JP6811717B2 - トピロキソスタット及びその中間体の調製のための方法 - Google Patents

トピロキソスタット及びその中間体の調製のための方法 Download PDF

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Publication number
JP6811717B2
JP6811717B2 JP2017544629A JP2017544629A JP6811717B2 JP 6811717 B2 JP6811717 B2 JP 6811717B2 JP 2017544629 A JP2017544629 A JP 2017544629A JP 2017544629 A JP2017544629 A JP 2017544629A JP 6811717 B2 JP6811717 B2 JP 6811717B2
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formula
compound
topiroxostat
pharmaceutically acceptable
hydrogen
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JP2018507858A5 (pt
JP2018507858A (ja
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テオチャリス ヴィー． コフティス，
テオチャリス ヴィー． コフティス，
エフストラティオス ネオコスミディス，
エフストラティオス ネオコスミディス，
サノス アンドレウ，
サノス アンドレウ，
クリストス スタサキス，
クリストス スタサキス，
ペトロス エル． グキジス，
ペトロス エル． グキジス，
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ファーマシェン エス．エー．
ファーマシェン エス．エー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2017544629A 2015-02-25 2016-02-24 トピロキソスタット及びその中間体の調製のための方法 Active JP6811717B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2015000430 2015-02-25
EPPCT/EP2015/000430 2015-02-25
PCT/EP2016/000343 WO2016134854A1 (en) 2015-02-25 2016-02-24 Methods for the preparation of topiroxostat and intermediates thereof

Publications (3)

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JP2018507858A JP2018507858A (ja) 2018-03-22
JP2018507858A5 JP2018507858A5 (pt) 2019-04-04
JP6811717B2 true JP6811717B2 (ja) 2021-01-13

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JP2017544629A Active JP6811717B2 (ja) 2015-02-25 2016-02-24 トピロキソスタット及びその中間体の調製のための方法

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JP (1) JP6811717B2 (pt)
CN (1) CN107531677A (pt)
WO (1) WO2016134854A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108250183A (zh) * 2016-12-29 2018-07-06 北京诚济制药有限公司 一种高纯度的托匹司他的制备方法
CN113666909B (zh) * 2020-05-14 2024-07-02 鲁南制药集团股份有限公司 一种托匹司他的制备方法
CN115308347B (zh) * 2022-09-01 2023-09-08 江苏知原药业股份有限公司 一种托吡司特中氮氧化物杂质的分析方法
CN115572747B (zh) * 2022-09-23 2023-05-05 湖南一格制药有限公司 托匹司他的制备方法
CN115477638A (zh) * 2022-10-09 2022-12-16 浙江神洲药业有限公司 一种托匹司他的制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2293733C2 (ru) * 2002-01-28 2007-02-20 Фуджи Якухин Ко., Лтд. Новые 1,2,4-триазольные соединения, способы их получения и содержащие их лекарственные средства
WO2005009991A1 (ja) 2003-07-24 2005-02-03 Fujiyakuhin Co., Ltd. １，２，４−トリアゾール化合物の製造方法及びその中間体
US20060189811A1 (en) * 2004-07-23 2006-08-24 Fujiyakuhin Co., Ltd. Process for producing 1,2,4-triazole compound and intermediate therefor
IN2014DN10530A (pt) 2012-07-25 2015-08-21 Fujiyakuhin Co Ltd
NZ703638A (en) 2012-07-25 2017-02-24 Fujiyakuhin Co Ltd 4-[5-(pyridine-4-yl)-1h-1,2,4-triazole-3-yl]pyridine-2-carbonitrile crystalline polymorph and production method therefor
CN103724329B (zh) * 2013-12-23 2015-02-18 济南百诺医药科技开发有限公司 4-[5-(吡啶-4-基)-1h-[1,2,4]三唑-3-基]吡啶-2-甲腈的制备方法

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CN107531677A (zh) 2018-01-02
WO2016134854A1 (en) 2016-09-01
JP2018507858A (ja) 2018-03-22

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