JP6630273B2 - 安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用 - Google Patents

安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用 Download PDF

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JP6630273B2
JP6630273B2 JP2016540463A JP2016540463A JP6630273B2 JP 6630273 B2 JP6630273 B2 JP 6630273B2 JP 2016540463 A JP2016540463 A JP 2016540463A JP 2016540463 A JP2016540463 A JP 2016540463A JP 6630273 B2 JP6630273 B2 JP 6630273B2
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pdgf
aptamer
nucleic acid
vegf
acid molecule
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JP2016529911A5 (enExample
JP2016529911A (ja
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ジャニック，ネボイサ
ドロレ，ダニエル・ダブリュー
ジュリナス，エイミー・ディー
ツァン，チ
ボークリャン，マイケル
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Somalogic Inc
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Somalogic Inc
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/16—Aptamers
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Urology & Nephrology (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2016540463A 2013-09-09 2014-09-08 安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用 Expired - Fee Related JP6630273B2 (ja)

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JP2019176480A JP6949916B2 (ja) 2013-09-09 2019-09-27 安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361875660P 2013-09-09 2013-09-09
US61/875,660 2013-09-09
PCT/US2014/054561 WO2015035305A1 (en) 2013-09-09 2014-09-08 Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders

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JP2019176480A Division JP6949916B2 (ja) 2013-09-09 2019-09-27 安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用

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JP2016529911A JP2016529911A (ja) 2016-09-29
JP2016529911A5 JP2016529911A5 (enExample) 2017-10-19
JP6630273B2 true JP6630273B2 (ja) 2020-01-15

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JP2016540463A Expired - Fee Related JP6630273B2 (ja) 2013-09-09 2014-09-08 安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用
JP2019176480A Expired - Fee Related JP6949916B2 (ja) 2013-09-09 2019-09-27 安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用
JP2021014100A Active JP7209025B2 (ja) 2013-09-09 2021-02-01 安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用
JP2023000811A Pending JP2023040156A (ja) 2013-09-09 2023-01-06 安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用

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JP2021014100A Active JP7209025B2 (ja) 2013-09-09 2021-02-01 安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用
JP2023000811A Pending JP2023040156A (ja) 2013-09-09 2023-01-06 安定性が向上したｐｄｇｆ及びｖｅｇｆアプタマー並びにｐｄｇｆ及びｖｅｇｆ媒介性の疾患及び障害の治療におけるそれらの使用

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US (3) US9695424B2 (enExample)
EP (2) EP3044334B1 (enExample)
JP (4) JP6630273B2 (enExample)
CA (2) CA3221709A1 (enExample)
ES (1) ES2834910T3 (enExample)
WO (1) WO2015035305A1 (enExample)

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WO2013149086A1 (en) 2012-03-28 2013-10-03 Somalogic, Inc. Aptamers to pdgf and vegf and their use in treating pdgf and vegf mediated conditions
CA3221709A1 (en) 2013-09-09 2015-03-12 Somalogic Operating Co., Inc. Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders
CA3012718A1 (en) * 2016-02-08 2017-08-17 Vitrisa Therapeutics, Inc. Compositions with improved intravitreal half-life and uses thereof
WO2020146731A1 (en) * 2019-01-11 2020-07-16 Drive Therapeutics Llc Compositions and methods for inhibiting vascular endothelial growth factor
CN119552875A (zh) * 2020-03-03 2025-03-04 爱普济德生物技术有限公司 适体和其用途

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US20160177307A1 (en) 2016-06-23
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EP3044334A1 (en) 2016-07-20
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US20180258432A1 (en) 2018-09-13
US9695424B2 (en) 2017-07-04
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US20170247702A1 (en) 2017-08-31
EP3044334B1 (en) 2020-08-12
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JP7209025B2 (ja) 2023-01-19
EP3693472A1 (en) 2020-08-12
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