JP6546161B2 - Ｂ型肝炎ウイルスを治療するための有機化合物 - Google Patents

Ｂ型肝炎ウイルスを治療するための有機化合物 Download PDF

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JP6546161B2
JP6546161B2 JP2016519839A JP2016519839A JP6546161B2 JP 6546161 B2 JP6546161 B2 JP 6546161B2 JP 2016519839 A JP2016519839 A JP 2016519839A JP 2016519839 A JP2016519839 A JP 2016519839A JP 6546161 B2 JP6546161 B2 JP 6546161B2
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strand
phosphate
end cap
mer
rnai agent
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JP2016534031A5 (enExample
JP2016534031A (ja
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リー バリザ，ジェレミー
リー バリザ，ジェレミー
ブロマーズ，マルセル
フェルナンデス，セザール
ゲノ，エリン
ゴセルト，アルバール
グリニッジ，ポレット
ヒュースケン，ディーター
フンツィカー，ユルク
ナット，フランソワ，ジャン−シャルル
パトナイク，アヌップ
パターソン，アンドリュー
ロンド，ジャン−ミシェル，レーヌ
バイラー，ヤン
チュー，メイチョン
ホルドルフ，メーガン
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ノバルティス アーゲー
ノバルティス アーゲー
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/322—2'-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/33—Chemical structure of the base
    • C12N2310/332—Abasic residue
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016519839A 2013-10-04 2014-09-30 Ｂ型肝炎ウイルスを治療するための有機化合物 Active JP6546161B2 (ja)

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US201361886760P 2013-10-04 2013-10-04
US61/886,760 2013-10-04
PCT/US2014/058314 WO2015050871A2 (en) 2013-10-04 2014-09-30 Organic compounds to treat hepatitis b virus

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JP2016534031A JP2016534031A (ja) 2016-11-04
JP2016534031A5 JP2016534031A5 (enExample) 2017-11-09
JP6546161B2 true JP6546161B2 (ja) 2019-07-17

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US (1) US10519446B2 (enExample)
EP (1) EP3052107B1 (enExample)
JP (1) JP6546161B2 (enExample)
CN (1) CN105792832B (enExample)
HK (1) HK1221912A1 (enExample)
WO (1) WO2015050871A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019135236A (ja) * 2013-10-04 2019-08-15 ノバルティス アーゲー ＲＮＡ干渉に使用するためのＲＮＡｉ剤用の３’末端キャップ

Families Citing this family (9)

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TWI695066B (zh) 2011-06-30 2020-06-01 美商艾羅海德製藥公司 用於抑制b型肝炎病毒基因表現之組合物及方法
CN105792832B (zh) 2013-10-04 2021-03-23 诺华股份有限公司 用于治疗乙肝病毒的有机化合物
EP3052627B1 (en) 2013-10-04 2018-08-22 Novartis AG Novel formats for organic compounds for use in rna interference
CA2996722A1 (en) * 2015-07-17 2017-01-26 Arcturus Therapeutics, Inc. Compositions and agents against hepatitis b virus and uses thereof
US20170137821A1 (en) 2015-07-17 2017-05-18 Arcturus Therapeutics, Inc. Molecules and agents for treating hepatitis b virus
CN108271387B (zh) 2015-08-07 2023-06-27 箭头药业股份有限公司 乙型肝炎病毒感染的RNAi疗法
JOP20170161A1 (ar) 2016-08-04 2019-01-30 Arrowhead Pharmaceuticals Inc عوامل RNAi للعدوى بفيروس التهاب الكبد ب
CN110446259B (zh) * 2018-05-04 2022-04-15 大唐移动通信设备有限公司 一种寻呼机会的位置确定方法及通信设备
WO2022038211A2 (en) * 2020-08-21 2022-02-24 F. Hoffmann-La Roche Ag Use of a1cf inhibitors for treating hepatitis b virus infection

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