JP2019515709A - 窒化物の電気的プラズマ合成のための送達システム及び方法 - Google Patents
窒化物の電気的プラズマ合成のための送達システム及び方法 Download PDFInfo
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- JP2019515709A JP2019515709A JP2018549852A JP2018549852A JP2019515709A JP 2019515709 A JP2019515709 A JP 2019515709A JP 2018549852 A JP2018549852 A JP 2018549852A JP 2018549852 A JP2018549852 A JP 2018549852A JP 2019515709 A JP2019515709 A JP 2019515709A
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Abstract
Description
本出願は、2016年3月25日に出願された米国仮特許出願第62/313,529号、発明の名称「一酸化窒素のプラズマ合成のための送達システム及び方法」に基づき優先権を主張すると共に本明細書に援用される。
適用しない。
以下の例は、NO発生システム100及び/又はNO発生装置102が使用又は実施され得る方法を詳細に記載し、当業者がその原理をより容易に理解することを可能にする。以下の例は、説明のために提示され、限定することを決して意図しない。
Claims (57)
- 一酸化窒素を生成するための装置であって、
凹部にアクセスするための開口が形成された第1の壁、及びガスの流れを通す第2の壁を含むハウジングと、
前記凹部内に配置された絶縁体と、
前記ハウジング内に配置され、前記絶縁体に少なくとも部分的に係合する1対の電極と、
前記1対の電極に電圧を印加して一酸化窒素を生成する化学反応を凹部内に誘発する、前記1対の電極に接続された電源と、
前記第2の壁の周りで微粒子を取り除くように配置された粒子フィルタと、
前記1対の電極の動作によって誘発される化学反応からの望ましくない副生成物の量を制御する、前記粒子フィルタに近接して配置された掃去剤と、
前記電源と連通し、前記1対の電極に選択的に通電して前記電極間に1つ又は複数の放電を生じさせて前記ハウジング内に前記一酸化窒素を発生させるように構成されたコントローラと、
前記一酸化窒素を、装置を使用して前記ハウジングの第2の壁を通って被験者の気道に非機械的に導くように構成された流路と、を備える
一酸化窒素を生成するための装置。 - 前記流路は、前記一組の電極間の前記一つ以上の放電中に生じる輸送現象を利用して、前記一酸化窒素を前記ハウジングの前記第2の壁を通して前記被験者の気道内に非機械的に導く、請求項1に記載の装置。
- 前記輸送現象が対流輸送を含む、請求項2に記載の装置。
- 前記ハウジングと前記絶縁体との間の容積が、前記一酸化窒素を前記流路に沿って前記被験者の気道へ実質的に瞬間的に送達するのに十分小さい反応チャンバを画定する、請求項1に記載の装置。
- 前記1対の電極が、炭化タングステン、炭素、ニッケル、イリジウム、チタン、レニウム及び白金の少なくとも1つを含む、請求項1に記載の装置。
- 前記1対の電極がイリジウムを含む、請求項1に記載の装置。
- 前記掃去剤が水酸化カルシウムから製造される、請求項1に記載の装置。
- 前記電源が共振高電圧電源を備える、請求項1に記載の装置。
- 前記電源が同期電源を備える、請求項1に記載の装置。
- 前記粒子フィルタは、約0.22マイクロメートルより大きな直径を有する粒子を取り除くように構成される、請求項1に記載の装置。
- 前記粒子フィルタがHEPAフィルタを備える、請求項1に記載の装置。
- 前記絶縁体がセラミック材料から製造される、請求項1に記載の装置。
- 前記ハウジングが複数の層を含む、請求項1に記載の装置。
- 前記複数の層が第1の層、第2の層、及び第3の層を含み、前記第2の層は前記第1の層と前記第3の層との間に配置される、請求項13に記載の装置。
- 前記第1の層及び前記第3の層は、前記第2の層よりも低い熱伝導率を有する電気絶縁材料から製造される、請求項14に記載の装置。
- 前記第2の層はヒートシンクに接続される、請求項14に記載の装置。
- 前記コントローラはさらに、吸気の開始を検出するように構成される、請求項1に記載の装置。
- 前記コントローラは、前記1対の電極に電圧を選択的に印加して、前記吸気の開始が検出された後に前記1つ又は複数の放電を生じるように構成されている、請求項17に記載の装置。
- 一酸化窒素を生成するための装置であって、
凹部にアクセスするための開口が形成された第1の壁、及び、ガスの流れを通す第2の壁を含むハウジングと、
前記凹部内に配置された絶縁体と、
前記ハウジングと前記絶縁体との間の容積によって画定される反応チャンバと、
前記ハウジング内に配置され、前記絶縁体に少なくとも部分的に係合する1対の電極と、
前記1対の電極に電圧を印加して一酸化窒素を生成する化学反応を前記反応チャンバ内に誘発する、前記1対の電極に接続された電源と、
前記第2の壁の周りで微粒子を取り除くように配置された粒子フィルタと、
前記1対の電極の動作によって誘発される化学反応からの望ましくない副生成物の量を制御する、前記粒子フィルタに近接して配置された掃去剤と、
前記電源と連通し、前記1対の電極に選択的に電圧を印加して前記電極間に1つ又は複数の放電を生じさせて前記反応チャンバ内に前記一酸化窒素を発生させるように構成されたコントローラと、を備え、
前記第2の壁は、装置を使って患者の気道に連結された呼吸管と係合する大きさとされ、前記反応チャンバは、一酸化窒素を前記第2の壁を通って被験者の気道に結合された前記呼吸管に向ける大きさとされる、
一酸化窒素を生成するための装置。 - 前記一酸化窒素は、前記第2の壁を通って前記被験者の気道に連結された前記呼吸管に非機械的に導かれる、請求項19に記載の装置。
- 前記反応チャンバは、前記1対の電極間の前記1つ又は複数の放電中に生じる輸送現象を利用して、前記一酸化窒素を前記第2の壁を通って前記被験者の前記気道に連結された前記呼吸管に導く、請求項19に記載の装置。
- 前記輸送現象が対流輸送を含む、請求項21に記載の装置。
- 前記反応チャンバは、前記一酸化窒素を前記呼吸管へ実質的に瞬時に送達するのを確実にするのに十分に小さい、請求項19に記載の装置。
- 前記1対の電極は、炭化タングステン、炭素、ニッケル、イリジウム、チタン、レニウム及び白金のうちの少なくとも1つを含む、請求項19に記載の装置。
- 前記1対の電極がイリジウムを含む、請求項19に記載の装置。
- 前記掃去剤が水酸化カルシウムから製造される、請求項19に記載の装置。
- 前記電源が共振高電圧電源を備える、請求項19に記載の装置。
- 前記電源が同期電源を含む、請求項19に記載の装置。
- 前記絶縁体がセラミック材料から製造される、請求項19に記載の装置。
- 前記粒子フィルタは、約0.22マイクロメートルを超える直径を有する粒子を取り除くように構成される、請求項19に記載の装置。
- 前記粒子フィルタがHEPAフィルタを備える、請求項19に記載の装置。
- 前記ハウジングが複数の層を含む、請求項19に記載の装置。
- 前記複数の層が第1の層、第2の層、及び第3の層を含み、前記第2の層は前記第1の層と前記第3の層との間に配置される、請求項32に記載の装置。
- 前記第1の層及び前記第3の層が、前記第2の層よりも低い熱伝導率を有する電気絶縁材料から製造される、請求項33に記載の装置。
- 前記第2の層がヒートシンクに接続される、請求項33に記載の装置。
- 前記コントローラが吸気の開始を検出するようにさらに構成される、請求項19に記載の装置。
- 前記コントローラは、前記吸気の開始が検出された後に前記1対の電極に選択的に電圧を印加して1つ又は複数の放電を達成するようにさらに構成される、請求項36に記載の装置。
- 被験者の気道に接続された呼吸管に連結される、一酸化窒素を生成するための装置であって、
凹部にアクセスするための開口部を有する第1の壁、及びガスの流れを通す前記呼吸管と流体連通する第2の壁を含むハウジングと、
前記凹部内に配置された絶縁体と、
前記ハウジング内に配置され、前記絶縁体に少なくとも部分的に係合する1対の電極と、
前記一対の電極に通電して一酸化窒素を生成する化学反応を凹部内に誘発する、前記1対の電極に接続された電源と、
前記第2の壁の周りで微粒子を取り除くように配置された粒子フィルタと、
前記1対の電極の動作によって誘発される化学反応からの望ましくない副生成物の量を制御する、前記粒子フィルタに近接して配置された掃去剤と、
患者の気道と1対の電極との間に配置され、一酸化窒素濃度、二酸化窒素濃度、酸素濃度、二酸化炭素濃度、及び/又は圧力のうちの少なくとも1つを測定する1つ又は複数のセンサと、
前記呼吸管内の流量を測定するように構成された流量計と、
前記電源、前記1つ又は複数のガスセンサ、及び前記流量計と連通し、前記1対の電極に通電して前記1対の電極間に1つ又は複数の放電を生じさせて前記ハウジング内に一酸化窒素を発生させるように構成された1対の電極と、
前記一酸化窒素を、前記ハウジングの第2の壁を通って前記呼吸管の中に非機械的に導くように構成された流路と、を備える
一酸化窒素を生成するための装置。 - 前記流路は、前記1対の電極間の前記1つ又は複数の放電中に生じる輸送現象を利用して、一酸化窒素を前記ハウジングの前記第2の壁を通って前記被験者の気道に非機械的に導く、請求項38に記載の装置。
- 前記輸送現象が対流輸送を含む、請求項39に記載の装置。
- 前記ハウジングと前記絶縁体との間の容積が、前記流路に沿って前記被験者の気道へ前記一酸化窒素を実質的に瞬間に送達するのに十分小さい反応チャンバを画定する、請求項38に記載の装置。
- 前記1つ又は複数のセンサと前記電極と前記患者の気道との間の流体連通を提供するサンプルラインをさらに備える、請求項38に記載の装置。
- 前記1つ又は複数のセンサが、それぞれ前記サンプルラインに配置され、一酸化窒素センサ、二酸化窒素センサ、酸素センサ、二酸化炭素センサ、及び圧力センサを含む、請求項42に記載の装置。
- 前記コントローラは、前記流量計及び前記1つ又は複数のセンサのうちの少なくとも1つからのフィードバックに基づいて前記患者の吸気を検出するようにさらに構成される、請求項38に記載の装置。
- 前記コントローラは、前記電源に前記電気信号を選択的に供給して、前記吸気の開始が検出された後に前記1つ又は複数の放電を開始し、前記吸気の終了前に前記電気信号を終了するようにさらに構成される、請求項44に記載の装置。
- 前記ハウジングが複数の層を含む、請求項38に記載の装置。
- 前記複数の層が第1の層、第2の層、及び第3の層を含み、前記第2の層が前記第1の層と前記第3の層との間に配置される、請求項46に記載の装置。
- 前記第1の層及び前記第3の層は、前記第2の層よりも低い熱伝導率を有する電気絶縁材料から製造される、請求項47に記載の装置。
- 前記第2の層がヒートシンクに接続されている、請求項47に記載の装置。
- 被験者の気道に連結された呼吸管内に一酸化窒素を発生させる方法であって、
前記呼吸管に一酸化窒素発生器を係合して、前記一酸化窒素発生器と前記呼吸管との間に流体連通を提供するステップと、
一酸化窒素生成器をトリガして一酸化窒素ガスの所望の濃度又は用量を生成するステップと、
所望の量の一酸化窒素ガスが生成されるように前記一酸化窒素発生器内に配置された1対の電極に送られる出力パラメータを決定するステップと、
前記出力パラメータを決定すると、前記出力パラメータを前記1対の電極に供給して前記所望の量の一酸化窒素ガスを生成するステップと、
前記発生した一酸化窒素ガスを前記一酸化窒素発生器から前記呼吸管の中に非機械的に導くステップと、が含まれる
一酸化窒素を発生させる方法。 - 前記一酸化窒素ガスが前記一酸化窒素発生器から導出されるように、前記生成された一酸化窒素ガス中の微粒子を粒子フィルタで取り除くステップをさらに含む、請求項50に記載の方法。
- 前記粒子フィルタがHEPAフィルタを備える、請求項51に記載の方法。
- 前記粒子フィルタが、約0.22マイクロメートルより大きな直径を有する粒子を取り除くように構成される、請求項51に記載の方法。
- 前記一酸化窒素ガスが前記一酸化窒素発生器から導出させつつ前記一酸化窒素ガスを掃去剤で掃気して、前記呼吸管に向けられた二酸化窒素ガス及びオゾンのうちの少なくとも1つの量を制御するステップをさらに含む、請求項50に記載の方法。
- 前記掃去剤が水酸化カルシウムを含む、請求項54に記載の方法。
- 一酸化窒素生成器をトリガして所望の濃度の一酸化窒素ガスを生成するステップに、
前記呼吸管内のガス流量、前記呼吸管内の温度、前記呼吸管内の圧力、前記呼吸管内の酸素濃度、及び前記呼吸管内の二酸化炭素濃度のうちの少なくとも1つを監視するステップと、
前記呼吸管内のガス流量、前記呼吸管内の温度、前記呼吸管内の圧力、前記呼吸管内の酸素濃度、及び前記呼吸管内の二酸化炭素濃度のうちの少なくとも1つの変化を検出するステップと、
検出された変化が被験体の吸気の徴候を示すものであると決定するステップと、が含まれる、請求項50に記載の方法。 - 前記一酸化窒素発生器と前記被験者の気道との間の前記呼吸管内の位置で、一酸化窒素濃度及び二酸化窒素濃度の少なくとも一方を取得するステップと、
前記一酸化窒素濃度及び前記二酸化窒素濃度の少なくとも一方が所望の濃度に等しくないことを決定するステップと、
前記一酸化窒素濃度及び前記二酸化窒素濃度の少なくとも一方が前記所望の濃度に等しくないと判定したことに応答して、前記1対の電極に供給される前記出力パラメータを変化させるステップと、がさらに含まれる、
請求項56に記載の方法。
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CN109310842A (zh) | 2019-02-05 |
BR112018069582A2 (pt) | 2019-01-22 |
WO2017165888A1 (en) | 2017-09-28 |
MX2018011433A (es) | 2019-01-10 |
EP3432965A4 (en) | 2019-11-20 |
EP3432965B1 (en) | 2021-09-29 |
RU2018137498A (ru) | 2020-04-27 |
RU2018137498A3 (ja) | 2020-06-18 |
CN109310842B (zh) | 2022-08-19 |
AU2017237252A1 (en) | 2018-10-11 |
CA3018379A1 (en) | 2017-09-28 |
US20200238041A1 (en) | 2020-07-30 |
JP2022068266A (ja) | 2022-05-09 |
RU2768488C2 (ru) | 2022-03-24 |
US11617850B2 (en) | 2023-04-04 |
EP3432965A1 (en) | 2019-01-30 |
KR20190005839A (ko) | 2019-01-16 |
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Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20211012 |