JP6617702B2 - Ｆｔｙ７２０のアザサイクリック拘束アナログ - Google Patents

Ｆｔｙ７２０のアザサイクリック拘束アナログ Download PDF

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Publication number
JP6617702B2
JP6617702B2 JP2016527039A JP2016527039A JP6617702B2 JP 6617702 B2 JP6617702 B2 JP 6617702B2 JP 2016527039 A JP2016527039 A JP 2016527039A JP 2016527039 A JP2016527039 A JP 2016527039A JP 6617702 B2 JP6617702 B2 JP 6617702B2
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Japan
Prior art keywords
compound
fty720
composition
group
medicament
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Expired - Fee Related
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JP2016527039A
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English (en)
Japanese (ja)
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JP2016529236A (ja
JP2016529236A5 (enExample
Inventor
エイミー エディンガー，
エイミー エディンガー，
スティーブン ハネシアン，
スティーブン ハネシアン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Montreal
University of California
University of California, Los Angeles
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University of Montreal
University of California, San Diego
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Publication of JP2016529236A5 publication Critical patent/JP2016529236A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
JP2016527039A 2013-07-15 2014-07-15 Ｆｔｙ７２０のアザサイクリック拘束アナログ Expired - Fee Related JP6617702B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361846506P 2013-07-15 2013-07-15
US61/846,506 2013-07-15
PCT/US2014/046711 WO2015009731A2 (en) 2013-07-15 2014-07-15 Azacyclic constrained analogs of fty720

Publications (3)

Publication Number Publication Date
JP2016529236A JP2016529236A (ja) 2016-09-23
JP2016529236A5 JP2016529236A5 (enExample) 2017-08-17
JP6617702B2 true JP6617702B2 (ja) 2019-12-11

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Family Applications (1)

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JP2016527039A Expired - Fee Related JP6617702B2 (ja) 2013-07-15 2014-07-15 Ｆｔｙ７２０のアザサイクリック拘束アナログ

Country Status (4)

Country Link
US (1) US10077236B2 (enExample)
EP (1) EP3022176B8 (enExample)
JP (1) JP6617702B2 (enExample)
WO (1) WO2015009731A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10995068B2 (en) 2015-09-24 2021-05-04 The Regents Of The University Of California Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015009731A2 (en) 2013-07-15 2015-01-22 The Regents Of The University Of California Azacyclic constrained analogs of fty720
US20210261583A1 (en) * 2018-06-14 2021-08-26 The Regents Of The University Of California Synthetic Cytotoxic Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment
WO2021062168A1 (en) * 2019-09-25 2021-04-01 The Regents Of The University Of California Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment
CA3158256A1 (en) * 2019-11-13 2021-05-20 Aimee EDINGER Drug formulations and methods of treatment for metabolic disorders
CN113979909A (zh) * 2021-10-21 2022-01-28 上海吉奉生物科技有限公司 一种(3s,5r)-5-(羟甲基)吡咯烷-3-醇盐酸盐的合成方法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10995068B2 (en) 2015-09-24 2021-05-04 The Regents Of The University Of California Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment
US11479530B2 (en) 2015-09-24 2022-10-25 The Regents Of The University Of California Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment
US11999693B2 (en) 2015-09-24 2024-06-04 The Regents Of The University Of California Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment

Also Published As

Publication number Publication date
EP3022176A4 (en) 2017-04-05
JP2016529236A (ja) 2016-09-23
EP3022176A2 (en) 2016-05-25
US10077236B2 (en) 2018-09-18
EP3022176B1 (en) 2019-09-11
WO2015009731A3 (en) 2015-03-19
WO2015009731A2 (en) 2015-01-22
EP3022176B8 (en) 2019-12-25
US20160159739A1 (en) 2016-06-09

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