JP6789595B2 - 溶媒補正曲線を測定する方法 - Google Patents
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N21/552—Attenuated total reflection
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- G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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Description
センサーチップCM5を取り付け、12000RUのヒト血清アルブミンを、GEヘルスケアからのアミン結合キットを使用してアミン結合によって固定化した。10mMの酢酸塩pH5.0中の50μg/mlのヒト血清アルブミンを、7分間にわたって注入した。
Claims (12)
- 溶媒補正曲線を確立するための方法であって、
(a)高濃度の有機溶媒を含む第1の溶液および低濃度の前記同じ有機溶媒を含む第2の溶液を用意するステップと、
(b)作動中に統合マイクロ流体カートリッジ(IFC)の流路で前記2種類の溶液を所定の割合で混合するステップであって、前記流路が、リガンドまたは類似物が固定化されていない光学センサ表面を有するフローセルを備えるステップと、
(c)前記ステップ(b)の前記光学センサ表面から前記混合された溶液のセンサーグラムを得るステップであって、前記センサーグラムが、該センサーグラムの安定セクションにレポートポイントを含むステップと、
(d)作動中に前記統合マイクロ流体カートリッジ(IFC)の別の流路で前記2種類の溶液を前記ステップ(b)と同じ前記所定の割合で混合するステップであって、前記流路が、リガンドまたは類似物が固定化された光学センサ表面を有するフローセルを備えるステップと、
(e)前記ステップ(d)の前記光学センサ表面から前記混合された溶液のセンサーグラムを得るステップであって、前記センサーグラムが、前記センサーグラムの安定セクションにレポートポイントを含むステップと、
(f)n回にわたってそれぞれ前記2種類の溶液の異なる所定の割合で前記ステップ(c)および前記ステップ(e)を繰り返すステップと、
(g)前記レポートポイントを使用して溶媒補正曲線を確立するステップと
を含み、前記nが、少なくとも3である方法。 - 前記2種類の溶液を混合する前記ステップが、前記2種類の溶液をそれぞれ予め設定した個々の流量で注入し、前記混合された溶液を前記フローセルを通して移動させ、前記混合された溶液が前記フローセルの2回目の通過を行うように流れを反転させることを含む、請求項1に記載の方法。
- 前記流れが、前記混合された溶液が前記フローセルの3回目の通過を行うようにもう1回反転される、請求項2に記載の方法。
- 前記2種類の溶液を混合する前記ステップが、前記2種類の溶液をそれぞれ予め設定した個々の流量で注入し、前記フローセルに流入させる前に、前記混合された溶液を流路および/または弁を通して移動させることを含む、請求項1に記載の方法。
- 前記2種類の溶液を混合する前記ステップが、前記溶液のそれぞれの流量を制御することによって実現される、請求項1に記載の方法。
- 前記溶液の流量が、1つ以上のポンプによって制御される、請求項1に記載の方法。
- 前記IFCが、多数の平行流路を備える、請求項1に記載の方法。
- 前記有機溶媒が、DMSOである、請求項1に記載の方法。
- 検体の補正された反応を得るための方法であって、
(a)固定化された前記検体のリガンドまたはリガンド類似物を含む光学センサ表面を含むフローセルで、前記検体を有する溶液のセンサーグラムを生成するステップと、
(b)固定化された前記検体のリガンドまたはリガンド類似物を含まない光学センサ表面を有する前記同じフローセルまたは別のフローセルで前記溶液のセンサーグラムを生成するステップと、
(c)最初に、修正されたセンサーグラムを生成するために各信号に関して工程(a)で生成されたセンサーグラムの信号から工程(b)で生成されたセンサーグラムの信号を差し引き、その後、請求項1に記載の前記補正曲線に従って前記修正されたセンサーグラムの信号または前記センサーグラムからのレポートポイントを調整することによって、補正された反応を得るステップと
を含む方法。 - 前記検体が、約80〜約1000ダルトンのサイズを有する小分子である、請求項9に記載の方法。
- 前記光学センサ表面が、エバネッセント波検知に基づく検出器の一部である、請求項9に記載の方法。
- 前記光学センサ表面が、表面プラズモン共鳴に基づく検出器の一部である、請求項9に記載の方法。
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US201462072574P | 2014-10-30 | 2014-10-30 | |
US62/072,574 | 2014-10-30 | ||
PCT/EP2015/074768 WO2016066591A1 (en) | 2014-10-30 | 2015-10-26 | Method to determine solvent correction curves |
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JP6789595B2 true JP6789595B2 (ja) | 2020-11-25 |
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US (1) | US11255852B2 (ja) |
EP (1) | EP3213071B1 (ja) |
JP (1) | JP6789595B2 (ja) |
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US20230032773A1 (en) * | 2019-12-24 | 2023-02-02 | Vsense Medical Llc | Analyte sensing system and cartridge thereof |
CN112683857B (zh) * | 2021-01-06 | 2022-10-14 | 上海药明生物医药有限公司 | 一种通过评估分析物的溶剂效应对亲和力实验的影响来指导spr检测前处理的方法 |
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JP4834608B2 (ja) * | 2007-05-22 | 2011-12-14 | 株式会社住化分析センター | 解離定数算出装置、結合様式判定装置、解離定数算出方法、解離定数算出プログラムおよびコンピュータ読み取り可能な記録媒体 |
CN102656464A (zh) * | 2009-12-22 | 2012-09-05 | 通用电气健康护理生物科学股份公司 | 具有改进混合的分析方法 |
EP2395356B1 (en) * | 2010-06-09 | 2014-10-01 | Konica Minolta Holdings, Inc. | Microchip solution sending system |
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