JP4824697B2 - 小滴分配装置 - Google Patents
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
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Description
‐ 開口部に少なくとも部分的に対向して配置された移送用電極と称される少なくとも一つの電極と、
‐ 少なくとも二つの小滴形成用電極と、
‐ 移送用電極と小滴分配用電極との間に配置されるか、移送用電極及び小滴形成用電極に対応していて、小滴形成用電極のそれぞれの面積の少なくとも三倍に等しい面積を有する、リザーバ電極と称される少なくとも一つの電極(48)とを含む。
‐ その少なくとも一部が開口部に少なくとも部分的に対向して配置されている移送用電極と称される電極とリザーバ電極との交互の組と、
‐ それぞれのリザーバ電極に対応した一続きの小滴形成用電極とを含み、
リザーバ電極の少なくとも一つは、対応する小滴形成用電極のそれぞれの面積の少なくとも三倍に等しい面積を有する。
‐ その少なくとも一部が開口部に少なくとも部分的に対向して配置されている移送用電極と称される多数の電極と、そのそれぞれが一つの移送用電極に対応している多数のリザーバ電極と、
‐ それぞれのリザーバ電極に対応した一続きの小滴形成用電極とを含み、
リザーバ電極の少なくとも一つは、対応する小滴形成用電極のそれぞれの面積の少なくとも三倍に等しい面積を有する。
‐ 液体供給用開口部から直列的に配置され、移送用電極と交互になるか、または、
‐ この開口部の周りに並列的に配置され、そのそれぞれは一つの移送用電極によって供給が行われる。
‐ ウェルに少なくとも部分的に対向して配置された移送用電極と称される電極の補助を用いて、所謂リザーバ電極にウェルから液体を完全にまたは部分的に移送する段階を含む。液体リザーバ内の圧力は、ウェル内の液体の圧力に依存しない。
1‐全ての電極は停止状態である(状態0)、
2‐移送用電極44を状態1に設定し、ウェル内の液体をリザーバ電極48の近傍に移動させる、
3‐リザーバ電極48を状態1に設定し、液体がリザーバ電極48の上方の空間を満たす、
4‐移送用電極44を状態0にリセットする。そうして、リザーバ電極に多量の小滴51が形成されるが(図4B)、この小滴は最早ウェルに物理的に接触していない。
5‐形成される新たな小滴のそれぞれに対して、例えば、
5.1‐リザーバ電極48を非活性化させる、
5.2‐分配用電極50〜56の(少なくとも)二つを活性化させる、
5.3‐分配用電極50〜56の少なくとも一つを非活性化させ(電極が二つしかない場合には、電極50を非活性化する)、電極48及び電極52活性化させて、極僅かな量の液体を抽出する。一般的に、リザーバ51から最も離れている分配用電極以外の分配用電極を非活性化させる。
5.4‐リザーバ電極48を活性化させ、分割動作を容易にする。これによって、新たな小滴の形成及び放出が生じる。
4 電極のネットワーク
4−1,4−2 電極
6 誘電体層
8 疎水性層
9 基板
10 対向基板
20 液体のセグメント
22 小滴
31 電極
30 液体
35 ウェル
36 上部カバー
40 ウェル
42,46 基板
44 移送用電極
47 対向電極
48 リザーバ電極
50,52,54,56 小滴形成用電極
60,62 壁
61,63 開口部
100 ウェル
101,103,105,107 移送用電極
104,106,108,110 リザーバ電極
154,156,158,160 小滴形成用電極
200 ウェル
201,203,205 移送用電極
204,206,208 リザーバ電極
254,256,258 小滴形成用電極
Claims (23)
- 流体注入用の開口部(40)を備えた第一基板(42)と、多数の電極を備えた第二基板(46)とを含む液体分配装置であり、前記多数の電極は、
‐ 前記開口部(40)に少なくとも部分的に対向して配置された移送用電極と称される少なくとも一つの電極(44)と、
‐ 少なくとも二つの小滴形成用電極(50、52)と、
‐ 前記移送用電極(44)及び前記小滴形成用電極(50、52)に対応していて、前記小滴形成用電極のそれぞれの面積の少なくとも三倍に等しい面積を有する、リザーバ電極と称される少なくとも一つの電極(48)とを含み、
前記リザーバ電極は前記移送用電極を活性化させることなく活性化可能であり、前記移送用電極は前記リザーバ電極を活性化させることなく活性化可能である装置。 - 少なくとも一つの第二のリザーバ電極(104、106、108、110)と、隣接する二つの前記リザーバ電極の間に、または、隣接する二つ前記リザーバ電極に対応して、配置された少なくとも一つの第二の移送用電極(101、103、105、107)とを更に含み、前記リザーバ電極のそれぞれに対応した少なくとも二つの小滴形成用電極(154、156、158、160)を備えた請求項1に記載の装置。
- 少なくとも一つの第二のリザーバ電極(204、206、208)と、前記開口部(40)に少なくとも部分的に対向して配置された少なくとも一つの第二の移送用電極(201、203、205)と、前記第二のリザーバ電極に対応した少なくとも一つの小滴形成用電極(254、256、258)とを更に含む請求項1に記載の装置。
- 前記少なくとも一つの第二のリザーバ電極は、対応する前記小滴形成用電極の面積の少なくとも三倍に等しい面積を有する請求項2または請求項3のいずれかに記載の装置。
- 前記リザーバ電極(48)の少なくとも一つは、対応する前記小滴形成用電極の面積の少なくとも十倍に等しい面積を有する請求項1から請求項4のいずれか一項に記載の装置。
- 前記リザーバ電極の少なくとも一つは櫛型または尖った形状を有する請求項1から請求項5のいずれか一項に記載の装置。
- 前記櫛型または尖った形状は、前記移送用電極側において徐々に細くなる歯の部分を有する請求項6に記載の装置。
- 前記リザーバ電極の少なくとも一つは星型である請求項1から請求項7のいずれか一項に記載の装置。
- 前記少なくとも一つのリザーバ電極と前記開口部(40)との間に収容壁(60)を含む請求項1から請求項8のいずれか一項に記載の装置。
- 前記少なくとも一つのリザーバ電極のまわりに少なくとも一つの収容壁(62)を含む請求項1から請求項9のいずれか一項に記載の装置。
- 前記小滴形成用電極の少なくとも一つは、一方の側が円形で、他方が尖っている請求項1から請求項10のいずれか一項に記載の装置。
- 前記第一基板は導電手段(47)を含む請求項1から請求項11のいずれか一項に記載の装置。
- 前記第一基板(42)は疎水性表面を有する請求項1から請求項12のいずれか一項に記載の装置。
- 前記第二基板は疎水性表面(8)を有する請求項1から請求項13のいずれか一項に記載の装置。
- 前記第二基板は前記疎水性表面(8)の下に誘電体層を有する請求項14に記載の装置。
- ループ(402)の形状に配置され、エレクトロウェッティングによって小滴を移動させる手段を更に含む請求項1から請求項15のいずれか一項に記載の装置。
- 前記ループ(402)のまわりに配置された一つ以上の副リザーバ(350、352、354、356、358、351、353、355)を更に含む請求項16に記載の装置。
- 前記副リザーバのそれぞれは、一つ以上の移送用電極(361、362、363、364、366)によって前記ループ(402)に接続されている請求項17に記載の装置。
- 液体のウェル(40)から液体リザーバ(51)を形成する段階と、少なくともn個(n≧2)の小滴形成用電極(50、52)の活性化によって液体の小滴を形成する段階と、前記リザーバ電極に近い方のn−1個の前記電極の中から少なくとも一つを非活性化させて、極僅かな量の液体を取り出す段階とを含む、液体の小滴を分配する方法であって、
前記液体のウェル(40)から液体リザーバ(51)を形成する段階が、
‐ 前記ウェル(40)に少なくとも部分的に対向して配置された移送用電極と称される電極(44)の補助を用いて、リザーバ電極と称される電極(48)に前記ウェル(40)から液体を移送する段階と
‐ 前記移送用電極(44)を非活性化させる段階とを含み、
前記液体リザーバ内の圧力は前記ウェル(40)内の液体の圧力に依存せず、
前記リザーバ電極(48)は、前記小滴形成用電極のそれぞれの面積の少なくとも三倍に等しい面積を有し、
前記移送用電極が前記ウェルと前記リザーバ電極との間に配置されている、方法。 - 請求項1から請求項18のいずれか一項に記載の装置を用いて液体の小滴を分配する方法であり、前記リザーバ電極に対向した液体リザーバ(51)を形成する段階と、n個(n≧2)の小滴形成用電極を活性化させることによって液体の小滴を放出する段階と、前記リザーバ電極に近い方のn−1個の前記電極の中から少なくとも一つを非活性化させる段階とを含む方法。
- 請求項16から請求項18のいずれか一項に記載の装置を用いて液体の小滴を分配する方法。
- 形成される小滴がループ(402)の形状の経路に沿って輸送される請求項21に記載の方法。
- 形成される小滴が前記ループ(402)の周りに配置されたリザーバからの一つ以上の小滴と混合される請求項22の記載の方法。
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FR0453211A FR2879946B1 (fr) | 2004-12-23 | 2004-12-23 | Dispositif de dispense de gouttes |
FR0453211 | 2004-12-23 | ||
PCT/FR2005/051131 WO2006070162A1 (fr) | 2004-12-23 | 2005-12-22 | Dispositif de dispense de gouttes |
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JP4824697B2 true JP4824697B2 (ja) | 2011-11-30 |
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US (1) | US7922886B2 (ja) |
EP (1) | EP1827694B1 (ja) |
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CA2606750C (en) | 2005-05-11 | 2015-11-24 | Nanolytics, Inc. | Method and device for conducting biochemical or chemical reactions at multiple temperatures |
FR2888912B1 (fr) | 2005-07-25 | 2007-08-24 | Commissariat Energie Atomique | Procede de commande d'une communication entre deux zones par electromouillage, dispositif comportant des zones isolables les unes des autres et procede de realisation d'un tel dispositif |
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US7922886B2 (en) | 2011-04-12 |
WO2006070162A1 (fr) | 2006-07-06 |
FR2879946B1 (fr) | 2007-02-09 |
FR2879946A1 (fr) | 2006-06-30 |
EP1827694B1 (fr) | 2013-02-20 |
US20080142376A1 (en) | 2008-06-19 |
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JP2008525778A (ja) | 2008-07-17 |
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