JP6811717B2 - トピロキソスタット及びその中間体の調製のための方法 - Google Patents
トピロキソスタット及びその中間体の調製のための方法 Download PDFInfo
- Publication number
- JP6811717B2 JP6811717B2 JP2017544629A JP2017544629A JP6811717B2 JP 6811717 B2 JP6811717 B2 JP 6811717B2 JP 2017544629 A JP2017544629 A JP 2017544629A JP 2017544629 A JP2017544629 A JP 2017544629A JP 6811717 B2 JP6811717 B2 JP 6811717B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- topiroxostat
- pharmaceutically acceptable
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2015000430 | 2015-02-25 | ||
EPPCT/EP2015/000430 | 2015-02-25 | ||
PCT/EP2016/000343 WO2016134854A1 (en) | 2015-02-25 | 2016-02-24 | Methods for the preparation of topiroxostat and intermediates thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2018507858A JP2018507858A (ja) | 2018-03-22 |
JP2018507858A5 JP2018507858A5 (pt) | 2019-04-04 |
JP6811717B2 true JP6811717B2 (ja) | 2021-01-13 |
Family
ID=55484946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017544629A Active JP6811717B2 (ja) | 2015-02-25 | 2016-02-24 | トピロキソスタット及びその中間体の調製のための方法 |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP6811717B2 (pt) |
CN (1) | CN107531677A (pt) |
WO (1) | WO2016134854A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108250183A (zh) * | 2016-12-29 | 2018-07-06 | 北京诚济制药有限公司 | 一种高纯度的托匹司他的制备方法 |
CN113666909B (zh) * | 2020-05-14 | 2024-07-02 | 鲁南制药集团股份有限公司 | 一种托匹司他的制备方法 |
CN115308347B (zh) * | 2022-09-01 | 2023-09-08 | 江苏知原药业股份有限公司 | 一种托吡司特中氮氧化物杂质的分析方法 |
CN115572747B (zh) * | 2022-09-23 | 2023-05-05 | 湖南一格制药有限公司 | 托匹司他的制备方法 |
CN115477638A (zh) * | 2022-10-09 | 2022-12-16 | 浙江神洲药业有限公司 | 一种托匹司他的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2293733C2 (ru) * | 2002-01-28 | 2007-02-20 | Фуджи Якухин Ко., Лтд. | Новые 1,2,4-триазольные соединения, способы их получения и содержащие их лекарственные средства |
WO2005009991A1 (ja) | 2003-07-24 | 2005-02-03 | Fujiyakuhin Co., Ltd. | 1,2,4−トリアゾール化合物の製造方法及びその中間体 |
US20060189811A1 (en) * | 2004-07-23 | 2006-08-24 | Fujiyakuhin Co., Ltd. | Process for producing 1,2,4-triazole compound and intermediate therefor |
IN2014DN10530A (pt) | 2012-07-25 | 2015-08-21 | Fujiyakuhin Co Ltd | |
NZ703638A (en) | 2012-07-25 | 2017-02-24 | Fujiyakuhin Co Ltd | 4-[5-(pyridine-4-yl)-1h-1,2,4-triazole-3-yl]pyridine-2-carbonitrile crystalline polymorph and production method therefor |
CN103724329B (zh) * | 2013-12-23 | 2015-02-18 | 济南百诺医药科技开发有限公司 | 4-[5-(吡啶-4-基)-1h-[1,2,4]三唑-3-基]吡啶-2-甲腈的制备方法 |
-
2016
- 2016-02-24 JP JP2017544629A patent/JP6811717B2/ja active Active
- 2016-02-24 CN CN201680023004.9A patent/CN107531677A/zh active Pending
- 2016-02-24 WO PCT/EP2016/000343 patent/WO2016134854A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN107531677A (zh) | 2018-01-02 |
WO2016134854A1 (en) | 2016-09-01 |
JP2018507858A (ja) | 2018-03-22 |
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