴナドトロピン放出ホルモン;ゴナドトロピン放出ホルモン拮抗薬;ゴナドトロピン;I群抗不整脈薬;II群抗不整脈薬;III群抗不整脈薬;IV群抗不整脈薬;V群抗不整脈薬;成長ホルモン受容体遮断薬;成長ホルモン;H.ピロリ除菌薬;H2拮抗薬;造血幹細胞動員剤;へパリン拮抗薬;へパリン;HER2阻害薬;植物製品;ヒストン脱アセチル化酵素阻害薬;ホルモン補充療法;ホルモン;ホルモン/抗腫瘍薬;ヒダントイン抗痙攣薬;違法(ストリート)薬物;免疫グロブリン;免疫薬;免疫抑制薬;インポテンス薬;インビボ診断生物製剤;インクレチンミメティクス;吸入抗感染症薬;吸入コルチコステロイド;強心薬;インスリン;インスリン様増殖因子;インテグラーゼ鎖移転阻害薬;インターフェロン;静脈内栄養製品;ヨード造影剤;イオン化ヨード造影剤;鉄製品;ケトライド;緩下薬;抗らい薬;ロイコトリエン調整剤;リンコマイシン誘導体;脂質化グリコペプチド;局所注射麻酔薬;ループ利尿薬;肺表面活性剤;リンパ管染色剤;リソソーム酵素;マクロライド誘導体;マクロライド;磁気共鳴イメージング造影剤;肥満細胞安定化剤;医療用ガス;メグリチニド;代謝薬;メチルキサンチン;ミネラルコルチコイド;ミネラル及び電解質;種々の薬剤;種々の鎮痛薬;種々の抗生剤;種々の抗痙攣薬;種々の抗うつ薬;種々の抗糖尿病薬;種々の制吐剤;種々の抗真菌剤;種々の高脂血症用薬;種々の抗マラリア薬;種々の抗腫瘍薬;種々の抗パーキンソン薬;種々の抗精神病薬;種々の抗結核薬;種々の抗ウイルス薬;種々の抗不安薬、鎮静薬及び催眠薬;種々の生物製剤;種々の骨吸収阻害薬;種々の心血管作動薬;種々の中枢神経系薬;種々の凝固調整剤;種々の利尿薬;種々の尿生殖管薬;種々のGI薬;種々のホルモン;種々の代謝薬;種々の眼科薬;種々の耳科用薬;種々の呼吸薬;種々の性ホルモン;種々の局所薬;種々の未分類薬;種々の腟用薬;有糸分裂阻害薬;モノアミン酸化酵素阻害薬;モノクローナル抗体;口及び咽喉用製品;mTOR阻害薬;mTORキナーゼ阻害薬;粘液溶解薬;マルチキナーゼ阻害薬;筋弛緩薬;散瞳薬;麻薬性鎮痛薬配合剤;麻薬性鎮痛薬;経鼻抗感染症薬;経鼻抗ヒスタミン及び充血除去薬;経鼻潤滑及び洗浄剤;経鼻用製剤;経鼻ステロイド;天然ペニシリン;ノイラミニダーゼ阻害薬;神経筋遮断薬;次世代セファロスポリン;ニコチン酸誘導体;硝酸塩;NNRTI;非心選択性β遮断薬;非ヨード造影剤;非イオン性ヨード造影剤;非スルホニル尿素;非ステロイド抗炎症薬;ノルエピネフィリン再取り込み阻害薬;ノルエピネフィリン−ドーパミン再取り込み阻害薬;ヌクレオシド逆転写酵素阻害薬(NRTI);栄養補助食品;栄養製品;眼科用麻酔薬;眼科用抗感染症薬;眼科用抗炎症薬;眼科用抗ヒスタミン薬及び充血除去薬;眼科用診断薬;眼科用緑内障薬;眼科用潤滑剤及び洗浄剤;眼科用製剤;眼科用ステロイド;抗感染症薬含有眼科用ステロイド;眼科手術用薬;経口栄養補助食;耳科用麻酔薬;耳科用抗感染症薬;耳科用製剤;耳科用ステロイド;抗感染症薬含有耳科用ステロイド;オキサゾリジンジオン系抗痙攣薬;上皮小体ホルモン及び類似体;ペニシリナーゼ耐性ペニシリン;ペニシリン;末梢性オピオイド受容体拮抗薬;末梢血管拡張薬;末梢作用型抗肥満薬;フェノチアジン制吐剤;フェノチアジン抗精神病薬;フェニルピペラジン抗うつ薬;血漿増量剤;血小板凝集阻害薬;血小板刺激剤;ポリエン;カリウム保持性利尿薬;プロバイオティクス;黄体ホルモン受容体調節薬;プロゲスチン;プロラクチン阻害薬;プロスタグランジンD2拮抗薬;タンパク分解酵素阻害薬;プロトンポンプ阻害薬;ソラレン;精神治療薬;精神治療薬配合剤;プリンヌクレオシド;ピロリジン抗痙攣薬;キノロン;造影剤;放射線補助剤;放射線剤;放射線結合化剤;放射性医薬品;RANKリガンド阻害薬;遺伝子組換えヒトエリスロポエチン;レニン阻害薬;呼吸薬;呼吸吸入製品;リファマイシン誘導体;サリチル酸塩;硬化剤;第2世代セファロスポリン;選択的エストロゲン受容体調節薬;選択的セロトニン再取り込み阻害薬;セロトニン−ノルエピネフィリン再取り込み阻害薬;セロトニン作動性神経腸調節薬;性ホルモン配合剤;性ホルモン;骨格筋弛緩薬配合剤;骨格筋弛緩薬;禁煙薬;ソマトスタチン及びソマトスタチン類似体;殺精子剤;スタチン;滅菌洗浄溶液;ストレプトマイセス誘導体;スクシンイミド抗痙攣薬;スルホンアミド;スルホニル尿素;合成排卵誘発剤;四環系抗うつ薬;テトラサイクリン;治療用放射性医薬品;チアジド利尿薬;チアゾリジンジオン;チオキサンテン;第3世代セファロスポリン;トロンビン阻害剤;血栓溶解薬;甲状腺剤;子宮収縮抑制薬;局所ニキビ剤;局所薬;局所麻酔薬;局所抗感染症薬;局所抗生剤;局所抗真菌薬;局所抗ヒスタミン薬;局所抗乾癬薬;局所抗ウイルス薬;局所収斂薬;局所排膿促進薬;局所脱色剤;局所皮膚軟化薬;局所角質溶解薬;局所ステロイド;抗感染症剤含有局所ステロイド;トキソイド;トリアジン抗痙攣薬;三環系抗うつ薬;三官能性モノクローナル抗体;腫瘍壊死因子(TNF)阻害薬;チロシンキナーゼ阻害薬;超音波造影剤;上気道用配合剤;尿素抗痙攣薬;尿路抗感染症薬;尿路鎮痙薬;尿pH調整剤;子宮収縮薬;ワクチン;混合ワクチン;腟抗感染薬;膣用製剤;血管拡張薬;バソプレッシン拮抗薬;昇圧剤;VEGF/VEGFR阻害薬;ウィルスワクチン;関節内補充薬;ビタミンミネラル混合物;ビタミン。
17−ヒドロキシプロゲステロン;ACE(アンジオテンシンI変換酵素);アセトアミノフェン;酸ホスファターゼ;ACTH;活性化凝固時間;活性化プロテインC耐性;副腎皮質刺激ホルモン(ACTH);アラニンアミノトランスフェラーゼ(ALT);アルブミン;アルドラーゼ;アルドステロン;アルカリフォスファターゼ;アルカリフォスファターゼ(ALP);α1−抗トリプシン;α−フェトプロテイン;α−フェトプロティエン(fetoprotien);アンモニアレベル;アミラーゼ;ANA(抗核アントボディ(antinuclear antbodies));ANA(抗核抗体);アンジオテンシン変換酵素(ACE);アニオンギャップ;抗カルジオリピン抗体;抗カルジオリピンアンティブボディ(antivbodies)(ACA);抗セントロメア抗体;抗利尿ホルモン;抗−DNA;抗デオキシリボヌクレアーゼB;抗グリアジン抗体;抗糸球体基底膜抗体;抗−HBc(B型肝炎コア抗体;抗−HBs(B型肝炎表面抗体;抗リン脂質抗体;抗−RNAポリメラーゼ;抗スミス(Sm)抗体;抗平滑筋抗体;抗ストレプトリジンO(ASO);抗トロンビンIII;抗Xa活性;抗Xaアッセイ;アポリポタンパク質;ヒ素;アスパラギン酸アミノトランスフェラーゼ(AST);B12;好塩基球;β2−ミクログロブリン;β−ヒドロキシブチレート;B−HCG;ビリルビン;直接ビリルビン;間接ビリルビン;総ビリルビン;出血時間;血液ガス(動脈性);血液尿素窒素(BUN);BUN;BUN(血液尿素窒素);CA125;CA15−3;CA19−9;カルシトニン;カルシウム;カルシウム(イオン化);一酸化炭素(CO);癌胎児性抗原(CEA);CBC;CEA;CEA(癌胎児性抗原);セルロプラスミン;CH50クロライド;コレステロール;コレステロール、HDL;血餅溶解時間;血餅収縮時間;CMP;CO2;寒冷凝集素;補体C3;銅;コルチコトロピン放出ホルモン(CRH)刺激試験;コルチゾル;コートロシン刺激試験;C−ペプチド;CPK(総);CPK−MB;C−反応性タンパク質;クレアチニン;クレアチニンキナーゼ(CK);クリオグロブリン;DAT(直接抗グロブリン試験);D−ダイマー;デキタメタゾン抑制試験;DHEA−S;希釈ラッセルクサリ蛇毒;楕円赤血球;好酸球;赤血球沈降速度(ESR);エストラジオール;エストリオール;エタノール;エチレングリコール;ユーグロブリン溶解;第V因子ライデン;第VIII因子阻害薬;第VIII因子レベル;フェリチン;フィブリン分解物;フィブリノーゲン;葉酸塩;葉酸塩(血清;ナトリウム分画排泄率(FENA));FSH(卵胞刺激因子);FTA−ABS;γグルタミルトランスフェラーゼ(GGT);ガストリン;GGTP(γグルタミルトランスフェラーゼ);グルコース;成長ホルモン;ハプトグロビン;HBeAg(B型肝炎e抗原);HBs−Ag(B型肝炎表面抗原);ヘリコバクターピロリ;ヘマトクリット;ヘマトクリット(HCT);ヘモグロビン;ヘモグロビンA1C;ヘモグロビン電気泳動;A型肝炎抗体;C型肝炎抗体;IAT(間接抗グロブリン試験);免疫固定法(IFE);鉄;乳酸脱水素酵素(LDH);乳酸(乳酸塩);LDH;LH(黄体形成ホルモン);リパーゼ;ループス抗凝固因子;リンパ球;マグネシウム;MCH(平均赤血球ヘモグロビン量);MCHC(平均赤血球ヘモグロビン濃度);MCV(平均赤血球容積);マロン酸メチル;単球;MPV(平均血小板容積);ミオグロビン;好中球;上皮小体ホルモン(PTH);リン;血小板(plt);カリウム;プレアルブミン;プロラクチン;前立腺特異抗原(PSA);タンパク質C;タンパク質S;PSA(前立腺特異抗原);PT(プロトロンビン時間);PTT(部分トロンボプラスチン時間);RDW(赤血球分布幅);レニン;レンニン;網状赤血球数;網状赤血球;リウマチ因子(RF);血沈速度;血清グルタミン酸ピルビン酸トランスアミナーゼ(SGPT);血清タンパク電気泳動(SPEP);ナトリウム;T3レジン摂取率(T3RU);フリーT4;トロンビン時間;甲状腺刺激ホルモン(TSH);チロキシン(T4);全鉄結合能(TIBC);総タンパク;トランスフェリン;トランスフェリン飽和度;トリグリセリド(TG);トロポニン;尿酸;ビタミンB12;白血球(WBC);ウィダール試験。
外面コーティングされたプラスチック容器は、次の方法によって製造できる:
・射出ブロー成形したCOP容器
・大気圧のコロナ型空気プラズマでの前処理
・真空蒸着、浸漬、フラッドコーティング、注型、噴射、噴霧、又は刷毛塗布による、好ましくは噴霧による、ORMOCERラッカーでのCOP容器のコーティング
・UV若しくはIR照射による、又は60〜150℃、特には130℃での加熱処理による、ラッカーの完全硬化。
以下は、耐擦り傷性かつ帯電防止性のコーティングを含む、外面コーティングされたプラスチック容器のための代表的な配合である。
接着−クロスカットテープ試験(DIN ISO 2409)
擦り傷:Scotch−Brite(登録商標)摩耗−Scotch−Brite(登録商標)摩耗試験は、標準的な摩耗研磨パッドでの接触研磨に対するコーティングの耐性を測定する。研磨パッドの上の垂直荷重は10ポンド(4.54kg)に設定し、研磨パッドは10,000回のストローク毎に交換する。プラスチックがむき出しになるまでコーティングを擦り落とすのに必要とされるサイクル数を決定してコーティング系の耐摩耗性を評価する。
帯電防止性:静電気センサーを使用した測定(KV/インチ)は、3M静電気センサー718の表面上に帯電した静電荷に関連する電圧を測定する。
(i)式RmSiX4-mのシラン(式中、
R=架橋可能な有機ラジカル、
X=加水分解可能かつ縮合可能な基、
m=1又は2又は3(1が好ましい))
と金属化合物とから合成される加水分解縮合物、
(ii)シランのラジカルRと架橋可能なプレポリマー、
(iii)1種以上の(特には1種又は2種)任意選択的な非架橋性の有機官能基を有するシラン、及び
(iv)任意選択的な低揮発性酸化物、
を含む、又はこれらから本質的になる、又はこれらからなる、ハイブリッド有機−無機ポリマーコーティング(例えば(ORMOCER(登録商標))を備えていてもよい。
(i)エポキシ基を有するシランとプレポリマーとしてのエポキシ樹脂及び/又は、
(ii)ビニルラジカルを有するシランと架橋可能な二重結合を有するプレポリマー及び/又は、
(iii)重合可能な二重結合を有するシランと架橋可能な二重結合を有するプレポリマー及び/又は、
(iv)メルカプト基含有シランと架橋可能な二重結合を有するプレポリマー及び/又は、
(v)イソシアネート基含有シランとプレポリマーとしてのポリオール及び/又は、
(vi)ヒドロキシル基含有シランとプレポリマーとしてのイソシアネート及び/又は、
(vii)アミノ基含有シランとプレポリマーとしてのエポキシ樹脂。
R’=非架橋性の有機ラジカル、
X=加水分解可能かつ縮合可能な基、
m=1又は2又は3)
の、任意選択的な非架橋性の有機官能基を有するシランが供され得る。
耐擦り傷性/帯電防止性層でのコーティング
複数のバイアルを、手袋をはめた手でチェーンコンベア上のバイアルスピンドル又はホルダーの上に載せた。バイアルを最初にイオン化した空気に曝露して粒子を除去した。その後2つのノズルからの大気圧の空気プラズマを使用して表面を更に洗浄及び活性化した。各ノズルがバイアル表面から1cmであるプラズマ区域の中で各バイアルを回転させた。バイアルが通過するに伴い、1つのノズルが上面を処理し、もう一方が側面を処理した。処理条件は次の通りである:プラズマ出力=20Hz、プラズマサイクル=100%(すなわち、1つの容器の処理全長のための、1つの連続的なプラズマインパルス)、プラズマ電圧=260V、及びプラズマアンペア=3.4A。
耐擦り傷性の効果の測定
この実施例の目的は、摩耗の深刻な原因によるバイアルの擦り傷に対しての保護のための、実施例3による耐擦り傷性かつ帯電防止性のコーティングの効果を示すことであった。4つのコーティングされた試験バイアル(A〜D)と、4つの未コーティングの対照バイアル(E〜H)を、擦り傷が付く前後の透過率について試験した。未コーティングのバイアルをUV/VIS分光光度計(紫外光と可視光の両方を含むスペクトルを有する分光光度計)(Perkin ElmerモデルLambda 45)の中に置いた。各バイアルの%光透過率(%T)を、1nmの間隔で400nm〜500nmの可視光波長の間で測定した。擦り傷が付く前の各バイアルA〜Hのスペクトル全体の平均透過率と標準偏差が表3に示されている。
帯電防止効果の測定
この実施例の目的は、コーティングされた容器上の絶対静電荷密度を低減するための、及びコーティングされた容器上の静電荷の放電率を増加させるための、実施例3による耐擦り傷性かつ帯電防止性のコーティングの効果を示すことであった。
帯電防止効果の測定
この実施例は、実施例3に記載の帯電防止性かつ耐擦り傷性のコーティングあり及びなしでの、長時間にわたる5mLのバイアルの平均静電負荷(kV)を示した。コーティングあり及びなしのバイアルを上述の通りに帯電させ、その後平均静電負荷を0〜5分の毎分測定し、その後10分間隔で10〜60分測定した。結果は図12に示されている。未コーティングのCOPバイアル(プロット78)はより高い初期平均静電負荷を有しており、これは約4分で約1.3kVまで低下し、その後比較的一定のままであり、60分後に1kVに保たれていた。コーティングされたCOPバイアル(プロット80)は、60分の試験を通して約0kVの平均静電負荷を有しており、そのため静電負荷は実質的に完全に又は完全に放電されていた。
実施例3の本発明のコーティングを設けることの実際の影響が図13〜図14に示されている。図13に示されている、実施例3の帯電防止性かつ耐擦り傷性のコーティングを有するCOPバイアルに、実施例2に記載の通りに静電荷を帯電させ、たばこの灰(大気中の粒子状汚染物質に相当)が入った蓋のされていないペトリ皿の近くに上部フランジによって保持した。灰はバイアルに引き付けられなかった。コーティングされていないことを除いては同じタイプのバイアルで試験を再び行うと、図14に示されているように、たばこの灰はバイアルの表面全体に引き付けられ、バイアルの表面全体に分布した。
実施例3の帯電防止性かつ耐擦り傷性の層でコーティングされたバイアルを、100℃で24時間MilliQ水の中で沸騰させた。沸騰プロセスの後、沸騰によって生じる剥離又は他の欠陥の何等かの兆候についてバイアルを目視で検査した。バイアルのコーティングされた表面上に、コーティングの剥離及び他の目立った欠陥は観察されなかった。しかしながら、バイアルのコーティングされていない内側は、沸騰後に明らかな粒子による汚染を有し、沸騰によって欠陥が生じたことが示された。
Claims (43)
- 容器(10、12、12a、12b、12c)であって、
内部空間(18)を覆う内表面(16)と、外表面(26a)とを有し、シクロオレフィンポリマー(COP)又はシクロオレフィンコポリマー(COC)から作られた壁(52)、及び
前記外表面上の帯電防止性かつ耐擦り傷性のコーティング(26)であって、擦り傷防止剤及び帯電防止剤を含有する無機−有機ハイブリッドポリマーコーティングであるコーティング(26)
を含み、
前記無機−有機ハイブリッドポリマーが、
(i)金属化合物と式R m SiX 4-m (式中、Rは架橋可能な有機ラジカルであり、Xは加水分解可能かつ縮合可能な基であり、mは1、2又は3である)のシランとから合成される加水分解縮合物;及び
(ii)前記加水分解縮合物の前記シランの前記ラジカルRと架橋するプレポリマー;
の反応生成物を含む、
シリンジ、カートリッジ、バイアル、血液チューブ、又はアンプルである
容器。 - 前記帯電防止性かつ耐擦り傷性のコーティングが、静電荷を実質的に放電するのに十分な導電性である、請求項1に記載の容器。
- 帯電させて60分間保持した後の静電負荷が0.5kV未満である、請求項1又は2に記載の容器。
- 前記壁(52)がCOP樹脂から本質的になる、請求項1〜3のいずれか1項に記載の容器。
- 前記無機−有機ハイブリッドポリマーが、さらに1種以上の非架橋性の有機官能基を有するシランを含む、請求項1〜4のいずれか1項に記載の容器。
- 前記帯電防止性かつ耐擦り傷性のコーティングが、低揮発性酸化物を更に含む、請求項1〜5のいずれか1項に記載の容器。
- Rがアルキル、アルケニル、アルキニル、アリール、アリールアルキル、アルキルアリール、アリールアルケニル、アルケニルアリール、アリールアルキニル、及びアルキニルアリールからなる群から選択される、請求項1〜6のいずれか1項に記載の容器。
- 各Rが独立に、無置換のラジカルであるか、ハロゲン、無置換アミノ、アミド、アルデヒド、ケト、アルキルカルボニル、カルボキシ、メルカプト、シアノ、イソシアノ、シアナト、イソシアナト、ヒドロキシ、アルコキシ、アルコキシカルボニル、スルホン酸、リン酸、アクリル、アクリルオキシ、メタクリル、メタクリルオキシ、グリシジル、グリシジルオキシ、エポキシ、及びビニル基からなる群から選択される1つ以上の置換基によって置換されているラジカルである、請求項1〜7のいずれか1項に記載の容器。
- mが2又は3であり、各Rが独立に、アルコキシ、アリールオキシ、アクリルオキシ、アルキルカルボニル、アルコキシカルボニル、ヒドロキシ、ハロゲン、水素、又は置換若しくは無置換のアミノ基である、請求項1〜8のいずれか1項に記載の容器。
- 前記プレポリマーが反応性基を有し、前記反応性基がアルキル、アルケニル、アルキニル、アリール、アリールアルキル、アルキルアリール、アリールアルケニル、アルケニルアリール、アリールアルキニル、及びアルキニルアリールである、請求項1〜9のいずれか1項に記載の容器。
- 前記プレポリマーが反応性基を有し、前記反応性基が、無置換のラジカルであるか、ハロゲン、無置換アミノ、アミド、アルデヒド、ケト、アルキルカルボニル、カルボキシ、メルカプト、シアノ、イソシアノ、シアナト、イソシアナト、ヒドロキシ、アルコキシ、アルコキシカルボニル、スルホン酸、リン酸、アクリル、アクリルオキシ、メタクリル、メタクリルオキシ、グリシジル、グリシジルオキシ、エポキシ、若しくはビニル基からなる群から選択される1つ以上の置換基によって置換されているラジカルである、請求項1〜10のいずれか1項に記載の容器。
- 前記プレポリマーが反応性基を有し、前記反応性基が前記加水分解縮合物の前記シランのRと同じである、請求項1〜11のいずれか1項に記載の容器。
- 前記無機−有機ハイブリッド耐擦り傷性ポリマーにおいて:
(i)前記シランがエポキシ基若しくはエポキシ基類を有し、前記プレポリマーがエポキシ樹脂である;又は、
(ii)前記シランがビニルラジカルを有し、前記プレポリマーが架橋可能な二重結合を有する;又は、
(iii)前記シランが重合可能な二重結合を有し、前記プレポリマーが架橋可能な二重結合を有する;又は、
(iv)前記シランがメルカプト基を有し、前記プレポリマーが架橋可能な二重結合を有する;又は、
(v)前記シランがイソシアネート基を有し、前記プレポリマーがポリオールである;又は、
(vi)前記シランがヒドロキシル基を有し、前記プレポリマーがイソシアネートである;又は、
(vii)前記シランがアミノ基を有し、前記プレポリマーがエポキシ樹脂である;請求項1〜12のいずれか1項に記載の容器。 - 前記加水分解縮合物がアクリル基を有するシランであり、前記プレポリマーがアクリレートである、請求項1〜13のいずれか1項に記載の容器。
- 前記非架橋性の有機官能基を有するシランが、式R’mSiX4-m(式中、R’は非架橋性の有機ラジカルであり、Xは加水分解可能かつ縮合可能な基であり、mは1、2又は3である)を有する、請求項5〜14のいずれか1項に記載の容器。
- R’がアルキル、シクロアルキル、アリール、アリールアルキル、及びアルキルアリールからなる群から選択される、請求項15に記載の容器。
- 各R’が独立に、無置換のラジカルであるか、ハロゲン原子、無置換アミド、アルデヒド、ケト、アルキルカルボニル、カルボキシ、シアノ、アルコキシ、アルコキシカルボニル基からなる群から選択される1つ以上の置換基によって置換されているラジカルである、請求項15又は16に記載の容器。
- mが1又は2であり、各Xが独立に、アルコキシ、アリールオキシ、アルキルカルボニル、アルコキシカルボニル、ヒドロキシ、ハロゲン、水素、又は置換若しくは無置換のアミノ基である、請求項15〜17のいずれか1項に記載の容器。
- 前記低揮発性酸化物が、
(i)Ia、IIa、IIIa、IVa、若しくはVaの主族;又は
(ii)IIb、IIIb、Vb、VIb、VIIb、若しくはVIIIbの亜族;
からの元素を含み、前記元素はアルミニウムではない、請求項6〜18のいずれか1項に記載の容器。 - 前記低揮発性酸化物が、酸化ホウ素(B2O3)、五酸化二リン(P2O5)、二酸化スズ(SnO2)、又はこれらの2つ以上の組み合わせである、請求項19に記載の容器。
- 1ml〜1000mlの容積を有する、請求項1〜20のいずれか1項に記載の容器。
- 2ml〜100mlの容積を有する、請求項21に記載の容器。
- 1ml〜20mlの容積を有する、請求項21に記載の容器。
- 前記帯電防止性かつ耐擦り傷性のコーティングが1μm〜100μmの厚さを有する、請求項1〜23のいずれか1項に記載の容器。
- 前記帯電防止性かつ耐擦り傷性のコーティングが2μm〜30μmの厚さを有する、請求項1〜24のいずれか1項に記載の容器。
- 前記帯電防止性かつ耐擦り傷性のコーティングが8μm〜20μmの厚さを有する、請求項1〜25のいずれか1項に記載の容器。
- 前記容器に医薬品が充填されて蓋がされている、請求項1〜26のいずれか1項に記載の容器。
- 前記Rに、O、S、N、又はNH基のうちの1つ以上が1箇所以上挟み込まれており、「挟み込まれる」は、前記ラジカルRが任意選択的にRa−Y−Rb−(式中、Ra−Rb−は前記シランの式のRの前記定義を満たし、Yはここでは−O−、−S−、−N<、及び/又は−NH−である連結基又は挟み込まれている基である)の構造を有することを意味する、請求項1〜27のいずれか1項に記載の容器。
- 前記Rに、O、S、N、又はNH基が1箇所以上挟み込まれている、請求項28に記載の容器。
- 前記Rが、末端のOH、SH、又はNH2基を有する、請求項1〜29のいずれか1項に記載の容器。
- Rが置換されている、請求項1〜30のいずれか1項に記載の容器。
- 前記反応性基に、O、S、N、又はNH基のうちの1つ以上が1箇所以上挟み込まれている、請求項10〜31のいずれか1項に記載の容器。
- 前記反応性基が、末端のOH、SH、又はNH2基を有する、請求項10〜32のいずれか1項に記載の容器。
- 前記R’に、O、S、N、又はNH基のうちの1つ以上が1箇所以上挟み込まれている、請求項15〜33のいずれか1項に記載の容器。
- 前記R’が、末端のOH、SH、又はNH2基を有する、請求項15〜34のいずれか1項に記載の容器。
- 前記帯電防止剤が、エトキシル化アルキルアミン、エトキシル化アルキルアミド、ステアリン酸グリセロール、脂肪酸エステル、ポリオールのエステル若しくはエーテル、アルキル硫酸ナトリウム、カチオン性ポリアクリレート、四級アンモニウム化合物、アルキルリン酸塩、及びこれらの2種以上の組み合わせからなる材料の群から選択される添加剤である、請求項1〜35のいずれか1項に記載の容器。
- 前記帯電防止剤が0.1〜3重量%で無機−有機ハイブリッドポリマーの中にブレンドされる添加剤である、請求項1〜36のいずれか1項に記載の容器。
- 真空蒸着、浸漬、ディップコーティング、フラッドコーティング、注型、噴射、噴霧、又は刷毛による塗布によってコーティングされる、請求項1〜37のいずれか1項に記載の容器。
- 前記帯電防止性かつ耐擦り傷性のコーティングが設けられる前に、最初に大気圧のコロナ空気型プラズマでの前処理が行われる、請求項1〜38のいずれか1項に記載の容器。
- 前記帯電防止性かつ耐擦り傷性のコーティングが、UV若しくはIRの照射又は60〜150℃での加熱処理によって硬化する、請求項1〜39のいずれか1項に記載の容器。
- 前記内表面が、プラズマ誘起化学蒸着(PECVD)タイコーティング若しくは層、バリアコーティング若しくは層、及びpH保護コーティング若しくは層、又は前記個々のコーティング若しくは層のうちの1つを含む、請求項1〜40のいずれか1項に記載の容器。
- 前記タイコーティング若しくは層がSiOxCyHz又はSiNxCyHzであり、ここで、X線光電子分光(XPS)によって測定されるxは0.5〜2.4であり、XPSによって測定されるyは0.6〜3であり、ラザフォード後方散乱分析(RBS)又は水素前方散乱分析(HFS)によって測定されるzは2〜9である、請求項41に記載の容器。
- 帯電させて60分間保持した後の静電負荷が0kVである、請求項3に記載の容器。
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US10780021B2 (en) | 2020-09-22 |
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