CA2972577A1 - Digital microfluidic dilution apparatus, systems, and related methods - Google Patents
Digital microfluidic dilution apparatus, systems, and related methods Download PDFInfo
- Publication number
- CA2972577A1 CA2972577A1 CA2972577A CA2972577A CA2972577A1 CA 2972577 A1 CA2972577 A1 CA 2972577A1 CA 2972577 A CA2972577 A CA 2972577A CA 2972577 A CA2972577 A CA 2972577A CA 2972577 A1 CA2972577 A1 CA 2972577A1
- Authority
- CA
- Canada
- Prior art keywords
- electrode
- droplet
- area
- electrodes
- volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000010790 dilution Methods 0.000 title claims description 86
- 239000012895 dilution Substances 0.000 title claims description 86
- 230000003213 activating effect Effects 0.000 claims abstract description 20
- 239000003085 diluting agent Substances 0.000 claims description 172
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- 238000007865 diluting Methods 0.000 abstract description 9
- 238000000151 deposition Methods 0.000 abstract description 7
- 239000000523 sample Substances 0.000 description 181
- 238000012545 processing Methods 0.000 description 34
- 238000003113 dilution method Methods 0.000 description 19
- 238000003860 storage Methods 0.000 description 19
- 238000013207 serial dilution Methods 0.000 description 18
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Micromachines (AREA)
- Accessories For Mixers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462098679P | 2014-12-31 | 2014-12-31 | |
| US62/098,679 | 2014-12-31 | ||
| PCT/US2015/067021 WO2016109279A1 (en) | 2014-12-31 | 2015-12-21 | Digital microfluidic dilution apparatus, systems, and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2972577A1 true CA2972577A1 (en) | 2016-07-07 |
Family
ID=55273514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2972577A Abandoned CA2972577A1 (en) | 2014-12-31 | 2015-12-21 | Digital microfluidic dilution apparatus, systems, and related methods |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10369565B2 (enExample) |
| EP (1) | EP3240634A1 (enExample) |
| JP (2) | JP6622811B2 (enExample) |
| CN (2) | CN107249743B (enExample) |
| CA (1) | CA2972577A1 (enExample) |
| WO (1) | WO2016109279A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3240634A1 (en) | 2014-12-31 | 2017-11-08 | Abbott Laboratories | Digital microfluidic dilution apparatus, systems, and related methods |
| US12364538B2 (en) * | 2018-11-05 | 2025-07-22 | Biosense Webster (Israel) Ltd. | Indifferent electrode with selectable area |
| CN109652287B (zh) * | 2019-01-03 | 2021-04-30 | 京东方科技集团股份有限公司 | 一种微控基板及其制作方法和微流控芯片 |
| WO2020154642A1 (en) * | 2019-01-24 | 2020-07-30 | Fluxergy, Llc | Microfluidic device with constant heater uniformity |
| CN112295616B (zh) * | 2020-09-11 | 2022-03-18 | 东南大学 | 一种微液滴混合强化微流控装置 |
| CN114166615A (zh) * | 2021-11-22 | 2022-03-11 | 南方科技大学 | 一种数字微流控液滴的稀释方法 |
| CN114534805B (zh) * | 2022-02-09 | 2024-08-06 | 上海天马微电子有限公司 | 微流控装置及其驱动方法、制作方法 |
| US20250153181A1 (en) * | 2022-09-09 | 2025-05-15 | Nicoya Lifesciences Inc. | Microfluidics device including ganged reservoir configurations and methods of using same |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8927377D0 (en) | 1989-12-04 | 1990-01-31 | Univ Edinburgh | Improvements in and relating to amperometric assays |
| US5104480A (en) | 1990-10-12 | 1992-04-14 | General Electric Company | Direct patterning of metals over a thermally inefficient surface using a laser |
| GB9221099D0 (en) | 1992-10-07 | 1992-11-18 | Ecossensors Ltd | Improvements in and relating to gas permeable membranes for amperometric gas electrodes |
| US6803019B1 (en) | 1997-10-15 | 2004-10-12 | Aclara Biosciences, Inc. | Laminate microstructure device and method for making same |
| US6662439B1 (en) | 1999-10-04 | 2003-12-16 | Roche Diagnostics Corporation | Laser defined features for patterned laminates and electrodes |
| TWI286629B (en) | 2000-07-20 | 2007-09-11 | Samsung Electronics Co Ltd | Liquid crystal display device and flexible circuit board |
| DE10212639A1 (de) | 2002-03-21 | 2003-10-16 | Siemens Ag | Vorrichtung und Verfahren zur Laserstrukturierung von Funktionspolymeren und Verwendungen |
| JP3492350B2 (ja) | 2002-04-12 | 2004-02-03 | 新藤電子工業株式会社 | 回路基板および回路基板の製造方法 |
| US6911132B2 (en) | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
| WO2005019875A2 (en) | 2003-08-22 | 2005-03-03 | Stratos Biosystems, Llc | Electrowetting sample presentation device |
| FR2871076A1 (fr) * | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique |
| WO2008027090A2 (en) * | 2006-05-17 | 2008-03-06 | The Regents Of The University Of California | Control of materials and porous magnetic particles |
| JP4185904B2 (ja) * | 2004-10-27 | 2008-11-26 | 株式会社日立ハイテクノロジーズ | 液体搬送基板、分析システム、分析方法 |
| JP4500733B2 (ja) | 2005-05-30 | 2010-07-14 | 株式会社日立ハイテクノロジーズ | 化学分析装置 |
| US8802214B2 (en) | 2005-06-13 | 2014-08-12 | Trillion Science, Inc. | Non-random array anisotropic conductive film (ACF) and manufacturing processes |
| US20060280912A1 (en) | 2005-06-13 | 2006-12-14 | Rong-Chang Liang | Non-random array anisotropic conductive film (ACF) and manufacturing processes |
| WO2008055256A2 (en) | 2006-11-02 | 2008-05-08 | The Regents Of The University Of California | Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip |
| US8178028B2 (en) | 2006-11-06 | 2012-05-15 | Samsung Electronics Co., Ltd. | Laser patterning of nanostructure-films |
| WO2008091848A2 (en) | 2007-01-22 | 2008-07-31 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
| US8409417B2 (en) * | 2007-05-24 | 2013-04-02 | Digital Biosystems | Electrowetting based digital microfluidics |
| KR101451955B1 (ko) | 2007-08-24 | 2014-10-21 | 어드밴스드 리퀴드 로직, 아이엔씨. | 액적 작동기 상에서의 비드 조작법 |
| EP2232535A4 (en) | 2007-12-10 | 2016-04-13 | Advanced Liquid Logic Inc | DROPLET ACTUATOR CONFIGURATIONS AND METHODS |
| US20100270156A1 (en) * | 2007-12-23 | 2010-10-28 | Advanced Liquid Logic, Inc. | Droplet Actuator Configurations and Methods of Conducting Droplet Operations |
| EP2672260A1 (en) | 2008-05-13 | 2013-12-11 | Advanced Liquid Logic, Inc. | Droplet actuator devices, systems and methods |
| CN101294971A (zh) * | 2008-06-05 | 2008-10-29 | 复旦大学 | 基于介质上电润湿效应的数字微流控器件及其控制方法 |
| CA2757699A1 (en) * | 2009-03-19 | 2010-09-23 | Figure 8 Surgical, Inc. | Systems and methods for sternum repair |
| US8448530B2 (en) | 2009-03-27 | 2013-05-28 | CSEM Centre Suisee d'Electronique et de Microtechnique SA-Recherche et Developpement | Roll-to-roll compatible pressure sensitive event sensing label |
| WO2011002957A2 (en) | 2009-07-01 | 2011-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
| US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
| CN101773814B (zh) * | 2010-01-21 | 2012-03-14 | 高婧 | 多稳态微流控器件 |
| US8815070B2 (en) * | 2010-03-09 | 2014-08-26 | Sparkle Power, Inc. | Microelectrode array architecture |
| EP2553473A4 (en) | 2010-03-30 | 2016-08-10 | Advanced Liquid Logic Inc | DROPLET OPERATION PLATFORM |
| US20110266151A1 (en) | 2010-04-23 | 2011-11-03 | Fredrik Jansson | Microfluidic systems with electronic wettability switches |
| EP2588322B1 (en) | 2010-06-30 | 2015-06-17 | Advanced Liquid Logic, Inc. | Droplet actuator assemblies and methods of making same |
| US20130018611A1 (en) | 2011-07-11 | 2013-01-17 | Advanced Liquid Logic Inc | Systems and Methods of Measuring Gap Height |
| AU2013284425B2 (en) * | 2012-06-27 | 2017-07-27 | Advanced Liquid Logic Inc. | Techniques and droplet actuator designs for reducing bubble formation |
| US8847078B2 (en) | 2012-09-27 | 2014-09-30 | Ibiden Co., Ltd. | Printed wiring board and method for manufacturing printed wiring board |
| CN103170384B (zh) * | 2013-05-06 | 2015-03-04 | 复旦大学 | 一种基于大小液滴操控的数字微流芯片 |
| CN108656746B (zh) | 2014-04-16 | 2020-03-20 | 雅培制药有限公司 | 液滴致动器制造装置、系统和相关方法 |
| EP3240634A1 (en) | 2014-12-31 | 2017-11-08 | Abbott Laboratories | Digital microfluidic dilution apparatus, systems, and related methods |
-
2015
- 2015-12-21 EP EP15831018.5A patent/EP3240634A1/en active Pending
- 2015-12-21 WO PCT/US2015/067021 patent/WO2016109279A1/en not_active Ceased
- 2015-12-21 JP JP2017534963A patent/JP6622811B2/ja active Active
- 2015-12-21 CA CA2972577A patent/CA2972577A1/en not_active Abandoned
- 2015-12-21 US US14/976,684 patent/US10369565B2/en active Active
- 2015-12-21 CN CN201580077138.4A patent/CN107249743B/zh active Active
- 2015-12-21 CN CN201911326727.8A patent/CN110935496A/zh active Pending
-
2019
- 2019-08-05 US US16/531,253 patent/US11213817B2/en active Active
- 2019-09-13 JP JP2019167003A patent/JP6917425B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6917425B2 (ja) | 2021-08-11 |
| JP2018500573A (ja) | 2018-01-11 |
| JP2020024206A (ja) | 2020-02-13 |
| CN107249743B (zh) | 2020-01-10 |
| US20190351411A1 (en) | 2019-11-21 |
| CN110935496A (zh) | 2020-03-31 |
| CN107249743A (zh) | 2017-10-13 |
| US11213817B2 (en) | 2022-01-04 |
| US10369565B2 (en) | 2019-08-06 |
| WO2016109279A1 (en) | 2016-07-07 |
| US20160184823A1 (en) | 2016-06-30 |
| JP6622811B2 (ja) | 2019-12-18 |
| EP3240634A1 (en) | 2017-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170628 |
|
| FZDE | Discontinued |
Effective date: 20211221 |
|
| FZDE | Discontinued |
Effective date: 20211221 |