JP6783787B2 - エテルカルセチドの調製のための液相方法 - Google Patents

エテルカルセチドの調製のための液相方法 Download PDF

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Publication number
JP6783787B2
JP6783787B2 JP2017550117A JP2017550117A JP6783787B2 JP 6783787 B2 JP6783787 B2 JP 6783787B2 JP 2017550117 A JP2017550117 A JP 2017550117A JP 2017550117 A JP2017550117 A JP 2017550117A JP 6783787 B2 JP6783787 B2 JP 6783787B2
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Japan
Prior art keywords
protected
fragment
etelcalcetide
coupling
arg
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JP2017550117A
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English (en)
Japanese (ja)
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JP2018512415A (ja
JP2018512415A5 (enExample
Inventor
シェン・ツイ
クリシュナクマール・ランガナタン
リチャード・クロケット
イン・チェン
アレクサンダー・スウィートロウ
ケビン・クロスリー
ユン・シ
カレル・デクロース
エティエンヌ・モニオット
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Amgen Inc
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Amgen Inc
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Publication of JP2018512415A5 publication Critical patent/JP2018512415A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017550117A 2015-03-26 2016-03-25 エテルカルセチドの調製のための液相方法 Active JP6783787B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562138903P 2015-03-26 2015-03-26
US62/138,903 2015-03-26
PCT/US2016/024308 WO2016154580A1 (en) 2015-03-26 2016-03-25 Solution phase method for preparing etelcalcetide

Publications (3)

Publication Number Publication Date
JP2018512415A JP2018512415A (ja) 2018-05-17
JP2018512415A5 JP2018512415A5 (enExample) 2019-05-09
JP6783787B2 true JP6783787B2 (ja) 2020-11-11

Family

ID=55911037

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017550117A Active JP6783787B2 (ja) 2015-03-26 2016-03-25 エテルカルセチドの調製のための液相方法

Country Status (7)

Country Link
US (1) US10858389B2 (enExample)
EP (1) EP3274360B1 (enExample)
JP (1) JP6783787B2 (enExample)
AU (1) AU2016238233B2 (enExample)
CA (1) CA2980960C (enExample)
ES (1) ES2806200T3 (enExample)
WO (1) WO2016154580A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10858389B2 (en) 2015-03-26 2020-12-08 Amgen Inc. Solution phase method for preparing etelcalcetide
CN106928321B (zh) * 2015-12-31 2019-07-26 深圳翰宇药业股份有限公司 一种合成Etelcalcetide的方法
CN108101959B (zh) * 2016-11-24 2021-07-09 四川科伦药物研究院有限公司 一种制备高纯度多肽或其类似物的方法
CN106967155B (zh) * 2017-03-17 2018-05-15 兰州凯博药业股份有限公司 一种多肽液相合成缩宫素的方法
CN110498835B (zh) * 2018-05-17 2021-06-08 深圳翰宇药业股份有限公司 一种合成etelcalcetide的方法
EP3613757A1 (en) 2018-08-20 2020-02-26 Wntresearch AB Solution phase routes for wnt hexapeptides
CN109280078B (zh) * 2018-10-30 2019-06-25 成都诺和晟泰生物科技有限公司 一种制备维拉卡肽的方法
CN109734778A (zh) * 2019-03-07 2019-05-10 苏州科技大学 一种维拉卡肽的制备方法
CN112175042B (zh) * 2019-07-03 2022-05-31 深圳翰宇药业股份有限公司 Etelcalcetide的合成方法
EP4021920A4 (en) * 2019-08-26 2023-08-16 Auro Peptides LTD IMPROVED PROCESS FOR PRODUCTION OF ETELCALCETIDE HYDROCHLORIDE
CN112521450A (zh) * 2019-09-19 2021-03-19 深圳市健翔生物制药有限公司 一种固液相结合制备维拉卡肽的方法
CN110668984B (zh) * 2019-12-03 2020-04-10 凯莱英医药集团（天津）股份有限公司 一种依特卡肽中间体及依特卡肽的合成方法
CN111925415A (zh) * 2020-08-10 2020-11-13 海南中和药业股份有限公司 一种维拉卡肽杂质的制备方法
US20230331778A1 (en) 2020-08-31 2023-10-19 Usv Private Limited An improved process for fmoc synthesis of etelcalcetide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001005757A2 (en) 1999-07-19 2001-01-25 Nycomed Imaging As Process for the deprotection of protected thiols
US9409946B2 (en) 2008-06-17 2016-08-09 Peptisyntha Peptide manufacturing process
EP3539555B1 (en) * 2009-07-29 2020-12-30 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels
US8987377B2 (en) 2010-11-19 2015-03-24 Alnylam Pharmaceuticals, Inc. Poly(amide) polymers for the delivery of oligonucleotides
PE20210413A1 (es) * 2013-06-28 2021-03-04 Amgen Inc Formulacion liquida estable que comprende etelcalcetida (amg416), un agente tamponante y agente de tonicidad
US10858389B2 (en) 2015-03-26 2020-12-08 Amgen Inc. Solution phase method for preparing etelcalcetide

Also Published As

Publication number Publication date
JP2018512415A (ja) 2018-05-17
WO2016154580A1 (en) 2016-09-29
EP3274360A1 (en) 2018-01-31
US10858389B2 (en) 2020-12-08
AU2016238233B2 (en) 2019-11-21
AU2016238233A1 (en) 2017-10-19
CA2980960C (en) 2024-05-28
EP3274360B1 (en) 2020-05-06
US20180079777A1 (en) 2018-03-22
CA2980960A1 (en) 2016-09-29
ES2806200T3 (es) 2021-02-16

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