JP6810028B2 - 組換え片利共生皮膚微生物による皮膚疾患の治療処置 - Google Patents

組換え片利共生皮膚微生物による皮膚疾患の治療処置 Download PDF

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JP6810028B2
JP6810028B2 JP2017515014A JP2017515014A JP6810028B2 JP 6810028 B2 JP6810028 B2 JP 6810028B2 JP 2017515014 A JP2017515014 A JP 2017515014A JP 2017515014 A JP2017515014 A JP 2017515014A JP 6810028 B2 JP6810028 B2 JP 6810028B2
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pharmaceutical composition
skin
composition according
filaggrin
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モミン ミューニバー アジム
モミン ミューニバー アジム
マイケル ウィットフィル トラビス
マイケル ウィットフィル トラビス
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アジトラ，インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
JP2017515014A 2014-05-30 2015-05-28 組換え片利共生皮膚微生物による皮膚疾患の治療処置 Active JP6810028B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462005652P 2014-05-30 2014-05-30
US201462005558P 2014-05-30 2014-05-30
US62/005,652 2014-05-30
US62/005,558 2014-05-30
PCT/US2015/032972 WO2015184134A1 (en) 2014-05-30 2015-05-28 Therapeutic tratment of skin disease with recombinant commensal skin microorganisms

Related Child Applications (1)

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JP2020205127A Division JP2021038271A (ja) 2014-05-30 2020-12-10 組換え片利共生皮膚微生物による皮膚疾患の治療処置

Publications (3)

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JP2017518370A JP2017518370A (ja) 2017-07-06
JP2017518370A5 JP2017518370A5 (https=) 2018-07-12
JP6810028B2 true JP6810028B2 (ja) 2021-01-06

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JP2017515014A Active JP6810028B2 (ja) 2014-05-30 2015-05-28 組換え片利共生皮膚微生物による皮膚疾患の治療処置
JP2020205127A Pending JP2021038271A (ja) 2014-05-30 2020-12-10 組換え片利共生皮膚微生物による皮膚疾患の治療処置

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US (3) US10702558B2 (https=)
EP (2) EP4144756A1 (https=)
JP (2) JP6810028B2 (https=)
ES (1) ES2929579T3 (https=)
MA (1) MA40057A (https=)
WO (1) WO2015184134A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4144756A1 (en) 2014-05-30 2023-03-08 Azitra, Inc. Therapeutic treatment of skin disease with recombinant commensal skin microorganisms
US9889165B2 (en) 2016-04-21 2018-02-13 Naked Biome, Inc. Compositions and methods for treatment of skin disorders
WO2018232300A1 (en) * 2017-06-16 2018-12-20 Azitra Inc Compositions and methods for treatment of netherton syndrome with lekti expressing recombinant microbes
MX2020002013A (es) * 2017-08-31 2020-07-13 Univ California Bacterioterapia molecular para control de la actividad enzimatica de la piel.
KR102834865B1 (ko) * 2017-09-05 2025-07-17 아지트라 인코포레이티드 재조합 미생물을 사용하여 염증성 피부 질환을 치료하기 위한 방법 및 조성물
AU2018379996A1 (en) 2017-12-05 2020-06-25 BioPlx, Inc. Methods and compositions to prevent microbial infection
JP7121969B2 (ja) * 2018-02-23 2022-08-19 株式会社北里コーポレーション 培養液保護用液状物
CN112236153B (zh) * 2018-04-05 2025-04-29 阿兹特拉公司 用重组微生物治疗皮肤疾病的方法和组合物
AU2019203692B2 (en) * 2018-08-30 2024-12-12 Kenvue Brands Llc Topical composition containing glycerin and yeast extract
CA3266235A1 (en) * 2018-09-26 2025-11-29 Krystal Biotech, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF SKIN DISEASES
US20210355192A1 (en) * 2018-10-08 2021-11-18 Yale University Selective Binding and Aggregation of Human Keratin in the Skin Barrier Using Human Filaggrin Subdomains SD67 and SD150
AU2019378003A1 (en) * 2018-11-16 2021-05-20 Azitra Inc Auxotrophic strains of Staphylococcus bacterium
CZ308231B6 (cs) * 2019-02-11 2020-03-11 BiomCare s.r.o. Kombinované několikastupňové mikrobiální přípravky a způsob jejich aplikace
EP3946412A4 (en) * 2019-04-05 2023-01-04 Azitra, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF ATOPIC DERMATITIS WITH RECOMBINANT MICROORGANISMS
CA3143498A1 (en) * 2019-06-19 2020-12-24 Chan Zuckerberg Biohub, Inc. Bacteria-engineered to elicit antigen-specific t-cells
KR20220133262A (ko) * 2020-01-29 2022-10-04 더 잭슨 래보라토리 박테리아 혼합물
WO2022087065A1 (en) * 2020-10-21 2022-04-28 The Jackson Laboratory Antimicrobial biosensors
JP2024506463A (ja) * 2021-01-05 2024-02-14 ラクトバイオ アー／エス 菌株、組成物および使用方法
CA3228922A1 (en) * 2021-10-11 2023-04-20 Ajinomoto Co., Inc. Bacterium modified to express heterologous tat protein

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0637384B2 (ja) * 1985-09-21 1994-05-18 株式会社資生堂 皮膚化粧料
US4659774A (en) 1985-11-01 1987-04-21 American Hoechst Corporation Support for solid-phase oligonucleotide synthesis
DE4221268C2 (de) 1992-06-26 1997-06-12 Lancaster Group Ag Verwendung eines Dermatikums zur Unterstützung des Sauerstofftransportes in der Haut
DE4221255C2 (de) 1992-06-26 1994-09-15 Lancaster Group Ag Phospholipide enthaltendes Kosmetikum
US20120295952A1 (en) * 2009-09-25 2012-11-22 Curna, Inc. Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity
ES2645416T3 (es) 2009-11-23 2017-12-05 Research Development Foundation Polipéptidos de filagrina recombinantes para la importación a células
WO2011150127A2 (en) 2010-05-25 2011-12-01 The Board Of Trustees Of The University Of Illinois Novel systems, vectors, and methods for delivery of biomolecules to eukaryotic cells
MX2015001751A (es) * 2012-08-07 2015-11-13 Topgenix Inc Composicion topica comprendiendo bacterias transformadas que expresan un compuesto de interes.
KR101491240B1 (ko) 2013-03-15 2015-02-11 현대자동차주식회사 인비저블 슬라이딩 도어 링크 구조
EP4144756A1 (en) 2014-05-30 2023-03-08 Azitra, Inc. Therapeutic treatment of skin disease with recombinant commensal skin microorganisms

Also Published As

Publication number Publication date
WO2015184134A1 (en) 2015-12-03
EP3148569A1 (en) 2017-04-05
US20180161380A1 (en) 2018-06-14
US10702558B2 (en) 2020-07-07
EP3148569A4 (en) 2017-11-22
CA2979079A1 (en) 2015-12-03
ES2929579T3 (es) 2022-11-30
JP2017518370A (ja) 2017-07-06
US12036248B2 (en) 2024-07-16
EP3148569B1 (en) 2022-07-06
US20250009810A1 (en) 2025-01-09
US20210379120A1 (en) 2021-12-09
MA40057A (fr) 2015-12-03
JP2021038271A (ja) 2021-03-11
EP4144756A1 (en) 2023-03-08

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