JP6689188B2 - 一酸化窒素の吸気合成 - Google Patents
一酸化窒素の吸気合成 Download PDFInfo
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- JP6689188B2 JP6689188B2 JP2016502789A JP2016502789A JP6689188B2 JP 6689188 B2 JP6689188 B2 JP 6689188B2 JP 2016502789 A JP2016502789 A JP 2016502789A JP 2016502789 A JP2016502789 A JP 2016502789A JP 6689188 B2 JP6689188 B2 JP 6689188B2
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- pulse
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Description
本出願は、2013年3月15日に出願された米国特許第61/789,161号明細書、および米国特許第61/792,473号明細書の優先権を主張し、その内容の全体を本明細書に参照として組み込むものとする。
約32Kgの体重の4頭の子羊が試験された。全身麻酔が、酸素内に5%の吸入イソフルラン(イリノイ州、Deerfield、Baxter、1−クロロ−2、2、2−トリフルオロエチルジフルオロメチルエーテル)でマスクを介して導入され、次いで0.40の最初の吸入酸素濃度(FiO2)で1〜4%のイソフルランで維持された。気管挿管の後、動物は留置式頸動脈および肺動脈スワンガンツカテーテルを取り付けられた。すべての血流力学測定が、麻酔下の子羊の体内で実施された。すべての子羊が、一回呼吸量400mlおよび速度12呼吸/分で、機械換気装置(カリフォルニア州、Pleasanton、Puritan Bennett、7200型)によって換気された。
ミニスパークプラグ(ワシントン州、Benton市、Rimfireの6mmHEXを含むMicro Viper Z3および10−40THRD)が、羊#1の気道内に設置された。ミニスパークプラグは、吸気時に吸気ガス温度の変化を測定した呼吸センサによって引き起こされた。ミニスパークプラグの電極が、図3を参照して説明するように、一連のスパークを生成した。
図34は、羊の気道シミュレータを用いて、呼吸によって引き起こされるマイクロスパークプラグ(流量制御された、NICOモニタ)を使用するベンチテスト設定を示す。
Claims (33)
- 一酸化窒素を発生するための医療機器の作動方法であって、
前記医療機器は、呼吸センサと、酸素センサと、制御装置と、電極と、を備え、
前記方法は、
前記呼吸センサと前記酸素センサの少なくとも1つが、呼吸システムに付随する1つまたはそれ以上のトリガイベントに関連する情報を収集することと、
前記制御装置が、前記収集された情報に基づいて1つまたはそれ以上の制御パラメータを決定することと、
前記決定された制御パラメータに基づいて前記反応ガス内で一酸化窒素を発生させ、製品ガスを生産するために、前記電極が、スパークチャンバ内で一連の電気アークを起動することと
を含み、
収集された前記情報は、反応ガス中の酸素濃度に関する前記酸素センサからの情報を含み、
前記制御パラメータは、前記酸素センサおよび前記スパークチャンバと通信するように構成されたプロセッサの形態の前記制御装置が決定することを特徴とする方法。 - 前記トリガイベントが、ガスの吸気又はガスの流れの少なくとも1つによる温度低下である、請求項1に記載の方法。
- 1つまたはそれ以上のトリガイベントに関連する前記情報が、吸気の開始時間、吸気の一回呼吸量、吸気ガスの温度および反応ガス中の酸素濃度の1つまたはそれ以上を含む、請求項1に記載の方法。
- 前記トリガイベントが発生する時、又は前記トリガイベントが発生するより予め規定された時間量だけ前、のいずれか1つの場合に、前記一連の電気アークが生成される、請求項1に記載の方法。
- パルス列が前記一連の電気アークを起動し、前記パルス列が、異なるパルス幅を含むパルスを含むパルス群を備える、請求項1に記載の方法。
- 前記パルス群の1つの中の初期パルスのパルス幅が、前記パルス群の中の他のパルスよりも幅広い、請求項5に記載の方法。
- 前記一連の電気アークが、低減したレベルの二酸化窒素またはオゾンを発生させるように構成された、請求項5に記載の方法。
- 前記低減したレベルの二酸化窒素の濃度が、前記発生した一酸化窒素の濃度の20%未満である、請求項7に記載の方法。
- 前記呼吸システムが、気管切開チューブ、気管内チューブ、及び患者が装着できるマスクの少なくとも1つを含む、請求項1に記載の方法。
- 呼吸システムに付随する1つまたはそれ以上のトリガイベントに関連する情報を収集するための呼吸センサと、
反応ガス内の酸素濃度に関連する情報を収集するための酸素センサと、
前記呼吸センサ及び前記酸素センサからの前記収集された情報に基づいて1つまたはそれ以上の制御パラメータを決定するように構成された、前記呼吸センサ、前記酸素センサ、およびスパークチャンバと通信するプロセッサの形態の制御装置と、
前記制御装置から前記スパークチャンバに伝達された前記決定された制御パラメータに基づいて前記反応ガス内で一酸化窒素を発生させ、製品ガスを生産するために、前記スパークチャンバ内で一連の電気アークを起動するための電極と、を備える装置。 - 前記トリガイベントが、ガスの吸気による温度低下又は前記呼吸センサを通過するガスの流れの少なくとも1つである、請求項10に記載の装置。
- 1つまたはそれ以上のトリガイベントに関連する前記情報が、吸気の開始時間、吸気の一回呼吸量、吸気ガスの温度および反応ガス中の酸素濃度の1つまたはそれ以上を含む、請求項10に記載の装置。
- 前記トリガイベントが発生する時、又は前記トリガイベントが発生するより予め規定された時間量だけ前、のいずれか1つの場合に、前記電極が、前記一連の電気アークを生成する、請求項10に記載の装置。
- パルス列が前記一連の電気アークを起動し、前記パルス列が、異なるパルス幅を含むパルスを含むパルス群を備える、請求項10に記載の装置。
- 前記パルス群の1つの中の初期パルスのパルス幅が、前記パルス群の中の他のパルスよりも幅広い、請求項14に記載の装置。
- 前記一連の電気アークが、低減したレベルの二酸化窒素またはオゾンを発生させる、請求項14に記載の装置。
- 前記低減したレベルの二酸化窒素の濃度が、前記発生した一酸化窒素濃度の20%未満である、請求項16に記載の装置。
- 前記呼吸システムが、気管、気管切開チューブ、気管内チューブ、及び患者が装着できるマスクの少なくとも1つを含む、請求項10に記載の装置。
- 前記患者が装着できるマスクが、吸気ガス流を呼気ガス流から分離するための1つまたはそれ以上の弁を含む、請求項18に記載の装置。
- 前記センサまたは前記電極が、気管の中に配置されるように構成されている、請求項10に記載の装置。
- 前記電極が、貴金属、イリジウム、及びニッケルの少なくとも1つを含む、請求項10に記載の装置。
- 一酸化窒素を生成するためのシステムが、哺乳動物の気管内に配置される装置であって、前記気管に付随する1つまたはそれ以上のトリガイベントに関連する情報を収集するための呼吸センサと、
反応ガス内の酸素濃度に関連する情報を収集するための酸素センサと、
前記反応ガス内で一酸化窒素を発生させ、製品ガスを生産するために、一連の電気アークを起動するための、スパークチャンバ内の1つまたはそれ以上の電極対と、を備える装置と、
前記呼吸センサおよび前記酸素センサによって収集された情報に基づいて、1つまたはそれ以上の制御パラメータを決定するように構成された、前記呼吸センサ、前記酸素センサ、および前記スパークチャンバと通信するプロセッサの形態の制御装置と
を備えるシステムであって、
前記一連の電気アークが、前記制御装置によって決定された前記制御パラメータに基づいて起動される、システム。 - 前記トリガイベントが、ガスの吸気による温度低下、及び、前記呼吸センサを通過するガスの流れの少なくとも1つである、請求項22に記載のシステム。
- 1つまたはそれ以上のトリガイベントに関連する前記情報が、吸気の開始時間、吸気の一回呼吸量、吸気ガスの温度および反応ガス中の酸素濃度の1つまたはそれ以上を含む、請求項22に記載のシステム。
- 前記トリガイベントが発生する時、又は前記トリガイベントが発生するより予め規定された時間量だけ前、のいずれか1つの場合に、前記電極が、前記一連の電気アークを生成する、請求項22に記載のシステム。
- パルス列が前記一連の電気アークを起動し、前記パルス列が、異なるパルス幅を含むパルスを含むパルス群を備える、請求項22に記載のシステム。
- 前記パルス群の1つの中の初期パルスのパルス幅が、前記パルス群の中の他のパルスよりも幅広い、請求項26に記載のシステム。
- 前記一連の電気アークが、低減したレベルの二酸化窒素またはオゾンを発生させる、請求項26に記載のシステム。
- 前記低減したレベルの二酸化窒素の濃度が、前記発生した一酸化窒素の濃度の20%未満である、請求項28に記載のシステム。
- 前記電極が、貴金属、イリジウム、及びニッケルの少なくとも1つを含む、請求項22に記載のシステム。
- 首の中の軟骨間リングの中に移植可能な装置であって、呼吸システムに付随する1つまたはそれ以上のトリガイベントに関連する情報を収集するための呼吸センサと、
反応ガス内の酸素濃度に関連する情報を収集するための酸素センサと、
前記呼吸センサ及び前記酸素センサからの前記収集された情報に基づいて、1つまたはそれ以上の制御パラメータを決定するように構成された、前記呼吸センサ、前記酸素センサ、およびスパークチャンバと通信するプロセッサの形態の制御装置と、
前記スパークチャンバ内部に存する1つまたはそれ以上の電極対であって、前記制御装置から前記スパークチャンバに伝達された前記決定された制御パラメータに基づいて一酸化窒素を発生させ、製品ガスを生産するために、一連の電気アークを起動するための1つまたはそれ以上の電極と
を備える装置であって、
前記スパークチャンバが、一酸化窒素に対して浸透性であり、二酸化窒素およびオゾンに対して不浸透性である膜によって外部環境から分離されている、装置。 - 前記膜から粘液を除去するための掃除手段を更に備える、請求項31に記載の装置。
- セルディンガー法を使用して、哺乳動物の気管内に移植可能な装置であって、呼吸システムに付随する1つまたはそれ以上のトリガイベントに関連する情報を収集するための呼吸センサと、
反応ガス内の酸素濃度に関連する情報を収集するための酸素センサと、
前記呼吸センサ及び前記酸素センサからの前記収集された情報に基づいて1つまたはそれ以上の制御パラメータを決定するように構成された、前記呼吸センサ、前記酸素センサ、およびスパークチャンバと通信するプロセッサの形態の制御装置と、
前記制御装置から前記スパークチャンバに伝達された前記決定された制御パラメータに基づいて一酸化窒素を発生させ、製品ガスを生産するために、前記スパークチャンバ内で一連の電気アークを起動するための1つまたはそれ以上の電極対と
を備える装置。
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