JP6770524B2 - コクリエート、及び薬理活性物質の組織透過性を高めるためにそれを使用する方法 - Google Patents

コクリエート、及び薬理活性物質の組織透過性を高めるためにそれを使用する方法 Download PDF

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JP6770524B2
JP6770524B2 JP2017546149A JP2017546149A JP6770524B2 JP 6770524 B2 JP6770524 B2 JP 6770524B2 JP 2017546149 A JP2017546149 A JP 2017546149A JP 2017546149 A JP2017546149 A JP 2017546149A JP 6770524 B2 JP6770524 B2 JP 6770524B2
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JP2018508523A5 (enExample
JP2018508523A (ja
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ラファエル ジェイ． マンニーノ
ラファエル ジェイ． マンニーノ
ルーイン ルー
ルーイン ルー
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マティナス バイオファーマ ナノテクノロジーズ，インコーポレーテッド
マティナス バイオファーマ ナノテクノロジーズ，インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A—HUMAN NECESSITIES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Dispersion Chemistry (AREA)
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  • Wood Science & Technology (AREA)
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JP2017546149A 2015-03-03 2016-03-03 コクリエート、及び薬理活性物質の組織透過性を高めるためにそれを使用する方法 Active JP6770524B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201562127799P 2015-03-03 2015-03-03
US62/127,799 2015-03-03
US201562162425P 2015-05-15 2015-05-15
US62/162,425 2015-05-15
US201562163212P 2015-05-18 2015-05-18
US62/163,212 2015-05-18
US201562239675P 2015-10-09 2015-10-09
US62/239,675 2015-10-09
US201562247641P 2015-10-28 2015-10-28
US62/247,641 2015-10-28
US201562264164P 2015-12-07 2015-12-07
US62/264,164 2015-12-07
PCT/US2016/020722 WO2016141203A1 (en) 2015-03-03 2016-03-03 Cochleates and methods of using the same to enhance tissue penetration of pharmacologically active agent

Publications (3)

Publication Number Publication Date
JP2018508523A JP2018508523A (ja) 2018-03-29
JP2018508523A5 JP2018508523A5 (enExample) 2019-03-28
JP6770524B2 true JP6770524B2 (ja) 2020-10-14

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JP2017546149A Active JP6770524B2 (ja) 2015-03-03 2016-03-03 コクリエート、及び薬理活性物質の組織透過性を高めるためにそれを使用する方法

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US (1) US11389407B2 (enExample)
EP (1) EP3265060B1 (enExample)
JP (1) JP6770524B2 (enExample)
KR (1) KR20180004104A (enExample)
CN (1) CN107847443A (enExample)
AU (1) AU2016226151B2 (enExample)
CA (1) CA2978308C (enExample)
WO (1) WO2016141203A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200060424A (ko) * 2017-09-20 2020-05-29 아토픽 메디컬, 엘엘씨. 호흡기 질환 및 점막 염증의 치료 및 개선을 위한 조성물 및 방법
CN107621514B (zh) * 2017-11-10 2020-09-29 成都美域高制药有限公司 高效液相色谱法测定磷酸特地唑胺对映异构体含量的方法
KR101989789B1 (ko) * 2017-11-30 2019-06-18 (주) 에이치엔에이파마켐 포스파티딜세린/음이온계면활성제/염화칼슘을 이용한 코킬레이트
WO2019199238A1 (en) * 2018-04-09 2019-10-17 Vet Products Research And Innovation Center Company Limited Inorganic mineral entrapped in nanoparticle production method thereof
WO2021030553A1 (en) * 2019-08-13 2021-02-18 Matinas Biopharma Nanotechnologies, Inc. Methods of treating cryptococcus infections
WO2024039733A1 (en) 2022-08-16 2024-02-22 Matinas Biopharma Nanotechnologies, Inc. Methods of controlling lipid nanocrystal particle size and lipid nanocrystals produced by such methods

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871488A (en) * 1985-04-22 1989-10-03 Albany Medical College Of Union University Reconstituting viral glycoproteins into large phospholipid vesicles
US5994318A (en) 1993-10-04 1999-11-30 Albany Medical College Cochleate delivery vehicles
US5643574A (en) * 1993-10-04 1997-07-01 Albany Medical College Protein- or peptide-cochleate vaccines and methods of immunizing using the same
US6153217A (en) 1999-01-22 2000-11-28 Biodelivery Sciences, Inc. Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
US20030219473A1 (en) * 2002-03-26 2003-11-27 Leila Zarif Cochleates made with purified soy phosphatidylserine
CN1674869A (zh) * 2002-08-06 2005-09-28 金拓 非金属阳离子作桥联剂的脂质卷
US20050008686A1 (en) * 2003-01-15 2005-01-13 Mannino Raphael J. Cochleate preparations of fragile nutrients
WO2005110361A2 (en) * 2004-04-09 2005-11-24 Biodelivery Sciences International, Inc. Nucleotide-cochleate compositions and methods of use
EP1631669A2 (en) * 2003-04-09 2006-03-08 Biodelivery Sciences International, Inc. Cochleate compositions directed against expression of proteins
US20050013854A1 (en) * 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
AU2004257373B2 (en) * 2003-07-16 2011-03-24 Arbutus Biopharma Corporation Lipid encapsulated interfering RNA
EP2704688B1 (en) 2011-05-05 2019-07-10 Matinas BioPharma Nanotechnologies, Inc. Cochleate compositions and methods of making and using same
WO2013085152A1 (en) * 2011-12-07 2013-06-13 Union Korea Pharm Co., Ltd. Combined antibiotics comprising cephalosporins and beta-lactamase inhibitors
RU2659729C2 (ru) 2012-07-30 2018-07-03 Матинас Биофарма Нанотекнолоджис, Инк. Кохлеаты, полученные с использованием фосфатидилсерина сои
ES2867152T3 (es) 2015-04-22 2021-10-20 Matinas Biopharma Nanotechnologies Inc Composiciones y métodos para el tratamiento de infecciones y enfermedad pulmonar por micobacterias
JP2018517736A (ja) 2015-06-18 2018-07-05 マティナス バイオファーマ ナノテクノロジーズ，インコーポレーテッド 炎症性疾患又は病態を治療する組成物及び方法

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CA2978308C (en) 2024-02-13
KR20180004104A (ko) 2018-01-10
EP3265060B1 (en) 2020-10-21
AU2016226151B2 (en) 2021-02-25
EP3265060A1 (en) 2018-01-10
US20180042849A1 (en) 2018-02-15
CN107847443A (zh) 2018-03-27
CA2978308A1 (en) 2016-09-09
JP2018508523A (ja) 2018-03-29
WO2016141203A1 (en) 2016-09-09
US11389407B2 (en) 2022-07-19
EP3265060A4 (en) 2018-08-22
AU2016226151A1 (en) 2017-09-21

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