JP6793114B2 - フューリンを分泌する哺乳動物の発現系における、完全に処理され機能的な第ｘ因子の産生 - Google Patents
フューリンを分泌する哺乳動物の発現系における、完全に処理され機能的な第ｘ因子の産生 Download PDFInfo
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- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- C12N15/09—Recombinant DNA-technology
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- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
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- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21075—Furin (3.4.21.75)
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| US62/036,438 | 2014-08-12 | ||
| PCT/US2015/044883 WO2016025615A1 (en) | 2014-08-12 | 2015-08-12 | Production of fully processed and functional factor x in a furin-secreting mammalian expression system |
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| JP2017524366A JP2017524366A (ja) | 2017-08-31 |
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| US8241623B1 (en) | 2009-02-09 | 2012-08-14 | David Bermudes | Protease sensitivity expression system |
| SG11201912962RA (en) | 2017-06-23 | 2020-01-30 | Baxalta Inc | Purification of factor viii subspecies |
| WO2020257942A1 (en) * | 2019-06-28 | 2020-12-30 | Peel Sean A F | A method for increasing yields and the specific activity of certain recombinant proteins in mammalian cells by co-expressing full-length furin |
| GB202018320D0 (en) * | 2020-11-20 | 2021-01-06 | Univ Newcastle | Methods of producing recombinant complement proteins |
| CN115298204B (zh) * | 2022-01-25 | 2023-04-25 | 青岛万明赛伯药业有限公司 | proNGF突变体及其用途 |
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| JP4236698B2 (ja) | 1990-11-26 | 2009-03-11 | ジェネティックス インスティチュート，リミテッド ライアビリティ カンパニー | 宿主細胞でのｐａｃｅの発現およびその使用法 |
| AT404838B (de) * | 1995-11-24 | 1999-03-25 | Immuno Ag | Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen |
| JPH09295945A (ja) * | 1996-04-30 | 1997-11-18 | Hoechst Yakuhin Kogyo Kk | 成熟型骨誘導因子の製造方法 |
| US5876923A (en) | 1996-07-26 | 1999-03-02 | Arch Development Corporation | Herpes simplex virus ICP4 as an inhibitor of apoptosis |
| EP1233986A4 (en) | 1999-11-12 | 2003-01-02 | Baxter Biotech Tech Sarl | HEMOGLOBIN COMPOSITIONS WITH REDUCED SIDE EFFECTS |
| US6596526B1 (en) * | 2000-06-09 | 2003-07-22 | Baxter Aktiengesellschaft | Furin polypeptides with improved characteristics |
| EP1622928A4 (en) * | 2003-05-09 | 2006-06-14 | Res Dev Foundation | INSERTION OF FURINE PROTEASE CLEAVAGE SITES IN MEMBRANE PROTEINS AND USES THEREOF |
| PL1969127T5 (pl) * | 2005-12-21 | 2018-02-28 | Cnj Holdings, Inc | Metoda wytwarzania biologicznie czynnych białek zależnych od witaminy K metodami rekombinacji |
| JP5053435B2 (ja) * | 2007-05-18 | 2012-10-17 | バクスター・インターナショナル・インコーポレイテッド | Ｖｗｆプロペプチドから成熟ｖｗｆを産生するための方法。 |
| CA2710260C (en) * | 2007-12-31 | 2023-07-11 | Barbara Plaimauer | Substantially animal protein-free recombinant furin and methods for producing same |
| KR101544245B1 (ko) | 2009-02-03 | 2015-08-12 | 아뮤닉스 오퍼레이팅 인코포레이티드 | 연장된 재조합 폴리펩티드 및 이를 포함하는 조성물 |
| RU2610436C2 (ru) * | 2011-06-02 | 2017-02-10 | Баксалта Инкорпорейтед | Составы рекомбинантного фурина |
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| US9873892B2 (en) | 2018-01-23 |
| JP2017524366A (ja) | 2017-08-31 |
| CA2958056A1 (en) | 2016-02-18 |
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| EA201790360A1 (ru) | 2017-06-30 |
| EA035444B1 (ru) | 2020-06-17 |
| TW201625791A (zh) | 2016-07-16 |
| MX377236B (es) | 2025-03-07 |
| NZ729729A (en) | 2023-07-28 |
| EP3180427B1 (en) | 2019-05-22 |
| CN107002041A (zh) | 2017-08-01 |
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