JP6652497B2 - 組換え単純ヘルペスウィルス2(hsv−2)ワクチンベクター - Google Patents

組換え単純ヘルペスウィルス2(hsv−2)ワクチンベクター Download PDF

Info

Publication number
JP6652497B2
JP6652497B2 JP2016555659A JP2016555659A JP6652497B2 JP 6652497 B2 JP6652497 B2 JP 6652497B2 JP 2016555659 A JP2016555659 A JP 2016555659A JP 2016555659 A JP2016555659 A JP 2016555659A JP 6652497 B2 JP6652497 B2 JP 6652497B2
Authority
JP
Japan
Prior art keywords
hsv
glycoprotein
virus
vaccine
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016555659A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017510262A5 (enExample
JP2017510262A (ja
Inventor
ジェーコブス、ウィリアム
ゴンサレス・ムノス、パブロ・エイ
ヘロルド、ベッツィ
ペトロ、クリストファー
Original Assignee
アルバート アインシュタイン カレッジ オブ メディシン
アルバート アインシュタイン カレッジ オブ メディシン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アルバート アインシュタイン カレッジ オブ メディシン, アルバート アインシュタイン カレッジ オブ メディシン filed Critical アルバート アインシュタイン カレッジ オブ メディシン
Publication of JP2017510262A publication Critical patent/JP2017510262A/ja
Publication of JP2017510262A5 publication Critical patent/JP2017510262A5/ja
Application granted granted Critical
Publication of JP6652497B2 publication Critical patent/JP6652497B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • C07K16/087Herpes simplex virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/245Herpetoviridae, e.g. herpes simplex virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16621Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16661Methods of inactivation or attenuation
    • C12N2710/16662Methods of inactivation or attenuation by genetic engineering
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16671Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016555659A 2014-03-03 2015-03-02 組換え単純ヘルペスウィルス2(hsv−2)ワクチンベクター Active JP6652497B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461946965P 2014-03-03 2014-03-03
US61/946,965 2014-03-03
US201462080663P 2014-11-17 2014-11-17
US62/080,663 2014-11-17
PCT/US2015/018272 WO2015134368A2 (en) 2014-03-03 2015-03-02 Recombinant herpes simplex virus 2 (hsv-2) vaccine vectors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020009043A Division JP6844045B2 (ja) 2014-03-03 2020-01-23 組換え単純ヘルペスウィルス2(hsv−2)ワクチンベクター

Publications (3)

Publication Number Publication Date
JP2017510262A JP2017510262A (ja) 2017-04-13
JP2017510262A5 JP2017510262A5 (enExample) 2018-04-12
JP6652497B2 true JP6652497B2 (ja) 2020-02-26

Family

ID=54055977

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016555659A Active JP6652497B2 (ja) 2014-03-03 2015-03-02 組換え単純ヘルペスウィルス2(hsv−2)ワクチンベクター
JP2020009043A Active JP6844045B2 (ja) 2014-03-03 2020-01-23 組換え単純ヘルペスウィルス2(hsv−2)ワクチンベクター
JP2021026943A Active JP7050193B2 (ja) 2014-03-03 2021-02-24 組換え単純ヘルペスウィルス2(hsv-2)ワクチンベクター

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020009043A Active JP6844045B2 (ja) 2014-03-03 2020-01-23 組換え単純ヘルペスウィルス2(hsv−2)ワクチンベクター
JP2021026943A Active JP7050193B2 (ja) 2014-03-03 2021-02-24 組換え単純ヘルペスウィルス2(hsv-2)ワクチンベクター

Country Status (7)

Country Link
US (5) US9999665B2 (enExample)
EP (2) EP3113801B1 (enExample)
JP (3) JP6652497B2 (enExample)
CN (2) CN106456805B (enExample)
AU (2) AU2015225499B2 (enExample)
CA (1) CA2942166A1 (enExample)
WO (1) WO2015134368A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106456805B (zh) 2014-03-03 2020-01-10 阿尔伯特爱因斯坦医学院公司 重组单纯疱疹病毒2(hsv-2)疫苗载体
US10918712B2 (en) * 2014-03-03 2021-02-16 Albert Einstein College Of Medicine Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors
CA3095187A1 (en) 2018-04-27 2019-10-31 Krystal Biotech, Inc. Recombinant nucleic acids encoding cosmetic protein(s) for aesthetic applications
US20210236625A1 (en) * 2018-05-01 2021-08-05 Albert Einstein College Of Medicine HSV-2-DELTA-gD VACCINES AND METHODS FOR THEIR PRODUCTION AND USE
WO2020056411A1 (en) * 2018-09-14 2020-03-19 Excell Biotech, Llc Recombinant herpes simplex virus 1 (hsv-1)
IL282135B2 (en) * 2018-10-17 2025-06-01 Albert Einstein College Medicine Method of enhancing antibody-dependent cell-mediated cytotoxicity (adcc
EP3906052A1 (en) * 2019-01-03 2021-11-10 Albert Einstein College of Medicine Passive transfer of immunity using recombinant herpes simplex virus 2 (hsv-2) vaccine vectors
US20230111803A1 (en) * 2020-04-07 2023-04-13 Albert Einstein College Of Medicine Method of treating and preventing ocular disease with hsv-2 delta gd
IL298288B2 (en) * 2020-05-29 2025-03-01 Albert Einstein College Medicine Methods for using Delta-gD of single-stranded HSV-2 virus and recombinant HSV-2 glycoprotein D
JP2023542535A (ja) 2020-09-24 2023-10-10 アルベルト・アインシュタイン・カレッジ・オブ・メディシン Attb細胞系、それに由来するトランスジェニック細胞系、およびそれらを製造する方法
WO2023245159A1 (en) * 2022-06-16 2023-12-21 Albert Einstein College Of Medicine Recombinant herpes simplex virus 2 (hsv-2) vectors and engineered transgenic vero cell lines
EP4565270A4 (en) * 2022-08-05 2025-11-19 Immvira Biopharmaceuticals Co Ltd HERPES SIMPLEX VIRUS TYPE 1 VACCINE INCOMPETENT FOR REPLICATION
WO2024081865A2 (en) * 2022-10-14 2024-04-18 Arizona Board Of Regents On Behalf Of Arizona State University Recombinant immune complexes targeting herpes simplex virus
WO2025231288A2 (en) 2024-05-01 2025-11-06 Viradigm, Inc. Hsv vectors having improved safety profiles

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT77014B (en) * 1982-07-20 1986-01-24 Molecular Genetics Inc Production of herpes simplex viral proteins
NZ209308A (en) * 1983-08-30 1991-08-27 Genentech Inc Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein
US4810634A (en) * 1985-07-29 1989-03-07 The Upjohn Company Pseudorabies virus mutants incapable of producing glycoprotein X
US5646041A (en) * 1987-02-12 1997-07-08 Harfeldt; Elisabeth Monoclonal antibody to herpes simplex virus and cell line producing same
JPH08507784A (ja) * 1993-03-19 1996-08-20 キャンタブ ファーマシューティカルズ リサーチ リミティド ウイルス・ワクチン
US20030083289A1 (en) * 1995-10-19 2003-05-01 Boursnell Michael Edward Griffith Herpesvirus vectors and their uses
CN1120238C (zh) * 1998-05-04 2003-09-03 本元正阳基因技术股份有限公司 以粘粒为基础构建重组单纯疱疹病毒及其用途
EP1238086B1 (en) * 1999-12-17 2006-03-08 Wyeth Holdings Corporation Vaccine for enhancing immune responses to herpes simplex virus
WO2005005637A2 (en) * 2003-05-09 2005-01-20 Medigene, Inc. Herpes simplex virus comprising a genetically modified glycoprotein d
US6984492B2 (en) * 2003-09-05 2006-01-10 Talecris Biotherapeutics, Inc. Methods and compositions for treating herpes infections
WO2006004878A1 (en) * 2004-06-29 2006-01-12 Wyeth Attenuated herpes simplex virus type-2, vectors thereof and immunogenic compositions thereof
EP1774447A2 (en) 2004-07-26 2007-04-18 Koninklijke Philips Electronics N.V. Decision support system for simulating execution of an executable clinical guideline
US8865185B2 (en) * 2006-09-08 2014-10-21 The Trustees Of The University Of Pennsylvania Methods of use for HSV-1 and HSV-2 vaccines
CA2663109A1 (en) * 2006-09-08 2008-03-13 The Trustees Of The University Of Pennsylvania Hsv-1 and hsv-2 vaccines and methods of use thereof
JP6144448B2 (ja) * 2006-12-28 2017-06-07 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 単純ヘルペスウイルス複合サブユニットワクチンおよびその使用方法
EP2240595B2 (en) * 2008-01-03 2019-07-24 Cornell Research Foundation, Inc. Glycosylated protein expression in prokaryotes
CN101288770A (zh) * 2008-03-14 2008-10-22 浙江省医学科学院 新型单纯疱疹病毒ⅱ型dna疫苗
ES2732815T3 (es) * 2009-05-22 2019-11-26 Genocea Biosciences Inc Vacunas frente al virus del herpes simple de tipo 2: composiciones y métodos para provocar una respuesta inmunitaria
CN102695524B (zh) * 2009-09-18 2014-07-09 弗劳恩霍费尔美国股份有限公司 包含与植物病毒衣壳蛋白融合的靶蛋白的病毒样颗粒
CN106456805B (zh) * 2014-03-03 2020-01-10 阿尔伯特爱因斯坦医学院公司 重组单纯疱疹病毒2(hsv-2)疫苗载体
US10918712B2 (en) 2014-03-03 2021-02-16 Albert Einstein College Of Medicine Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors

Also Published As

Publication number Publication date
CA2942166A1 (en) 2015-09-11
US10391165B2 (en) 2019-08-27
JP2020079245A (ja) 2020-05-28
AU2020217310B2 (en) 2023-07-13
JP6844045B2 (ja) 2021-03-17
AU2020217310A1 (en) 2020-08-27
EP3113801A4 (en) 2017-10-25
CN106456805B (zh) 2020-01-10
EP3943106A1 (en) 2022-01-26
EP3113801A2 (en) 2017-01-11
US10751411B2 (en) 2020-08-25
CN106456805A (zh) 2017-02-22
US20170202952A1 (en) 2017-07-20
US20200376114A1 (en) 2020-12-03
JP2021088590A (ja) 2021-06-10
US10076568B2 (en) 2018-09-18
US9999665B2 (en) 2018-06-19
US20190111127A1 (en) 2019-04-18
WO2015134368A2 (en) 2015-09-11
WO2015134368A3 (en) 2015-11-26
US20200023058A1 (en) 2020-01-23
CN110938604B (zh) 2024-04-05
AU2015225499B2 (en) 2020-05-14
JP7050193B2 (ja) 2022-04-07
JP2017510262A (ja) 2017-04-13
EP3113801B1 (en) 2020-10-07
AU2015225499A1 (en) 2016-10-20
US20160158343A1 (en) 2016-06-09
US10980874B2 (en) 2021-04-20
CN110938604A (zh) 2020-03-31

Similar Documents

Publication Publication Date Title
JP7050193B2 (ja) 組換え単純ヘルペスウィルス2(hsv-2)ワクチンベクター
US20170028058A1 (en) Herpes simplex virus vaccines
US10918712B2 (en) Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors
JP2024016032A (ja) 組み換え単純ヘルペスウイルス2(hsv-2)ワクチンベクターを使用する免疫の受動伝達
US20220088185A1 (en) Passive transfer of immunity using recombinant herpes simplex virus 2 (hsv-2) vaccine vectors
HK40022690B (zh) 重组单纯疱疹病毒2(hsv-2)疫苗载体
HK1229721B (zh) 重组单纯疱疹病毒2(hsv-2)疫苗载体
WO2023245159A1 (en) Recombinant herpes simplex virus 2 (hsv-2) vectors and engineered transgenic vero cell lines
HK40022690A (en) Recombinant herpes simplex virus 2 (hsv-2) vaccine vectors
HK1229721A1 (en) Recombinant herpes simplex virus 2 (hsv-2) vaccine vectors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180301

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180301

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20190121

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190129

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190422

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190628

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190725

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20191224

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200123

R150 Certificate of patent or registration of utility model

Ref document number: 6652497

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250