JP6789579B2 - 特定の患者集団において神経変性障害を処置する方法 - Google Patents
特定の患者集団において神経変性障害を処置する方法 Download PDFInfo
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- JP6789579B2 JP6789579B2 JP2018512564A JP2018512564A JP6789579B2 JP 6789579 B2 JP6789579 B2 JP 6789579B2 JP 2018512564 A JP2018512564 A JP 2018512564A JP 2018512564 A JP2018512564 A JP 2018512564A JP 6789579 B2 JP6789579 B2 JP 6789579B2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (9)
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| US201562216404P | 2015-09-10 | 2015-09-10 | |
| US62/216,404 | 2015-09-10 | ||
| US201662290287P | 2016-02-02 | 2016-02-02 | |
| US62/290,287 | 2016-02-02 | ||
| US201662302027P | 2016-03-01 | 2016-03-01 | |
| US62/302,027 | 2016-03-01 | ||
| US201662365809P | 2016-07-22 | 2016-07-22 | |
| US62/365,809 | 2016-07-22 | ||
| PCT/US2016/051091 WO2017044840A1 (fr) | 2015-09-10 | 2016-09-09 | Méthodes de traitement de troubles neurodégénératifs dans une population spécifique de patients |
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| JP2018526407A JP2018526407A (ja) | 2018-09-13 |
| JP2018526407A5 JP2018526407A5 (fr) | 2019-10-24 |
| JP6789579B2 true JP6789579B2 (ja) | 2020-11-25 |
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| JP2020161995A Active JP7128536B2 (ja) | 2015-09-10 | 2020-09-28 | 特定の患者集団において神経変性障害を処置する方法 |
| JP2022128786A Pending JP2022145949A (ja) | 2015-09-10 | 2022-08-12 | 特定の患者集団において神経変性障害を処置する方法 |
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| JP2020161995A Active JP7128536B2 (ja) | 2015-09-10 | 2020-09-28 | 特定の患者集団において神経変性障害を処置する方法 |
| JP2022128786A Pending JP2022145949A (ja) | 2015-09-10 | 2022-08-12 | 特定の患者集団において神経変性障害を処置する方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US11191742B2 (fr) |
| EP (2) | EP4275750A3 (fr) |
| JP (3) | JP6789579B2 (fr) |
| KR (2) | KR102547164B1 (fr) |
| CN (3) | CN116712422A (fr) |
| AU (1) | AU2016319107B2 (fr) |
| CA (1) | CA2997376C (fr) |
| DK (1) | DK3347002T3 (fr) |
| ES (1) | ES2952727T3 (fr) |
| FI (1) | FI3347002T3 (fr) |
| HK (1) | HK1257874A1 (fr) |
| HR (1) | HRP20230809T1 (fr) |
| HU (1) | HUE062511T2 (fr) |
| LT (1) | LT3347002T (fr) |
| MD (1) | MD3347002T2 (fr) |
| MX (2) | MX2018003023A (fr) |
| PL (1) | PL3347002T3 (fr) |
| PT (1) | PT3347002T (fr) |
| RS (1) | RS64481B1 (fr) |
| SI (1) | SI3347002T1 (fr) |
| WO (1) | WO2017044840A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015230972B2 (en) | 2014-03-21 | 2021-05-27 | Alzheon, Inc. | Methods for treating neurological disorders |
| LT3347002T (lt) * | 2015-09-10 | 2023-09-11 | Alzheon, Inc. | Alzheimerio ligos gydymas tam tikroje pacientų populiacijoje |
| CN108623501B (zh) | 2017-03-21 | 2022-04-19 | 润佳（苏州）医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸衍生物及其用途 |
| CN110003058B (zh) * | 2018-01-04 | 2022-01-25 | 润佳（苏州）医药科技有限公司 | 3-((l-缬氨酰基)氨基)-3,3-二氘-1-丙磺酸晶型、制备方法及用途 |
| SG11202100767XA (en) * | 2018-08-01 | 2021-02-25 | Alzheon Inc | Methods for treating neurodegenerative disorders |
| US20220087967A1 (en) * | 2018-08-01 | 2022-03-24 | Alzheon, Inc. | Sulfopropanoic acid derivatives for treating neurodegenerative disorders |
| CN111170901A (zh) * | 2018-11-13 | 2020-05-19 | 润佳（苏州）医药科技有限公司 | 3-((l-缬氨酰基)氨基)-1-丙磺酸晶型、制备方法及其用途 |
| WO2020257159A1 (fr) | 2019-06-17 | 2020-12-24 | Alzheon, Inc. | Procédés de traitement de troubles neurodégénératifs |
| AU2022405026A1 (en) * | 2021-12-09 | 2024-06-20 | Alzheon, Inc. | Alz-801 for use in treating alzheimer's disease |
| WO2023150381A1 (fr) * | 2022-02-07 | 2023-08-10 | Alzheon, Inc. | Alz -801 pour utilisation dans le traitement d'un symptôme neurologique associé à la covid -19 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| JP3265577B2 (ja) | 1992-10-13 | 2002-03-11 | デューク・ユニバーシティ | アポリポ蛋白ｅの４型イソ型の測定法 |
| US20050031651A1 (en) | 2002-12-24 | 2005-02-10 | Francine Gervais | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| US20050142191A1 (en) | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| US20070010573A1 (en) | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US20060079578A1 (en) | 2003-06-23 | 2006-04-13 | Julie Laurin | Pharmaceutical formulations of amyloid inhibiting compounds |
| SG145784A1 (en) | 2003-08-11 | 2008-09-29 | California Inst Of Techn | Microfluidic large scale integration |
| CA2611586A1 (fr) | 2005-04-12 | 2007-06-21 | Neurochem (International) Limited | Formulations pharmaceutiques de composes inhibiteurs d'amyloide |
| WO2009019534A2 (fr) | 2006-10-12 | 2009-02-12 | Bellus Health (International) Limited | Procédés, composés, compositions et véhicules permettant de délivrer l'acide 3-amino-1-propane sulfonique |
| US20100183513A1 (en) | 2006-11-24 | 2010-07-22 | Wolfgang Froestl | N-(methyl) -1h-pyrazol-3-amine, n-(methyl)-pyridin-2-amine and n-(methyl)-thiazol-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| US20120009125A1 (en) | 2010-07-06 | 2012-01-12 | Lombard Jay L | Apoe4 and apoj biomarker-based prevention and treatment of dementia |
| ES2705027T3 (es) | 2010-08-19 | 2019-03-21 | Buck Institute For Age Res | Métodos de tratamiento del deterioro cognitivo leve (DCL) y trastornos relacionados |
| ES2740127T3 (es) * | 2013-05-06 | 2020-02-05 | Baxalta Inc | Tratamiento de subpoblaciones con enfermedad de Alzheimer con inmunoglobulina G combinada |
| KR20160111039A (ko) | 2014-02-08 | 2016-09-23 | 제넨테크, 인크. | 알츠하이머 질환을 치료하는 방법 |
| AU2015230972B2 (en) | 2014-03-21 | 2021-05-27 | Alzheon, Inc. | Methods for treating neurological disorders |
| LT3347002T (lt) * | 2015-09-10 | 2023-09-11 | Alzheon, Inc. | Alzheimerio ligos gydymas tam tikroje pacientų populiacijoje |
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