JP6709217B2 - 皮膚の修復および／または再生において使用するためのヘパラン硫酸 - Google Patents

皮膚の修復および／または再生において使用するためのヘパラン硫酸 Download PDF

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Publication number
JP6709217B2
JP6709217B2 JP2017526910A JP2017526910A JP6709217B2 JP 6709217 B2 JP6709217 B2 JP 6709217B2 JP 2017526910 A JP2017526910 A JP 2017526910A JP 2017526910 A JP2017526910 A JP 2017526910A JP 6709217 B2 JP6709217 B2 JP 6709217B2
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Japan
Prior art keywords
fgf2
cells
skin
heparin
binding
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Expired - Fee Related
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JP2017526910A
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English (en)
Japanese (ja)
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JP2017536454A5 (enExample
JP2017536454A (ja
Inventor
クール，サイモン
ヌルカム，ビクター
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Agency for Science Technology and Research Singapore
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Agency for Science Technology and Research Singapore
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2017526910A 2014-11-19 2015-11-19 皮膚の修復および／または再生において使用するためのヘパラン硫酸 Expired - Fee Related JP6709217B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SG10201408007P 2014-11-19
SG10201408007P 2014-11-19
PCT/SG2015/050464 WO2016080916A1 (en) 2014-11-19 2015-11-19 Heparan sulphates for use in repair and/or regeneration of skin

Publications (3)

Publication Number Publication Date
JP2017536454A JP2017536454A (ja) 2017-12-07
JP2017536454A5 JP2017536454A5 (enExample) 2018-12-27
JP6709217B2 true JP6709217B2 (ja) 2020-06-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017526910A Expired - Fee Related JP6709217B2 (ja) 2014-11-19 2015-11-19 皮膚の修復および／または再生において使用するためのヘパラン硫酸

Country Status (6)

Country Link
US (1) US10471091B2 (enExample)
EP (1) EP3220922B1 (enExample)
JP (1) JP6709217B2 (enExample)
CN (1) CN107249599A (enExample)
SG (1) SG11201704085QA (enExample)
WO (1) WO2016080916A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015015814A (es) 2013-05-16 2016-06-02 Agency Science Tech & Res Sulfatos de heparán.
WO2016080915A1 (en) 2014-11-19 2016-05-26 Agency For Science, Technology And Research Cosmetic use of heparan sulphate
CA2998170C (en) 2015-09-15 2023-10-03 Savage Medical, Inc. Devices and methods for anchoring a sheath in a tissue cavity
EP3405245A4 (en) 2016-01-18 2019-09-11 Fisher&Paykel Healthcare Limited HUMIDIFICATION OF BREATHING GASES
JP6815782B2 (ja) * 2016-07-29 2021-01-20 小林製薬株式会社 α−ＳＭＡ産生抑制剤
CN106544318A (zh) * 2016-11-28 2017-03-29 广东万海细胞生物科技有限公司 促进脐带间充质干细胞定向分化为脂肪细胞的方法
CN108715833B (zh) * 2018-06-01 2021-09-14 天晴干细胞股份有限公司 一种负载血小板裂解液的微球制备方法
JPWO2024080183A1 (enExample) * 2022-10-14 2024-04-18

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019087A (en) 1986-10-06 1991-05-28 American Biomaterials Corporation Nerve regeneration conduit
JPH0240399A (ja) 1988-07-27 1990-02-09 Takeda Chem Ind Ltd 線維芽細胞増殖因子ムテインの複合体あるいは組成物
GB9017008D0 (en) 1990-08-02 1990-09-19 Erba Carlo Spa Process for the enzymatic preparation of basic fibroblast growth factor
MX9201801A (es) 1991-04-16 1992-10-30 Seikagaku Kogyo Co Ltd Oligosacarido que tiene afinidad para el factor de desarrollo del fibroplasto y procedimiento para producirlo.
GB9206291D0 (en) 1992-03-23 1992-05-06 Cancer Res Campaign Tech Oligosaccharides having growth factor binding affinity
WO1996023003A1 (en) 1995-01-27 1996-08-01 Amrad Operations Pty. Ltd. A therapeutic molecule
FR2812551B1 (fr) * 2000-08-07 2003-03-28 Virsol Forme pharmaceutique comprenant un materiau support a base de methylidene malonate et un facteur de regulation cellulaire
JP4768936B2 (ja) * 2000-08-07 2011-09-07 生化学工業株式会社 硫酸基を有するオリゴ糖
US20060183712A1 (en) 2005-02-17 2006-08-17 The Texas A&M University System Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor
WO2010011185A1 (en) 2008-07-21 2010-01-28 Agency For Science, Technology And Research Stem cells obtained through in vitro culture with heparan sulfate
GB2463474B (en) 2008-09-11 2012-05-02 Agency Science Tech & Res Therapeutic bone growth and regeneration
GB0818255D0 (en) 2008-10-06 2008-11-12 Agency Science Tech & Res Isolation and identification of glycosaminoglycans
US9498494B2 (en) * 2008-09-11 2016-11-22 Agency For Science, Technology And Research Glycosaminoglycans
JP2012509289A (ja) 2008-11-20 2012-04-19 ラボラトリ・デリバティ・オルガニシ・エス・ピー・エイ ヘパラン硫酸の精製方法並びに美容用及び皮膚用調製物中におけるその使用
FR2940610B1 (fr) 2008-12-30 2011-05-06 Oreal Association de monosaccharides avec des derives c-glycosides et son utilisation en cosmetique
SG188756A1 (en) * 2011-09-16 2013-04-30 Agency Science Tech & Res Glycosaminoglycans
MX2015015814A (es) * 2013-05-16 2016-06-02 Agency Science Tech & Res Sulfatos de heparán.
WO2016080915A1 (en) 2014-11-19 2016-05-26 Agency For Science, Technology And Research Cosmetic use of heparan sulphate

Also Published As

Publication number Publication date
US20170319615A1 (en) 2017-11-09
EP3220922A4 (en) 2018-07-11
EP3220922B1 (en) 2020-10-14
EP3220922A1 (en) 2017-09-27
WO2016080916A1 (en) 2016-05-26
CN107249599A (zh) 2017-10-13
US10471091B2 (en) 2019-11-12
JP2017536454A (ja) 2017-12-07
SG11201704085QA (en) 2017-06-29

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US10245301B2 (en) Glycosaminoglycans
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