JP6622811B2 - デジタルマイクロ流体希釈装置、システムおよび関連方法 - Google Patents

デジタルマイクロ流体希釈装置、システムおよび関連方法 Download PDF

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Publication number
JP6622811B2
JP6622811B2 JP2017534963A JP2017534963A JP6622811B2 JP 6622811 B2 JP6622811 B2 JP 6622811B2 JP 2017534963 A JP2017534963 A JP 2017534963A JP 2017534963 A JP2017534963 A JP 2017534963A JP 6622811 B2 JP6622811 B2 JP 6622811B2
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electrode
area
droplet
electrodes
sample
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JP2018500573A (ja
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フィッシャー,アンドリュー
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Abbott Laboratories
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Abbott Laboratories
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0645Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/089Virtual walls for guiding liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427Electrowetting

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Accessories For Mixers (AREA)
JP2017534963A 2014-12-31 2015-12-21 デジタルマイクロ流体希釈装置、システムおよび関連方法 Active JP6622811B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019167003A JP6917425B2 (ja) 2014-12-31 2019-09-13 デジタルマイクロ流体希釈装置、システムおよび関連方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098679P 2014-12-31 2014-12-31
US62/098,679 2014-12-31
PCT/US2015/067021 WO2016109279A1 (en) 2014-12-31 2015-12-21 Digital microfluidic dilution apparatus, systems, and related methods

Related Child Applications (1)

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JP2019167003A Division JP6917425B2 (ja) 2014-12-31 2019-09-13 デジタルマイクロ流体希釈装置、システムおよび関連方法

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JP2018500573A JP2018500573A (ja) 2018-01-11
JP6622811B2 true JP6622811B2 (ja) 2019-12-18

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JP2017534963A Active JP6622811B2 (ja) 2014-12-31 2015-12-21 デジタルマイクロ流体希釈装置、システムおよび関連方法
JP2019167003A Active JP6917425B2 (ja) 2014-12-31 2019-09-13 デジタルマイクロ流体希釈装置、システムおよび関連方法

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US (2) US10369565B2 (enExample)
EP (1) EP3240634A1 (enExample)
JP (2) JP6622811B2 (enExample)
CN (2) CN107249743B (enExample)
CA (1) CA2972577A1 (enExample)
WO (1) WO2016109279A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3240634A1 (en) 2014-12-31 2017-11-08 Abbott Laboratories Digital microfluidic dilution apparatus, systems, and related methods
US12364538B2 (en) * 2018-11-05 2025-07-22 Biosense Webster (Israel) Ltd. Indifferent electrode with selectable area
CN109652287B (zh) * 2019-01-03 2021-04-30 京东方科技集团股份有限公司 一种微控基板及其制作方法和微流控芯片
WO2020154642A1 (en) * 2019-01-24 2020-07-30 Fluxergy, Llc Microfluidic device with constant heater uniformity
CN112295616B (zh) * 2020-09-11 2022-03-18 东南大学 一种微液滴混合强化微流控装置
CN114166615A (zh) * 2021-11-22 2022-03-11 南方科技大学 一种数字微流控液滴的稀释方法
CN114534805B (zh) * 2022-02-09 2024-08-06 上海天马微电子有限公司 微流控装置及其驱动方法、制作方法
US20250153181A1 (en) * 2022-09-09 2025-05-15 Nicoya Lifesciences Inc. Microfluidics device including ganged reservoir configurations and methods of using same

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927377D0 (en) 1989-12-04 1990-01-31 Univ Edinburgh Improvements in and relating to amperometric assays
US5104480A (en) 1990-10-12 1992-04-14 General Electric Company Direct patterning of metals over a thermally inefficient surface using a laser
GB9221099D0 (en) 1992-10-07 1992-11-18 Ecossensors Ltd Improvements in and relating to gas permeable membranes for amperometric gas electrodes
US6803019B1 (en) 1997-10-15 2004-10-12 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US6662439B1 (en) 1999-10-04 2003-12-16 Roche Diagnostics Corporation Laser defined features for patterned laminates and electrodes
TWI286629B (en) 2000-07-20 2007-09-11 Samsung Electronics Co Ltd Liquid crystal display device and flexible circuit board
DE10212639A1 (de) 2002-03-21 2003-10-16 Siemens Ag Vorrichtung und Verfahren zur Laserstrukturierung von Funktionspolymeren und Verwendungen
JP3492350B2 (ja) 2002-04-12 2004-02-03 新藤電子工業株式会社 回路基板および回路基板の製造方法
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
WO2005019875A2 (en) 2003-08-22 2005-03-03 Stratos Biosystems, Llc Electrowetting sample presentation device
FR2871076A1 (fr) * 2004-06-04 2005-12-09 Univ Lille Sciences Tech Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique
WO2008027090A2 (en) * 2006-05-17 2008-03-06 The Regents Of The University Of California Control of materials and porous magnetic particles
JP4185904B2 (ja) * 2004-10-27 2008-11-26 株式会社日立ハイテクノロジーズ 液体搬送基板、分析システム、分析方法
JP4500733B2 (ja) 2005-05-30 2010-07-14 株式会社日立ハイテクノロジーズ 化学分析装置
US8802214B2 (en) 2005-06-13 2014-08-12 Trillion Science, Inc. Non-random array anisotropic conductive film (ACF) and manufacturing processes
US20060280912A1 (en) 2005-06-13 2006-12-14 Rong-Chang Liang Non-random array anisotropic conductive film (ACF) and manufacturing processes
WO2008055256A2 (en) 2006-11-02 2008-05-08 The Regents Of The University Of California Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip
US8178028B2 (en) 2006-11-06 2012-05-15 Samsung Electronics Co., Ltd. Laser patterning of nanostructure-films
WO2008091848A2 (en) 2007-01-22 2008-07-31 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
US8409417B2 (en) * 2007-05-24 2013-04-02 Digital Biosystems Electrowetting based digital microfluidics
KR101451955B1 (ko) 2007-08-24 2014-10-21 어드밴스드 리퀴드 로직, 아이엔씨. 액적 작동기 상에서의 비드 조작법
EP2232535A4 (en) 2007-12-10 2016-04-13 Advanced Liquid Logic Inc DROPLET ACTUATOR CONFIGURATIONS AND METHODS
US20100270156A1 (en) * 2007-12-23 2010-10-28 Advanced Liquid Logic, Inc. Droplet Actuator Configurations and Methods of Conducting Droplet Operations
EP2672260A1 (en) 2008-05-13 2013-12-11 Advanced Liquid Logic, Inc. Droplet actuator devices, systems and methods
CN101294971A (zh) * 2008-06-05 2008-10-29 复旦大学 基于介质上电润湿效应的数字微流控器件及其控制方法
CA2757699A1 (en) * 2009-03-19 2010-09-23 Figure 8 Surgical, Inc. Systems and methods for sternum repair
US8448530B2 (en) 2009-03-27 2013-05-28 CSEM Centre Suisee d'Electronique et de Microtechnique SA-Recherche et Developpement Roll-to-roll compatible pressure sensitive event sensing label
WO2011002957A2 (en) 2009-07-01 2011-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
CN101773814B (zh) * 2010-01-21 2012-03-14 高婧 多稳态微流控器件
US8815070B2 (en) * 2010-03-09 2014-08-26 Sparkle Power, Inc. Microelectrode array architecture
EP2553473A4 (en) 2010-03-30 2016-08-10 Advanced Liquid Logic Inc DROPLET OPERATION PLATFORM
US20110266151A1 (en) 2010-04-23 2011-11-03 Fredrik Jansson Microfluidic systems with electronic wettability switches
EP2588322B1 (en) 2010-06-30 2015-06-17 Advanced Liquid Logic, Inc. Droplet actuator assemblies and methods of making same
US20130018611A1 (en) 2011-07-11 2013-01-17 Advanced Liquid Logic Inc Systems and Methods of Measuring Gap Height
AU2013284425B2 (en) * 2012-06-27 2017-07-27 Advanced Liquid Logic Inc. Techniques and droplet actuator designs for reducing bubble formation
US8847078B2 (en) 2012-09-27 2014-09-30 Ibiden Co., Ltd. Printed wiring board and method for manufacturing printed wiring board
CN103170384B (zh) * 2013-05-06 2015-03-04 复旦大学 一种基于大小液滴操控的数字微流芯片
CN108656746B (zh) 2014-04-16 2020-03-20 雅培制药有限公司 液滴致动器制造装置、系统和相关方法
EP3240634A1 (en) 2014-12-31 2017-11-08 Abbott Laboratories Digital microfluidic dilution apparatus, systems, and related methods

Also Published As

Publication number Publication date
JP6917425B2 (ja) 2021-08-11
JP2018500573A (ja) 2018-01-11
JP2020024206A (ja) 2020-02-13
CN107249743B (zh) 2020-01-10
US20190351411A1 (en) 2019-11-21
CN110935496A (zh) 2020-03-31
CA2972577A1 (en) 2016-07-07
CN107249743A (zh) 2017-10-13
US11213817B2 (en) 2022-01-04
US10369565B2 (en) 2019-08-06
WO2016109279A1 (en) 2016-07-07
US20160184823A1 (en) 2016-06-30
EP3240634A1 (en) 2017-11-08

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