JP6531990B2 - 心肺血行動態を改善するための無機亜硝酸塩 - Google Patents

心肺血行動態を改善するための無機亜硝酸塩 Download PDF

Info

Publication number
JP6531990B2
JP6531990B2 JP2015560384A JP2015560384A JP6531990B2 JP 6531990 B2 JP6531990 B2 JP 6531990B2 JP 2015560384 A JP2015560384 A JP 2015560384A JP 2015560384 A JP2015560384 A JP 2015560384A JP 6531990 B2 JP6531990 B2 JP 6531990B2
Authority
JP
Japan
Prior art keywords
nitrite
administered
pulmonary
inorganic nitrite
agent according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015560384A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016510040A (ja
JP2016510040A5 (enExample
Inventor
トーマス グラッドウィン，マーク
トーマス グラッドウィン，マーク
クレイ チャンピオン，ハンター
クレイ チャンピオン，ハンター
パセリ，エドウィン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Publication of JP2016510040A publication Critical patent/JP2016510040A/ja
Publication of JP2016510040A5 publication Critical patent/JP2016510040A5/ja
Application granted granted Critical
Publication of JP6531990B2 publication Critical patent/JP6531990B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2015560384A 2013-02-28 2014-02-28 心肺血行動態を改善するための無機亜硝酸塩 Active JP6531990B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361771063P 2013-02-28 2013-02-28
US61/771,063 2013-02-28
PCT/US2014/019703 WO2014134585A1 (en) 2013-02-28 2014-02-28 Inorganic nitrite to improve cardiopulmonary hemodynamics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019088704A Division JP2019123754A (ja) 2013-02-28 2019-05-09 心肺血行動態を改善するための無機亜硝酸塩

Publications (3)

Publication Number Publication Date
JP2016510040A JP2016510040A (ja) 2016-04-04
JP2016510040A5 JP2016510040A5 (enExample) 2017-03-30
JP6531990B2 true JP6531990B2 (ja) 2019-06-19

Family

ID=51428880

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015560384A Active JP6531990B2 (ja) 2013-02-28 2014-02-28 心肺血行動態を改善するための無機亜硝酸塩
JP2019088704A Pending JP2019123754A (ja) 2013-02-28 2019-05-09 心肺血行動態を改善するための無機亜硝酸塩
JP2022103254A Pending JP2022121544A (ja) 2013-02-28 2022-06-28 心肺血行動態を改善するための無機亜硝酸塩

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019088704A Pending JP2019123754A (ja) 2013-02-28 2019-05-09 心肺血行動態を改善するための無機亜硝酸塩
JP2022103254A Pending JP2022121544A (ja) 2013-02-28 2022-06-28 心肺血行動態を改善するための無機亜硝酸塩

Country Status (5)

Country Link
US (3) US20160008394A1 (enExample)
EP (1) EP2961479A4 (enExample)
JP (3) JP6531990B2 (enExample)
CA (1) CA2902965C (enExample)
WO (1) WO2014134585A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5564157B2 (ja) 2003-07-09 2014-07-30 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ 心臓血管状態の処置のための亜硝酸塩の使用方法
CN105101977A (zh) * 2013-02-07 2015-11-25 宾夕法尼亚大学理事会 治疗心力衰竭的方法
CA2902965C (en) * 2013-02-28 2023-08-29 Aires Pharmaceuticals, Inc. Inorganic nitrite to improve cardiopulmonary hemodynamics
CA3049003A1 (en) * 2017-01-03 2018-07-12 Cardioxyl Pharmaceuticals, Inc. Method of administering nitroxyl donating compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4509515A (en) 1982-02-23 1985-04-09 Fisons Plc Inhalation device
US4889116A (en) 1987-11-17 1989-12-26 Phospho Energetics, Inc. Adaptive control of neonatal fractional inspired oxygen
ES2082732T3 (es) 1990-12-05 1997-12-16 Gen Hospital Corp Tratamiento de la vasoconstriccion pulmonar reversible y de la broncoconstriccion.
US5427797A (en) 1993-04-06 1995-06-27 Brigham And Women's Hospital Systemic effects of nitric oxide inhalation
EP1337283A4 (en) * 2000-10-27 2005-05-18 Nitromed Inc METHODS OF TREATING VASCULAR DISEASES CHARACTERIZED BY NITROGEN MONOXIDE INSUFFICIENCY
JP5564157B2 (ja) 2003-07-09 2014-07-30 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ 心臓血管状態の処置のための亜硝酸塩の使用方法
AU2008219834C1 (en) 2007-02-26 2015-11-12 Heartbeet Ltd. New use of nitrites and nitrates and compositions containing these
ES2618655T3 (es) * 2007-02-26 2017-06-21 Heartbeet Ltd. Composición que mejora el rendimiento y uso de la misma
US8551536B2 (en) * 2007-08-31 2013-10-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitrite and nitrite-metheme therapy to detoxify stroma-free hemoglobin based blood substitutes
WO2011056572A1 (en) 2009-10-27 2011-05-12 The Board Of Trustees Of The University Of Illinois Methods of diagnosing diastolic dysfunction
GB201020811D0 (en) * 2010-12-08 2011-01-19 Solvotrin Innovations Ltd Compounds
WO2012142413A2 (en) * 2011-04-14 2012-10-18 Theravasc Inc. Nitrite compositions and uses thereof
WO2013116194A2 (en) * 2012-01-30 2013-08-08 O'connell Timothy D Method of treating or limiting development of heart failure with preserved ejection fraction and tissue fibrosis
CN105101977A (zh) * 2013-02-07 2015-11-25 宾夕法尼亚大学理事会 治疗心力衰竭的方法
CA2902965C (en) * 2013-02-28 2023-08-29 Aires Pharmaceuticals, Inc. Inorganic nitrite to improve cardiopulmonary hemodynamics

Also Published As

Publication number Publication date
US11986493B2 (en) 2024-05-21
CA2902965A1 (en) 2014-09-04
JP2022121544A (ja) 2022-08-19
WO2014134585A1 (en) 2014-09-04
US20220088065A1 (en) 2022-03-24
US11219640B2 (en) 2022-01-11
EP2961479A1 (en) 2016-01-06
JP2016510040A (ja) 2016-04-04
JP2019123754A (ja) 2019-07-25
US20180360873A1 (en) 2018-12-20
US20160008394A1 (en) 2016-01-14
EP2961479A4 (en) 2017-07-05
CA2902965C (en) 2023-08-29

Similar Documents

Publication Publication Date Title
KR100849103B1 (ko) 산화질소 흡입의 치료 효능 향상
JP2022121544A (ja) 心肺血行動態を改善するための無機亜硝酸塩
JP2017503801A (ja) 小児における急性呼吸促迫症候群の治療のための吸入一酸化窒素ガスを使用する方法
Grasso et al. Hemodynamic influence of acepromazine or dexmedetomidine premedication in isoflurane-anesthetized dogs
JP2011201907A (ja) ベンゾインデンプロスタグランジンの吸入送達法
CN100443119C (zh) 一氧化氮的吸入
RU2685706C2 (ru) Фармацевтические композиции, содержащие 15-гэпк, и способы лечения астмы и заболеваний легких с их применением
Raja et al. Effects of escalating doses of sildenafil on hemodynamics and gas exchange in children with pulmonary hypertension and congenital cardiac defects
Findlay et al. Inhaled nitric oxide reduces pulmonary artery pressures in portopulmonary hypertension
Duke et al. Decreased arterial, not O2 content, increases blood flow through intrapulmonary arteriovenous anastomoses at rest
Manara et al. Lactic acidosis following intentional overdose by inhalation of salmeterol and fluticasone
Sharpe et al. Alfentanil-midazolam anaesthesia has no electrophysiological effects upon the normal conduction system or accessory pathways in patients with Wolff-Parkinson-White syndrome
Bhat et al. Evaluation of the effects of RP5063, a novel, multimodal, serotonin receptor modulator, as single-agent therapy and co-administrated with sildenafil, bosentan, and treprostinil in a monocrotaline-induced pulmonary arterial hypertension rat model
Kumar et al. Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension
US20120107423A1 (en) Methods of Using Inhaled Nitric Oxide Gas for Treatment of Acute Respiratory Distress Syndrome
JP2024506840A (ja) 化学ガス曝露を処置する方法
JP2009534360A (ja) アルファ−ケトグルタレートを含む組成物およびその筋性能を調節するための使用
Drollmann et al. Effect of dual bronchodilation with QVA149 on cardiac safety in healthy volunteers
Pérez-Peñate et al. Long-term inhaled nitric oxide plus dipyridamole for pulmonary arterial hypertension
TWI889805B (zh) 器官損傷的預防和治療
RU2043765C1 (ru) Способ лечения хронических неспецифических заболеваний легких
Otsuka et al. Pulmonary Hypertension Associated with Severe Interstitial Pneumonia Successfully Treated with Inhaled Treprostinil: A Case Report
Roshan et al. Acute naphthalene toxicity following ingestion of mothballs and ethyl alcohol: a case report
O'Gallagher downloaded from the King’s Research Portal at https://kclpure. kcl. ac. uk/portal
Khaldi et al. Comparison of inhaled nebulised

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170227

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170227

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171107

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180207

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180227

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180731

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190409

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20190411

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20190411

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190509

R150 Certificate of patent or registration of utility model

Ref document number: 6531990

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250