AU2015314771B2 - Wnt signaling agonist molecules - Google Patents

Wnt signaling agonist molecules Download PDF

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Publication number
AU2015314771B2
AU2015314771B2 AU2015314771A AU2015314771A AU2015314771B2 AU 2015314771 B2 AU2015314771 B2 AU 2015314771B2 AU 2015314771 A AU2015314771 A AU 2015314771A AU 2015314771 A AU2015314771 A AU 2015314771A AU 2015314771 B2 AU2015314771 B2 AU 2015314771B2
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Prior art keywords
wnt
cells
wnt signaling
agonist
binding domain
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AU2015314771A1 (en
Inventor
David Baker
Luke DANG
Kenan Christopher GARCIA
Claudia Yvonne JANDA
James Daniel MOODY
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University of Washington
Leland Stanford Junior University
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University of Washington
Leland Stanford Junior University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
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    • C07K2318/00—Antibody mimetics or scaffolds
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    • C07K2319/00—Fusion polypeptide

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AU2015314771A 2014-09-12 2015-09-11 Wnt signaling agonist molecules Active AU2015314771B2 (en)

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AU2021203059A AU2021203059A1 (en) 2014-09-12 2021-05-13 Wnt signaling agonist molecules

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US201462049949P 2014-09-12 2014-09-12
US62/049,949 2014-09-12
US201562206150P 2015-08-17 2015-08-17
US62/206,150 2015-08-17
PCT/US2015/049829 WO2016040895A1 (en) 2014-09-12 2015-09-11 Wnt signaling agonist molecules

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AU2015314771A1 AU2015314771A1 (en) 2017-03-09
AU2015314771B2 true AU2015314771B2 (en) 2021-04-01

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US (4) US11142577B2 (https=)
EP (2) EP3191526B1 (https=)
JP (3) JP6796059B2 (https=)
AU (2) AU2015314771B2 (https=)
WO (1) WO2016040895A1 (https=)

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US11142577B2 (en) 2014-09-12 2021-10-12 The Board Of Trustees Of The Leland Stanford Junior University WNT signaling agonist molecules
US20170349659A1 (en) * 2016-06-03 2017-12-07 The Board Of Trustees Of The Leland Stanford Junior University Wnt signaling agonist molecules
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US20220064337A1 (en) * 2018-12-19 2022-03-03 Surrozen, Inc. Antigen binding formats for receptor complexes
JP7663501B2 (ja) * 2019-02-11 2025-04-16 スロゼン オペレーティング， インコーポレイテッド 眼障害におけるｗｎｔシグナル伝達の調節
US20220195053A1 (en) * 2019-03-11 2022-06-23 Surrozen Operating Inc. Modulation of wnt signaling in gastrointestinal disorders
CN120025448A (zh) * 2019-06-11 2025-05-23 安托拉诊疗公司 多价fzd和wnt结合分子及其用途
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TW202233656A (zh) 2020-11-16 2022-09-01 美商蘇羅森營運公司 肝特異性wnt訊號增強分子及其用途
US20240165165A1 (en) * 2021-01-26 2024-05-23 The Trustees Of Indiana University Pharmaceutical compositions and their methods of use
JP2024509266A (ja) * 2021-03-10 2024-02-29 スロゼン オペレーティング， インコーポレイテッド 胃腸障害におけるｗｎｔシグナル伝達のモジュレーション
EP4448009A4 (en) * 2021-12-17 2025-12-10 Surrozen Operating Inc WNT SUBSTITUTION AGENTS AND LACRYMAL GLAND REGENERATION METHODS
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