JP6768515B2 - 二重アシル化ｇｌｐ−１化合物 - Google Patents
二重アシル化ｇｌｐ−１化合物 Download PDFInfo
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- JP6768515B2 JP6768515B2 JP2016561311A JP2016561311A JP6768515B2 JP 6768515 B2 JP6768515 B2 JP 6768515B2 JP 2016561311 A JP2016561311 A JP 2016561311A JP 2016561311 A JP2016561311 A JP 2016561311A JP 6768515 B2 JP6768515 B2 JP 6768515B2
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
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- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
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- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14163697.7 | 2014-04-07 | ||
| EP14163697 | 2014-04-07 | ||
| PCT/EP2015/057442 WO2015155151A1 (en) | 2014-04-07 | 2015-04-07 | Double-acylated glp-1 compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514801A JP2017514801A (ja) | 2017-06-08 |
| JP2017514801A5 JP2017514801A5 (https=) | 2018-05-10 |
| JP6768515B2 true JP6768515B2 (ja) | 2020-10-14 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| JP2016561311A Active JP6768515B2 (ja) | 2014-04-07 | 2015-04-07 | 二重アシル化ｇｌｐ−１化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10689429B2 (https=) |
| EP (1) | EP3129041B1 (https=) |
| JP (1) | JP6768515B2 (https=) |
| CN (1) | CN106132985B (https=) |
| ES (1) | ES2741507T3 (https=) |
| WO (1) | WO2015155151A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| WO2017149070A1 (en) | 2016-03-03 | 2017-09-08 | Novo Nordisk A/S | Glp-1 derivatives and uses thereof |
| AR112015A1 (es) | 2017-06-09 | 2019-09-11 | Novo Nordisk As | Composiciones sólidas para administración oral |
| HRP20240485T1 (hr) | 2017-08-24 | 2024-07-05 | Novo Nordisk A/S | Pripravci glp-1 i njihova upotreba |
| PL3746111T3 (pl) | 2018-02-02 | 2024-01-15 | Novo Nordisk A/S | Stałe kompozycje zawierające agonistę glp-1 i sól kwasu n-(8-(2- hydroksybenzoilo)amino kaprylowego i substancję poślizgową |
| WO2019200594A1 (zh) * | 2018-04-19 | 2019-10-24 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| AR116632A1 (es) | 2018-10-11 | 2021-05-26 | Intarcia Therapeutics Inc | Polipéptidos análogos de la amilina humana y sus métodos de uso |
| CN111378027B (zh) * | 2018-12-29 | 2022-04-15 | 万新医药科技(苏州)有限公司 | 一种索玛鲁肽前体的制备方法 |
| CN114340655A (zh) * | 2019-09-02 | 2022-04-12 | 诺和诺德股份有限公司 | 生产包含glp-1肽的片剂的方法 |
| CA3154744A1 (en) | 2019-11-06 | 2021-05-14 | Sarah FRIEDRICH | Glp-1 receptor agonists in dementia |
| CN114641276A (zh) | 2019-11-07 | 2022-06-17 | 诺和诺德股份有限公司 | 包含glp-1激动剂、sglt2抑制剂和n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐的固体组合物 |
| PE20230819A1 (es) | 2020-02-18 | 2023-05-19 | Novo Nordisk As | Composiciones y usos de glp-1 |
| EP4142695B1 (en) | 2020-04-29 | 2025-11-05 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
| EP4211468A4 (en) * | 2020-09-11 | 2024-10-09 | Glympse Bio, Inc. | DETECTION OF EX VIVO PROTEASE ACTIVITY FOR DETECTION/DIAGNOSTIC, STAGING, MONITORING AND TREATMENT OF DISEASES |
| CN114729060B (zh) | 2020-09-30 | 2022-11-25 | 北京质肽生物医药科技有限公司 | 多肽缀合物和使用方法 |
| WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
| EP4323413A4 (en) | 2022-03-30 | 2025-10-15 | Beijing Ql Biopharmaceutical Co Ltd | LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF |
| CA3266547A1 (en) | 2022-08-29 | 2024-03-07 | Eli Lilly And Company | COMPOSITIONS FOR ORAL ADMINISTRATION |
| TW202421645A (zh) | 2022-11-25 | 2024-06-01 | 丹麥商諾佛 儂迪克股份有限公司 | 如ｇｌｐ—１之肽治療劑的口服投與 |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| EP4686757A1 (en) | 2024-07-31 | 2026-02-04 | e-therapeutics PLC | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025196502A1 (en) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| IL128332A0 (en) * | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| JP2002512175A (ja) | 1998-02-27 | 2002-04-23 | ノボ ノルディスク アクティーゼルスカブ | Ｇｌｐ−１類似体の誘導体類 |
| JP2003522099A (ja) | 1998-02-27 | 2003-07-22 | ノボ ノルディスク アクティーゼルスカブ | 遅延作用プロファイルを有するｇｌｐ−１のｇｌｐ−１誘導体及びエキセンジン |
| DE69922043T2 (de) | 1998-12-07 | 2005-11-24 | Société de Conseils de Recherches et d'Applications Scientifiques S.A.S. | Glp-1 analoge |
| EP1239871A1 (en) | 1999-11-12 | 2002-09-18 | Novo Nordisk A/S | Use of glp-1 agonists for the inhibition of beta cell degeneration |
| US6693094B2 (en) * | 2001-03-22 | 2004-02-17 | Chrono Rx Llc | Biguanide and sulfonylurea formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus |
| CA2502118A1 (en) | 2002-10-11 | 2004-05-06 | Sanwa Kagaku Kenkyusho Co., Ltd. | Glp-1 derivatives and transmicosal absorption preparations thereof |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| US20100261637A1 (en) | 2007-09-05 | 2010-10-14 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| EP2512518A1 (en) | 2009-12-16 | 2012-10-24 | Novo Nordisk A/S | Glp-1 receptor agonist compounds with a modified n-terminus |
| EP2637698B1 (en) | 2010-11-09 | 2022-04-20 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| US20140004198A1 (en) * | 2011-01-19 | 2014-01-02 | Novo Nordisk A/S | Glp-1 particles and compositions |
| RU2602601C2 (ru) * | 2011-04-12 | 2016-11-20 | Ново Нордиск А/С | Дважды ацилированные производные glp-1 |
| EP2753642B8 (en) * | 2011-09-06 | 2017-12-13 | Novo Nordisk A/S | Glp-1 derivatives |
| JP6250034B2 (ja) * | 2012-05-08 | 2017-12-20 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
| ES2629735T3 (es) | 2012-05-08 | 2017-08-14 | Novo Nordisk A/S | Derivados de GLP-1 doblemente acilados |
| AU2014210751A1 (en) * | 2013-01-29 | 2015-08-06 | Oshadi Drug Administration Ltd. | Pharmaceutical compositions for oral treatment of diabetes |
-
2015
- 2015-04-07 US US15/301,960 patent/US10689429B2/en active Active
- 2015-04-07 WO PCT/EP2015/057442 patent/WO2015155151A1/en not_active Ceased
- 2015-04-07 CN CN201580018073.6A patent/CN106132985B/zh active Active
- 2015-04-07 EP EP15713772.0A patent/EP3129041B1/en active Active
- 2015-04-07 JP JP2016561311A patent/JP6768515B2/ja active Active
- 2015-04-07 ES ES15713772T patent/ES2741507T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3129041A1 (en) | 2017-02-15 |
| CN106132985A (zh) | 2016-11-16 |
| CN106132985B (zh) | 2020-10-13 |
| EP3129041B1 (en) | 2019-06-12 |
| US20170114116A1 (en) | 2017-04-27 |
| WO2015155151A1 (en) | 2015-10-15 |
| ES2741507T3 (es) | 2020-02-11 |
| US10689429B2 (en) | 2020-06-23 |
| JP2017514801A (ja) | 2017-06-08 |
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