JP6630426B2 - Ｔａｕ結合抗体 - Google Patents

Ｔａｕ結合抗体 Download PDF

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Publication number
JP6630426B2
JP6630426B2 JP2018500423A JP2018500423A JP6630426B2 JP 6630426 B2 JP6630426 B2 JP 6630426B2 JP 2018500423 A JP2018500423 A JP 2018500423A JP 2018500423 A JP2018500423 A JP 2018500423A JP 6630426 B2 JP6630426 B2 JP 6630426B2
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seq
amino acid
variable region
acid sequence
chain variable
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Japanese (ja)
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JP2018524001A (ja
JP2018524001A5 (enExample
Inventor
エドワード オーモンド ナイト、デイヴィッド
エドワード オーモンド ナイト、デイヴィッド
シーワード ベイカー、テレンス
シーワード ベイカー、テレンス
ジェイムズ マクミラン、デイヴィッド
ジェイムズ マクミラン、デイヴィッド
アンソニー グリフィン、ロバート
アンソニー グリフィン、ロバート
− コエーロ、ジョルジュ メイレ
− コエーロ、ジョルジュ メイレ
ダウニー、パトリック
− フィリップ コーレード、ジャン
− フィリップ コーレード、ジャン
Original Assignee
ユーシービー バイオファルマ エスピーアールエル
ユーシービー バイオファルマ エスピーアールエル
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Application filed by ユーシービー バイオファルマ エスピーアールエル, ユーシービー バイオファルマ エスピーアールエル filed Critical ユーシービー バイオファルマ エスピーアールエル
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
JP2018500423A 2015-07-06 2016-07-05 Ｔａｕ結合抗体 Active JP6630426B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15175522 2015-07-06
EP15175522.0 2015-07-06
PCT/EP2016/065813 WO2017005734A1 (en) 2015-07-06 2016-07-05 Tau-binding antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019220807A Division JP7100008B2 (ja) 2015-07-06 2019-12-06 Ｔａｕ結合抗体

Publications (3)

Publication Number Publication Date
JP2018524001A JP2018524001A (ja) 2018-08-30
JP2018524001A5 JP2018524001A5 (enExample) 2019-09-12
JP6630426B2 true JP6630426B2 (ja) 2020-01-15

Family

ID=53524640

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018500423A Active JP6630426B2 (ja) 2015-07-06 2016-07-05 Ｔａｕ結合抗体
JP2019220807A Active JP7100008B2 (ja) 2015-07-06 2019-12-06 Ｔａｕ結合抗体
JP2022105415A Active JP7413448B2 (ja) 2015-07-06 2022-06-30 Ｔａｕ結合抗体

Family Applications After (2)

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JP2019220807A Active JP7100008B2 (ja) 2015-07-06 2019-12-06 Ｔａｕ結合抗体
JP2022105415A Active JP7413448B2 (ja) 2015-07-06 2022-06-30 Ｔａｕ結合抗体

Country Status (25)

Country Link
US (4) US10287343B2 (enExample)
EP (1) EP3319983A1 (enExample)
JP (3) JP6630426B2 (enExample)
KR (2) KR102770650B1 (enExample)
CN (1) CN107849104B (enExample)
AR (1) AR105267A1 (enExample)
AU (1) AU2016289755C1 (enExample)
CA (1) CA2991451A1 (enExample)
CL (1) CL2018000043A1 (enExample)
CO (1) CO2017012971A2 (enExample)
EA (1) EA037092B1 (enExample)
EC (1) ECSP18000887A (enExample)
IL (1) IL256685B (enExample)
MA (2) MA41670A1 (enExample)
MX (1) MX2017015817A (enExample)
MY (1) MY193677A (enExample)
PE (1) PE20180481A1 (enExample)
PH (1) PH12017502207B1 (enExample)
SG (1) SG10202010735PA (enExample)
TN (1) TN2017000539A1 (enExample)
TW (1) TWI745295B (enExample)
UA (1) UA124616C2 (enExample)
UY (1) UY36773A (enExample)
WO (1) WO2017005734A1 (enExample)
ZA (1) ZA201800027B (enExample)

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Publication number Publication date
AU2016289755B2 (en) 2020-12-03
IL256685B (en) 2022-02-01
HK1246804A1 (zh) 2018-09-14
MA42377A (fr) 2018-05-16
NZ738058A (en) 2021-07-30
JP2020055849A (ja) 2020-04-09
IL256685A (en) 2018-03-29
ZA201800027B (en) 2019-06-26
CN107849104B (zh) 2021-08-27
MX2017015817A (es) 2018-04-10
KR20180025962A (ko) 2018-03-09
TN2017000539A1 (en) 2019-04-12
CL2018000043A1 (es) 2018-05-18
JP2018524001A (ja) 2018-08-30
AU2016289755C1 (en) 2021-08-19
AU2016289755A1 (en) 2018-01-04
US11732034B2 (en) 2023-08-22
KR102770650B1 (ko) 2025-02-19
KR20250027278A (ko) 2025-02-25
US20230416350A1 (en) 2023-12-28
EA201890172A1 (ru) 2018-10-31
MA41670A1 (fr) 2018-05-31
PH12017502207B1 (en) 2022-08-10
SG10202010735PA (en) 2020-11-27
CO2017012971A2 (es) 2018-03-09
TW201713689A (zh) 2017-04-16
UY36773A (es) 2017-01-31
CN107849104A (zh) 2018-03-27
BR112017028102A2 (en) 2018-09-04
ECSP18000887A (es) 2018-03-31
US10287343B2 (en) 2019-05-14
US20180201666A1 (en) 2018-07-19
JP7413448B2 (ja) 2024-01-15
US20210115121A1 (en) 2021-04-22
US20190284267A1 (en) 2019-09-19
AR105267A1 (es) 2017-09-20
JP2022141689A (ja) 2022-09-29
UA124616C2 (uk) 2021-10-20
EA037092B1 (ru) 2021-02-04
WO2017005734A1 (en) 2017-01-12
JP7100008B2 (ja) 2022-07-12
TWI745295B (zh) 2021-11-11
EP3319983A1 (en) 2018-05-16
CA2991451A1 (en) 2017-01-12
MY193677A (en) 2022-10-25
PH12017502207A1 (en) 2018-06-11
PE20180481A1 (es) 2018-03-07
US10889640B2 (en) 2021-01-12

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