JP6660053B2 - エンドリーク発生防止剤 - Google Patents
エンドリーク発生防止剤 Download PDFInfo
- Publication number
- JP6660053B2 JP6660053B2 JP2018128554A JP2018128554A JP6660053B2 JP 6660053 B2 JP6660053 B2 JP 6660053B2 JP 2018128554 A JP2018128554 A JP 2018128554A JP 2018128554 A JP2018128554 A JP 2018128554A JP 6660053 B2 JP6660053 B2 JP 6660053B2
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- JP
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- Prior art keywords
- cilostazol
- aneurysm
- group
- shows
- endoleak
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
Landscapes
- Prostheses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
(1) シロスタゾール又はその薬学的に許容される塩を有効成分とし、ステントグラフトを内挿された動脈瘤における瘤内への血液の流入を防止するために用いられる、エンドリーク発生防止剤。
(2) 1日当たりの投与量が、シロスタゾール換算で50〜300mgである、前記(1)のエンドリーク発生防止剤。
腹部大動脈瘤にEVARを施行した患者94名をランダムに2群に分け、一方の群にシロスタゾールを投与し(シロスタゾール群)、他方の群にはシロスタゾールを投与せず(非シロスタゾール群)、2年間、エンドリークの有無、動脈瘤の大きさ、血液中の脂質(中性脂肪(TG)、総コレステロール(T−Chol)、高密度リポタンパク質(HDL)、低密度リポタンパク質(LDL))について経過観察を行った。なお、当該試験は、国立大学法人浜松医科大学の倫理委員会の承認を得て、予め試験内容の説明を行って試験参加の同意を得た患者に対して行った。各群の患者背景を表1に示す。各群の患者背景には特段の差はなかった。
Claims (2)
- シロスタゾール又はその薬学的に許容される塩を有効成分とし、ステントグラフトを内挿された動脈瘤における瘤内への血液の流入を防止するために用いられる、エンドリーク発生防止剤。
- 1日当たりの投与量が、シロスタゾール換算で50〜300mgである、請求項1に記載のエンドリーク発生防止剤。
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