JP6615200B2 - Composition for prevention and treatment of benign prostatic hyperplasia containing carrot seed oil, and formulation obtained by formulating the composition - Google Patents

Description

  The present invention relates to a composition containing carrot seed oil and effective in preventing and treating male prostatic hypertrophy.

  Panax ginseng CA Meyer is a plant belonging to the genus Carrot, a herbal medicine that has been used in 2,000 years ago in Korea, China, Japan and other regions. It has been used to prevent disease and extend lifespan. The effects and effects of ginseng known so far are the action on the central nervous system, anti-carcinogenic action, anti-cancer activity action, immune function regulating action, anti-diabetic action, liver function enhancement effect, cardiovascular disorder improvement, anti-arteriosclerosis Known for its effects on blood pressure, blood pressure regulation, menopause, osteoporosis, anti-stress, anti-fatigue, anti-oxidation, anti-aging effects, etc. Ginseng Tobacco Research Institute, 56-112, 1996).

  On the other hand, carrot seeds contain about 15 to 26% oil (Beveridge et al. 2002; Matsumoto et al. 1986), and the content of oleic acid (C18: 1), which is a monovalent unsaturated fatty acid, as the main fatty acid component. Is high and has a fatty acid composition similar to olive oil.

  In addition, it has become clear that carrot seed oil contains various phytosterols such as squalene, oxidosqualene, campesterol, stigmasterol, sitosterol, etc., which have the effect of reducing blood cholesterol, and carrots as a functional ingredient. The availability of seed oil is emerging. Other studies on carrot seeds to date include studies on ginsenoside composition of carrot seeds and carrot roots (Hu et al. 2008), research on saponin composition of carrot seeds and pulp, composition and oxidation stability of carrot seed oil by mountain Studies on the ginsenoside composition of carrot seeds and the composition of carrot seed oil have been reported, including comparative studies and antioxidant effects of carrot seeds by high-pressure sterilization. In this way, the foodological value of carrot seed oil has been continuously researched, but the results are insignificant compared to research on carrot roots and fruits.

  Therefore, as a result of researches on the novel use of carrot seed oil for human health, the present inventors have found that carrot seed oil effectively acts to alleviate male benign prostatic hyperplasia, leading to the completion of the present invention. It was.

  Accordingly, an object of the present invention is to provide a composition containing carrot seed oil and effective in preventing and treating male prostatic hypertrophy.

  In order to achieve the above-mentioned object, the present invention provides a composition for preventing and treating male prostatic hypertrophy, which contains carrot seed oil as an active ingredient.

  The composition of the present invention is effective not only to alleviate and prevent symptoms of prostatic hypertrophy in men, but also to promote human health such as fatigue recovery, weight loss, cholesterol and neutral fat improvement, Thereby, it can be used in various ways in the food and pharmaceutical fields.

It is a diagram which shows the step which processes carrot seed oil.

  The present invention relates to a composition containing carrot seed oil and capable of effectively acting in the prevention and treatment of male prostatic hypertrophy symptoms.

  The processing method of the carrot seed oil used in the present invention is not particularly limited. For example, the carrot seed oil can be manufactured by the processing steps shown in FIG. Specifically, the following steps are included.

(A) obtaining carrot seeds from carrot fruit;
(B) A step of obtaining carrot seed oil by extracting the carrot seed obtained in the above step.

  In the step (a), the carrot seeds contain everything that does not sprout or emerge, and may be raw carrot seeds, or may be dried through sunlight drying or hot air drying.

  The method for extracting carrot seeds in the present invention is not particularly limited, and various known methods can be used.

  In one embodiment according to the present invention, the carrot seed oil of the present invention can be obtained by a squeezing method of squeezing carrot seeds by extracting carrot seeds into an oil press and extracting useful components. At this time, if it is a food oil press, it can be used without limitation, and the oil extraction time is preferably 3 to 20 minutes, and oil extraction is usually carried out at room temperature.

  In another embodiment according to the present invention, carrot seed oil can be extracted by Supercritical Water Extraction. Supercritical extraction uses a supercritical fluid in a state exceeding the critical point, and the type of supercritical fluid to be used is not particularly limited. However, pentane, carbon dioxide, etc. can be used, particularly dioxide. Carbon can be used. Moreover, the kind of solvent to be used is not particularly limited. In particular, in the present invention, alcohol or purified water can be used as a solvent.

  In another embodiment according to the present invention, carrot seed oil can be extracted by a Subcritical Water Extraction method. Subcritical extraction can be used as an extraction solvent in a state where the solvent does not exceed the critical point, and can exhibit the same performance as supercritical extraction depending on what is selected as the solvent, and the type of solvent used is particularly limited However, in the present invention, alcohol or purified water can be used as a solvent.

  In another embodiment according to the present invention, carrot seed oil can be extracted by a microwave extraction method. The microwave extraction method is a method that can extract the target component within a short time while reducing the solvent to the maximum while saving energy, and the type of the solvent to be used is not particularly limited, In the present invention, alcohol or purified water can be used as a solvent.

  In another embodiment according to the present invention, carrot seed oil can be extracted by an ultrasonic extraction method. The ultrasonic extraction method is a method capable of efficiently extracting useful components within a short time without denaturation or loss of the extract, and the type of solvent used is not particularly limited. Alcohol or purified water can be used as the solvent.

  The composition of the present invention may contain carrot seed oil in an amount of 0.01 to 100% by weight based on the total weight of the composition, depending on the form of the composition.

  The composition of the present invention can be formulated as a pharmaceutical composition or a food composition in the form of tablets, pills, pills, capsules, granules, powders, ointments, drinks or injections. .

  The present invention provides a pharmaceutical composition containing carrot seed oil extract by conventional methods. In the production of a pharmaceutical preparation, it is preferable to mix or dilute the active ingredient together with a carrier, or encapsulate it in a carrier in a container form. When a carrier is used as a diluent, it can be a solid, semi-solid or liquid material that acts in a carrier, excipient or medium for the active ingredient. Therefore, the preparation may be in the form of tablets, pills, powders, sachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols, soft or hard gelatin capsules, sterile injections, sterile powders, etc. it can.

  Examples of preferred carriers, excipients and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methyl hydroxybenzoate, hydroxybenzoic acid Mention may be made of propyl, talc, magnesium stearate and mineral oil. The formulation can further include fillers, anti-aggregating agents, lubricants, wetting agents, perfumes, emulsifiers, preservatives and the like. The compositions of the present invention can be formulated using methods well known in the art so that they can provide rapid, sustained or delayed release of the active ingredient after administration to a mammal. .

  The pharmaceutical composition of the present invention can be administered through various routes including oral, transdermal, subcutaneous, intravenous, peritoneal, muscle, topical application, patch and iontophoresis, in which topical application And oral administration is preferred.

  In the case of humans, the active compound usually has a daily dosage in the range of 1-100 mg / kg body weight, preferably 5-70 mg / kg body weight, and can be administered in one or several divided doses. However, it should be understood that the actual dosage of the active ingredient will depend on various relevant factors such as the disease being treated, the route of administration, the patient's age, sex, weight and severity of the disease, thereby The above doses do not limit the scope of the present invention in any way.

  Moreover, this invention provides the food composition containing a carrot seed extract by a normal method.

  The food composition of the present invention has a liquid or solid dosage form, but the dosage form is not particularly limited, and can be formulated into tablets, granules, drinks, caramel, diet bars, and the like. In addition to the active ingredients, each dosage form of the food composition can be appropriately selected and blended with various ingredients normally used in the field according to the dosage form or purpose of use without difficulty by those skilled in the art. In doing so, a synergistic effect can occur.

  Hereinafter, the present invention will be described through the following examples and test examples. Examples and test examples are for explaining the present invention in more detail, and the scope of the present invention is not limited to the scope of the following examples.

  It is obvious that any person having ordinary knowledge in the technical field can make various modifications and corrections within the scope of the appended claims without departing from the scope of the technical idea of the present invention. It is a fact.

[Example 1] Carrot seed oil production
Carrot seed pretreatment Raw carrot fruits were harvested and seeds were separated to obtain carrot seeds.
Production of carrot seed oil Carrot seed oil was obtained from carrot seeds obtained as described above using a food oil press (DS-1500, Dasan Food Industrial Machinery, Korea) for 5 minutes at room temperature. 5-2%).

  The carrot seed oil thus obtained was used in the following test examples.

[Test Example 1]
<Results of analysis of fatty acids and lipids in carrot seed oil>
The analysis results of fatty acids and lipids of the carrot seed oil produced in Example 1 are as follows.

  As the results of Table 1 above, fatty acids and lipids were detected in the carrot seed oil according to the present invention.

[Test Example 2] Questionnaire for evaluation of quality of life related to benign prostatic hyperplasia (BPH QoL-K1)
In order to evaluate the quality of life related to benign prostatic hyperplasia, a questionnaire was conducted on the following items in Korea (Development of a questionnaire on quality of life related to benign prostatic hyperplasia: Reliability and validity verification, Journal of Korean Urological Association 41 Volume 1, 2000, 35-46).

(1) I usually want to urinate frequently, which is inconvenient.
(2) It is inconvenient because you have to get up frequently and urinate while sleeping at night.
(3) It is inconvenient for the urine to fall and wet the underwear after urine.
(4) Feeling irritated but inconvenient because urine does not come out quickly.
(5) Even if urine is pissed, it is not clean and inconvenient.
(6) It is inconvenient because it is difficult to put up with urine.
(7) The urine line is thin and inconvenient.
(8) When the body gets tired, urination does not occur well, which is inconvenient.
(9) The genital area is heavy and inconvenient.
(10) Even after pissing, the lower abdomen is heavy and inconvenient because it feels crisp.

(11) I'm worried about frequent urination and can't drink.
(12) Frequent urination is an obstacle to work.
(13) It is inconvenient to frequently urinate when traveling long distances.
(14) It is inconvenient to go to the toilet more frequently than others at liquor seats.
(15) It is inconvenient to climb a mountain or do outdoor activities.
(16) I'm worried about going out for frequent urination.
(17) I feel nervous about getting in the car for a long time.
(18) It is difficult to go into deep sleep.
(19) Nothing is aggressive or motivated.
(20) It is difficult to concentrate on one job.

(21) The person who raises the nerve without any special reason.
(22) There are many worries and worries about anything.
(23) Frequent urination is difficult and it is difficult to do religious activities such as going to churches and temples.
(24) I'm interested in participating in gatherings and other people.
(25) I am not confident that I can live a healthy life after retirement.
(26) I have a lot of concerns about my health.
(27) The condition gets worse as he gets older, and he is worried about whether to continue treatment.
(28) I am worried that my illness will be malignant.
(29) I'm worried that if the disease gets worse in the future, I can't piss at all.
(30) Libido decreased compared to before.

(31) The erection is not successful.
(32) Even if an erection occurs, it quickly wilts and semen is not discharged easily.
(33) I am not confident because of some lack of sex.
(34) I feel tired well.
(35) It is difficult to act as desired because the body is weak.

  The above 35 kinds of items correspond to “0: not at all inconvenient. 1: almost inconvenient. 2: tolerable. 3: inconvenient. 4: very inconvenient. 5: unable to withstand.” Check the score and combine the total score to assess the quality of life associated with benign prostatic hyperplasia.

The first questionnaire was created as a diagnostic questionnaire for 60 men in their 40s who usually feel inconvenient for urine, and then the 60 were divided into three groups of 20 each. For one of these groups, the carrot seed oil of Example 1 was placed in a spoid container capable of fractionating 1 ml at a time and contained in the milk 28 times. That is, 28 ml of standardized carrot seed oil was taken once a day (carrot seed oil intake group). For the other group, lauric acid was taken for comparison. Specifically, 2.5 mg of lauric acid was dissolved in 1 ml of soybean oil, and 28 ml of soybean oil dissolved in lauric acid was contained once a day (that is, the total content of lauric acid was 70 mg and carrot seed oil was contained in 28 ml of carrot seed oil). (Same as the amount of lauric acid). In addition, for one other group, 28 ml of soybean oil containing no other active ingredient was taken once a day (non-intake group). After ingesting for about 4 weeks in this way, a diagnostic questionnaire was prepared again to compare before and after ingestion of carrot seed oil, lauric acid or soybean oil.
The results are shown in Table 2 in terms of changes in the diagnostic questionnaire evaluation score (N = 60).

  As shown in Table 2 above, the diagnostic questionnaire scores of subjects who took carrot seed oil were lower. This shows that the degree of improvement is remarkably greater than when lauric acid, which is known to be good for the health of the prostate, is relaxed by the relaxation of the prostate smooth muscle and the symptoms of prostatic hypertrophy are alleviated. Therefore, it can be confirmed that the symptoms of benign prostatic hyperplasia are improved by taking carrot seed oil.

  Hereinafter, exemplary dosage forms of the composition according to an embodiment of the present invention will be described. However, various other dosage forms can be applied, which is not intended to limit the present invention but to specifically illustrate the present invention. Is.

[Formulation Example 1] Carrot Seed Oil 100% Extract After the carrot seed oil of Example 1 is produced, the carrot seed oil is concentrated so that the solid content is 20% or more, ripened at low temperature, and then 100% in liquid form. An extract product was produced.

[Dosage Form Example 2] Soft capsule 110 mg of carrot seed oil of Example 1, 0.8 mg of palm oil, 0.48 mg of vegetable hardened oil, 2.4 mg of yellow wax and 3.6 mg of lecithin are mixed and mixed in a usual manner. Filled to produce soft capsules.

[Formulation Example 3] Tablet 160 mg of carrot seed oil of Example 1, 200 mg of sucrose and 196 mg of dextrin are mixed, granulated using a fluid bed dryer, and then 7 mg of sugar ester is added to make a tablet. Tablets were produced by tableting with a machine.

[Dosage Form Example 4] Production of Maru 0.9 g of carrot seed oil of Example 1, 0.3 g of sugar, 1.91 g of starch and 0.56 g of glycerin were mixed, and a circle was produced using a round machine.

[Production Example 5] Granules 160 mg of carrot seed oil of Example 1, 200 mg of sucrose and 196 mg of dextrin were mixed, granulated using a fluid bed dryer, and then filled into a sachet to produce granules.

[Production Example 6] Drink agent After mixing 110 mg of carrot seed oil of Example 1, 10 g of sucrose, and 2 g of citric acid, 188 g of purified water was added and 200 ml of each bottle was filled. After filling the bottle, it was sterilized at 90 ° C. for 2 to 3 hours to produce a drink.

Claims (4)

A composition for prevention and treatment of benign prostatic hyperplasia containing carrot seed oil obtained by squeezing carrot seeds as an active ingredient.   The composition for preventing and treating prostatic hypertrophy according to claim 1, wherein the composition contains carrot seed oil in an amount of 0.01 to 100% by weight based on the total weight of the composition. . The composition for preventing and treating prostatic hypertrophy according to claim 1 or 2, wherein the composition is formulated as a pharmaceutical composition or a food composition. A preparation for the prevention and treatment of benign prostatic hyperplasia comprising a composition containing carrot seed oil obtained by squeezing carrot seeds as an active ingredient.

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