JP6672157B2 - 肥満を処置するための化合物およびその使用方法 - Google Patents

肥満を処置するための化合物およびその使用方法 Download PDF

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Publication number
JP6672157B2
JP6672157B2 JP2016554826A JP2016554826A JP6672157B2 JP 6672157 B2 JP6672157 B2 JP 6672157B2 JP 2016554826 A JP2016554826 A JP 2016554826A JP 2016554826 A JP2016554826 A JP 2016554826A JP 6672157 B2 JP6672157 B2 JP 6672157B2
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Japan
Prior art keywords
obese
pharmaceutical formulation
administered
formulation
leptin
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English (en)
Japanese (ja)
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JP2016537431A (ja
JP2016537431A5 (OSRAM
Inventor
ウムット オズカン，
ウムット オズカン，
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Boston Childrens Hospital
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Boston Childrens Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016554826A 2013-11-26 2014-11-25 肥満を処置するための化合物およびその使用方法 Active JP6672157B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361908998P 2013-11-26 2013-11-26
US61/908,998 2013-11-26
PCT/US2014/067393 WO2015081093A1 (en) 2013-11-26 2014-11-25 Compounds for the treatment of obesity and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019226600A Division JP2020059744A (ja) 2013-11-26 2019-12-16 肥満を処置するための化合物およびその使用方法

Publications (3)

Publication Number Publication Date
JP2016537431A JP2016537431A (ja) 2016-12-01
JP2016537431A5 JP2016537431A5 (OSRAM) 2017-11-24
JP6672157B2 true JP6672157B2 (ja) 2020-03-25

Family

ID=52134396

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016554826A Active JP6672157B2 (ja) 2013-11-26 2014-11-25 肥満を処置するための化合物およびその使用方法
JP2019226600A Pending JP2020059744A (ja) 2013-11-26 2019-12-16 肥満を処置するための化合物およびその使用方法

Family Applications After (1)

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JP2019226600A Pending JP2020059744A (ja) 2013-11-26 2019-12-16 肥満を処置するための化合物およびその使用方法

Country Status (18)

Country Link
US (1) US20160375039A1 (OSRAM)
EP (1) EP3074033B1 (OSRAM)
JP (2) JP6672157B2 (OSRAM)
AU (2) AU2014354831B2 (OSRAM)
CA (1) CA2931826C (OSRAM)
CY (1) CY1122551T1 (OSRAM)
DK (1) DK3074033T3 (OSRAM)
ES (1) ES2709976T3 (OSRAM)
HR (1) HRP20190219T1 (OSRAM)
HU (1) HUE042196T2 (OSRAM)
LT (1) LT3074033T (OSRAM)
PL (1) PL3074033T3 (OSRAM)
PT (1) PT3074033T (OSRAM)
RS (1) RS58422B1 (OSRAM)
SI (1) SI3074033T1 (OSRAM)
SM (1) SMT201900064T1 (OSRAM)
TR (1) TR201901299T4 (OSRAM)
WO (1) WO2015081093A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015153933A1 (en) * 2014-04-03 2015-10-08 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
CN106008657B (zh) * 2016-05-20 2017-11-21 天津中医药大学 苦蘵苦素i及提取方法及用途
IT201800005336A1 (it) * 2018-05-14 2019-11-14 Composizioni per uso nel trattamento dell’obesità
WO2021072139A1 (en) * 2019-10-11 2021-04-15 Massachusetts Institute Of Technology Formulations for gastrointestinal delivery of oligonucleotides
CN113599502A (zh) * 2021-07-22 2021-11-05 廖儒佳 一种醉茄素a和瘦素的组合物及其在制备预防和或治疗出血性脑卒中药物中的应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA791659B (en) 1978-04-17 1980-04-30 Ici Ltd Process and apparatus for spraying liquid
GB8504253D0 (en) 1985-02-19 1985-03-20 Ici Plc Electrostatic spraying apparatus
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
MY107937A (en) 1990-02-13 1996-06-29 Takeda Chemical Industries Ltd Prolonged release microcapsules.
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
US6429290B1 (en) 1994-08-17 2002-08-06 The Rockefeller University OB polypeptides, modified forms and derivatives
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US5827734A (en) 1995-01-20 1998-10-27 University Of Washington Materials and methods for determining ob protein in a biological sample
US5552522A (en) 1995-01-31 1996-09-03 Eli Lilly And Company Anti-obesity proteins
US5552524A (en) 1995-01-31 1996-09-03 Eli Lilly And Company Anti-obesity proteins
US5552523A (en) 1995-01-31 1996-09-03 Eli Lilly And Company Anti-obesity proteins
US5532336A (en) 1995-01-31 1996-07-02 Eli Lilly And Company Anti-obesity proteins
US5521283A (en) 1995-01-31 1996-05-28 Eli Lilly And Company Anti-obesity proteins
WO1996040912A1 (en) 1995-06-07 1996-12-19 Amgen Inc. Ob protein compositions and method
IL122718A0 (en) 1995-06-30 1998-08-16 Lilly Co Eli Methods for treating diabetes
EP0865294B1 (en) 1995-08-17 2004-02-18 Amgen Inc. Methods of reducing or maintaining reduced levels of blood lipids using ob protein compositions
US20030040467A1 (en) 1998-06-15 2003-02-27 Mary Ann Pelleymounter Ig/ob fusions and uses thereof.
ES2217327T3 (es) 1995-11-22 2004-11-01 Amgen Inc., Proteina ob para aumentar la masa de tejido magro.
US6936439B2 (en) 1995-11-22 2005-08-30 Amgen Inc. OB fusion protein compositions and methods
WO1997038014A1 (en) 1996-04-04 1997-10-16 Amgen Inc. Fibulin pharmaceutical compositions and related methods
CA2258504A1 (en) * 1996-06-20 1997-12-24 Merck & Co., Inc. Gene therapy for obesity
JP2001501177A (ja) 1996-08-30 2001-01-30 アムジエン・インコーポレーテツド Ｏｂタンパク質受容体をアップレギュレートすることによりｏｂタンパク質に対する個体の感受性を増加させる方法
BR9711513A (pt) 1996-09-20 1999-08-24 Hoechst Ag Uso de antagonistas de leptina para o tratamento de resistencia a insulina em diabete do tipo ii
EP0839525B1 (en) 1996-10-31 2004-08-04 Takeda Chemical Industries, Ltd. Sustained-release preparation
EA004790B1 (ru) 1996-12-20 2004-08-26 Амген Инк. Композиции на основе слитого белка ов и способы их применения
ATE223229T1 (de) 1997-04-17 2002-09-15 Amgen Inc Zusammensetzungen aus konjugaten des stabilen, aktiven, menschlichen ob proteins mit der fc kette von immunoglobulinen und damit zusammenhängende verfahren
TR199902980T2 (xx) 1997-06-06 2000-05-22 Smithkline Beecham P.L.C. Diabetin tedavisi i�in leptin antagonistlerinin kullan�m�.
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6541033B1 (en) 1998-06-30 2003-04-01 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of leptin
PT1107793E (pt) 1998-08-10 2005-02-28 Amgen Inc Conjugados de dextrano-leptina, composicoes farmaceuticas e processos relacionados
AU6396999A (en) 1998-10-02 2000-04-26 Amgen, Inc. Method to determine a predisposition to leptin treatment
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
CA2359840C (en) 1999-02-12 2012-10-23 Amgen Inc. Glycosylated leptin compositions and related methods
PL214862B1 (pl) 2001-10-22 2013-09-30 Amgen Sposób in vitro do okreslania predyspozycji pacjenta ludzkiego z lipoatrofia do reagowania na leczenie bialkiem leptyny, kompozycje farmaceutyczne do zastosowania do leczenia lipoatrofii i kompozycje farmaceutyczne zawierajace bialko leptyny
WO2004039832A2 (en) 2002-10-31 2004-05-13 Albany Medical College Leptin-related peptides
JP4585186B2 (ja) * 2003-07-31 2010-11-24 杏林製薬株式会社 肥満、糖尿病及び脂質代謝異常の新規な予防又は治療剤
JP2009541423A (ja) * 2006-06-23 2009-11-26 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ コリンエステラーゼ阻害剤と５‐ｈｔ６レセプター親和性の化合物との組合せ
US20110230551A1 (en) * 2008-09-15 2011-09-22 Leslie Gunatilaka Withaferin a analogs and uses thereof
WO2010053655A2 (en) * 2008-11-07 2010-05-14 University Of Kansas Therapeutic methods with withaferin a and analogs
US8598339B2 (en) * 2011-02-01 2013-12-03 University Of Kansas Withanolide isolated from Physalis longifolia and analogs and methods of use thereof

Also Published As

Publication number Publication date
HUE042196T2 (hu) 2019-06-28
EP3074033B1 (en) 2018-11-07
RS58422B1 (sr) 2019-04-30
AU2018200517A1 (en) 2018-02-15
ES2709976T3 (es) 2019-04-22
SI3074033T1 (sl) 2019-03-29
US20160375039A1 (en) 2016-12-29
LT3074033T (lt) 2019-02-25
DK3074033T3 (en) 2019-02-11
WO2015081093A1 (en) 2015-06-04
AU2014354831B2 (en) 2017-10-26
CY1122551T1 (el) 2021-01-27
CA2931826A1 (en) 2015-06-04
AU2014354831A1 (en) 2016-06-09
EP3074033A1 (en) 2016-10-05
PL3074033T3 (pl) 2019-08-30
JP2016537431A (ja) 2016-12-01
SMT201900064T1 (it) 2019-02-28
JP2020059744A (ja) 2020-04-16
HRP20190219T1 (hr) 2019-03-22
TR201901299T4 (tr) 2019-02-21
AU2018200517B2 (en) 2019-12-19
CA2931826C (en) 2021-11-16
PT3074033T (pt) 2019-02-08

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