AU2014332214B2 - Amphotericin B derivatives with improved therapeutic index - Google Patents

Amphotericin B derivatives with improved therapeutic index Download PDF

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Publication number
AU2014332214B2
AU2014332214B2 AU2014332214A AU2014332214A AU2014332214B2 AU 2014332214 B2 AU2014332214 B2 AU 2014332214B2 AU 2014332214 A AU2014332214 A AU 2014332214A AU 2014332214 A AU2014332214 A AU 2014332214A AU 2014332214 B2 AU2014332214 B2 AU 2014332214B2
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AU
Australia
Prior art keywords
amb
sub
compound
sup
synthesis
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AU2014332214A
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English (en)
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AU2014332214A1 (en
Inventor
Martin D. Burke
Ian DAILEY
Stephen Davis
Kaitlyn C. Gray
David M. Knapp
Nagarjuna PALYAM
Justin Struble
Brice E. Uno
Pulin Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
Original Assignee
University of Illinois at Urbana Champaign
University of Illinois System
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Publication of AU2014332214A1 publication Critical patent/AU2014332214A1/en
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Priority to AU2019279928A priority Critical patent/AU2019279928B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU2014332214A 2013-10-07 2014-10-06 Amphotericin B derivatives with improved therapeutic index Active AU2014332214B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019279928A AU2019279928B2 (en) 2013-10-07 2019-12-09 Amphotericin B derivatives with improved therapeutic index

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361887729P 2013-10-07 2013-10-07
US61/887,729 2013-10-07
US201462045956P 2014-09-04 2014-09-04
US62/045,956 2014-09-04
PCT/US2014/059334 WO2015054148A1 (en) 2013-10-07 2014-10-06 Amphotericin b derivatives with improved therapeutic index

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019279928A Division AU2019279928B2 (en) 2013-10-07 2019-12-09 Amphotericin B derivatives with improved therapeutic index

Publications (2)

Publication Number Publication Date
AU2014332214A1 AU2014332214A1 (en) 2016-05-19
AU2014332214B2 true AU2014332214B2 (en) 2019-10-03

Family

ID=52813555

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2014332214A Active AU2014332214B2 (en) 2013-10-07 2014-10-06 Amphotericin B derivatives with improved therapeutic index
AU2019279928A Active AU2019279928B2 (en) 2013-10-07 2019-12-09 Amphotericin B derivatives with improved therapeutic index

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2019279928A Active AU2019279928B2 (en) 2013-10-07 2019-12-09 Amphotericin B derivatives with improved therapeutic index

Country Status (11)

Country Link
US (4) US10323057B2 (OSRAM)
EP (1) EP3055030B1 (OSRAM)
JP (2) JP6600303B2 (OSRAM)
KR (2) KR102321482B1 (OSRAM)
CN (2) CN105848721B (OSRAM)
AU (2) AU2014332214B2 (OSRAM)
CA (1) CA2925904C (OSRAM)
DK (1) DK3055030T3 (OSRAM)
ES (1) ES2682328T3 (OSRAM)
SG (1) SG11201602570WA (OSRAM)
WO (1) WO2015054148A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3055030B1 (en) 2013-10-07 2018-05-02 The Board of Trustees of the University of Illionis Amphotericin b derivatives with improved therapeutic index
TWI702223B (zh) * 2014-06-12 2020-08-21 日商塩野義製藥股份有限公司 多烯巨環內酯衍生物
US20180273571A1 (en) * 2015-01-08 2018-09-27 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
EP3283171B1 (en) 2015-04-15 2021-05-26 Sfunga Therapeutics, Inc. Derivatives of amphotericin b
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
DK3439668T3 (da) * 2016-04-08 2024-09-02 Univ Illinois Småmolekylemedieret genoprettelse af luftvejsoverfladefysiologi i lungeepiteler ved human cystisk fibrose
WO2018106571A1 (en) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
JP7477177B2 (ja) * 2018-09-07 2024-05-01 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 毒性が低減されたハイブリッドアムホテリシンｂ誘導体
EP4009984A4 (en) * 2019-08-08 2023-09-06 The Board Of Trustees Of The University Of Illinois HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY
CN111909226A (zh) * 2020-08-11 2020-11-10 深圳市儿童医院 一种葡萄糖酸修饰的两性霉素b衍生物及其用途
KR20240164801A (ko) 2022-03-21 2024-11-20 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 암포테리신 b의 지질-코팅된 결정을 포함하는 이온 채널 보형 조성물
EP4551584A2 (en) * 2022-07-08 2025-05-14 The Board Of Trustees Of The University Of Illinois Transfer of c2'-epimerized sugars to the amphotericin b aglycone

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016090A1 (en) * 1992-02-12 1993-08-19 Smithkline Beecham Plc Amphotericin b derivative

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
WO2006078032A1 (ja) 2005-01-24 2006-07-27 Microbial Chemistry Research Foundation 抗ペニシリン耐性肺炎球菌剤及び新規１６員環マクロライド誘導体
AU2006226257A1 (en) 2005-03-23 2006-09-28 Consejo Superior De Investigaciones Cientificas Polyene antibiotics, compositions containing said antibiotics, method and micro-organisms used to obtain same and applications thereof
WO2007096137A1 (en) * 2006-02-23 2007-08-30 Eth Zurich Amphotericin derivatives
US20070238746A1 (en) * 2006-04-06 2007-10-11 Trixi Brandl Thiazolyl-dihydro-chinazoline
DE102006060008A1 (de) 2006-12-19 2008-06-26 Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH Lampe mit verbesserter Quetschungsgeometrie
GB0712881D0 (en) 2007-07-03 2007-08-15 Biosergen As Compounds
MX365184B (es) 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2014165676A1 (en) 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
EP3055030B1 (en) 2013-10-07 2018-05-02 The Board of Trustees of the University of Illionis Amphotericin b derivatives with improved therapeutic index
EP3283171B1 (en) 2015-04-15 2021-05-26 Sfunga Therapeutics, Inc. Derivatives of amphotericin b

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016090A1 (en) * 1992-02-12 1993-08-19 Smithkline Beecham Plc Amphotericin b derivative

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. N. TEVYASHOVA ET AL, "Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, US, (2013-08-01), vol. 57, no. 8, pages 3815 - 3822 *
BYRNE B ET AL, "Biosynthesis of deoxyamphotericines and deoxyamphoteronolides by engineered strains of Streptomyces nodosus", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, (2003-12-01), vol. 10, no. 12, pages 1215 - 1224 *

Also Published As

Publication number Publication date
KR102321482B1 (ko) 2021-11-02
JP2016531894A (ja) 2016-10-13
NZ719529A (en) 2021-06-25
KR20210132248A (ko) 2021-11-03
CA2925904C (en) 2021-11-23
JP2020019804A (ja) 2020-02-06
CN105848721B (zh) 2019-08-23
DK3055030T3 (en) 2018-08-13
EP3055030B1 (en) 2018-05-02
US11028114B2 (en) 2021-06-08
US11117920B2 (en) 2021-09-14
US20160215012A1 (en) 2016-07-28
KR102548341B1 (ko) 2023-06-26
SG11201602570WA (en) 2016-04-28
AU2019279928A1 (en) 2020-01-16
AU2014332214A1 (en) 2016-05-19
EP3055030A1 (en) 2016-08-17
CN110407898A (zh) 2019-11-05
US20190345187A1 (en) 2019-11-14
US10323057B2 (en) 2019-06-18
ES2682328T3 (es) 2018-09-20
EP3055030A4 (en) 2017-03-15
US11970512B2 (en) 2024-04-30
US20200002368A1 (en) 2020-01-02
US20220056066A1 (en) 2022-02-24
AU2019279928B2 (en) 2020-07-23
KR20160068861A (ko) 2016-06-15
WO2015054148A1 (en) 2015-04-16
CN105848721A (zh) 2016-08-10
CA2925904A1 (en) 2015-04-16
CN110407898B (zh) 2023-12-01
JP7469862B2 (ja) 2024-04-17
NZ757647A (en) 2021-06-25
JP6600303B2 (ja) 2019-10-30

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