JP6796059B2 - Ｗｎｔシグナリングアゴニスト分子 - Google Patents

Ｗｎｔシグナリングアゴニスト分子 Download PDF

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JP6796059B2
JP6796059B2 JP2017510495A JP2017510495A JP6796059B2 JP 6796059 B2 JP6796059 B2 JP 6796059B2 JP 2017510495 A JP2017510495 A JP 2017510495A JP 2017510495 A JP2017510495 A JP 2017510495A JP 6796059 B2 JP6796059 B2 JP 6796059B2
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binding domain
wnt
wnt signaling
fzd
cells
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JP2017530099A (ja
JP2017530099A5 (https=
Inventor
クリストファー ガルシア，ケナン
クリストファー ガルシア，ケナン
デイビッド ベイカー，
デイビッド ベイカー，
クラウディア イヴォンヌ ジャンダ，
クラウディア イヴォンヌ ジャンダ，
ルーク ダン，
ルーク ダン，
ジェイムズ ダニエル ムーディー，
ジェイムズ ダニエル ムーディー，
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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JP2017510495A 2014-09-12 2015-09-11 Ｗｎｔシグナリングアゴニスト分子 Active JP6796059B2 (ja)

Applications Claiming Priority (5)

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US201462049949P 2014-09-12 2014-09-12
US62/049,949 2014-09-12
US201562206150P 2015-08-17 2015-08-17
US62/206,150 2015-08-17
PCT/US2015/049829 WO2016040895A1 (en) 2014-09-12 2015-09-11 Wnt signaling agonist molecules

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JP2017530099A JP2017530099A (ja) 2017-10-12
JP2017530099A5 JP2017530099A5 (https=) 2018-09-13
JP6796059B2 true JP6796059B2 (ja) 2020-12-02

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JP2020138446A Withdrawn JP2020186267A (ja) 2014-09-12 2020-08-19 Ｗｎｔシグナリングアゴニスト分子
JP2023080152A Pending JP2023091081A (ja) 2014-09-12 2023-05-15 Ｗｎｔシグナリングアゴニスト分子

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JP2023080152A Pending JP2023091081A (ja) 2014-09-12 2023-05-15 Ｗｎｔシグナリングアゴニスト分子

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US (4) US11142577B2 (https=)
EP (2) EP3191526B1 (https=)
JP (3) JP6796059B2 (https=)
AU (2) AU2015314771B2 (https=)
WO (1) WO2016040895A1 (https=)

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JP7377288B2 (ja) * 2019-06-11 2023-11-09 アントレラ セラピューティクス インコーポレイテッド 多価ｆｚｄおよびｗｎｔ結合分子とその使用
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JP2023549854A (ja) 2020-11-16 2023-11-29 スロゼン オペレーティング， インコーポレイテッド 肝臓特異的Ｗｎｔシグナル増強分子およびその使用
WO2022164786A1 (en) * 2021-01-26 2022-08-04 The Trustees Of Indiana University Pharmaceutical compositions and their methods of use
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