JP2019505764A5 - - Google Patents
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- JP2019505764A5 JP2019505764A5 JP2018529642A JP2018529642A JP2019505764A5 JP 2019505764 A5 JP2019505764 A5 JP 2019505764A5 JP 2018529642 A JP2018529642 A JP 2018529642A JP 2018529642 A JP2018529642 A JP 2018529642A JP 2019505764 A5 JP2019505764 A5 JP 2019505764A5
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- 239000012491 analyte Substances 0.000 description 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 22
- 239000012634 fragment Substances 0.000 description 13
- 238000000034 method Methods 0.000 description 12
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 11
- 229910052757 nitrogen Inorganic materials 0.000 description 11
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 10
- 238000004949 mass spectrometry Methods 0.000 description 10
- QVGXLLKOCUKJST-NJFSPNSNSA-N oxygen-18 atom Chemical compound [18O] QVGXLLKOCUKJST-NJFSPNSNSA-N 0.000 description 9
- 238000001819 mass spectrum Methods 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- 239000003607 modifier Substances 0.000 description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 125000000623 heterocyclic group Chemical group 0.000 description 3
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
- 0 CC*C1N(C)CC(C)N(C)C1C Chemical compound CC*C1N(C)CC(C)N(C)C1C 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
- DYMYLBQTHCJHOQ-UHFFFAOYSA-N CCCC(ON(C(CC1)=O)C1=O)=O Chemical compound CCCC(ON(C(CC1)=O)C1=O)=O DYMYLBQTHCJHOQ-UHFFFAOYSA-N 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 238000001360 collision-induced dissociation Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1521903.3 | 2015-12-11 | ||
| GBGB1521903.3A GB201521903D0 (en) | 2015-12-11 | 2015-12-11 | Isorbaric mass labels |
| PCT/EP2016/080534 WO2017098029A1 (en) | 2015-12-11 | 2016-12-09 | Isobaric mass labels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019505764A JP2019505764A (ja) | 2019-02-28 |
| JP2019505764A5 true JP2019505764A5 (enExample) | 2019-12-26 |
| JP6793196B2 JP6793196B2 (ja) | 2020-12-02 |
Family
ID=55274607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018529642A Active JP6793196B2 (ja) | 2015-12-11 | 2016-12-09 | アイソバリック質量標識 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11453621B2 (enExample) |
| EP (1) | EP3387445B1 (enExample) |
| JP (1) | JP6793196B2 (enExample) |
| CN (1) | CN108463728B (enExample) |
| CA (1) | CA3007430C (enExample) |
| GB (1) | GB201521903D0 (enExample) |
| WO (1) | WO2017098029A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3859340B1 (en) | 2017-07-06 | 2025-04-09 | Thermo Finnigan LLC | Methods of mass spectrometry quantitation using cleavable isobaric tags and neutral loss fragmentation |
| JP7518765B2 (ja) | 2017-11-22 | 2024-07-18 | コンサート ファーマシューティカルズ インコーポレイテッド | Ｄ－セリンの重水素化類似体およびその使用 |
| CN110297056A (zh) * | 2019-06-29 | 2019-10-01 | 南京谱利健生物技术有限公司 | 一种同量异位标签试剂的制备及应用 |
| WO2021124272A1 (en) * | 2019-12-19 | 2021-06-24 | Liminal Biosciences Limited | Cycloalkyl-containing carboxylic acids and uses thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1248531A (en) * | 1984-04-17 | 1989-01-10 | Jeffrey C. Watkins | 4-substituted piperazine-2-carboxylic acids |
| GB0006141D0 (en) | 2000-03-14 | 2000-05-03 | Brax Group Ltd | Mass labels |
| CN1313328A (zh) | 2000-03-15 | 2001-09-19 | 上海博德基因开发有限公司 | 一种新的多肽——人原钙粘素14和编码这种多肽的多核苷酸 |
| WO2003013571A1 (en) | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| MXPA04009784A (es) | 2002-04-08 | 2004-12-13 | Torrent Pharmaceuticlas Ltd | Tiazolidin-4-carbonitrilos y analogos y su uso como inhibidores de dipeptidil-peptidas. |
| US20040106802A1 (en) | 2002-04-08 | 2004-06-03 | Torrent Pharmaceuticals Ltd. | Novel compounds and therapeutic uses thereof |
| JP4613299B2 (ja) * | 2003-01-30 | 2011-01-12 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 分析物分析に関する方法、混合物、キット、および組成物 |
| GB0306756D0 (en) * | 2003-03-24 | 2003-04-30 | Xzillion Gmbh & Co Kg | Mass labels |
| DE602004009824T2 (de) * | 2003-11-26 | 2008-03-06 | Applera Corp., Framingham | Analyse von massenspektraldaten in den ruhigen gebieten |
| US7307169B2 (en) * | 2004-01-05 | 2007-12-11 | Applera Corporation | Isotopically enriched N-substituted piperazines and methods for the preparation thereof |
| US20050148087A1 (en) * | 2004-01-05 | 2005-07-07 | Applera Corporation | Isobarically labeled analytes and fragment ions derived therefrom |
| GB0414233D0 (en) * | 2004-06-25 | 2004-07-28 | Bioinvent Int Ab | Analysis method |
| GB0515323D0 (en) * | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
| GB0525957D0 (en) * | 2005-12-21 | 2006-02-01 | Astrazeneca Ab | Methods |
| US8975404B2 (en) * | 2006-01-24 | 2015-03-10 | Dh Technologies Development Pte. Ltd. | Labeling reagents for analyte determination and methods and compounds used in making the same |
| CA2667854C (en) * | 2006-05-26 | 2015-04-07 | Applied Biosystems, Llc | Tagging reagents and methods for hydroxylated compounds |
| US8362242B2 (en) * | 2006-06-30 | 2013-01-29 | Dh Technologies Development Pte. Ltd. | Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label |
| US7906341B2 (en) * | 2006-06-30 | 2011-03-15 | Dh Technologies Development Pte, Ltd. | Methods, mixtures, kits and compositions pertaining to analyte determination |
| EP1918714A1 (en) * | 2006-11-02 | 2008-05-07 | Koninklijke Philips Electronics N.V. | Compounds and methods for double labelling of polypeptides to allow multiplexing in mass spectrometric analysis |
| GB0811298D0 (en) * | 2008-06-19 | 2008-07-30 | Trillion Genomics Ltd | Characterising polypeptides |
| GB0811574D0 (en) * | 2008-06-24 | 2008-07-30 | Trillion Genomics Ltd | Characterising planar samples by mass spectrometry |
| EP2373977A1 (en) * | 2008-12-17 | 2011-10-12 | The Lubrizol Corporation | Optically active functional fluid markers |
| US8486712B2 (en) * | 2009-03-10 | 2013-07-16 | University Of Maryland, College Park | Deuterium isobaric tag reagents for quantitative analysis |
| US20110003395A1 (en) * | 2009-05-31 | 2011-01-06 | Dh Technologies Development Pte. Ltd. | Specific analysis of analytes using reagent compounds, labeling strategies, and mass spectrometry workflow |
| GB0916881D0 (en) | 2009-09-25 | 2009-11-11 | Electrophoretics Ltd | Mass labels |
| US8492163B2 (en) * | 2011-01-31 | 2013-07-23 | Dh Technologies Development Pte. Ltd. | Methods, mixtures, kits and compositions pertaining to analyte determination |
| US9388132B2 (en) * | 2011-09-15 | 2016-07-12 | Wisconsin Alumni Research Foundation | Isobaric tandem mass tags for quantitative proteomics and peptidomics |
| WO2013138210A1 (en) | 2012-03-14 | 2013-09-19 | Ning Xi | Substituted cyclic compounds and methods of use |
| EP2847594B1 (en) * | 2012-05-10 | 2016-06-22 | Thermo Finnigan LLC | Method for highly multiplexed quantitation of peptides by mass spectrometry and labeling reagent sets therefor |
| US9835629B2 (en) * | 2012-05-18 | 2017-12-05 | Pierce Biotechnology, Inc. | Methods and reagents for biomolecule labeling, enrichment and gentle elution |
| GB201308765D0 (en) * | 2013-05-15 | 2013-06-26 | Electrophoretics Ltd | Mass Tag Reagents |
| GB201322567D0 (en) * | 2013-12-19 | 2014-02-05 | Electrophoretics Ltd | Mass labels |
| GB201410523D0 (en) * | 2014-06-12 | 2014-07-30 | Electrophoretics Ltd | Mass labels |
-
2015
- 2015-12-11 GB GBGB1521903.3A patent/GB201521903D0/en not_active Ceased
-
2016
- 2016-12-09 WO PCT/EP2016/080534 patent/WO2017098029A1/en not_active Ceased
- 2016-12-09 EP EP16816622.1A patent/EP3387445B1/en active Active
- 2016-12-09 CN CN201680078597.9A patent/CN108463728B/zh active Active
- 2016-12-09 JP JP2018529642A patent/JP6793196B2/ja active Active
- 2016-12-09 CA CA3007430A patent/CA3007430C/en active Active
- 2016-12-09 US US16/061,136 patent/US11453621B2/en active Active
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