JP6793196B2 - アイソバリック質量標識 - Google Patents

アイソバリック質量標識 Download PDF

Info

Publication number
JP6793196B2
JP6793196B2 JP2018529642A JP2018529642A JP6793196B2 JP 6793196 B2 JP6793196 B2 JP 6793196B2 JP 2018529642 A JP2018529642 A JP 2018529642A JP 2018529642 A JP2018529642 A JP 2018529642A JP 6793196 B2 JP6793196 B2 JP 6793196B2
Authority
JP
Japan
Prior art keywords
mass
labels
label
analyte
reporter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018529642A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019505764A (ja
JP2019505764A5 (enExample
Inventor
フギン トンプソン アンドリュー，
フギン トンプソン アンドリュー，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proteome Sciences PLC
Original Assignee
Electrophoretics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Electrophoretics Ltd filed Critical Electrophoretics Ltd
Publication of JP2019505764A publication Critical patent/JP2019505764A/ja
Publication of JP2019505764A5 publication Critical patent/JP2019505764A5/ja
Application granted granted Critical
Publication of JP6793196B2 publication Critical patent/JP6793196B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2018529642A 2015-12-11 2016-12-09 アイソバリック質量標識 Active JP6793196B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1521903.3A GB201521903D0 (en) 2015-12-11 2015-12-11 Isorbaric mass labels
GB1521903.3 2015-12-11
PCT/EP2016/080534 WO2017098029A1 (en) 2015-12-11 2016-12-09 Isobaric mass labels

Publications (3)

Publication Number Publication Date
JP2019505764A JP2019505764A (ja) 2019-02-28
JP2019505764A5 JP2019505764A5 (enExample) 2019-12-26
JP6793196B2 true JP6793196B2 (ja) 2020-12-02

Family

ID=55274607

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018529642A Active JP6793196B2 (ja) 2015-12-11 2016-12-09 アイソバリック質量標識

Country Status (7)

Country Link
US (1) US11453621B2 (enExample)
EP (1) EP3387445B1 (enExample)
JP (1) JP6793196B2 (enExample)
CN (1) CN108463728B (enExample)
CA (1) CA3007430C (enExample)
GB (1) GB201521903D0 (enExample)
WO (1) WO2017098029A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3425405B1 (en) 2017-07-06 2021-03-10 Thermo Finnigan LLC Methods of mass spectrometry quantitation using cleavable isobaric tags and neutral loss fragmentation
JP7518765B2 (ja) 2017-11-22 2024-07-18 コンサート ファーマシューティカルズ インコーポレイテッド Ｄ－セリンの重水素化類似体およびその使用
CN110297056A (zh) * 2019-06-29 2019-10-01 南京谱利健生物技术有限公司 一种同量异位标签试剂的制备及应用
CA3162302A1 (en) * 2019-12-19 2021-06-24 Lyne Gagnon Cycloalkyl-containing carboxylic acids and uses thereof

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
GB0006141D0 (en) 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
CN1313328A (zh) 2000-03-15 2001-09-19 上海博德基因开发有限公司 一种新的多肽——人原钙粘素14和编码这种多肽的多核苷酸
US7354923B2 (en) 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
EP1425029A4 (en) 2001-08-10 2006-06-07 Palatin Technologies Inc PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
MXPA04009784A (es) 2002-04-08 2004-12-13 Torrent Pharmaceuticlas Ltd Tiazolidin-4-carbonitrilos y analogos y su uso como inhibidores de dipeptidil-peptidas.
US20040106802A1 (en) 2002-04-08 2004-06-03 Torrent Pharmaceuticals Ltd. Novel compounds and therapeutic uses thereof
US20040219685A1 (en) * 2003-01-30 2004-11-04 Applera Corporation Methods and mixtures pertaining to analyte determination using electrophilic labeling reagents
GB0306756D0 (en) * 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
DE602004009824T2 (de) * 2003-11-26 2008-03-06 Applera Corp., Framingham Analyse von massenspektraldaten in den ruhigen gebieten
US20050148771A1 (en) * 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US20050148087A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
GB0414233D0 (en) * 2004-06-25 2004-07-28 Bioinvent Int Ab Analysis method
GB0515323D0 (en) * 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
GB0525957D0 (en) * 2005-12-21 2006-02-01 Astrazeneca Ab Methods
US8975404B2 (en) * 2006-01-24 2015-03-10 Dh Technologies Development Pte. Ltd. Labeling reagents for analyte determination and methods and compounds used in making the same
AU2007266530B2 (en) * 2006-05-26 2013-05-02 Dh Technologies Development Pte. Ltd. Tagging reagents and methods for hydroxylated compounds
US8362242B2 (en) * 2006-06-30 2013-01-29 Dh Technologies Development Pte. Ltd. Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label
US7906341B2 (en) * 2006-06-30 2011-03-15 Dh Technologies Development Pte, Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
EP1918714A1 (en) * 2006-11-02 2008-05-07 Koninklijke Philips Electronics N.V. Compounds and methods for double labelling of polypeptides to allow multiplexing in mass spectrometric analysis
GB0811298D0 (en) * 2008-06-19 2008-07-30 Trillion Genomics Ltd Characterising polypeptides
GB0811574D0 (en) * 2008-06-24 2008-07-30 Trillion Genomics Ltd Characterising planar samples by mass spectrometry
EP2373977A1 (en) * 2008-12-17 2011-10-12 The Lubrizol Corporation Optically active functional fluid markers
US8486712B2 (en) * 2009-03-10 2013-07-16 University Of Maryland, College Park Deuterium isobaric tag reagents for quantitative analysis
CA2762277C (en) * 2009-05-31 2018-08-14 Dh Technologies Development Pte. Ltd. Specific analysis of ketone and aldehyde analytes using reagent compounds, labeling strategies, and mass spectrometry workflow
GB0916881D0 (en) * 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
US8492163B2 (en) * 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US9388132B2 (en) * 2011-09-15 2016-07-12 Wisconsin Alumni Research Foundation Isobaric tandem mass tags for quantitative proteomics and peptidomics
WO2013138210A1 (en) 2012-03-14 2013-09-19 Ning Xi Substituted cyclic compounds and methods of use
WO2013170067A1 (en) * 2012-05-10 2013-11-14 Thermo Finnigan Llc Method for highly multiplexed quantitation of peptides by mass spectrometry and labeling reagent sets therefor
US9835629B2 (en) 2012-05-18 2017-12-05 Pierce Biotechnology, Inc. Methods and reagents for biomolecule labeling, enrichment and gentle elution
GB201308765D0 (en) * 2013-05-15 2013-06-26 Electrophoretics Ltd Mass Tag Reagents
GB201322567D0 (en) * 2013-12-19 2014-02-05 Electrophoretics Ltd Mass labels
GB201410523D0 (en) * 2014-06-12 2014-07-30 Electrophoretics Ltd Mass labels

Also Published As

Publication number Publication date
US20180362416A1 (en) 2018-12-20
CN108463728B (zh) 2023-03-24
WO2017098029A1 (en) 2017-06-15
EP3387445A1 (en) 2018-10-17
CA3007430A1 (en) 2017-06-15
CA3007430C (en) 2023-10-17
GB201521903D0 (en) 2016-01-27
EP3387445B1 (en) 2023-02-08
JP2019505764A (ja) 2019-02-28
CN108463728A (zh) 2018-08-28
US11453621B2 (en) 2022-09-27

Similar Documents

Publication Publication Date Title
JP6374931B2 (ja) 質量標識体
JP6793196B2 (ja) アイソバリック質量標識
JP2016525677A (ja) 質量標識体
JP5054694B2 (ja) 質量標識体
US10527629B2 (en) Isobaric mass labels
JP2022023059A (ja) アイソバリック質量標識
WO2022108507A1 (en) Chemoselective probes and uses thereof
Pektas Application of Mass Spectrometry in Proteomics
Ma Mass spectrometry dissociation studies of protein-protein and protein-nucleic acid complexes and 13C flux of amino acids

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191115

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20191115

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200923

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201013

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201109

R150 Certificate of patent or registration of utility model

Ref document number: 6793196

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250