JP2017510262A5 - - Google Patents
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- Publication number
- JP2017510262A5 JP2017510262A5 JP2016555659A JP2016555659A JP2017510262A5 JP 2017510262 A5 JP2017510262 A5 JP 2017510262A5 JP 2016555659 A JP2016555659 A JP 2016555659A JP 2016555659 A JP2016555659 A JP 2016555659A JP 2017510262 A5 JP2017510262 A5 JP 2017510262A5
- Authority
- JP
- Japan
- Prior art keywords
- hsv
- recombinant
- glycoprotein
- herpes simplex
- simplex virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 43
- 108010090054 Membrane Glycoproteins Proteins 0.000 claims 12
- 102000012750 Membrane Glycoproteins Human genes 0.000 claims 12
- 239000000232 Lipid Bilayer Substances 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000003886 Glycoproteins Human genes 0.000 claims 6
- 108090000288 Glycoproteins Proteins 0.000 claims 6
- 229960005486 vaccine Drugs 0.000 claims 5
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 4
- 229920002978 Vinylon Polymers 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 210000000170 cell membrane Anatomy 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 244000045947 parasite Species 0.000 claims 3
- 210000002845 virion Anatomy 0.000 claims 3
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102100022717 Atypical chemokine receptor 1 Human genes 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 208000037952 HSV-1 infection Diseases 0.000 claims 1
- 101000678879 Homo sapiens Atypical chemokine receptor 1 Proteins 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461946965P | 2014-03-03 | 2014-03-03 | |
| US61/946,965 | 2014-03-03 | ||
| US201462080663P | 2014-11-17 | 2014-11-17 | |
| US62/080,663 | 2014-11-17 | ||
| PCT/US2015/018272 WO2015134368A2 (en) | 2014-03-03 | 2015-03-02 | Recombinant herpes simplex virus 2 (hsv-2) vaccine vectors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020009043A Division JP6844045B2 (ja) | 2014-03-03 | 2020-01-23 | 組換え単純ヘルペスウィルス２（ｈｓｖ−２）ワクチンベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510262A JP2017510262A (ja) | 2017-04-13 |
| JP2017510262A5 true JP2017510262A5 (enExample) | 2018-04-12 |
| JP6652497B2 JP6652497B2 (ja) | 2020-02-26 |
Family
ID=54055977
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555659A Active JP6652497B2 (ja) | 2014-03-03 | 2015-03-02 | 組換え単純ヘルペスウィルス２（ｈｓｖ−２）ワクチンベクター |
| JP2020009043A Active JP6844045B2 (ja) | 2014-03-03 | 2020-01-23 | 組換え単純ヘルペスウィルス２（ｈｓｖ−２）ワクチンベクター |
| JP2021026943A Active JP7050193B2 (ja) | 2014-03-03 | 2021-02-24 | 組換え単純ヘルペスウィルス２（ｈｓｖ－２）ワクチンベクター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020009043A Active JP6844045B2 (ja) | 2014-03-03 | 2020-01-23 | 組換え単純ヘルペスウィルス２（ｈｓｖ−２）ワクチンベクター |
| JP2021026943A Active JP7050193B2 (ja) | 2014-03-03 | 2021-02-24 | 組換え単純ヘルペスウィルス２（ｈｓｖ－２）ワクチンベクター |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US9999665B2 (enExample) |
| EP (2) | EP3113801B1 (enExample) |
| JP (3) | JP6652497B2 (enExample) |
| CN (2) | CN106456805B (enExample) |
| AU (2) | AU2015225499B2 (enExample) |
| CA (1) | CA2942166A1 (enExample) |
| WO (1) | WO2015134368A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106456805B (zh) | 2014-03-03 | 2020-01-10 | 阿尔伯特爱因斯坦医学院公司 | 重组单纯疱疹病毒2(hsv-2)疫苗载体 |
| US10918712B2 (en) * | 2014-03-03 | 2021-02-16 | Albert Einstein College Of Medicine | Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors |
| CA3095187A1 (en) | 2018-04-27 | 2019-10-31 | Krystal Biotech, Inc. | Recombinant nucleic acids encoding cosmetic protein(s) for aesthetic applications |
| US20210236625A1 (en) * | 2018-05-01 | 2021-08-05 | Albert Einstein College Of Medicine | HSV-2-DELTA-gD VACCINES AND METHODS FOR THEIR PRODUCTION AND USE |
| WO2020056411A1 (en) * | 2018-09-14 | 2020-03-19 | Excell Biotech, Llc | Recombinant herpes simplex virus 1 (hsv-1) |
| IL282135B2 (en) * | 2018-10-17 | 2025-06-01 | Albert Einstein College Medicine | Method of enhancing antibody-dependent cell-mediated cytotoxicity (adcc |
| EP3906052A1 (en) * | 2019-01-03 | 2021-11-10 | Albert Einstein College of Medicine | Passive transfer of immunity using recombinant herpes simplex virus 2 (hsv-2) vaccine vectors |
| US20230111803A1 (en) * | 2020-04-07 | 2023-04-13 | Albert Einstein College Of Medicine | Method of treating and preventing ocular disease with hsv-2 delta gd |
| IL298288B2 (en) * | 2020-05-29 | 2025-03-01 | Albert Einstein College Medicine | Methods for using Delta-gD of single-stranded HSV-2 virus and recombinant HSV-2 glycoprotein D |
| JP2023542535A (ja) | 2020-09-24 | 2023-10-10 | アルベルト・アインシュタイン・カレッジ・オブ・メディシン | Ａｔｔｂ細胞系、それに由来するトランスジェニック細胞系、およびそれらを製造する方法 |
| WO2023245159A1 (en) * | 2022-06-16 | 2023-12-21 | Albert Einstein College Of Medicine | Recombinant herpes simplex virus 2 (hsv-2) vectors and engineered transgenic vero cell lines |
| EP4565270A4 (en) * | 2022-08-05 | 2025-11-19 | Immvira Biopharmaceuticals Co Ltd | HERPES SIMPLEX VIRUS TYPE 1 VACCINE INCOMPETENT FOR REPLICATION |
| WO2024081865A2 (en) * | 2022-10-14 | 2024-04-18 | Arizona Board Of Regents On Behalf Of Arizona State University | Recombinant immune complexes targeting herpes simplex virus |
| WO2025231288A2 (en) | 2024-05-01 | 2025-11-06 | Viradigm, Inc. | Hsv vectors having improved safety profiles |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT77014B (en) * | 1982-07-20 | 1986-01-24 | Molecular Genetics Inc | Production of herpes simplex viral proteins |
| NZ209308A (en) * | 1983-08-30 | 1991-08-27 | Genentech Inc | Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein |
| US4810634A (en) * | 1985-07-29 | 1989-03-07 | The Upjohn Company | Pseudorabies virus mutants incapable of producing glycoprotein X |
| US5646041A (en) * | 1987-02-12 | 1997-07-08 | Harfeldt; Elisabeth | Monoclonal antibody to herpes simplex virus and cell line producing same |
| JPH08507784A (ja) * | 1993-03-19 | 1996-08-20 | キャンタブ ファーマシューティカルズ リサーチ リミティド | ウイルス・ワクチン |
| US20030083289A1 (en) * | 1995-10-19 | 2003-05-01 | Boursnell Michael Edward Griffith | Herpesvirus vectors and their uses |
| CN1120238C (zh) * | 1998-05-04 | 2003-09-03 | 本元正阳基因技术股份有限公司 | 以粘粒为基础构建重组单纯疱疹病毒及其用途 |
| EP1238086B1 (en) * | 1999-12-17 | 2006-03-08 | Wyeth Holdings Corporation | Vaccine for enhancing immune responses to herpes simplex virus |
| WO2005005637A2 (en) * | 2003-05-09 | 2005-01-20 | Medigene, Inc. | Herpes simplex virus comprising a genetically modified glycoprotein d |
| US6984492B2 (en) * | 2003-09-05 | 2006-01-10 | Talecris Biotherapeutics, Inc. | Methods and compositions for treating herpes infections |
| WO2006004878A1 (en) * | 2004-06-29 | 2006-01-12 | Wyeth | Attenuated herpes simplex virus type-2, vectors thereof and immunogenic compositions thereof |
| EP1774447A2 (en) | 2004-07-26 | 2007-04-18 | Koninklijke Philips Electronics N.V. | Decision support system for simulating execution of an executable clinical guideline |
| US8865185B2 (en) * | 2006-09-08 | 2014-10-21 | The Trustees Of The University Of Pennsylvania | Methods of use for HSV-1 and HSV-2 vaccines |
| CA2663109A1 (en) * | 2006-09-08 | 2008-03-13 | The Trustees Of The University Of Pennsylvania | Hsv-1 and hsv-2 vaccines and methods of use thereof |
| JP6144448B2 (ja) * | 2006-12-28 | 2017-06-07 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 単純ヘルペスウイルス複合サブユニットワクチンおよびその使用方法 |
| EP2240595B2 (en) * | 2008-01-03 | 2019-07-24 | Cornell Research Foundation, Inc. | Glycosylated protein expression in prokaryotes |
| CN101288770A (zh) * | 2008-03-14 | 2008-10-22 | 浙江省医学科学院 | 新型单纯疱疹病毒ⅱ型dna疫苗 |
| ES2732815T3 (es) * | 2009-05-22 | 2019-11-26 | Genocea Biosciences Inc | Vacunas frente al virus del herpes simple de tipo 2: composiciones y métodos para provocar una respuesta inmunitaria |
| CN102695524B (zh) * | 2009-09-18 | 2014-07-09 | 弗劳恩霍费尔美国股份有限公司 | 包含与植物病毒衣壳蛋白融合的靶蛋白的病毒样颗粒 |
| CN106456805B (zh) * | 2014-03-03 | 2020-01-10 | 阿尔伯特爱因斯坦医学院公司 | 重组单纯疱疹病毒2(hsv-2)疫苗载体 |
| US10918712B2 (en) | 2014-03-03 | 2021-02-16 | Albert Einstein College Of Medicine | Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors |
-
2015
- 2015-03-02 CN CN201580022222.6A patent/CN106456805B/zh active Active
- 2015-03-02 WO PCT/US2015/018272 patent/WO2015134368A2/en not_active Ceased
- 2015-03-02 EP EP15758673.6A patent/EP3113801B1/en active Active
- 2015-03-02 EP EP20195405.4A patent/EP3943106A1/en active Pending
- 2015-03-02 AU AU2015225499A patent/AU2015225499B2/en active Active
- 2015-03-02 JP JP2016555659A patent/JP6652497B2/ja active Active
- 2015-03-02 CA CA2942166A patent/CA2942166A1/en active Pending
- 2015-03-02 CN CN201911344961.3A patent/CN110938604B/zh active Active
-
2016
- 2016-02-04 US US15/015,322 patent/US9999665B2/en active Active
-
2017
- 2017-03-10 US US15/455,495 patent/US10076568B2/en active Active
-
2018
- 2018-06-01 US US15/995,471 patent/US10391165B2/en active Active
-
2019
- 2019-07-30 US US16/526,056 patent/US10751411B2/en active Active
-
2020
- 2020-01-23 JP JP2020009043A patent/JP6844045B2/ja active Active
- 2020-08-10 AU AU2020217310A patent/AU2020217310B2/en active Active
- 2020-08-18 US US16/995,926 patent/US10980874B2/en active Active
-
2021
- 2021-02-24 JP JP2021026943A patent/JP7050193B2/ja active Active
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