JP6746606B2 - 開口サンプリングインターフェース - Google Patents
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- H—ELECTRICITY
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- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
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- H01J49/02—Details
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/443—Evaluating skin constituents, e.g. elastin, melanin, water
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/20—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
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- A—HUMAN NECESSITIES
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- G—PHYSICS
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- G01N1/00—Sampling; Preparing specimens for investigation
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- G01N2030/027—Liquid chromatography
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Description
本出願は、2015年4月9日に出願された「開口サンプリングインターフェース」と題された米国非仮出願第14/682,837号に対する優先権を主張し、その内容の全体は、参照により本明細書に組み込まれる。
連邦政府による資金提供を受けた研究開発の記載
Claims (17)
- 開口端を持つ外プローブ収容部と、
液体を前記収容部の前記開口端に送出するように配置された流出口が設けられ、前記収容部の中にある液体供給管であって、液体を液体供給流量で前記収容部の前記開口端に送出させるために、液体供給部に接続されている液体供給管と、
前記収容部の中にあって、前記収容部の前記開口端から液体を取り除く排液管と、
が設けられたプローブと、
前記排液管と流体接続する排液システムであって、前記排液システムは前記排液管から液体を取り除き、排液を排液流量で送出する排液システムと、
前記液体供給流量と前記排液流量との流量バランスにより形成されて前記開口端に存在する液体ドームを監視し、前記開口端に近接して配置されるセンサーと、
前記センサーから信号を受信し、前記液体供給流量および前記排液流量を調節して、前記液体ドームの高さを調節するように構成されたプロセッサと、
前記液体供給流量が前記排液流量を上回るときに、前記プローブの前記開口端から越流液を回収する越流回収システムと、
が備えられ、システムの操作時に前記開口端で液体が試料材料を受け取り、試料材料を含有する液体が、前記排液管に引き込まれて通過することを特徴とする、試料材料サンプリング用システム。 - 前記システムが越流しないように運転する請求項1記載のシステム。
- 前記センサーが光学ベースのセンサーであることを特徴とする請求項1に記載のシステム。
- 前記排液管が前記外プローブ収容部の内に配置される管状の導管であり、前記液体供給管は、前記排液管と前記外プローブ収容部の内壁との間の環状空間により形成されていることを特徴とする請求項1に記載のシステム。
- 開口端を持つ外プローブ収容部と、液体を前記収容部の前記開口端に送出させるように配置された流出口が設けられ、前記収容部の中にある液体供給管と、前記収容部の中にあって、前記収容部の前記開口端から液体を取り除く排液管と、を備えるプローブを提供するステップと、
前記排液管と流体連通し、前記排液管から液体を取り除く排液システムを提供するステップと、
前記液体供給管の液体供給流量を制御するステップと、
前記排液管の中にある液体の排液流量を制御するステップと、
液体ドームを監視するセンサーを前記開口端に近接して提供するステップと、
前記センサーに接続されたプロセッサを提供するステップと、
前記液体供給管に液体を流して液体を送出し、前記排液システムに液体を流すことにより前記開口端に液体ドームを形成するステップであって、前記液体ドームが前記開口端で試料を含有する対象物を受け取り、前記試料が前記対象物から前記液体ドームの中へと抽出され、前記排液管の中に引きこまれて通過するステップと、
前記センサーを介して液体ドームの高さを感知し、信号を前記プロセッサに引き渡すステップであって、前記プロセッサが前記液体ドームの高さを制御するようになっているステップと、
が備えられ、
前記液体供給管における前記開口端への液体供給流量を第1体積流量とし、前記排液管における排液流量を第2体積流量としたとき、前記第1体積流量が前記第2体積流量を上回り、液体が前記開口端から越流する、
ことを特徴とする方法。 - 前記対象物が指であることを特徴とする請求項5に記載の方法。
- 前記指が前記開口端を封止して係合することを特徴とする請求項6に記載の方法。
- 前記排液管が前記外プローブ収容部の内に配置される管状の導管であり、前記液体供給管は、前記排液管と前記外プローブ収容部の内壁との間の環状空間により形成されていることを特徴とする請求項5に記載の方法。
- 開口端を持つ外プローブ収容部と、
液体を前記収容部の前記開口端に送出させるように配置された流出口が設けられ、前記収容部の中にある液体供給管と、
前記収容部の中にあって、前記収容部の前記開口端から液体を取り除く排液管と、
を備えるプローブを提供するステップと、
前記排液管と流体接続し、前記排液管から液体を取り除く排液システムを提供するステップと、
前記液体供給管に液体を流して、前記収容部の前記開口端に液体を第1体積流量で送出させるステップと、
前記排液システムに液体を第2体積流量で流し、前記第1体積流量が前記第2体積流量を上回るステップであって、前記開口端で液体が試料を受け取り、前記試料を含有する液体が前記排液管の中に引きこまれて通過し、前記開口端から液体が越流するステップと、
前記試料材料を含有する対象物を前記開口端の液体に接触させるステップと、
前記試料材料を前記対象物から液体に抽出させるステップと、
が備えられていることを特徴とする、試料材料をサンプリングするための方法。 - 前記対象物が指であることを特徴とする請求項9に記載の方法。
- 前記指が前記開口端を完全に封止することを特徴とする請求項10に記載の方法。
- 前記排液システムからくる液体に化学分析を行うステップをさらに備えることを特徴とする請求項9に記載の方法。
- 前記化学分析が、高速液体クロマトグラフィーおよび質量分析からなる群より選択される少なくとも1つの化学分析であることを特徴とする請求項12に記載の方法。
- 前記プローブに液体越流回収システムが設けられ、前記回収システムを用いて越流液を回収するステップがさらに備えられていることを特徴とする請求項9に記載の方法。
- 前記回収システムから化学分析装置に越流液を案内するステップをさらに備えることを特徴とする請求項14に記載の方法。
- 前記越流液が還流となって前記排液管の液体に混合されることを特徴とする請求項14に記載の方法。
- 前記第1体積流量が前記第2体積流量より少なくとも5%だけ上回ることを特徴とする請求項9に記載の方法。
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