JP6600303B2 - 治療指数が改善されたアンフォテリシンｂ誘導体 - Google Patents

治療指数が改善されたアンフォテリシンｂ誘導体 Download PDF

Info

Publication number
JP6600303B2
JP6600303B2 JP2016519955A JP2016519955A JP6600303B2 JP 6600303 B2 JP6600303 B2 JP 6600303B2 JP 2016519955 A JP2016519955 A JP 2016519955A JP 2016519955 A JP2016519955 A JP 2016519955A JP 6600303 B2 JP6600303 B2 JP 6600303B2
Authority
JP
Japan
Prior art keywords
amb
synthesis
compound
scheme
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016519955A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016531894A (ja
JP2016531894A5 (OSRAM
Inventor
ディー バーク，マーティン
デイヴィス，スティーヴン
イー ウノ，ブライス
ストラブル，ジャスティン
デイリー，イアン
シー グレイ，ケイリン
エム ナップ，デイヴィッド
ワン，プリン
パリアム，ナーガルジュナ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
Original Assignee
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois System filed Critical University of Illinois System
Publication of JP2016531894A publication Critical patent/JP2016531894A/ja
Publication of JP2016531894A5 publication Critical patent/JP2016531894A5/ja
Priority to JP2019183577A priority Critical patent/JP7469862B2/ja
Application granted granted Critical
Publication of JP6600303B2 publication Critical patent/JP6600303B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2016519955A 2013-10-07 2014-10-06 治療指数が改善されたアンフォテリシンｂ誘導体 Active JP6600303B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019183577A JP7469862B2 (ja) 2013-10-07 2019-10-04 治療指数が改善されたアンフォテリシンｂ誘導体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361887729P 2013-10-07 2013-10-07
US61/887,729 2013-10-07
US201462045956P 2014-09-04 2014-09-04
US62/045,956 2014-09-04
PCT/US2014/059334 WO2015054148A1 (en) 2013-10-07 2014-10-06 Amphotericin b derivatives with improved therapeutic index

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019183577A Division JP7469862B2 (ja) 2013-10-07 2019-10-04 治療指数が改善されたアンフォテリシンｂ誘導体

Publications (3)

Publication Number Publication Date
JP2016531894A JP2016531894A (ja) 2016-10-13
JP2016531894A5 JP2016531894A5 (OSRAM) 2017-11-16
JP6600303B2 true JP6600303B2 (ja) 2019-10-30

Family

ID=52813555

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016519955A Active JP6600303B2 (ja) 2013-10-07 2014-10-06 治療指数が改善されたアンフォテリシンｂ誘導体
JP2019183577A Active JP7469862B2 (ja) 2013-10-07 2019-10-04 治療指数が改善されたアンフォテリシンｂ誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019183577A Active JP7469862B2 (ja) 2013-10-07 2019-10-04 治療指数が改善されたアンフォテリシンｂ誘導体

Country Status (11)

Country Link
US (4) US10323057B2 (OSRAM)
EP (1) EP3055030B1 (OSRAM)
JP (2) JP6600303B2 (OSRAM)
KR (2) KR102321482B1 (OSRAM)
CN (2) CN105848721B (OSRAM)
AU (2) AU2014332214B2 (OSRAM)
CA (1) CA2925904C (OSRAM)
DK (1) DK3055030T3 (OSRAM)
ES (1) ES2682328T3 (OSRAM)
SG (1) SG11201602570WA (OSRAM)
WO (1) WO2015054148A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3055030B1 (en) 2013-10-07 2018-05-02 The Board of Trustees of the University of Illionis Amphotericin b derivatives with improved therapeutic index
TWI702223B (zh) * 2014-06-12 2020-08-21 日商塩野義製藥股份有限公司 多烯巨環內酯衍生物
US20180273571A1 (en) * 2015-01-08 2018-09-27 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
EP3283171B1 (en) 2015-04-15 2021-05-26 Sfunga Therapeutics, Inc. Derivatives of amphotericin b
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
DK3439668T3 (da) * 2016-04-08 2024-09-02 Univ Illinois Småmolekylemedieret genoprettelse af luftvejsoverfladefysiologi i lungeepiteler ved human cystisk fibrose
WO2018106571A1 (en) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
JP7477177B2 (ja) * 2018-09-07 2024-05-01 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 毒性が低減されたハイブリッドアムホテリシンｂ誘導体
EP4009984A4 (en) * 2019-08-08 2023-09-06 The Board Of Trustees Of The University Of Illinois HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY
CN111909226A (zh) * 2020-08-11 2020-11-10 深圳市儿童医院 一种葡萄糖酸修饰的两性霉素b衍生物及其用途
KR20240164801A (ko) 2022-03-21 2024-11-20 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 암포테리신 b의 지질-코팅된 결정을 포함하는 이온 채널 보형 조성물
EP4551584A2 (en) * 2022-07-08 2025-05-14 The Board Of Trustees Of The University Of Illinois Transfer of c2'-epimerized sugars to the amphotericin b aglycone

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
AU3460693A (en) * 1992-02-12 1993-09-03 Smithkline Beecham Plc Amphotericin B derivative
WO2006078032A1 (ja) 2005-01-24 2006-07-27 Microbial Chemistry Research Foundation 抗ペニシリン耐性肺炎球菌剤及び新規１６員環マクロライド誘導体
AU2006226257A1 (en) 2005-03-23 2006-09-28 Consejo Superior De Investigaciones Cientificas Polyene antibiotics, compositions containing said antibiotics, method and micro-organisms used to obtain same and applications thereof
WO2007096137A1 (en) * 2006-02-23 2007-08-30 Eth Zurich Amphotericin derivatives
US20070238746A1 (en) * 2006-04-06 2007-10-11 Trixi Brandl Thiazolyl-dihydro-chinazoline
DE102006060008A1 (de) 2006-12-19 2008-06-26 Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH Lampe mit verbesserter Quetschungsgeometrie
GB0712881D0 (en) 2007-07-03 2007-08-15 Biosergen As Compounds
MX365184B (es) 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2014165676A1 (en) 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
EP3055030B1 (en) 2013-10-07 2018-05-02 The Board of Trustees of the University of Illionis Amphotericin b derivatives with improved therapeutic index
EP3283171B1 (en) 2015-04-15 2021-05-26 Sfunga Therapeutics, Inc. Derivatives of amphotericin b

Also Published As

Publication number Publication date
KR102321482B1 (ko) 2021-11-02
JP2016531894A (ja) 2016-10-13
NZ719529A (en) 2021-06-25
KR20210132248A (ko) 2021-11-03
CA2925904C (en) 2021-11-23
JP2020019804A (ja) 2020-02-06
CN105848721B (zh) 2019-08-23
DK3055030T3 (en) 2018-08-13
EP3055030B1 (en) 2018-05-02
US11028114B2 (en) 2021-06-08
US11117920B2 (en) 2021-09-14
US20160215012A1 (en) 2016-07-28
KR102548341B1 (ko) 2023-06-26
SG11201602570WA (en) 2016-04-28
AU2019279928A1 (en) 2020-01-16
AU2014332214A1 (en) 2016-05-19
EP3055030A1 (en) 2016-08-17
CN110407898A (zh) 2019-11-05
US20190345187A1 (en) 2019-11-14
AU2014332214B2 (en) 2019-10-03
US10323057B2 (en) 2019-06-18
ES2682328T3 (es) 2018-09-20
EP3055030A4 (en) 2017-03-15
US11970512B2 (en) 2024-04-30
US20200002368A1 (en) 2020-01-02
US20220056066A1 (en) 2022-02-24
AU2019279928B2 (en) 2020-07-23
KR20160068861A (ko) 2016-06-15
WO2015054148A1 (en) 2015-04-16
CN105848721A (zh) 2016-08-10
CA2925904A1 (en) 2015-04-16
CN110407898B (zh) 2023-12-01
JP7469862B2 (ja) 2024-04-17
NZ757647A (en) 2021-06-25

Similar Documents

Publication Publication Date Title
JP6600303B2 (ja) 治療指数が改善されたアンフォテリシンｂ誘導体
JP6726192B2 (ja) アムホテリシンｂの尿素誘導体の簡便な合成法
JP7477177B2 (ja) 毒性が低減されたハイブリッドアムホテリシンｂ誘導体
IL300482A (en) Macrophage-targeting drug conjugate
IL300441A (en) Hybrid amide derivatives of amphotericin b
NZ757647B2 (en) Amphotericin B derivatives with improved therapeutic index
HK40089361A (zh) 巨噬细胞靶向的药物缀合物
JP2000086655A (ja) トリアゾール化合物、その製造法および用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160603

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20160704

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171005

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171005

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171101

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20181003

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20181227

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190304

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190402

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190904

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20191004

R150 Certificate of patent or registration of utility model

Ref document number: 6600303

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250