JP6680672B2 - 膣挿入されるエストラジオール薬学的組成物及び方法 - Google Patents

膣挿入されるエストラジオール薬学的組成物及び方法 Download PDF

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Publication number
JP6680672B2
JP6680672B2 JP2016516086A JP2016516086A JP6680672B2 JP 6680672 B2 JP6680672 B2 JP 6680672B2 JP 2016516086 A JP2016516086 A JP 2016516086A JP 2016516086 A JP2016516086 A JP 2016516086A JP 6680672 B2 JP6680672 B2 JP 6680672B2
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Japan
Prior art keywords
estradiol
pessary
vaginal
treatment
pharmaceutical composition
Prior art date
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JP2016516086A
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English (en)
Japanese (ja)
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JP2016534025A (ja
Inventor
エー バーニック ブライアン
エー バーニック ブライアン
トルステインソン トールスティン
トルステインソン トールスティン
エイチ アール ペルシカナー ピーター
エイチ アール ペルシカナー ピーター
ルイーズ カカセ ジャニス
ルイーズ カカセ ジャニス
エム アマディオ ジュリア
エム アマディオ ジュリア
ディー サンスキリオ フレデリック
ディー サンスキリオ フレデリック
イラニ ネダ
イラニ ネダ
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TherapeuticsMD Inc
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TherapeuticsMD Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/099,562 external-priority patent/US8987237B2/en
Application filed by TherapeuticsMD Inc filed Critical TherapeuticsMD Inc
Priority claimed from PCT/US2014/061811 external-priority patent/WO2015073177A1/en
Publication of JP2016534025A publication Critical patent/JP2016534025A/ja
Application granted granted Critical
Publication of JP6680672B2 publication Critical patent/JP6680672B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
JP2016516086A 2013-10-10 2014-10-22 膣挿入されるエストラジオール薬学的組成物及び方法 Active JP6680672B2 (ja)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201361889483P 2013-10-10 2013-10-10
US201361894411P 2013-10-22 2013-10-22
US61/894,411 2013-10-22
US14/099,562 2013-12-06
US14/099,562 US8987237B2 (en) 2011-11-23 2013-12-06 Natural combination hormone replacement formulations and therapies
US201461932140P 2014-01-27 2014-01-27
US61/932,140 2014-01-27
PCT/US2014/061811 WO2015073177A1 (en) 2013-10-10 2014-10-22 Vaginal inserted estradiol pharmaceutical compositons and methods

Publications (2)

Publication Number Publication Date
JP2016534025A JP2016534025A (ja) 2016-11-04
JP6680672B2 true JP6680672B2 (ja) 2020-04-15

Family

ID=55697531

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016516086A Active JP6680672B2 (ja) 2013-10-10 2014-10-22 膣挿入されるエストラジオール薬学的組成物及び方法

Country Status (8)

Country Link
EP (1) EP3060179A4 (he)
JP (1) JP6680672B2 (he)
KR (2) KR102335160B1 (he)
AU (3) AU2014349132A1 (he)
BR (1) BR112016009008B8 (he)
IL (1) IL245139B (he)
MX (1) MX2022002614A (he)
RU (1) RU2713888C2 (he)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2739558B1 (fr) * 1995-10-05 1997-11-28 Innothera Lab Sa Forme galenique unitaire pour hormonotherapie locale de la secheresse vaginale
FR2759292B1 (fr) * 1997-02-10 2000-08-11 Cird Galderma Utilisation de retinoides en tant qu'agents induisant la pigmentation
EP1030629A4 (en) * 1997-11-03 2001-09-05 Deschutes Medical Products Inc PESSAR WITH A CARTRIDGE CONTAINING DRUGS
CA2293605A1 (en) * 1998-04-11 1999-10-21 Paolo Luca Maria Giorgetti Pharmaceutical preparations containing hydrosoluble ketoprofen salts and their application
EP1441707A1 (en) * 2001-11-09 2004-08-04 Pharmacia AB Anti-muscarinic agent and estrogen-agonist for treating unstable or overactive bladder
AU2003290071A1 (en) * 2002-12-18 2004-07-09 Ferrer Internacional, S.A. Pharmaceutical compositions of sertaconazole for vaginal use
US20060040904A1 (en) * 2004-08-17 2006-02-23 Ahmed Salah U Vaginal cream compositions, kits thereof and methods of using thereof
BRPI0614625A2 (pt) * 2005-08-12 2011-04-12 Drugtech Corp composição farmacêutica que compreende pelo menos um composto estrogênico, sistema de distribuição de estrogênio vaginal, uso de uma composição e kit que compreende uma pluralidade de cremes vaginais
EP1872775A1 (en) * 2006-06-29 2008-01-02 Polichem S.A. Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders
PT2782584T (pt) * 2011-11-23 2021-09-02 Therapeuticsmd Inc Preparações e terapias de substituição para hormonoterapias naturais combinadas
WO2013112947A1 (en) * 2012-01-26 2013-08-01 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
WO2013130535A1 (en) * 2012-02-27 2013-09-06 Newgen Biopharma Corporation Topical delivery of hormonal and non hormonal nano formulations, methods of making and using the same

Also Published As

Publication number Publication date
RU2016118396A (ru) 2017-11-28
IL245139B (he) 2020-08-31
KR20210148435A (ko) 2021-12-07
BR112016009008B1 (pt) 2022-09-06
MX2022002614A (es) 2022-04-11
EP3060179A1 (en) 2016-08-31
JP2016534025A (ja) 2016-11-04
AU2014349132A1 (en) 2016-04-14
BR112016009008B8 (pt) 2023-01-31
RU2016118396A3 (he) 2018-07-17
IL245139A0 (he) 2016-06-30
AU2014349132A8 (en) 2016-07-14
AU2021218231A1 (en) 2021-09-09
AU2019204658B2 (en) 2021-05-20
KR102488424B1 (ko) 2023-01-12
BR112016009008A2 (he) 2017-08-01
KR20160062097A (ko) 2016-06-01
RU2713888C2 (ru) 2020-02-10
EP3060179A4 (en) 2017-05-17
KR102335160B1 (ko) 2021-12-03
AU2019204658A1 (en) 2019-07-18

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